Search Result

Search Results for " hela "

Targets

180

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T8513	Spastazoline		Others
	Spastazoline is a potent and selective inhibitor of spastin(Human spastin with IC50 of 99 nM ).		Others
T23552	YZ9		Glucokinase
	PFKFB3 inhibitor		Glucokinase
T0855	(R)-Naproxen		COX
	(R)-Naproxen, an anti-inflammatory agent, has antipyretic and analgesic properties. Both the acid and its sodium salt are used in the therapy of acute gout or dysmenorrhea, musculoskeletal disorders, rheumatoid arthritis...		COX
T21992	Vacuolin-1		PI3K , Autophagy
	Vacuolin-1 is a cell-permeable inhibitor of Ca2+ dependent fusion of lysosomes to the cell membrane. It acts by inhibiting release of lysosomal content.vacuolin‐1 is a potent and selective PIKfyve inhibitor and inhibits ...		PI3K , Autophagy
T9119	SU0268		Others
	SU0268 is a potent and specific 8-Oxoguanine DNA glycosylase 1 (OGG1) inhibitor. SU0268 regulates inflammatory responses during Pseudomonas aeruginosa infection.		Others
T11563	Histone Acetyltransferase Inhibitor II		Epigenetic Reader Domain , Histone Acetyltransferase
	Histone Acetyltransferase Inhibitor II is a selective and cell permeable inhibitor of p300 histone acetyltransferase(IC50 : 5 μM).with anti-acetylase activity in mammalian cells.		Epigenetic Reader Domain , Histone Acetyltransferase
T23372	SMIFH2		Others
	SMIFH2 is formin homology 2 (FH2) domains inhibitor.		Others
T6421	BRD73954		HDAC
	BRD73954, an effective and specific HDAC inhibitor, which is with IC50 of 36 nM and 120 nM for HDAC6 and HDAC8, respectively.		HDAC
T11553	Heptamidine dimethanesulfonate	SBi4211 dimethanesulfonate	Others
	Heptamidine dimethanesulfonate (SBi4211 dimethanesulfonate) serves as a potent inhibitor related to Pentamidine, targeting the calcium-binding protein S100B with a dissociation constant (Kd) of 6.9 µM. It demonstrates sp...		Others
T5399	GeA-69		PARP
	GeA-69 (GeA69) is a selective and allosteric PARP14 macrodomain 2 (MD2) inhibitor (Kd: 0.86 μM in ITC assays).		PARP
T34603	L-Selenocystine	L-Selenocystine	Others
	L-Selenocystine (L-Selenocystine) can be used as a building block in biologically active selenol compounds.		Others
T50005	Sertaconazole		Antifungal
	Sertaconazole is a broad-spectrum antifungal.		Antifungal
T12006	Metarrestin	ML246	DNA/RNA Synthesis
	Metarrestin (ML246) is a first-in-class perinucleolar compartment inhibitor with a favorable PK profile, which effectively suppresses metastasis. Metarrestin disrupts the nucleolar structure and inhibits RNA polymerase (...		DNA/RNA Synthesis
T12579	RAMB4	PTP1B-IN-9	Proteasome
	RAMB4 (PTP1B-IN-9) is a ubiquitin-proteasome system (UPS)-stressor,with anticancer activity.		Proteasome
T3076	GLPG0634 analog	GLPG0634 analogue	Tyrosine Kinases , JAK
	GLPG0634 analog (GLPG0634 analogue) is a specific JAK1 inhibitor with IC50 of 10/28/810/116 nM for JAK1/2/3 and TYK2, respectively.		Tyrosine Kinases , JAK
T9024	OUL35	NSC39047	Others , PARP
	OUL35 (NSC-39047) is a selective PARP-10 inhibitor, and small-molecule ARTD10 inhibitor. OUL35 has been shown to rescue cells from ARTD10-induced cell death.		Others , PARP
T9350	IMP-1088		Others , DNA/RNA Synthesis
	IMP-1088 is a potent inhibitor of human N-myristoyltransferases NMT1 and NMT2 dual.		Others , DNA/RNA Synthesis
T9098	DMG-PEG 2000	DMG-PEG2000	Others
	DMG-PEG 2000 (DMG-PEG2000) is a lipid excipient that has been used in combination with other lipids in the formation of lipid nanoparticles. Formulations containing DMG-PEG 2000 have been used in the development of lipid...		Others
T0711	Niclosamide	BAY2353,Niclocide	Antibiotic , STAT , Parasite
	Niclosamide (Niclocide)(BAY2353) is used to treat most tapeworm infections by inhibiting DNA replication.		Antibiotic , STAT , Parasite
T3103	L67	DNA Ligase Inhibitor	DNA , DNA/RNA Synthesis
	L67 (DNA Ligase Inhibitor) is a competitive human DNA ligase inhibitor, inhibits DNA ligases I and III (IC50: 10 μM).		DNA , DNA/RNA Synthesis
T9079	Apostatin-1	Apt-1	Others
	Apostatin-1 (Apt-1) is a novel TRADD inhibitor. Apostatin-1 can bind to a pocket on the N-terminal TRAF2 binding domain of TRADD.		Others
T2617	SNS-314 Mesylate	SNS-314	Aurora Kinase
	SNS-314 Mesylate (SNS-314) is an effective and specific Aurora A/B/C inhibitor (IC50: 9/31/3 nM). It is less inhibition of Trk A/B, Fms, Flt4, c-Raf, Axl, and DDR2.		Aurora Kinase
T7020	Z-VAD-FMK	Z-VAD(OH)-FMK,Caspase Inhibitor VI,Z-VAD	Caspase
	Z-VAD-FMK (Caspase Inhibitor VI) is a broad-spectrum inhibitor of caspases with irreversible properties. Z-VAD-FMK binds to activated caspases, thereby inhibiting apoptosis.		Caspase
T0455	Clozapine	HF 1854,LX 100-129	Dopamine Receptor , Adrenergic Receptor , AChR
	Clozapine (HF 1854) is a tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a...		Dopamine Receptor , Adrenergic Receptor , AChR
T4327	Prexasertib dihydrochloride	LY2606368 (dihydrochloride),Prexasertib HCl,LY2606368	Apoptosis , Chk , S6 Kinase
	Prexasertib dihydrochloride (LY2606368) is an ATP-competitive CHK1 inhibitor (Ki: 0.9 nmol/L). in the cell-free assay, its IC50 values are 8 nM and 9 nM for CHK2 and RSK, respectively.		Apoptosis , Chk , S6 Kinase
T6665	Sertaconazole nitrate	FI-7045,Ginedermofix,FI7056,Ertaczo	Antibiotic , Antifungal
