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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T14342 | Atorvastatin lactone | HMG-CoA Reductase | |
Atorvastatin lactone is a prodrug form of atorvastatin. Which is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor. | |||
T20765 | Atorvastatin | HMG-CoA Reductase , Autophagy | |
Atorvastatin is an orally active HMG-CoA reductase inhibitor that has the ability to effectively lower blood lipids by activating liver cytochrome p450 to accelerate metabolism. Atorvastatin inhibited proliferation and i... | |||
T79520 | HMG-CoA Reductase-IN-1 | ||
HMG-CoA Reductase-IN-1 is an inhibitor of HMG-CoA reductase, demonstrating strong inhibitory activity on HMGR and affinity for OATP1B1, with pIC50 and pKm values of 8.54 and 1.98, respectively. It is utilized in hypercho... | |||
T1487 | Fluvastatin sodium | XU 62320 sodium,XU-62-320,Fluvastatin sodium salt | Ferroptosis , HMG-CoA Reductase , Autophagy |
Fluvastatin sodium (Fluvastatin sodium salt), a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), is a commonly used cholesterol lowering agent. | |||
T6450 | Clinofibrate | S-8527,Lipoclin | HMG-CoA Reductase , Autophagy |
Clinofibrate (Lipoclin)(IC50 of 0.47 mM), a lipid-lowering agent, inhibits hydroxymethylglutaryl coenzyme A reductase (HMGCR). It is utilized to control high cholesterol and triacylglyceride levels in the blood. | |||
T6994 | SR12813 | SR-12813,SR 12813,GW 485801 | HMG-CoA Reductase , Autophagy |
SR12813 (GW 485801) is a pregnane X receptor (PXR) agonist. | |||
T12092 | Monacolin J | Antibiotic MB 530A,Lovastatin diol lactone | HMG-CoA Reductase , Autophagy |
Monacolin J (Antibiotic MB 530A) is a cholesterol biosynthesis inhibitor. | |||
T1676 | Rosuvastatin | ZD 4522 | Potassium Channel , HMG-CoA Reductase , Autophagy |
Rosuvastatin (ZD 4522) is an antilipemic agent that competitively inhibits hydroxymethyl-glutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting... | |||
T3116 | Atorvastatin hemicalcium salt | Lipitor,Atorvastatin hemicalcium,Atorvastatin Calcium,CI-981,Sortis | Ferroptosis , HMG-CoA Reductase , Autophagy |
Atorvastatin hemicalcium salt (Atorvastatin Calcium), an effective HMG-CoA reductase inhibitor (IC50 = 8 nM), is utilized as a cholesterol-lowering medication. | |||
T2534 | Pitavastatin calcium | P-872441,nisvastatin,itavastatin,Pitavastatin hemicalcium,NK-104 | Apoptosis , Mitophagy , Endogenous Metabolite , HMG-CoA Reductase , Autophagy |
Pitavastatin calcium (NK-104) is a potent inhibitor of HMG-CoA reductase (Ki: 1.7 nM). It lowers both total cholesterol and low-density lipoprotein cholesterol in animals and humans. Metabolism of pitavastatin by the cyt... | |||
T1510 | Rosuvastatin calcium | ZD 4522 Calcium,ZD4522,Rosuvastatin hemicalcium | Potassium Channel , HMG-CoA Reductase , Autophagy |
Rosuvastatin calcium (ZD4522) , a selective and competitive inhibitor of hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, has antilipidemic activity. | |||
T21405 | Fluvastatin | Canef,XU-62320,Vastin,Cranoc,Lescol | HMG-CoA Reductase |
Fluvastatin (XU-62320) is a potent and competitive HMG-CoA reductase inhibitor (IC50: 8 nM) that inhibits oxidative stress in vascular smooth muscle cells through an Nrf2-dependent pathway, and is used for the reduction ... | |||
T13131 | Tert-Buthyl Pitavastatin | HMG-CoA Reductase | |
tert-Buthyl Pitavastatin is Pitavastatin metabolite. Pitavastatin is a potent inhibitor of HMG-CoA reductase. | |||
T10324 | Anhydrosimvastatin | Dehydro simvastatin | HMG-CoA Reductase |
Anhydrosimvastatin (Dehydro simvastatin) is an impurity of Simvastatin. Simvastatin is an HMG-CoA reductase inhibitor. | |||
T25285 | Dalvastatin | RG-12561,RG 12561,RG12561 | HMG-CoA Reductase |
Dalvastatin (RG-12561) is an orally available inhibitor of HMG-CoA reductase and cholesterol-lowering synthesis.Dalvastatin competitively inhibits rat hepatic HMG-CoA reductase with an IC50 value of 3.4 nmol / l. Dalvast... | |||
