Search Result

Search Results for " hepg2 "

Targets

Others Reactive Oxygen Species Antifungal

181

Compounds

117

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T5116	Iprodione		Others , Reactive Oxygen Species , Antifungal
	Iprodione is a fungicide. Iprodione is also used in cannabis testing kits as a component of pesticide mixes.		Others , Reactive Oxygen Species , Antifungal
T9753	LEI110		Phospholipase
	LEI110 is a potent Phospholipase A2, group XVI (PLA2G16) inhibitor with an Ki value of 20 nM. LEI110 is a selective pan-inhibitor of the HRASLS family of thiol hydrolases (i.e., PLA2G16, HRASLS2, RARRES3 and iNAT).		Phospholipase
T7149	S29434		NADPH , Autophagy
	S29434 (NMDPEF) is a potent, competitiveinhibitor of quinone reductase 2 (QR2;IC50:5-16nM).		NADPH , Autophagy
T15371	Gardiquimod		TLR , HIV Protease
	Gardiquimod is a TLR7/8 agonist. When used at concentrations below 10 μM, Gardiquimod specifically activates TLR7. Gardiquimod could inhibit HIV-1 infection of macrophages and activated peripheral blood mononuclear cells...		TLR , HIV Protease
T7955	EB-3D		Apoptosis , AMPK , AChR
	EB-3D is a potent and selective choline kinase alpha 1 (ChoKα1) inhibitor(IC50 : 1 μM).with anti-cancer activity.		Apoptosis , AMPK , AChR
T11669	IR415		HBV
	IR415 selectively interacts with Hepatitis B virus X protein (HBx, Kd = 2 nM) and blocks HBV-mediated RNAi suppression, reverses the inhibitory effect of HBx protein on the activity of the dicer endoribonuclease. IR415 i...		HBV
T27478	GSK3987		Liver X Receptor
	GSK3987 is an LXR ligand. GSK3987 recruits the steroid receptor coactivator-1 to human LXRalpha and LXRbeta with EC50s of 40 nM.		Liver X Receptor
T2496	(Z)-Semaxinib	SU5416	VEGFR
	(Z)-Semaxinib (SU5416) is a potent and selective VEGFR(Flk-1/KDR) inhibitor (IC50: 1.23 μM), 20-fold more selective for VEGFR over PDGFRβ, no inhibition for FGFR, InsR, and EGFR. (Z)-Semaxinib is a quinolone derivative w...		VEGFR
T4235	Roblitinib	FGF-401	FGFR
	Roblitinib (FGF-401) is an inhibitor of human fibroblast growth factor receptor 4 (FGFR4), with potential antineoplastic activity. Upon administration, Roblitinib binds to and inhibits the activity of FGFR4, which leads ...		FGFR
T26674	AT-130	AT 130	HBV , DNA/RNA Synthesis
	AT-130 is a HBV virus inhibitor with improved potency (IC50 = 0.13 μM) and reduced toxicity in the HepAD38 cell line. AT-130 blocks HBV replication at the level of viral RNA packaging.		HBV , DNA/RNA Synthesis
T9276	SBC-115337		Others , Serine/threonin kinase
	SBC-115337 is a PCSK9 inhibitor.		Others , Serine/threonin kinase
T4264	Takinib	EDHS-206	Apoptosis , MAPK
	Takinib (EDHS-206) is a specific and effective TAK1 inhibitor(IC50= 9.5 nM).		Apoptosis , MAPK
T1889	CP-640186	CP 640186	Acetyl-CoA Carboxylase
	CP-640186 is an isozyme-nonselective Acetyl-CoA carboxylase (ACCase) inhibitor. The IC50s of CP-640186(CP 640186) is 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively.		Acetyl-CoA Carboxylase
T9098	DMG-PEG 2000	DMG-PEG2000	Others
	DMG-PEG 2000 (DMG-PEG2000) is a lipid excipient that has been used in combination with other lipids in the formation of lipid nanoparticles. Formulations containing DMG-PEG 2000 have been used in the development of lipid...		Others
T9984	Antimalarial agent 13	N2-(3-chlorophenyl)-N4-(furan-2-ylmethyl)quinazoline-2,4-diamine	Parasite
	Antimalarial agent 13 (N2-(3-chlorophenyl)-N4-(furan-2-ylmethyl)quinazoline-2,4-diamine) is a potent antimalarial agent.		Parasite
T16961	Supinoxin	RX-5902	Apoptosis , DNA/RNA Synthesis
	Supinoxin (RX-5902) is an orally active inhibitor of phosphorylated-p68 RNA helicase and a potent first-in-class anti-cancer agent. Supinoxin induces cell apoptosis and inhibits the growth of TNBC cancer cell lines (IC50...		Apoptosis , DNA/RNA Synthesis
T1057	Azilsartan	TAK-536	RAAS
	Azilsartan (TAK-536) is an Angiotensin 2 Receptor Blocker. The mechanism of action of azilsartan is as an Angiotensin 2 Type 1 Receptor Antagonist. The physiologic effect of azilsartan is by means of Decreased Blood Pres...		RAAS
T8445	PU02	PU-02,6-[(1-Naphthalenylmethyl)thio]-9H-purine	Apoptosis , 5-HT Receptor
	PU02 (6-[(1-Naphthalenylmethyl)thio]-9H-purine) is a potent and selective antagonist of 5-HT3 receptor.		Apoptosis , 5-HT Receptor