	Sertaconazole nitrate (FI-7045), a topical broad-spectrum antifungal, is developed to supply an additional agent for the treatment of superficial cutaneous and mucosal infections.		Antibiotic , Antifungal
T15396	GN44028	N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine	HIF
	GN44028 (N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine) is a hypoxia-inducible factor inhibitor of (HIF)-1 (IC50: 14 nM). GN44028 inhibits hypoxia-induced HIF-1α transcriptional activity. H...		HIF
T4310	Prexasertib	LY2606368	Apoptosis , Chk
	Prexasertib (LY2606368) is an inhibitor of checkpoint kinase 1 (chk1) with potential antineoplastic activity.		Apoptosis , Chk
T13639	Deferasirox (Fe3+ chelate)		Apoptosis
	Deferasirox (Fe3+ chelate) is an orally available iron chelator with potential anticancer activity, inhibits the anti-apoptotic activity of MCL-1, and can be used to study iron overload.		Apoptosis
T81480	Phytochelatin 2 (PC2) (TFA)
	Phytochelatin 2 (PC2) TFA, a heavy metal-binding peptide, facilitates metal chelation, mitigates metal toxicity, and promotes metal homeostasis within internal environments [1].
T81475	Phytochelatin 5	PC 5
	Phytochelatin 5, a metal-binding compound synthesized by plants, can potentially diminish the bioavailability of dietary toxic metals, including cadmium [1].
T81477	Phytochelatin 4	PC 4
	Phytochelatin 4 (PC 4), a cysteine-rich peptide featuring repeating γ-glutamyl-cysteine (γ-Glu-Cys) sequences, occurs in plants [1].
T81478	Phytochelatin 3 TFA	PC 3 TFA
	Phytochelatin 3 (PC 3) TFA is a small peptide known for its metal-chelating properties, particularly effective in binding heavy metals [1].
T81474	Phytochelatin 5 TFA	PC 5 TFA
	Phytochelatin 5 TFA, a metal-binding compound produced by plants, may reduce the bioavailability of dietary toxic metals, such as cadmium [1].
T124710	Trachelanthamidine
	Trachelanthamidine is a useful organic compound for research related to life sciences and the catalog number is T124710.
T81473	Phytochelatin 6	PC 6
	Phytochelatin 6, a metal-binding compound synthesized by plants, can potentially decrease the bioavailability of dietary toxic metals, including cadmium [1].
T41109	Phytochelatin 2 (PC2)
	Phytochelatin 2, a short plant peptide, serves as an essential metal-binding compound. Phytochelatins are a diverse group of plant compounds that play a crucial role in chelating metals, safeguarding against metal toxici...
T81472	Phytochelatin 6 TFA	PC 6 TFA
	Phytochelatin 6 TFA, a metal-binding compound synthesized by plants, can potentially decrease the bioavailability of dietary toxic metals like cadmium [1].
T81476	Phytochelatin 4 TFA	PC 4 TFA
	Phytochelatin 4 (PC 4) TFA is a cysteine-rich, plant-derived peptide characterized by repetitive γ-glutamyl-cysteine motifs [1].
T81479	Phytochelatin 3	PC 3
	Phytochelatin 3 (PC 3) is a small peptide with metal-chelating capabilities, particularly effective for sequestering heavy metals [1].
T30873	Chelator 1a	Chelator1a,Chelator-1a	Antifungal
	Chelator 1a has antifungal activity, inhibiting Aspergillus and Candida, and can be used to study fungal infections and cancer.		Antifungal
T8517	Belinostat	PX105684,PXD101,PXD-101	HDAC , Autophagy
	Belinostat (PXD101) is an inhibitor of hydroxamic acid-type histone deacetylase (HDAC, IC50 of 27 nM in HeLa cell extracts),and with antineoplastic activity.		HDAC , Autophagy
T11657	INH154		Others
	INH154 is a highly potent inhibitor for Nek2 and Hec1 binding (INH), with IC50s of 120 nM and 200 nM for INH in MB468 and Hela cells.		Others
T7181	IDO-IN-1		Indoleamine 2,3-Dioxygenase (IDO)
	IDO-IN-1 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor( IC50 values of 59 and 12 nM for human IDO enzymatic activity and HeLa cell assays, respectively.)		Indoleamine 2,3-Dioxygenase (IDO)
T25214	CCR-11	CCR11,CCR 11	Antibiotic
	CCR-11 is a tannin-containing derivative with antimicrobial activity. CCR-11 inhibits the proliferation of B. subtilis and HeLa cells. CCR-11 inhibits bacterial proliferation and bacterial cytoplasmic division by inhibit...		Antibiotic
T8623	TMIFRY8XAG	1,1'-(4-CHLOROBUTYLIDENE)BIS(4-FLUOROBENZENE),4-oxo-1,4-dihydroquinoline-2-carboxylic acid	Others
	TMIFRY8XAG (4-oxo-1,4-dihydroquinoline-2-carboxylic acid) is a derivative of Zerumbone with potential anti-tumor effects towards HeLa cancer cells.		Others
T5342	IWP-O1		Wnt/beta-catenin , Porcupine
	IWP-O1 is a highly potent Porcupine (Porcn) inhibitor (EC50: 80 pM), effectively suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells.		Wnt/beta-catenin , Porcupine
T77771	Compound 10w		Others
	Compound 10w, a substituted pyrazolo[1,5-a]pyrimidinamide compound, is a ZSTK474 analog that shows anticancer activity against HeLa cells.		Others
T25969	Poloxin-2	Poloxin2,Poloxin 2	PLK
	Poloxin-2 is a potent and selective Plk1 PBD inhibitor with anti-tumour activity that reduces the protein level of Plk1 in HeLa cells.		PLK
T8903	Retro-2	Retro 2,2-{[(5-methyl-2-thienyl)methylene]amino}	Others , Virus Protease , Parasite , Autophagy
	Retro-2 (2-{[(5-methyl-2-thienyl)methylene]amino}) is a plant toxin ricin inhibitor, itprotects HeLa cells against Ricin, Stx1 and Stx2, selectively blocks retrograde toxin trafficking at the early endosome-TGN (trans-Go...		Others , Virus Protease , Parasite , Autophagy