TQ0045 | 2-Hydroxy atorvastatin calcium salt | Drug Metabolite | |
2-Hydroxy atorvastatin calcium salt is a hydroxy metabolite of Atorvastatin calcium salt which is a potent HMG-CoA reductase inhibitor (IC50 = 8 nM). | |||
T12652 | (Rac)-5-Keto Fluvastatin | 5-Ketofluvastatin,3-Hydroxy-5-Keto Fluvastatin,rac 5-Keto Fluvastatin | Others |
(Rac)-5-Keto Fluvastatin (rac 5-Keto Fluvastatin) is an impurity of Fluvastatin which is an inhibitor of HMG-CoA reductase. | |||
T24865 | Tenivastatin | L-654969,L654969,Simvastatin acid,L 654969,Simvastatin hydroxy acid | ROS , HMG-CoA Reductase |
Tenivastatin (Simvastatin acid) is an anti-hyperlipidemic HMG-CoA reductase inhibitor that inhibits the production of reactive oxygen species (ROS) and can be used in the study of primary hyperlipidemia. | |||
T12490 | Pitavastatin lactone | Others | |
Pitavastatin lactone is a major Pitavastatin metabolite in humans. Pitavastatin is a potent competitive inhibitor of HMG-CoA reductase little metabolized in hepatic microsomes. | |||
T20887 | Atorvastatin Sodium | Lipitor | LDL , Aquaporin , HMG-CoA Reductase |
Atorvastatin Sodium (Lipitor) is a competitive inhibitor of HMG-CoA reductase and increases the expression of low density lipoprotein (LDL) receptors on hepatocytes. Atorvastatin Sodium treatment inhibits aquaporin 4 to ... | |||
T26644 | Apomine | SK&F-99085,APB-231-A2,APB-231-A-2,SR-9223i,SK&F-99085,SR-45023A | HMG-CoA Reductase |
Apomine (SR-9223i), an inhibitor of HMG-CoA-reductase, promotes apoptosis of myeloma cells in vitro and has been implicated in the regulation of myeloma in vivo. Apomine accelerates the degradation of 3-hydroxy-3-methylg... | |||
T19918 | Lovastatin hydroxy acid sodium | 6-α-Methylcompactin sodium,Lovastatin Na,Lovastatin Sodium,Mevinolin sodium | |
Lovastatin Sodium is an HMG-CoA reductase inhibitor. | |||
T14931 | Cerivastatin | Others | |
Cerivastatin is a highly potent, well-tolerated, and orally active HMG-CoA reductase inhibitor (Ki: 1.3 nM/L). Cerivastatin also inhibits proliferation and invasiveness of MDA-MB-231 cells, mainly by RhoA inhibition with... | |||
T11572 | HMG499 | HMG-CoA Reductase | |
HMG499 is a potent and selective HMG-CoA reductase inhibitor with an IC 50 of 0.41 μM. HMG499 can eliminate statins-induced accumulation of HMGCR, lower serum cholesterol levels and decrease atherosclerosis [1]. | |||
T24323 | L 669262 | L-669,262,L 669,262,L669,262,L-669262,L669262 | |
L 669262 is a potent inhibitor of HMG-CoA reductase. | |||
T10070 | 2'-Ethyl Simvastatin | HMG-CoA Reductase | |
2'-Ethyl Simvastatin is a Mevinolin analog with HMG-CoA reductase inhibition. | |||
T28440 | PPD 10558 | PPD-10558,RBx10558,RBx-10558,PPD10558,RBx 10558 | |
PPD 10558, a HMG-CoA reductase inhibitor, is used potentially for treatment of primary hypercholesterolemia. | |||
T21080 | (3S,5S)-Atorvastatin | ent-Atorvastatin,3S,5S-Atorvastatin | |
ent-Atorvastatin is a selective and competitive inhibitor of HMGCR (HMG-CoA reductase). | |||
T70633 | GR-92549 | ||
GR-92549 is an HMG-CoA reductase inhibitor. | |||
T22405 | Pravastatin | Others | |
Pravastatin is a lipoprotein-lowering drug via reversibly inhibiting hydroxymethylglutaryl-CoA (HMG-CoA) reductase and the synthesis of very-low-density lipoproteins. | |||
T71040 | GR-95030X | ||
GR-95030X is a a novel HMG-CoA reductase inhibitor. | |||
T21042 | Fluvastatin Methyl Ester | ||
Fluvastatin Methyl Ester is a precursor of Fluvastatin, a blocker of the enzyme HMG-CoA reductase in liver. | |||
T26044 | Rawsonol | ||
Rawsonol is a HMG-CoA reductase inhibitor from the tropical green alga Avrainvillea rawsoni. | |||
T13380 | (Z)-Pitavastatin calcium | Others | |
(Z)-Pitavastatin calcium is the Z-Isomer of Pitavastatin hemicacium. Pitavastatin calcium is a potent of hydroxymethylglutaryl-CoA (HMG-CoA) reductase. | |||
T69006 | Atorvastatin lysine | ||
Atorvastatin lysine is a selective and competitive HMGCR (HMG-CoA reductase) inhibitor. | |||
T10126 | (3R,5R)-Rosuvastatin | Others | |