T3622	CP-640186 hydrochloride	CP 640186 HCl	Acetyl-CoA Carboxylase
	CP-640186 hydrochloride (CP 640186 HCl) is an isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor, including rat liver ACC1 (IC50: 53 nM) and rat skeletal muscle ACC2 (IC50: 61 nM); with higher metabolic stabilit...		Acetyl-CoA Carboxylase
T22443	Triglycidyl isocyanurate	Tris(2,3-epoxypropyl) Isocyanurate,Teroxirone,TGIC,TGI	Apoptosis
	Triglycidyl isocyanurate (Teroxirone) is a triazene triepoxide with antineoplastic and antiangiogenic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. Triglycidyl isocyanurate alk...		Apoptosis
T9945	MNK8	3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione	STAT
	MNK8 (3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione) is a potent STAT3 inhibitor that reduces the ability of STAT3 to bind to DNA and also has a good growth inhibition effect on liver cancer cells [1].		STAT
T5045	GSK4112	1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate,SR6452	Autophagy
	GSK4112 (SR6452) is a Rev-erbα agonist with EC50 of 0.4 μM, also is a small molecule chemical probe for the cell biology of the nuclear heme receptor Rev-erbα.		Autophagy
T7606	Guanosine 5'-diphosphate disodium salt	5'-GDP-Na2	Endogenous Metabolite
	Guanosine 5'-diphosphate disodium salt (5'-GDP-Na2) is a nucleoside diphosphate, is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulating the interleukin-6 (IL-6)/stat-3 pathway.		Endogenous Metabolite
T6583	MG-101	ALLN,Ac-LLnL-CHO,Calpain inhibitor I,Calpain inhibitor-1,MG101	Cysteine Protease , Proteasome
	MG-101 (Calpain inhibitor I) is a cell-permeable and potent inhibitor of cysteine proteases including calpains and lysosomal cathepsins.		Cysteine Protease , Proteasome
T5858	Sertindole	Lu 23-174	Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor , Autophagy
	Sertindole (Lu 23-174) is an atypical antipsychotic that binds to dopamine D2 receptors and the serotonin (5-HT) receptor subtypes 5-HT1D, 5-HT2A, and 5-HT2C (Kds = 2.7, 20, 0.14, and 6 nM, respectively)
T1406	Amantadine hydrochloride	1-adamantanamine HCl,1-Adamantanamine hydrochloride,Symmetrel,CI-719,Amantadine HCl,1-Adamantylamine hydrochloride	Dopamine Receptor , Influenza Virus
	Amantadine hydrochloride (CI-719) is an antiviral that is used in the prophylactic or symptomatic treatment of influenza A and Parkinson disease.		Dopamine Receptor , Influenza Virus
T11321	FR194738 free base		Antifungal
	FR194738 free base inhibits squalene epoxidase activity in HepG2 cell homogenates with an IC50 of 9.8 nM.		Antifungal
T6412	CVT-12012		Stearoyl-CoA Desaturase (SCD)
	CVT-12012 is an orally bioavailable inhibitor of stearoyl-CoA desaturase (SCD; IC50 = 6.1 nM in HepG2 cells).		Stearoyl-CoA Desaturase (SCD)
T13356	XEN723		Dehydrogenase , Stearoyl-CoA Desaturase (SCD)
	XEN723 is a potent thiazolylimidazolidinone Stearoyl-CoA Desaturase (SCD1) inhibitor(IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively).		Dehydrogenase , Stearoyl-CoA Desaturase (SCD)
T12931	SLC13A5-IN-1		Stearoyl-CoA Desaturase (SCD)
	SLC13A5-IN-1 is a selective inhibitor of sodium-citrate co-transporter (SLC13A5),completely blocks the uptake of 14C-citrate(IC50 : 0.022 μM in HepG2 cells).		Stearoyl-CoA Desaturase (SCD)
T14766	BPH-715		Others , Parasite
	BPH-715 inhibits the liver-stage growth of P. falciparum with an IC50 of 10 μM for P. falciparum exoerythrocytic forms in HepG2 cells.		Others , Parasite
T28903	T-3364366	T 3364366,T3364366	Others
	T-3364366 is an inhibitor of thienopyrimidinone delta-5 desaturase (Δ5D) with IC50s of 1.9 nM and 2.1 nM in HepG2 and RLN-10 cells, respectively.		Others
T0085	Entecavir monohydrate	SQ 34676,BMS-200475,Entecavir hydrate	HBV
	Entecavir monohydrate (BMS-200475) is a selective inhibitor of the replication of the hepatitis B virus (HBV). It, a new deoxyguanine nucleoside analog.		HBV
T77728	Tubulin polymerization-IN-55		Microtubule Associated
	Tubulin polymerization-IN-55 is a potent Tubulin Polymerization inhibitor with potential anti-angiogenic and anti-tumour activity, showing anti-proliferative effects against A549, K562, HepG2, MDA-MB-231 and HFL-1.		Microtubule Associated
T65086	Cis-5-Norbornene-exo-2,3-dicarboxylic Anhydride		Apoptosis , Phosphatase