Compounds

Target: PI3K, Autophagy

Histone Acetyltransferase Inhibitor II

T11563

Synonym:

Target: Epigenetic Reader Domain, Histone Acetyltransferase

Heptamidine dimethanesulfonate

T11553

Synonym: SBi4211 dimethanesulfonate

Synonym: L-Selenocystine

Target: DNA/RNA Synthesis

Synonym: GLPG0634 analogue

Target: Tyrosine Kinases, JAK

Target: Others, DNA/RNA Synthesis

Synonym: BAY2353,Niclocide

Target: Antibiotic, STAT, Parasite

L67

T3103

Synonym: DNA Ligase Inhibitor

Target: DNA, DNA/RNA Synthesis

Target: Aurora Kinase

Z-VAD-FMK

T7020

Synonym: Z-VAD(OH)-FMK,Caspase Inhibitor VI,Z-VAD

Target: Caspase

Clozapine

T0455

Synonym: HF 1854,LX 100-129

Target: Dopamine Receptor, Adrenergic Receptor, AChR

Prexasertib dihydrochloride

T4327

Synonym: LY2606368 (dihydrochloride),Prexasertib HCl,LY2606368

Target: Apoptosis, Chk, S6 Kinase

Sertaconazole nitrate

T6665

Synonym: FI-7045,Ginedermofix,FI7056,Ertaczo

Target: Antibiotic, Antifungal

GN44028

T15396

Synonym: N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine

Target: Apoptosis, Chk

Deferasirox (Fe3+ chelate)

T13639

Synonym:

Target: Apoptosis

Phytochelatin 2 (PC2) (TFA)

Phytochelatin 2 (PC2)

Synonym: Chelator1a,Chelator-1a

Target: Antifungal

Belinostat

T8517

Synonym: PX105684,PXD101,PXD-101

Target: HDAC, Autophagy

Target: Indoleamine 2,3-Dioxygenase (IDO)

CCR-11

T25214

Synonym: CCR11,CCR 11

Target: Antibiotic

TMIFRY8XAG

T8623

Synonym: 1,1'-(4-CHLOROBUTYLIDENE)BIS(4-FLUOROBENZENE),4-oxo-1,4-dihydroquinoline-2-carboxylic acid

