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Search Result

Search Results for " histone acetyltransferase "

Targets

Histone Acetyltransferase Epigenetic Reader Domain Histone Acetyltransferase

55

Compounds

6

Natural Products

7

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T11563 Histone Acetyltransferase Inhibitor II Epigenetic Reader Domain , Histone Acetyltransferase
Histone Acetyltransferase Inhibitor II is a selective and cell permeable inhibitor of p300 histone acetyltransferase(IC50 : 5 μM).with anti-acetylase activity in mammalian cells.
T77560 Histone acetyltransferase p300 Inhibitor 4c Carbonic Anhydrase , AChE
Histone acetyltransferase p300 Inhibitor 4c is a 2-aminothiazole derivative. Histone acetyltransferase p300 Inhibitor 4c inhibited hCA I, hCA II, AChE and BChE with Ki values of 0.008 ± 0.001, 0.124 ± 0.017, 0.129 ± 0.03...
T3499 Remodelin Histone Acetyltransferase
Remodelin is an effective and specific inhibitor of the acetyl-transferase protein NAT10.
T8344 CPTH2 Apoptosis , Histone Acetyltransferase
CPTH2 is a histone acetyltransferase inhibitor modulating Gcn5 network.
T12098 MOZ-IN-2 Histone Acetyltransferase
MOZ-IN-2 is an protein MOZ inhibitor(IC50 of 125 μM).
T11807 L002 Others , Histone Acetyltransferase , STAT
L002, a potent, cell-permeable, reversible, and specific acetyltransferase p300 (KAT3B) inhibitor with an IC50 of 1.98 μM, directly binds the acetyl-CoA pocket and competitively inhibits the FATp300 catalytic domain. By ...
T6133 Remodelin hydrobromide Remodelin,Remodelin HBR RAAS , Histone Acetyltransferase
Remodelin hydrobromide (Remodelin HBR) is a novel potent and selective inhibitor of the acetyl-transferase protein NAT10.
T5468 YF-2 Others , Epigenetic Reader Domain , Histone Acetyltransferase
YF-2 is blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, CBP, PCAF, and GCN5 with EC50s of 2.75 μM, 29.04 μM and 49.31 μM , respectively
T4679 WM-1119 WM1119 Histone Acetyltransferase
WM-1119 is a highly potent, selective KAT6A/B inhibitor
T15216 EML 425 Epigenetic Reader Domain , Histone Acetyltransferase
EML 425 is a potent and selective inhibitor of CREB binding protein (CBP)/p300 (IC50s: 2.9 and 1.1 μM, respectively).
T15405 GNE-781 Epigenetic Reader Domain
GNE-781 is a highly potent and selective inhibitor of CBP (IC50: 0.94 nM in TR-FRET assay). GNE-781 also inhibits BRET and BRD4(1) (IC50s: 6.2 nM and 5100 nM, respectively).
T14073 A-485 Epigenetic Reader Domain , Histone Acetyltransferase
A-485 is a potent and selective catalytic p300/CBP inhibitor(IC50s of 9.8 nM and 2.6 nM for p300 and CBP, respectively).
T8778 TTK21 Epigenetic Reader Domain
TTK21 is an activator of CBP/p300 histone acetyltransferase activity.
T2452 C646 Apoptosis , Epigenetic Reader Domain , Histone Acetyltransferase , Autophagy
C646, a histone acetyltransferase inhibitor, inhibits p300 (Ki: 400 nM, in a cell-free assay).
T6811 CPI-637 CPI 637 Epigenetic Reader Domain , Histone Acetyltransferase
CPI-637 is a selective and cell-active benzodiazepinone CBP/EP300 bromodomain inhibitor.
T3969 I-CBP112 Epigenetic Reader Domain , Histone Acetyltransferase
I-CBP112 is a specific and potent acetyl-lysine competitive protein-protein interaction inhibitor targeting the CBP/p300 bromodomains.
T9541 CTB Cholera Toxin B subunit Epigenetic Reader Domain
CTB (Cholera Toxin B subunit) is an activator of p300 histone acetyltransferase and induces apoptosis in MCF-7 cells.