	Cis-5-Norbornene-exo-2,3-dicarboxylic Anhydride may cause sensitization. Cis-5-Norbornene-exo-2,3-dicarboxylic Anhydride promotes apoptosis in HepG2 (IC50= 62 μM) and SK-Hep1 (IC50= 151 μM) cells and inhibits protein pho...		Apoptosis , Phosphatase
TP1881L1	Pep 2-8 ammonium salt(1541011-97-5 free base)		Others
	Pep 2-8 ammonium salt is Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. Potent inhibitor of PCSK9 binding to LDL receptor (IC50 = 0.8 μM). Restores LDL uptake in HepG2 cells treated with PCSK9.		Others
T83627	Pim-1 kinase inhibitor 8		Pim , PKC
	Pim-1 kinase inhibitor 8 is a potent Pim-1 kinase inhibitor with anticancer activity and can effectively inhibit cell migration.Pim-1 kinase inhibitor 8 is cytotoxic to MCF-7 and HepG2 cells, and is a candidate compound ...		Pim , PKC
T64357	FA16	FA 16,FA-16	Ferroptosis
	FA16 is a selective, metabolically stable ferroptosis inducer with an IC50 value of 1.26 μM.FA16 is a derivative of 2-(trifluoromethyl)benzimidazole.FA16 inhibits the cystine/glutamate inverse transporter protein (system...		Ferroptosis
T15660	KHK-IN-1	KHK-IN-8,Ketohexokinase inhibitor 8	Others
	KHK-IN-1 (KHK-IN-8) is a selective and cell membrane permeable inhibitor of ketohexokinase (KHK, IC50=12 nM; F=34%). KHK-IN-1 inhibits F1P production in HepG2 cell lysates with IC50 of 400 nM. KHK-IN-1 has potential for ...		Others
T3132	SC66		Apoptosis , Akt
	SC66 is a AKT inhibitor in HepG2, HA22T/VGH, and PLC/PRF/5 cells (IC50: about 0.75 μg/ml, at 72 h).		Apoptosis , Akt
T60654	KDM4C-IN-1		Histone Demethylase
	KDM4C-IN-1 is a selective and potent KDM4C inhibitor (IC50: 8 nM) with potential anticancer activity.KDM4C-IN-1 inhibits the growth of HepG2 and A549 cells, and can be used for the study of leukaemia.		Histone Demethylase
T16727	Relacorilant	CORT 125134	Glucocorticoid Receptor
	Relacorilant is a selective and orally bioavailable antagonist of glucocorticoid receptor(Ki of 7.2 nM in HepG2 TAT assay, and also shows Kis of 12, 81.2, 210 nM for rat, human and monkey glucocorticoid receptor in cell-...		Glucocorticoid Receptor
T67776	PCSK9-IN-11		Others
	PCSK9-IN-11 (compound 5r) is a potent PCSK9 inhibitor with oral activity. PCSK9-IN-11 shows inhibitory activity of PCSK9 transcription in HepG2 cells (IC50= 5.7 μM). PCSK9-IN-11 can increase LDL receptor (LDLR) protein l...		Others
T7088	Diflubenzuron	Dimilin,Difubenzuron,Larvakil,Difluron	P450
	Diflubenzuron (Larvakil) is a benzoyl-urea insecticide, found to be a potent inhibitor of melanosome synthesis in mouse melanoma cells. Diflubenzuron has also been shown to inhibit TCDD-induced CYP1A1 expression in HepG2...		P450
T0085L	Entecavir	BMS200475,SQ34676	HBV
	Entecavir (SQ34676) is a guanosine nucleoside analogue used in the treatment of chronic hepatitis B virus (HBV) infection. Entecavir therapy can be associated with flares of the underlying hepatitis B during or after the...		HBV
T8740	COH-SR4	COH-SR4 (Mitochondria uncoupler SR4)	Others , AMPK
	COH-SR4 (COH-SR4 (Mitochondria uncoupler SR4)) is a uncoupler of mitochondrial oxidative phosphorylation. COH-SR4 modulates amp-dependent kinase (ampk)-mammalian target of rapamycin (mtor) signaling, and inhibiting proli...		Others , AMPK
T14878	CAY10566		Dehydrogenase , Stearoyl-CoA Desaturase (SCD)
	CAY10566 shows excellent cellular activity in blocking the conversion of saturated long-chain fatty acid-CoAs (LCFA-CoAs) to monounsaturated LCFA-CoAs in HepG2 cells (IC50=7.9 nM or 6.8 nM). CAY10566 is a potent, orally ...		Dehydrogenase , Stearoyl-CoA Desaturase (SCD)
T67791	BMS-903452		GPR
	BMS-903452 is a potent and selective GPR119 agonist with EC50 of 14 nM. BMS-903452 is indicated for the treatment of acute and chronic rodent diabetes. GPR119 was mainly expressed in pancreatic b cells and gastrointestin...		GPR
T37149	Carbamazepine 10,11-epoxide		Others
	Carbamazepine 10,11-epoxide is an active metabolite of the anticonvulsant carbamazepine.1,2It is formed from carbamazepine by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP2C8 in microsomes prepared from HepG2 cells e...		Others
T36126	TMP-153
	Acyl-CoA:cholesterol acyltransferase (ACAT) catalyses the esterification of excess cellular cholesterol with fatty acids and is important for intestinal cholesterol absorption, hepatic lipoprotein secretion, and choleste...