Target: Wnt/beta-catenin, Porcupine

Synonym: Poloxin2,Poloxin 2

Target: PLK

Retro-2

T8903

Synonym: Retro 2,2-{[(5-methyl-2-thienyl)methylene]amino}

Target: Others, Virus Protease, Parasite, Autophagy

Cat No.	Product Name	Synonyms	Targets
T11363	Ganoderic acid F		Others
	Ganoderic acid F exhibits antitumor and antimetastatic activities through inhibition of angiogenesis and alteration of proteins involving cell proliferation and/or cell death, carcinogenesis, oxidative stress, calcium si...		Others
TN7060	Methyl oleanonate		PPAR
	3-Oxoolean-12-en-28-oic acid methyl ester is a triterpenoid PPARγ agonist isolated from Pistacia with anticancer properties.		PPAR
T5S1133	Ganoderic acid D		Apoptosis , Sirtuin
	1. Ganoderic acid D is one of the major components in Ganoderma triterpenes. 2. Ganoderic acid D treatment for 48h inhibits the proliferation of HeLa human cervical carcinoma cells with an IC(5) value of 17.3 +/- .3 micr...		Apoptosis , Sirtuin
T2230	Paeoniflorin	Peoniflorin	HSP , COX
	Paeoniflorin (Peoniflorin) is a herbal constituent extracted from the root of Paeonia albiflora Pall.		HSP , COX
T6427	Butein	2’,3,4,4’-tetrahydroxy Chalcone	Apoptosis , EGFR , Others , PDE , Autophagy
	Butein (2’,3,4,4’-tetrahydroxy Chalcone), a plant polyphenol, is isolated from Rhus verniciflua. It can inhibit the activation of protein tyrosine kinase, NF-κB and STAT3, and also can inhibit EGFR.		Apoptosis , EGFR , Others , PDE , Autophagy
T4S21320	ISOGINKGETIN	4',4'''-Dimethylamentoflavone	MMP , Others
	1. ISOGINKGETIN (4',4'''-Dimethylamentoflavone), a compound derived from the leaves of Ginkgo biloba, to up-regulate adiponectin secretion with potency comparable to that of rosiglitazone, a known modulator of adiponecti...		MMP , Others
T13475	β-Aminopropionitrile	3-Aminopropionitrile,BAPN	Others , Endogenous Metabolite
	β-Aminopropionitrile (3-Aminopropionitrile) is a selective inhibitor of lysyl oxidase.		Others , Endogenous Metabolite
T3673	Mollugin	Rubimaillin	HER , JAK
	Mollugin (Rubimaillin) may be a JAK2 inhibitor and inhibits LPS-induced inflammatory responses by blocking the activation of the JAK-STAT pathway. Mollugin as a candidate for a chemotherapeutic agent in OSCCs via the upr...		HER , JAK
T14046	Anandamide	(5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide	Cannabinoid Receptor , Endogenous Metabolite
	Anandamide ((5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide), an immune modulator, acts via not only cannabinoid receptors (CB1 and CB2) but also other targets (e.g., GPR18/GPR55) in the central nervous sy...		Cannabinoid Receptor , Endogenous Metabolite
TN1915	Matairesinol 4′-O-β-D-glucopyranoside	Matairesinol 4'-O-beta-gentiobioside	Others
	Matairesinol 4′-O-β-D-glucopyranoside is a natural product isolated from Trachelospermum jasminoides.		Others
TC0014	Trachelanthine		Others
	Trachelanthine is a natural product from Eupatorium fortunei.		Others
TN5158	Trachelanthamine		Others
	Trachelanthamine is a natural product from Eupatorium fortunei.		Others
T4036	Solasodine	Solancarpidine,Purapuridine,Solasodin	Apoptosis , Others , E1/E2/E3 Enzyme , Antifungal
	Solasodine (Purapuridine)(Purapuridine) is a poisonous alkaloid chemical compound that occurs in plants of the Solanaceae family. Solasodine showed selective cytotoxicity against cervical cancer cell line (HeLa) and huma...		Apoptosis , Others , E1/E2/E3 Enzyme , Antifungal
TN4375	Kamebanin		Antifection
	Kamebanin, a natural diterpenoid, has antibacterial activity. It also shows efficient cytotoxic activity against HeLa and HL-60 cells.		Antifection
TN4618	N-trans-Sinapoyltyramine		Others
	N-trans-Sinapoyltyramine exhibited strong and selective cytotoxicity on the HeLa human cancer cell line with IC50 values of 9.77 ± 1.25 Μm.		Others
TQ0170	Desacetylcinobufagin	Deacetylcinobufagin	Others
	Desacetylcinobufagin (Deacetylcinobufagin) , a natural product, shows potent activities against Hela and A375 cells in vitro.		Others