(3R,5R)-Rosuvastatin is the (3R,5R)-enantiomer of Rosuvastatin. Rosuvastatin is a competitive HMG-CoA reductase inhibitor (IC50: 11 nM). | |||
T21363 | Atorvastatin calcium trihydrate | CI-981,atorvastatin, calcium salt,CI981,Atorvastatin,CI 981 | |
Atorvastatin is used to inhibits HMG-CoA reductase for lowering blood cholesterol and for prevention of events associated with cardiovascular disease. | |||
T10136 | 4-Acetylsimvastatin | Others | |
4-Acetylsimvastatin is acetylated simvastatin. Simvastatin is a competitive inhibitor of HMG-CoA reductase (Ki: 0.2 nM). | |||
T10132 | (3S,5S)-Pitavastatin calcium | Others | |
(3S,5S)-Pitavastatin calcium is the 3-epimer of Pitavastatin which is a potent HMG-CoA reductase inhibitor. | |||
T10130 | (3S,5R)-Pitavastatin calcium | Others | |
(3S,5R)-Pitavastatin calcium is the enantiomer of Pitavastatin which is a potent HMG-CoA reductase inhibitor. | |||
T40913 | 3α-Hydroxy pravastatin sodium | ||
3α-Hydroxy pravastatin sodium, the primary metabolite of Pravastatin, is a potent competitive inhibitor of HMG-CoA reductase. | |||
T71705 | Glenvastatin | ||
Glenvastatin is a HMG-CoA reductase inhibitor which has a pyridine-based structure. | |||
T24461 | Mevinolinic acid | L 154819,L-154819,MK 819,MSD 803 acid,Monacolinic K acid | |
Mevinolinic acid is an active metabolite of Lovastatin. Lovastatin is an HMG-CoA reductase inhibitor. | |||
T10131 | (3S,5R)-Rosuvastatin | Others | |
(3S,5R)-Rosuvastatin is the (3R,5R)-enantiomer of Rosuvastatin. Rosuvastatin is a competitive HMG-CoA reductase inhibitor (IC50: 11 nM). | |||
T70419 | Cerivastatin lactone | ||
Cerivastatin lactone is a metabolite of a competitive inhibitor of HMG-CoA reductase, Cerivastatin. Cerivastatin lactone shows inhibitory effects on CYP3A4/5 activity. | |||
T68566 | Pitavastatin methyl ester | ||
Pitavastatin methyl ester is the methyl ester derivative of Pitavastatin -- a competitive inhibitor of HMG-CoA reductase and an anti-lipemic agent. | |||
T38249 | 2-Hydroxy atorvastatin lactone | ||
2-Hydroxy atorvastatin lactone, a metabolite of Atorvastatin, is an orally active HMG-CoA reductase inhibitor that efficiently reduces blood lipids [1][2]. | |||
T10401 | Atorvastatin acetonide | Others | |
Atorvastatin acetonide is an impurity of Atorvastatin. Atorvastatin is an HMG-CoA reductase inhibitor and has the ability to effectively decrease blood lipids. | |||
T40557 | Simvastatin Acyl-β-D-glucuronide | ||
Simvastatin Acyl-β-D-glucuronide, a metabolite formed from Simvastatin, acts as a competitive inhibitor of HMG-CoA reductase, showcasing a potent Ki of 0.2 nM. | |||
T12488 | Pitavastatin D4 | NK-104 D4 | Others |
Pitavastatin D4 is deuterium labeled Pitavastatin. Pitavastatin is a potent inhibitor of HMG-CoA reductase. |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
TN1733 | Hesperetin 7-O-glucoside | Anti-infection , Antibacterial , HMG-CoA Reductase | |
Hesperetin 7-O-glucoside and prunin are direct precursors of naringin and neohesperidin, respectively, in C. aurantium. Hesperetin 7-O-glucoside shows inhibition of human HMG-CoA reductase, it also exhibits effective inh... | |||
TN6715 | 7-Ketocholesterol | Others | |
7-Ketocholesterol is a metabolite of Cholesterol | |||
TN1438 | Beta-Amyrin acetate | Antioxidant , HMG-CoA Reductase , Epoxide Hydrolase , Antifungal | |
beta-Amyrin acetate inhibits HMG-CoA Reductase (HMGCR) and sEH activity with IC50 of 3.4 μM. beta-Amyrin acetate has anti-inflammatory, antifungal, antioxidant, and anti-hyperlipidemic activities. | |||
T1207 | Lovastatin | MK-803,Mevinolin | Ferroptosis , HMG-CoA Reductase , Autophagy |
Lovastatin (MK-803) is an HMG-CoA Reductase Inhibitor, used for lowering cholesterol. | |||
T0683 | Mevastatin | Compactin,ML236B | Apoptosis , Antibacterial , Antibiotic , HMG-CoA Reductase , Autophagy , Lipid |
Mevastatin (ML236B) is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum. Mevastatin was the first statin to enter clinical trials. | |||