Compounds

Iprodione

T5116

Synonym:

Target: Others, Reactive Oxygen Species, Antifungal

LEI110

T9753

Synonym:

Target: Phospholipase

S29434

T7149

Synonym:

Target: NADPH, Autophagy

Gardiquimod

T15371

Synonym:

Target: TLR, HIV Protease

EB-3D

T7955

Synonym:

Target: Apoptosis, AMPK, AChR

Target: Liver X Receptor

Target: HBV, DNA/RNA Synthesis

SBC-115337

T9276

Synonym:

Target: Others, Serine/threonin kinase

Takinib

T4264

Synonym: EDHS-206

Target: Apoptosis, MAPK

CP-640186

T1889

Synonym: CP 640186

Target: Acetyl-CoA Carboxylase

Antimalarial agent 13

T9984

Synonym: N2-(3-chlorophenyl)-N4-(furan-2-ylmethyl)quinazoline-2,4-diamine

Target: Apoptosis, DNA/RNA Synthesis

Synonym: PU-02,6-[(1-Naphthalenylmethyl)thio]-9H-purine

Target: Apoptosis, 5-HT Receptor

CP-640186 hydrochloride

T3622

Synonym: CP 640186 HCl

Target: Acetyl-CoA Carboxylase

Triglycidyl isocyanurate

T22443

Synonym: Tris(2,3-epoxypropyl) Isocyanurate,Teroxirone,TGIC,TGI

Target: Apoptosis

MNK8

T9945

Synonym: 3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione

Target: STAT

GSK4112

T5045

Synonym: 1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate,SR6452

Target: Autophagy

Guanosine 5'-diphosphate disodium salt

T7606

Synonym: 5'-GDP-Na2

Target: Endogenous Metabolite

MG-101

T6583

Synonym: ALLN,Ac-LLnL-CHO,Calpain inhibitor I,Calpain inhibitor-1,MG101

Target: Cysteine Protease, Proteasome

Sertindole

T5858

Synonym: Lu 23-174

Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor, Autophagy

Amantadine hydrochloride

T1406

Synonym: 1-adamantanamine HCl,1-Adamantanamine hydrochloride,Symmetrel,CI-719,Amantadine HCl,1-Adamantylamine hydrochloride

Target: Dopamine Receptor, Influenza Virus

Target: Stearoyl-CoA Desaturase (SCD)

XEN723

T13356

Synonym:

Target: Dehydrogenase, Stearoyl-CoA Desaturase (SCD)

SLC13A5-IN-1

T12931

Synonym:

Target: Stearoyl-CoA Desaturase (SCD)

BPH-715

T14766

Synonym:

Target: Others, Parasite

T-3364366

T28903

Synonym: T 3364366,T3364366

Target: Others

Entecavir monohydrate

T0085

Synonym: SQ 34676,BMS-200475,Entecavir hydrate

Target: HBV

Tubulin polymerization-IN-55

T77728

Synonym:

Target: Microtubule Associated

Cis-5-Norbornene-exo-2,3-dicarboxylic Anhydride

T65086

Synonym:

Target: Apoptosis, Phosphatase

Pep 2-8 ammonium salt(1541011-97-5 free base)

TP1881L1

Synonym:

Target: Others

Pim-1 kinase inhibitor 8

Synonym: KHK-IN-8,Ketohexokinase inhibitor 8

Target: Apoptosis, Akt

KDM4C-IN-1

T60654

Synonym:

Target: Histone Demethylase

Relacorilant

T16727

Synonym: CORT 125134

Target: Glucocorticoid Receptor

Synonym: Dimilin,Difubenzuron,Larvakil,Difluron

Target: P450

Entecavir

T0085L

Synonym: BMS200475,SQ34676

Target: HBV

COH-SR4

T8740

Synonym: COH-SR4 (Mitochondria uncoupler SR4)

Target: Dehydrogenase, Stearoyl-CoA Desaturase (SCD)