T4362 WM-8014 MOZ-IN-3 Histone Acetyltransferase
WM-8014 (MOZ-IN-3) is an inhibitor of MOZ(IC50=55 nM), a member of histone acetyltransferases.
T6908 NSC 228155 NSC228155 EGFR , Epigenetic Reader Domain , DNA/RNA Synthesis , Histone Acetyltransferase
NSC 228155 is an activator of EGFR, binding to the sEGFR dimerization domain II and modulate EGFR tyrosine phosphorylation.
T6584 MG 149 MG149,Tip60 HAT inhibitor Apoptosis , Others , Epigenetic Reader Domain , Histone Acetyltransferase
MG 149 (Tip60 HAT inhibitor) is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF(IC50= 47 uM).
T6668 SGC-CBP30 Epigenetic Reader Domain , Histone Acetyltransferase
SGC-CBP30 is an effective CREBBP/EP300 inhibitor (IC50: 21/38 nM).
T12345 CBP/p300-IN-3 P300/CBP-IN-3 Histone Acetyltransferase
CBP/p300-IN-3 (P300/CBP-IN-3) is an inhibitor of p300/CBP histone acetyltransferase.
T7856 Naphthol AS-E nAS-E Epigenetic Reader Domain , Histone Acetyltransferase
Naphthol AS-E (nAS-E) is an the KIX-KID interaction and CREB-mediated gene transcription inhibitor.
T9102 WM-3835 Apoptosis , Histone Methyltransferase , Histone Acetyltransferase
WM-3835 is a novel and high-specific small molecule inhibitor of Lysine Acetyltransferase 7 (KAT7, MYST2, HBO1) , able to potently suppressed OS cell proliferation and migration, and leads to apoptosis activation.
T8658 NEO2734 EP31670 Epigenetic Reader Domain , Histone Acetyltransferase
NEO2734 (EP31670) is an orally active and selective inhibitor of p300/CBP and BET bromodomain(IC50 of <30 nM for both p300/CBP and BET bromodomains).
T9167 PF-9363 CTX-3648 Histone Acetyltransferase
PF-9363 (CTX-3648) is a potent and high selective KAT6A/KAT6B inhibitor. PF-9363 can be used for the research of cancer.
T3217 PF-CBP1 hydrochloride PF-CBP1 HCl Epigenetic Reader Domain , Histone Acetyltransferase
PF-CBP1 hydrochloride (PF-CBP1 HCl) is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP).It inhibits CREBBP and p300 bromodomains with IC50 of 125 and 363 nM respectively.
T9373 DCH36_06 (5E)-1-(3-chloro-4-methylphenyl)-5-[(2E)-3-(furan-2-yl)prop-2-en-1-ylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione Apoptosis , Epigenetic Reader Domain , Histone Acetyltransferase
DCH36_06 ((5E)-1-(3-chloro-4-methylphenyl)-5-[(2E)-3-(furan-2-yl)prop-2-en-1-ylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione)  as a bona fide is a potent p300/CBP inhibitor
T28471 PU139 PU 139,PU-139 Histone Acetyltransferase
PU139 is a novel inhibitor of histone acetyltransferase (HAT).
T15014 CTPB Histone Acetyltransferase
CTPB is a potent p300 histone acetyltransferase (HAT) activator that can be used in the preparation of hair growth promoters and/or hair loss treatments.
T71832 CTX-0124143 Histone Acetyltransferase
CTX-0124143 is a histone acetyltransferase inhibitor with an IC50 value of 1.0 μM for KAT6A.CTX-0124143 can be used to study cellular senescence.
T82008 JG-2016 Histone Acetyltransferase
JG-2016, as a small molecule histone acetyltransferase 1 (HAT1) inhibitor, inhibits the growth of human cancer cell lines, inhibits enzyme activity in cellulose, and interferes with tumor growth.
T71740 CID-4785700 CID4785700 GTPase
CID-4785700 is a potent pan-GTPase inhibitor that inhibits Rab7 and inhibits the fungal histone acetyltransferase Rtt109 that binds to Asf1 and Vps75, and can be used in the study of lupus.
T23095 NU 9056 NU9056 Histone Acetyltransferase