T5738	7-Epi 10-desacetyl paclitaxel	10-Deacetyl-7-epipaclitaxel,7-Epi-10-deacetyltaxol	Others
	7-Epi 10-desacetyl paclitaxel (10-Deacetyl-7-epipaclitaxel) shows IC50 values of 0.085 nM, against HeLa cells.		Others
TN3049	4-Methoxycinnamyl alcohol		Others
	4-Methoxycinnamyl alcohol showed toxicity to MCF-7, HeLa and DU145 cancer cell lines with IC50 values of 14.24, 7.82 and 22.10 μg/mL, respectively. 4-Methoxycinnamyl alcohol was isolated from Foeniculum vulgare. 4-Methox...		Others
TN1916	Matairesinol		ATPase , p38 MAPK , ROS
	Matairesinol has radical and superoxide scavenging activities,; it also has anti-angiogenic activity by suppressing mROS signaling , can decrease hypoxia-inducible factor-1α± in hypoxic HeLa cells.		ATPase , p38 MAPK , ROS
TN7041	(-)-Epipodophyllotoxin		Apoptosis
	(-)-Epipodophyllotoxin (2) is an antiproliferative agent against cancer cells with GI50s of 0.36 and 0.24 μM in HeLa cells and MCF-7 cells, respectively. (-)-Epipodophyllotoxin can inhibit mitotic spindle assembly in vit...		Apoptosis
TN1393	(-)-Anonaine		Apoptosis , Antioxidant , Parasite , Antifungal
	(-)-Anonaine can be extracted from several species of Magnoliaceae and Annelidae and has antimalarial, antibacterial, antifungal, antioxidant, anticancer, antidepressant and vasodilatory activities. (-)-Anonaine induces ...		Apoptosis , Antioxidant , Parasite , Antifungal
T3395	Timosaponin AIII	Filiferin B,AneMarsaponin A3,Timosaponin A3	AChE , mTOR
	Timosaponin AIII (Timosaponin A3) induces autophagy in HeLa cells followed by apoptotic cell death (IC50: 10 μM). The Timosaponin AIII cellular response is mediated via inhibition of mTORC1 and induction of ER stress (IC...		AChE , mTOR
TN2755	2-Desoxy-4-epi-pulchellin		Anti-infection
	2-Desoxy-4-epi-pulchellin has potent in vitro cytotoxicities against the K562, MCF-7, Hela, DU145, U937, H1975, SGC-7901, A549, MOLT-4, and HL60 cell lines with IC50 values ranging from 0.10 to 46.7uM, while it shows sig...		Anti-infection
T6213	Vinorelbine ditartrate	Vinorelbine Tartrate,Nor-5'-anhydrovinblastine ditartrate,KW-2307,Navelbine tartrate	Microtubule Associated , Autophagy
	Vinorelbine ditartrate (KW-2307), a semi-synthetic vinca alkaloid, interacts with tubulin resulting in mitosis inhibition.		Microtubule Associated , Autophagy
T3386	Kaempferitrin	Lespedin,Kaempferol,Lespenephryl,Lespenefril,Kaempferol 3,7-dirhamnoside	cell cycle arrest , Glucokinase , IGF-1R
	Kaempferitrin (Lespenephryl) has antidepressant-like effect related to the serotonergic system, principally 5-HT1A. Kaempferitrin exerts cytotoxic and antitumor effects against HeLa cells. Kaempferitrin stimulates glucos...		cell cycle arrest , Glucokinase , IGF-1R
T3002	Piperine	1-Piperoylpiperidine,Bioperine	P450 , Endogenous Metabolite , P-gp , Autophagy
	Piperine (Bioperine) , a alkaloid, has been used in trials studying the treatment of multiple myeloma and deglutition disorders.		P450 , Endogenous Metabolite , P-gp , Autophagy
T5S0055	Chelidonine	Helidonine,Khelidonin,Stylophorin	Apoptosis , Others , Influenza Virus
	1. Chelidonine (Stylophorin) isolated from Chelidonium majus efficiently induced apoptosis in HeLa cells through possible alteration of p38-p53 and AKT/PI3 kinase signalling pathways. 2. Chelidonine is a promising model ...		Apoptosis , Others , Influenza Virus
T1879	3-Methyladenine	3-MA,NSC 66389	Mitophagy , PI3K , Endogenous Metabolite , Autophagy
	3-Methyladenine (3-MA) is a PI3K inhibitor that selectively inhibits class IB PI3Kγ (IC50=60 μM) and class III VPS34 (IC50=25 μM). 3-Methyladenine inhibits autophagy.		Mitophagy , PI3K , Endogenous Metabolite , Autophagy
T0190	Vinorelbine	KW-2307 base	Microtubule Associated
	Vinorelbine (KW-2307 base) is a semisynthetic vinca alkaloid. Vinorelbine binds to tubulin and prevents the formation of the mitotic spindle, resulting in the arrest of tumor cell growth in metaphase.		Microtubule Associated