Carbamazepine 10,11-epoxide

Cat No.	Product Name	Synonyms	Targets
T8198	Visnagin		Others
	Visnagin has acute hypotensive, anti-inflammatory, and neuroprotective effects, it protects against doxorubicin-induced cardiomyopathy through modulation of mitochondrial malate dehydrogenase.		Others
T3S1251	Neoruscogenin		ROR
	1. Neoruscogenin represents a universal pharmacological tool for RORα research due to its specific selectivity profile versus other nuclear receptors.		ROR
T2963	Cholic Acid	Cholanic acid,Cholate,Colalin	Endogenous Metabolite
	Cholic Acid (Cholate) is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. Cholic acid facilitates fat absorption and cholesterol excretion.		Endogenous Metabolite
T4537	Cholic acid sodium	SodiumCholate	HIV Protease , Endogenous Metabolite
	Cholic acid sodium (SodiumCholate) exhibits a strong spermicidal and antiviral [anti-human immunodeficiency virus (HIV)-1] activity.		HIV Protease , Endogenous Metabolite
T7210	Guanosine 5'-diphosphate	GDP	Endogenous Metabolite
	Guanosine 5'-diphosphate (GDP) as Potential Iron Mobilizer, Preventing the Hepcidin-Ferroportin Interaction and Modulating the Interleukin-6/Stat-3 Pathway.		Endogenous Metabolite
T5S0106	Peimisine	Ebeiensine	RAAS , AChR
	1. Peimisine (Ebeiensine) can affect M-receptor, excit β-receptor, restrain the release of internal calcium, and promote to releaseing nitrogen monoxidum in order to relax tracheal smooth muscle and relieve asthma. 2. Pe...		RAAS , AChR
T4034	Solamargine	Solamargin,δ-Solanigrine	Apoptosis , p38 MAPK , P-gp , STAT
	Solamargine (δ-Solanigrine) is a major steroidal alkaloid glycoside extracted from a traditional Chinese medicine herb, Solanum nigrum L. (SNL); has been shown to inhibit growth and induce apoptosis of various cancer cel...		Apoptosis , p38 MAPK , P-gp , STAT
T3673	Mollugin	Rubimaillin	HER , JAK
	Mollugin (Rubimaillin) may be a JAK2 inhibitor and inhibits LPS-induced inflammatory responses by blocking the activation of the JAK-STAT pathway. Mollugin as a candidate for a chemotherapeutic agent in OSCCs via the upr...		HER , JAK
T0687	Simvastatin	MK-0733,MK 733	Apoptosis , Mitophagy , Ferroptosis , HMG-CoA Reductase , Autophagy
	Simvastatin (MK 733) is an HMG-CoA reductase inhibitor (Ki=0.2 nM) with oral activity. Simvastatin has hypolipidemic activity, inhibits hepatic production of cholesterol, and is also used for the prevention of cardiovasc...
T4939	Indole-3-pyruvic acid	3-(3-Indolyl)-2-oxopropanoic acid	Others
	Indole-3-pyruvic acid (3-(3-Indolyl)-2-oxopropanoic acid) is a compound involved in the biosynthesis of Indole-3-acetic acid, a plant hormone which plays important roles in regulating growth and responses to environmenta...		Others
T7060	Amantadine	1-Aminoadamantane,1-Adamantanamine,1-Adamantylamine	Others
	Amantadine (1-Aminoadamantane) is an antiviral, is a weak antagonist of the NMDA-type glutamate receptor, increases dopamine release, and blocks dopamine reuptake.		Others
T5A2455	Arenobufagin		Others
	Arenobufagin is a natural bufadienolide from toad venom with potent antineoplastic activity against HCC HepG2 cells and corresponding multidrug-resistant HepG2/ADM cells.		Others
T3844	Deltonin		ERK , Others , Akt , Endogenous Metabolite
	Deltonin has an inhibition of ERK1/2 and AKT activation. Deltonin shows cytotoxicity against human HepG2 cells (IC50: 7.66 μM), mouse C26 cells (IC50: 1.22 μM), and human MDA-MB-231 cells (IC50: 1.58 μM).		ERK , Others , Akt , Endogenous Metabolite
TMS0879	Asiaticoside B		Others
	Asiaticoside B is a triterpene glycoside isolated from Actaea asiatica. It has notable cytotoxicity against HepG2 and MCF-7 cancer cell lines.		Others
T1704	Diosmetin	Luteolin 4-methyl ether	P450 , Trk receptor
	Diosmetin (Luteolin 4-methyl ether) has been found to act as a weak TrkB receptor agonist.		P450 , Trk receptor
TN1058	Pelargonidin chloride		NOS , Reactive Oxygen Species , Nrf2 , NO Synthase
	Pelargonidin chloride shows protective effect against CTN-induced oxidative stress in HepG2 cells and up-regulated the activity of detoxification enzyme levels through Keap1/Nrf2 signaling pathway.		NOS , Reactive Oxygen Species , Nrf2 , NO Synthase
TN2100	Pratensein		Others , NF-κB
	Pratensein as a novel transcriptional up-regulator of scavenger receptor class B type I in HepG2 cells.		Others , NF-κB
T3776	Rhapontigenin	Protigenin	P450 , Antibacterial , Antifungal