T1664 | Meglutol | Dicrotalic acid,3-Hydroxy-3-methylglutaric acid | Endogenous Metabolite , HMG-CoA Reductase , Autophagy |
Meglutol (3-Hydroxy-3-methylglutaric acid) is an antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the conve... | |||
T0672 | Pravastatin sodium | CS-514 Sodium,CS-514 (sodium) | Ferroptosis , HMG-CoA Reductase , Autophagy |
Pravastatin sodium (CS-514 (sodium)), an HMG-CoA reductase inhibitor, inhibits sterol synthesis with IC50 of 5.6 μM. | |||
T0687 | Simvastatin | MK-0733,MK 733 | Apoptosis , Mitophagy , Ferroptosis , HMG-CoA Reductase , Autophagy |
Simvastatin (MK 733) is an HMG-CoA reductase inhibitor (Ki=0.2 nM) with oral activity. Simvastatin has hypolipidemic activity, inhibits hepatic production of cholesterol, and is also used for the prevention of cardiovasc... | |||
T4717 | 25-Hydroxycholesterol | Others , Endogenous Metabolite , HMG-CoA Reductase | |
25-Hydroxycholesterol is a steroid derivative that suppresses the cleavage of sterol regulatory element binding proteins (SREBPs). It inhibits HMG-CoA reductase and so it also plays a significant role in the in vivo regu... | |||
TN2111 | Prunin | Naringenin 7-0-glucoside | Phosphatase , Anti-infection , Virus Protease |
Prunin (Naringenin 7-0-glucoside) possesses anti-diabetic, and anti-abacterial properties, it can inhibit protein tyrosine phosphatase 1B (PTP1B) and stimulate glucose uptake in insulin-resistant HepG2 cells; it also can... | |||
T75626 | Ganoderenic acid K | ||
Ganoderenic Acid K, isolated from the fruiting bodies of Ganoderma lucidum, exhibits potent inhibitory activity against HMG-CoA reductase (HMGCR), demonstrating an IC50 of 16.5 μM [1]. | |||
T35400 | β-Muricholic Acid | β-MCA,5β-Cholanic Acid-3α,6β,7β-triol,β-Muricholic Acid | |
β-Muricholic acid (β-MCA) is a murine-specific primary bile acid.[1],[2] Dietary administration of β-MCA reduces HMG-CoA reductase activity in liver microsomes from mice fed a high cholesterol and cholic acid diet.[3] Di... |
Cat No. | Product Name | Species | Expression System |
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TMPY-00989 | LDLR Protein, Human, Recombinant (His) | Human | HEK293 |
LDL Receptor, also known as LDLR, is a mosaic protein that belongs to the Low-density lipoprotein receptor gene family. The low-density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved i... | |||
TMPY-05809 | LDLR Protein, Human, Recombinant (193D/A, His) | Human | HEK293 |
LDL Receptor, also known as LDLR, is a mosaic protein that belongs to the Low-density lipoprotein receptor gene family. The low-density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved i... | |||
TMPY-05348 | LDLR Protein, Mouse, Recombinant (His), Biotinylated | Mouse | HEK293 |
LDL Receptor, also known as LDLR, is a mosaic protein that belongs to the Low-density lipoprotein receptor gene family. The low-density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved i... | |||
TMPY-05499 | LDLR Protein, Human, Recombinant (His), Biotinylated | Human | HEK293 |
LDL Receptor, also known as LDLR, is a mosaic protein that belongs to the Low-density lipoprotein receptor gene family. The low-density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved i... | |||
TMPY-01014 | LDLR Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
LDL Receptor, also known as LDLR, is a mosaic protein that belongs to the Low-density lipoprotein receptor gene family. The low-density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved i... | |||
TMPY-05323 | LDLR Protein, Human, Recombinant (mFc) | Human | HEK293 |
LDL Receptor, also known as LDLR, is a mosaic protein that belongs to the Low-density lipoprotein receptor gene family. The low-density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved i... |
Cat No. | Product Name | ||
---|---|---|---|
L2510 | Lipid Metabolism Compound Library | 496 compounds | |
A unique collection of 496 compounds targeting lipid metabolism, can be used for high-throughput screening (HTS) and high-content screening (HCS). |