T0122	Bergenin	Cuscutin,Bengenin	Apoptosis , IL Receptor , Virus Protease , TNF , NF-κB , Antibacterial , NOD , Autophagy , Antifungal
	Bergenin (Bengenin) is a polyphenol, which is an effective antinarcotic agent with antioxidant action.
TN5287	3β,5α-Dihydroxyergosta-7,22-dien-6-one
	3β,5α-Dihydroxy-(22E,24R)-ergosta-7,22-dien-6-one exhibits strong or moderate cytotoxic activities against MCF-7, A549, Hela and KB cell lines with IC50 values 4.98 (MCF-7), 1.95 (A549), 0.68(Hela), and 1.50 uM (KB), res...
TN5574	Heudelotinone
	Heudelotinone shows cytotoxicity against three cancer cell lines A549, Hela, and SMMC-7721( IC50 values of 16.04, 10.67 and 21.68 uM , respectively).
TN4034	Eupaglehnin C		Others
	Eupaglehnin C shows cytotoxic (2.19 mg/ml) against HeLa-S3.		Others
TN6569	Cis-Moschamine
	cis-Moschamine exerts antitumour effects on HeLa, MCF7 and A431 cells.
T83481	1,1′-Disinomenine
	1,1′-Disinomenine, an alkaloid extracted from the stems of Sinomenium acutum, exhibits modest inhibitory activity against A549 and Hela cells [1].
TN5212	Uvedalin		Others
	Uvedalin shows cytotoxicity against HeLa, HL-60, and Murine B16-F10 melanoma cell lines.		Others
TN1477	Ceanothic acid		Others
	Ceanothic acid derivatives show cytotoxic effect against OVCAR-3 and HeLa cancer cell lines.		Others
T35234	Yadanzioside B
	Yadanzioside B belongs to bruceosides of quassinoids glucosides from Bruceae Fructus. Yadanzioside B inhibits protein synthesis in HeLa cells, but has little effect on in vitro translation.
TN2964	3'-Methylflavokawin		Others
	3'-Methylflavokawin shows cytotoxicity against HeLa cells, the IC 50 value comparable to xanthohumol (8.2-19.2 microM).		Others
TN3619	Cedrusin		PARP , Caspase
	Cedrusin shows a cytotoxic effect on A375 and HeLa cells.		PARP , Caspase
T40440	Isobyakangelicol	Isobyakangelicol,Anhydrobyakangelicin
	Isobyakangelicol, a coumarin compound present in Angelica dahurica roots, exhibits inhibitory effects on the growth of HeLa and HepG2 cells, with IC50 values of 70.04 μM and 17.97 μM, respectively.
T81818	Metachromins X
	Metachromin X, a sesquiterpene quinone, halts the cell cycle of HeLa/Fucci2 cells at the S/G2/M phase [1].
TN3605	Casegravol		Others
	Casegravol shows antiproliferative activity against human gastric adenocarcinoma (MK-1), human uterus carcinoma (HeLa), and murine melanoma (B16F10) cells.		Others
TN6399	1-(3',5'-dimethoxy)phenyl-2-[4''-O-beta-D-glucopyranosyl (6->1)-O-alpha-L-rhamnopyranosyl]phenylethane
	1-(3',5'-dimethoxy)phenyl-2-[4''-O-β-D-glucopyranosyl (6→1)-O-α-L-rhamnopyranosyl]phenylethane showed cytotoxic activities to Hela and hep2 cell lines.
TN1988	Nephthenol		Others
	Nephthenol shows antiproliferative activity against the cell lines HUVEC and K-562 and for cytotoxicity against the cell line HeLa.		Others
TN2142	Resibufagin		Others
	Resibufagin shows strong cytotoxic activity against HeLa cell line.		Others
TN1776	Isocucurbitacin B		Others
	Isocucurbitacin B has significant activities against HeLa and HT-29 human cancer cells with IC50 values ranging from 0.93 to 9.73uM.		Others
TN3837	Desmethoxycentaureidin		Others
	Desmethoxycentaureidin shows high inhibitory activity against HeLa cell growth (GI50 9 microM).		Others
TN5336	9-Oxo-10,11-dehydroageraphorone	4,7(11)-Cadinadiene-3,8-dione,DTD,7,11-Dehydro-8-oxoageraphorone
	9-Oxo-10,11-dehydroageraphorone has acaricidal activity. It induces hepatotoxicity and cholestasis in rats. 9-Oxo-10,11-dehydroageraphorone also effectively inhibits the proliferation of HeLa cells by arresting the cell ...
T79991	Condurango glycoside A
	Condurango glycoside A activates p53, induces ROS generation, up-regulates p53 expression, and triggers apoptosis as well as premature senescence associated with DNA damage in HeLa cells [1].
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Natural Products