	Rhapontigenin (Protigenin) is a mechanism-based, selective inactivator of cytochrome P450 1A1 (IC50: 400 nM), an aryl hydrocarbon hydroxylase which activates polycyclic aromatic hydrocarbons that act as procarcinogens. R...		P450 , Antibacterial , Antifungal
TN1644	Flavanomarein		Others
	Flavanomarein demonstrates potent antioxidative property, including free radical scavenging activity, inhibition of lipid peroxidation, as well as lipid-lowering effects in human HepG2 hepatocellular carcinoma cells trea...		Others
T4519	Alisol A	Alisol-A	Autophagy
	Alisol A (Alisol-A) may be an autophagic inducer, it has anti-cancer activity, it presents inhibitory effects on cancer cell lines tested(HepG2, MDA-MB-231, and MCF-7 cells).		Autophagy
T5S0506	Rotundic acid	Rutundic acid	Apoptosis , Others , p38 MAPK , Akt , mTOR
	Rotundic acid (Rutundic acid), a natural compound, exhibit cytotoxic activities toward human hepatocellular carcinoma (HepG2), malignant melanoma (A375), SCLC (NCI-H446), breast cancer (MCF-7), and colon cancer (HT-29) c...		Apoptosis , Others , p38 MAPK , Akt , mTOR
TN3972	Epimedokoreanin B		Apoptosis , Others , Antibacterial
	Epimedokoreanin B (EKB), an isoprenylated flavonoid isolated from Korean Epimedium, exhibited anticancer activity in human non-small cell lung cancer (NSCLC) A549 and NCI-H292 cells.Epimedokoreanin B also possesses anti-...		Apoptosis , Others , Antibacterial
TN6694	5,6-Benzoflavone	β-Naphthoflavone,beta-NF	Antioxidant
	5,6-Benzoflavone (β-Naphthoflavone) is an exogenous ligand for the aryl hydrocarbon receptor, which disrupts zinc homeostasis in human hepatocellular carcinoma HepG2 cells. 5,6-Benzoflavone (β-Naphthoflavone) possesses a...		Antioxidant
T7027	EURYCOMANONE	Pasakbumin A	Others
	Eurycomanone (Pasakbumin A) is cytotoxic on HepG2 cells by inducing apoptosis through the up-regulation of p53 and Bax, and down-regulation of Bcl-2.Eurycomanone has anti-cancer activity, inhibits A549 lung cancer cell p...		Others
T3904	Gomisin J		Calcium Channel , AMPK
	Gomisin J is a natural product and have vasodilatory activity. Gomisin J suppresses lipid accumulation by regulating the expression of lipogenic and lipolytic enzymes and inflammatory molecules through activation of AMPK...		Calcium Channel , AMPK
T5S1331	Herbacetin		c-Met/HGFR , Akt
	1. Herbacetin induces apoptosis in HepG2 cells, by ROS and PI3K/Akt pathway. 2. Herbacetin suppresses the HGF-induced motility of human breast cancer MDA-MB-231 cells by inhibiting c-Met and Akt phosphorylation.		c-Met/HGFR , Akt
TN2244	Sulfuretin		NF-κB , Autophagy
	Sulfuretin is a potent anti-oxidant, has protective effect against t-BHP-induced oxidative damage in human liver-derived HepG2 cells is attributable to its ability to scavenge ROS and up-regulate the activity of HO-1 thr...		NF-κB , Autophagy
T3S2325	Ardisiacrispin A	Saxifragifolin B,LTS-4,Deglucocyclamin	HSV
	Ardisiacrispin A (Deglucocyclamin) has cytotoxic activity toward HepG2 cancer cell with the GI(50) value of 1.56μM, it could inhibit the proliferation of Bel-7402 cells by inducing apoptosis and disassembling microtubule...		HSV
T6S2023	Harpagoside		Others , COX , NO Synthase
	1. Harpagoside has anti-inflammatory activity. 2. Harpagoside at 3 mM concentration, shows moderate inhibition of seed germination. 3. Harpagoside can inhibit lipopolysaccharide-induced mRNA levels and protein expression...		Others , COX , NO Synthase
TN2111	Prunin	Naringenin 7-0-glucoside	Phosphatase , Anti-infection , Virus Protease
	Prunin (Naringenin 7-0-glucoside) possesses anti-diabetic, and anti-abacterial properties, it can inhibit protein tyrosine phosphatase 1B (PTP1B) and stimulate glucose uptake in insulin-resistant HepG2 cells; it also can...		Phosphatase , Anti-infection , Virus Protease
T3867	Alpinetin	(-)-alpinetin	BCL , PPAR
	Alpinetin ((-)-alpinetin) has antibacterial activity.Alpinetin has anti-inflammatory activity.Alpinetin can enhance the sensitivity of HepG2 hepatoma cells to the chemotherapeutic agent CDDP. Alpinetin has strong anti-he...		BCL , PPAR
T2854	Phillyrin	Forsythin	P450 , Influenza Virus , AMPK
	Phillyrin (Forsythin) is a novel AMPK activator, has anti-obesity effects in nutritive obesity mice, it can prevent lipid accumulation in HepG2 cells by blocking the expression of SREBP-1c and FAS through LKB1/AMPK activ...		P450 , Influenza Virus , AMPK
TN1163	2'-Hydroxychalcone		Others