NU 9056 is an effective and selective inhibitor of KAT5 histone acetyltransferase with an IC50 of 2 µM. NU 9056 blocks DNA damage response and inhibits protein acetylation in prostate cancer cell lines.
T60558 NSC 694623 Histone Acetyltransferase
NSC 694623 is a potent histone acetyltransferase (HAT) inhibitor with IC50 of 15.9 μM against recombinant HAT p300/CBP associated factor (PCAF). NSC 694623 shows anti-proliferative activity against some cancer cells, whi...
T41180 JQAD1 Epigenetic Reader Domain
JQAD1 is a potent and selective histone acetyltransferase EP300 degrader (PROTAC®; DC50≤ 31.6 nM); comprises an EP300 inhibitor, A485, joined by a linker to a cereblon E3 ligase ligand. JQAD1 brings about degradation of ...
T12346 CBP/p300-IN-5 P300/CBP-IN-5 Epigenetic Reader Domain
P300/CBP-IN-5 is a potent inhibitor of p300/CBP histone acetyltransferase (IC50 of 18.8 nM).
T40407 Histone H3 (5-23) Histone H3 (5-23)
Histone H3 (5-23), a derivative of histone H3 consisting of amino acids 5-23, serves as a substrate for histone acetyltransferase (HAT) assays.
T28472 PU141 PU 141,PU-141
PU141 is a novel inhibitor of histone acetyltransferase (HAT).
T39945 SYY-B085-1 SYY-B085-1
SYY-B085-1 is a histone acetyltransferase (HAT) inhibitor.
T25149 BF1 BF 1,BF-1
BF1 is an inhibitor of HAT (histone acetyltransferase) active both in vitro and in vivo.
T14839 Butyrolactone 3 Others
Butyrolactone 3 is a specifical inhibitor of the histone acetyltransferase Gcn5 (IC50: 100 μM) with a high affinity to the Gcn5 enzyme comparable to that of its natural substrate, histone H3. Butyrolactone 3 shows weak i...
T17068 TH1834 dihydrochloride Others
TH1834 dihydrochloride is a specific Tip60 histone acetyltransferase inhibitor. TH1834 dihydrochloride causes apoptosis and enhances DNA damage in breast cancer.
T39554 TH1834 TH1834
TH1834 is a selective inhibitor of the Tip60 (KAT5) histone acetyltransferase (HAT). It effectively induces apoptosis and promotes DNA damage in breast cancer cells. Notably, TH1834 does not influence the activity of the...
T40993 Histone H3 (1-21) Histone H3 (1-21)
Histone H3 (1-21) is a truncated form of the Histone H3 protein consisting of amino acids 1 to 21. It serves as a common substrate for methyltransferase assays targeting Histone 3 at lysine 4 and lysine 9, as well as for...
T25215 CCT077791 CCT 077791,CCT-077791 Epigenetic Reader Domain , Histone Acetyltransferase
CCT077791 is a potent inhibitor of p300 and PCAF histone acetyltransferase activity for cancer research.
T36626 Lys-CoA
Selective p300 histone acetyltransferase (HAT) inhibitor (IC50 = 50-500 nM). Exhibits approximately 100-fold selectivity for p300 over PCAF (IC50 = 200 μM). Inhibits p300-dependent transcription. Active in vivo. Lau et a...
T35818 CAY10669
CAY10669 is an inhibitor of the histone acetyltransferase PCAF (p300/CREB-binding protein-associated factor; IC50 = 662 μM), displaying a 2-fold improvement in inhibitory potency over anacardic acid . At 30-60 μM, CAY106...
T62721 CPI-1612
CPI-1612 is a potent, orally active EP300/CBP histone acetyltransferase (HAT) inhibitor that acts on EP300 HAT (IC50: 8.1 nM). CPI-1612 exhibits anticancer effects.
T72815 CBP/p300-IN-10
CBP/p300-IN-10, a potent inhibitor targeting histone acetyltransferase enzymes EP300 and CREBBP, exhibits IC50 values of 26 nM and 39 nM, respectively. This compound shows potential for anticancer research applications.