Target: Apoptosis, Sirtuin

Synonym: 2’,3,4,4’-tetrahydroxy Chalcone

Target: Apoptosis, EGFR, Others, PDE, Autophagy

ISOGINKGETIN

T4S21320

Synonym: 4',4'''-Dimethylamentoflavone

Target: MMP, Others

β-Aminopropionitrile

T13475

Synonym: 3-Aminopropionitrile,BAPN

Target: Others, Endogenous Metabolite

Synonym: (5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide

Target: Cannabinoid Receptor, Endogenous Metabolite

Matairesinol 4′-O-β-D-glucopyranoside

TN1915

Synonym: Matairesinol 4'-O-beta-gentiobioside

Synonym: Solancarpidine,Purapuridine,Solasodin

Target: Apoptosis, Others, E1/E2/E3 Enzyme, Antifungal

N-trans-Sinapoyltyramine

Synonym: Deacetylcinobufagin

Target: Others

7-Epi 10-desacetyl paclitaxel

T5738

Synonym: 10-Deacetyl-7-epipaclitaxel,7-Epi-10-deacetyltaxol

Target: Others

4-Methoxycinnamyl alcohol

Target: ATPase, p38 MAPK, ROS

(-)-Epipodophyllotoxin

Target: Apoptosis, Antioxidant, Parasite, Antifungal

Timosaponin AIII

T3395

Synonym: Filiferin B,AneMarsaponin A3,Timosaponin A3

Target: AChE, mTOR

2-Desoxy-4-epi-pulchellin

TN2755

Synonym:

Target: Anti-infection

Vinorelbine ditartrate

T6213

Synonym: Vinorelbine Tartrate,Nor-5'-anhydrovinblastine ditartrate,KW-2307,Navelbine tartrate