	2'-Hydroxychalcone is a drug synthesis intermediate for the synthesis of flavonoids. 2'-Hydroxychalcone loaded in nanoemulsion showed fungicidal activity against Coccidioides parapsilosis in Danio rerio model.2'-Hydroxyc...		Others
T6S1495	Ginsenoside Rk3		Others , NF-κB
	1. Ginsenoside Rk3 and Rh4 could have a role in treating inflammatory diseases. 2. Ginsenoside Rk3 is often used as a major ingredient of the compound preparation for ischemic heart diseases.		Others , NF-κB
T3895	Polyphyllin I		Apoptosis , Akt , JNK , PDK , mTOR , Autophagy
	Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, cytochrome C, and cleaved-caspase-3 levels. Polyphyllin D ha...		Apoptosis , Akt , JNK , PDK , mTOR , Autophagy
T4S1637	Gamma-Mangostin	Normangostin	Others , 5-HT Receptor
	1. gamma-Mangostin (Normangostin) as a preventive agent of the metabolic syndrome. 2. Gamma-Mangostin has free radical scavenging activity, and antiproliferative and apoptotic activity in HepG2 cells. 3. Gamma-Mangostin ...		Others , 5-HT Receptor
T7529	Yamogenin		Others
	Yamogenin is a diastereomer of diosgenin, which we have identified as the compound responsible for the anti-hyperlipidemic effect of fenugreek.		Others
T6S1141	Ganoderic acid A		Apoptosis , NF-κB , Endogenous Metabolite , Autophagy
	1. Ganoderic acid A exhibits antitumor activity, mediated through its inhibitory effect on nuclear transcription factor-kappaB and activator protein-1. 2. Ganoderic acid A can induce proliferation inhibition, apoptosis a...		Apoptosis , NF-κB , Endogenous Metabolite , Autophagy
TL0008	Gigantol		Wnt/beta-catenin , Glucosidase
	Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. It inhibits Wnt/β-catenin signaling through downregulation of phosphorylated LRP6 and cytosolic β-catenin in breast cancer cells. Gigantol may be developed as a...		Wnt/beta-catenin , Glucosidase
TN1393	(-)-Anonaine		Apoptosis , Antioxidant , Parasite , Antifungal
	(-)-Anonaine can be extracted from several species of Magnoliaceae and Annelidae and has antimalarial, antibacterial, antifungal, antioxidant, anticancer, antidepressant and vasodilatory activities. (-)-Anonaine induces ...		Apoptosis , Antioxidant , Parasite , Antifungal
T4S0145	Corylifol A	Corylinin	hCE , STAT , UGT
	1. Corylifol A (Corylinin) displays cytotoxic activity against HepG2 and Hep3B hepatocellular carcinoma cell lines, with IC50 values of 4.6 and 13.5 ug/ml, respectively. 2. Corylifol A and Biochanin A can be the potentia...		hCE , STAT , UGT
TN1856	Leachianone A	Isokurarinone	SGLT
	Leachianone A (Isokurarinone) is a potential antitoxic agent, it shows inhibitory effects on cadmium- Induced cytotoxicity.		SGLT
TN1911	Marein		transporter , Akt , HDAC , AMPK
	Marein shows neuroprotective effect on PC12 cell damage induced by methylglyoxal, which is due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway, it may be a potent compound for ...		transporter , Akt , HDAC , AMPK
T3S1416	Decursin	Decursinol angelate,(+)-Decursin	Apoptosis , PKC
	1. Decursin (Decursinol angelate) is able to attenuate kainic acid-induced seizures and could have potential as an antiepileptic drug. 2. Decursin exhibits hepatoprotective effects , potentially by inhibiting the TGF-β1 ...		Apoptosis , PKC
TN5346	Psiguadial D
	Psiguadial D shows significant cytotoxicity toward HepG2 and HepG2/ADM cells.
TN3013	4,5-Dimethoxycanthin-6-one	Methylnigakinone	P450 , Antibacterial , PDE
	4,5-Dimethoxycanthin-6-one is an alkaloid isolated from Picrasma quassioides BENNET (Simaroubaceae).4,5-Dimethoxycanthin-6-one was isolated from Picrasma quassioides BENNET (Simaroubaceae) with antimicrobial activity.4,5...		P450 , Antibacterial , PDE
T81521	Penispidin A
	Penispidin A suppresses lipid accumulation in hepatic HepG2 cells.
T10045	15-Acetyl-deoxynivalenol		Others
	15-Acetyl-deoxynivalenol is a highly toxic trichothecene found in cereals and exhibits toxicity to HepG2 cells.		Others
TN1870	Ligupurpuroside C		AMPK
	Ligupurpuroside C can significantly inhibit lipid accumulation in HepG2 cell at the concentration of 50 μMol/L.		AMPK
T81531	Pedunculosumoside F
	Pedunculosumoside F, a homoflavonoid glucoside extracted from Ophioglossum pedunculosum, exhibits cytotoxicity against HepG2 22.15 cells, presenting a CC50 value of 56.7 μM, yet lacks anti-HBV activity. Conversely, its a...
------------------------ More ------------------------