Compounds

Histone Acetyltransferase Inhibitor II
T11563
Synonym:
Target: Epigenetic Reader Domain, Histone Acetyltransferase
Histone acetyltransferase p300 Inhibitor 4c
T77560
Synonym:
Target: Carbonic Anhydrase, AChE
Remodelin
T3499
Synonym:
Target: Histone Acetyltransferase
CPTH2
T8344
Synonym:
Target: Apoptosis, Histone Acetyltransferase
MOZ-IN-2
T12098
Synonym:
Target: Histone Acetyltransferase
L002
T11807
Synonym:
Target: Others, Histone Acetyltransferase, STAT
Remodelin hydrobromide
T6133
Synonym: Remodelin,Remodelin HBR
Target: RAAS, Histone Acetyltransferase
YF-2
T5468
Synonym:
Target: Others, Epigenetic Reader Domain, Histone Acetyltransferase
WM-1119
T4679
Synonym: WM1119
Target: Histone Acetyltransferase
EML 425
T15216
Synonym:
Target: Epigenetic Reader Domain, Histone Acetyltransferase
GNE-781
T15405
Synonym:
Target: Epigenetic Reader Domain
A-485
T14073
Synonym:
Target: Epigenetic Reader Domain, Histone Acetyltransferase
TTK21
T8778
Synonym:
Target: Epigenetic Reader Domain
C646
T2452
Synonym:
Target: Apoptosis, Epigenetic Reader Domain, Histone Acetyltransferase, Autophagy
CPI-637
T6811
Synonym: CPI 637
Target: Epigenetic Reader Domain, Histone Acetyltransferase
I-CBP112
T3969
Synonym:
Target: Epigenetic Reader Domain, Histone Acetyltransferase
CTB
T9541
Synonym: Cholera Toxin B subunit
Target: Epigenetic Reader Domain
WM-8014
T4362
Synonym: MOZ-IN-3
Target: Histone Acetyltransferase
NSC 228155
T6908
Synonym: NSC228155
Target: EGFR, Epigenetic Reader Domain, DNA/RNA Synthesis, Histone Acetyltransferase
MG 149
T6584
Synonym: MG149,Tip60 HAT inhibitor
Target: Apoptosis, Others, Epigenetic Reader Domain, Histone Acetyltransferase
SGC-CBP30
T6668
Synonym:
Target: Epigenetic Reader Domain, Histone Acetyltransferase
CBP/p300-IN-3
T12345
Synonym: P300/CBP-IN-3
Target: Histone Acetyltransferase
Naphthol AS-E
T7856
Synonym: nAS-E
Target: Epigenetic Reader Domain, Histone Acetyltransferase
WM-3835
T9102
Synonym:
Target: Apoptosis, Histone Methyltransferase, Histone Acetyltransferase
NEO2734
T8658
Synonym: EP31670
Target: Epigenetic Reader Domain, Histone Acetyltransferase
PF-9363
T9167
Synonym: CTX-3648
Target: Histone Acetyltransferase
PF-CBP1 hydrochloride
T3217
Synonym: PF-CBP1 HCl
Target: Epigenetic Reader Domain, Histone Acetyltransferase
DCH36_06
T9373
Synonym: (5E)-1-(3-chloro-4-methylphenyl)-5-[(2E)-3-(furan-2-yl)prop-2-en-1-ylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
Target: Apoptosis, Epigenetic Reader Domain, Histone Acetyltransferase
PU139
T28471
Synonym: PU 139,PU-139
Target: Histone Acetyltransferase
CTPB
T15014
Synonym:
Target: Histone Acetyltransferase
CTX-0124143
T71832
Synonym:
Target: Histone Acetyltransferase
JG-2016
T82008
Synonym:
Target: Histone Acetyltransferase
CID-4785700
T71740
Synonym: CID4785700
Target: GTPase
NU 9056
T23095
Synonym: NU9056
Target: Histone Acetyltransferase
NSC 694623
T60558
Synonym:
Target: Histone Acetyltransferase
JQAD1
T41180
Synonym:
Target: Epigenetic Reader Domain
CBP/p300-IN-5
T12346
Synonym: P300/CBP-IN-5
Target: Epigenetic Reader Domain
Histone H3 (5-23)
T40407
Synonym: Histone H3 (5-23)
Target:
PU141
T28472
Synonym: PU 141,PU-141
Target:
SYY-B085-1
T39945
Synonym: SYY-B085-1
Target:
BF1
T25149
Synonym: BF 1,BF-1
Target:
Butyrolactone 3
T14839
Synonym:
Target: Others
TH1834 dihydrochloride
T17068
Synonym:
Target: Others
TH1834
T39554
Synonym: TH1834
Target:
Histone H3 (1-21)
T40993
Synonym: Histone H3 (1-21)
Target:
CCT077791
T25215
Synonym: CCT 077791,CCT-077791
Target: Epigenetic Reader Domain, Histone Acetyltransferase
Lys-CoA
T36626
Synonym:
Target:
CAY10669
T35818
Synonym:
Target:
CPI-1612
T62721
Synonym:
Target:
CBP/p300-IN-10
T72815
Synonym:
Target:
1 2
Cat No. Product Name Synonyms Targets
T11366 Garcinol Apoptosis , Endogenous Metabolite , Histone Acetyltransferase , AChR , AChE
Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and anti-cancer activity. Garcinol, a polyisoprenylated benzophenone...
TN1150 Procyanidin B3 Histone Acetyltransferase
Procyanidin B3(B3) is a procyanidin dimer that is widely studied due to its high abundance in the human diet and antioxidant activity.
T6389 Anacardic Acid 6-pentadecylsalicylic Acid,Hydroginkgolic acid Others , Epigenetic Reader Domain , Histone Acetyltransferase , Antibacterial
Anacardic Acid (6-pentadecylsalicylic Acid) is an effective inhibitor of p300 and p300/CBP-associated factor histone acetyltranferases. It also has antimicrobial activity, antibacterial activity, and inhibits prostagland...
T0065 Acetaminophen 4-Acetamidophenol,4'-Hydroxyacetanilide,APAP,Paracetamol COX , Endogenous Metabolite , Histone Acetyltransferase
Acetaminophen (APAP) is a COX inhibitor that inhibits COX-1 and COX-2 (IC50=113.7/25.8 μM). Acetaminophen has antipyretic and analgesic activity as well as weak anti-inflammatory activity.
T1516 Curcumin Diferuloylmethane,Natural Yellow 3,Indian Saffron,Turmeric yellow Mitophagy , Epigenetic Reader Domain , Ferroptosis , Influenza Virus , Nrf2 , Histone Acetyltransferase , HDAC , Autophagy
Curcumin (Natural Yellow 3) is a phenolic natural product, an inhibitor of histone acetyltransferase p300/CREB (IC50=25 μM) with specificity. Curcumin has a wide range of pharmacological activities such as antitumor, ant...
TN1567 Delphinidin chloride Estrogen Receptor/ERR , VEGFR
Delphinidin chloride, a natural plant pigment found in berries and red wine, is a precursor of certain anthocyanins. Delphinidin chloride induces the release of nitric oxide from the vascular endothelium, resulting in va...