Target: Microtubule Associated, Autophagy

Kaempferitrin

T3386

Synonym: Lespedin,Kaempferol,Lespenephryl,Lespenefril,Kaempferol 3,7-dirhamnoside

Target: cell cycle arrest, Glucokinase, IGF-1R

Piperine

T3002

Synonym: 1-Piperoylpiperidine,Bioperine

Target: P450, Endogenous Metabolite, P-gp, Autophagy

Chelidonine

T5S0055

Synonym: Helidonine,Khelidonin,Stylophorin

Target: Apoptosis, Others, Influenza Virus

3-Methyladenine

T1879

Synonym: 3-MA,NSC 66389

Target: Mitophagy, PI3K, Endogenous Metabolite, Autophagy

Vinorelbine

T0190

Synonym: KW-2307 base

Target: Microtubule Associated

Bergenin

T0122

Synonym: Cuscutin,Bengenin

Target: Apoptosis, IL Receptor, Virus Protease, TNF, NF-κB, Antibacterial, NOD, Autophagy, Antifungal

3β,5α-Dihydroxyergosta-7,22-dien-6-one

Target: PARP, Caspase

Isobyakangelicol

T40440

Synonym: Isobyakangelicol,Anhydrobyakangelicin

1-(3',5'-dimethoxy)phenyl-2-[4''-O-beta-D-glucopyranosyl (6->1)-O-alpha-L-rhamnopyranosyl]phenylethane

Desmethoxycentaureidin

TN3837

Synonym:

Target: Others

9-Oxo-10,11-dehydroageraphorone

TN5336

Synonym: 4,7(11)-Cadinadiene-3,8-dione,DTD,7,11-Dehydro-8-oxoageraphorone

Target:

Condurango glycoside A

T79991

Synonym:

Target:

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Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPH-00265	Ferrochelatase, mitochondrial Protein, Bovine, Recombinant (His & Myc & SUMO)	Bovine	E. coli
	Catalyzes the ferrous insertion into protoporphyrin IX.
TMPH-01332	Ferrochelatase Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Catalyzes the ferrous insertion into protoporphyrin IX.
TMPY-00570	Alkaline Phosphatase/PLAP Protein, Human, Recombinant (His)	Human	Yeast
	Most importantly, placental alkaline phosphatase (ALPP), an ectoenzyme that locates on cell surface with catalytic domains outside the plasma membrane and is overexpressed on many cancer cells, dephosphorylate the d-tyro...
TMPY-02521	HIST3H2A Protein, Human, Recombinant	Human	E. coli
	Histones are a complex family of highly conserved basic proteins responsible for packaging chromosomal DNA into nucleosomes. There are subtype diversities: H1, H2A, H2B, and H3 or H4. It has become more and more evident ...
TMPH-00604	CDTA Protein, E. coli, Recombinant (His)	E. coli	E. coli
	CDTs are cytotoxins which induce host cell distension, growth arrest in G2/M phase, nucleus swelling, and chromatin fragmentation in HeLa cells. CdtA, along with CdtC, probably forms a heterodimeric subunit required for ...
TMPH-03026	CARDS Protein, Mycoplasma pneumoniae, Recombinant (His & Myc)	Mycoplasma pneumoniae	E. coli
	Acts as an ADP-ribosylating toxin, which may transfer the ADP-ribosyl group from NAD(+) to specific amino acids in target proteins. Elicits cytopathic effects in mammalian cells, such as disorganization and disruption of...
TMPJ-00546	EFNA1 Protein, Human, Recombinant (hFc)	Human	Human Cells
	Ephrin-A1 is a member of the A-type ephrin family of cell surface proteins that function as ligands for the A-type Eph receptor tyrosine kinase family. Ephrin-A1 can be induced by TNF and IL1B. Its expression levels can ...
TMPY-02132	LYPLA2 Protein, Human, Recombinant (His)	Human	E. coli
	Lysophospholipase II (LYPLA2, LPL-II, or LysoPLA II), also known as Acyl-protein thioesterase 2 (APT-2), belongs to the AB hydrolase 2 family. This enzyme has lysophospholipase activity and may hydrolyze fatty acids from...
TMPY-03397	TPPP3 Protein, Human, Recombinant (His)	Human	E. coli
	TPPP3, a member of the Tubulin polymerization-promoting protein family, is an intrinsically unstructured protein that induces tubulin polymerization. TPPP3 is a marker in the developing musculoskeletal system. In tendons...