Natural Products

Synonym: Cholanic acid,Cholate,Colalin

Target: Endogenous Metabolite

Cholic acid sodium

T4537

Synonym: SodiumCholate

Target: HIV Protease, Endogenous Metabolite

Guanosine 5'-diphosphate

T7210

Synonym: GDP

Target: Endogenous Metabolite

Synonym: Solamargin,δ-Solanigrine

Target: Apoptosis, p38 MAPK, P-gp, STAT

Synonym: MK-0733,MK 733

Target: Apoptosis, Mitophagy, Ferroptosis, HMG-CoA Reductase, Autophagy

Indole-3-pyruvic acid

T4939

Synonym: 3-(3-Indolyl)-2-oxopropanoic acid

Target: Others

Amantadine

T7060

Synonym: 1-Aminoadamantane,1-Adamantanamine,1-Adamantylamine

Target: ERK, Others, Akt, Endogenous Metabolite

Synonym: Luteolin 4-methyl ether

Target: P450, Trk receptor

Pelargonidin chloride

TN1058

Synonym:

Target: NOS, Reactive Oxygen Species, Nrf2, NO Synthase

Pratensein

TN2100

Synonym:

Target: Others, NF-κB

Rhapontigenin

T3776

Synonym: Protigenin

Target: P450, Antibacterial, Antifungal

Synonym: Rutundic acid

Target: Apoptosis, Others, p38 MAPK, Akt, mTOR

Epimedokoreanin B

TN3972

Synonym:

Target: Apoptosis, Others, Antibacterial

5,6-Benzoflavone

TN6694

Synonym: β-Naphthoflavone,beta-NF

Target: Antioxidant

EURYCOMANONE

T7027

Synonym: Pasakbumin A

Target: Calcium Channel, AMPK

Herbacetin

T5S1331

Synonym:

Target: c-Met/HGFR, Akt

Sulfuretin

TN2244

Synonym:

Target: NF-κB, Autophagy

Ardisiacrispin A

T3S2325

Synonym: Saxifragifolin B,LTS-4,Deglucocyclamin

Target: Others, COX, NO Synthase

Prunin

TN2111

Synonym: Naringenin 7-0-glucoside

Target: Phosphatase, Anti-infection, Virus Protease

Alpinetin

T3867

Synonym: (-)-alpinetin

Target: P450, Influenza Virus, AMPK

Target: Others, NF-κB

Polyphyllin I

T3895

Synonym:

Target: Apoptosis, Akt, JNK, PDK, mTOR, Autophagy

gamma-Mangostin

T4S1637

Synonym: Normangostin

Target: Others, 5-HT Receptor

Target: Apoptosis, NF-κB, Endogenous Metabolite, Autophagy

Gigantol

TL0008

Synonym:

Target: Wnt/beta-catenin, Glucosidase

(-)-Anonaine

TN1393

Synonym:

Target: Apoptosis, Antioxidant, Parasite, Antifungal

Corylifol A

T4S0145

Synonym: Corylinin

Target: hCE, STAT, UGT

Leachianone A

TN1856

Synonym: Isokurarinone

Target: transporter, Akt, HDAC, AMPK

Decursin

T3S1416

Synonym: Decursinol angelate,(+)-Decursin

Target: Apoptosis, PKC

4,5-Dimethoxycanthin-6-one

TN3013

Synonym: Methylnigakinone

Target: P450, Antibacterial, PDE

15-Acetyl-deoxynivalenol

--------- More ---------

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-00386	GLT8D2 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	GLT8D2 is a glycosyltransferase of apoB100 that regulates apoB100 levels in hepatocytes. GLT8D2 expression increased in steatosis HepG2 cells compared with that in normal HepG2 cells. GLT8D2 participated in nonalcoholic ...
TMPJ-01142	CDO1 Protein, Human, Recombinant (His)	Human	E. coli
	Cysteine Dioxygenase Type 1 (CDO1) is a mammalian non-heme iron enzyme that belongs to the cysteine dioxygenase family. CDO1 is highly expressed in the liver and placenta, and has a low expression in heart, brain and pan...
TMPY-01595	PCBP1 Protein, Human, Recombinant (His)	Human	E. coli
	Poly(rC)-binding protein 1, also known as Heterogeneous nuclear ribonucleoprotein E1, Alpha-CP1, Nucleic acid-binding protein SUB2.3 and PCBP1, is a family member of heterogeneous nuclear ribonucleoproteins (hnRNPs) that...

GLT8D2 Protein, Human, Recombinant (His)

TMPY-00386

Species: Human

Expression System: Baculovirus-Insect Cells

CDO1 Protein, Human, Recombinant (His)

TMPJ-01142

Species: Human

Expression System: E. coli

PCBP1 Protein, Human, Recombinant (His)

TMPY-01595

Species: Human

Expression System: E. coli