Natural Products

Garcinol
T11366
Synonym:
Target: Apoptosis, Endogenous Metabolite, Histone Acetyltransferase, AChR, AChE
Procyanidin B3
TN1150
Synonym:
Target: Histone Acetyltransferase
Anacardic Acid
T6389
Synonym: 6-pentadecylsalicylic Acid,Hydroginkgolic acid
Target: Others, Epigenetic Reader Domain, Histone Acetyltransferase, Antibacterial
Acetaminophen
T0065
Synonym: 4-Acetamidophenol,4'-Hydroxyacetanilide,APAP,Paracetamol
Target: COX, Endogenous Metabolite, Histone Acetyltransferase
Curcumin
T1516
Synonym: Diferuloylmethane,Natural Yellow 3,Indian Saffron,Turmeric yellow
Target: Mitophagy, Epigenetic Reader Domain, Ferroptosis, Influenza Virus, Nrf2, Histone Acetyltransferase, HDAC, Autophagy
Delphinidin chloride
TN1567
Synonym:
Target: Estrogen Receptor/ERR, VEGFR

Recombinant Proteins

Species：
Human (7)
Expression System：
E. coli (6)
Baculovirus-Insect Cells (1)
Tag：
GST (2)
His (2)
N-6His (1)
N-terminal 10xHis-tagged (1)
N-terminal 6xHis-tagged (1)
Cat No. Product Name Species Expression System
TMPH-03748 KAT14 Protein, Human, Recombinant (His) Human E. coli
Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to promote ATAC complex stability. Has also weak histone acetyltrans...
TMPY-02981 ING5 Protein, Human, Recombinant (GST) Human E. coli
ING5 belongs to the ING family. It contains 1 PHD-type zinc finger and is a component of the HBO1 complex. HBO1 complex has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is re...
TMPY-03498 ING4 Protein, Human, Recombinant (His) Human E. coli
ING4 is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. ING4 contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling...
TMPJ-01353 MBIPP Protein, Human, Recombinant (His) Human E. coli
MAP3K12-binding inhibitory protein 1 (MBIP) is a 39kD protein high expression in the heart and lung. It is a component of the ADA2A-containing complex (ATAC) complex, a complex with histone acetyltransferase activity on ...
TMPY-03283 HBP1 Protein, Human, Recombinant (GST) Human E. coli
HBP1 is a sequence-specific DNA-binding transcription factor. It is involved in many biological processes. It was reported that HBP1 binds to p16(INK4A) promoter and activates p16(INK4A) expression. We found that trichos...
TMPY-03263 RUVBL1 Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
RUVBL1, also known as RVB1, is a component of the NuA4 histone acetyltransferase complex and belongs to the RuvB family. RUVBL1 is ubiquitously expressed with high expression in heart, skeletal muscle and testis. It poss...
TMPH-01239 XPC Protein, Human, Recombinant (His) Human E. coli
Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B an...
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