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Search Results for " hl-60 "

Targets

37

Compounds

79

Natural Products

5

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T2099 ABT-737 Mitophagy , BCL , Autophagy
ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w (EC50s: 78.7/30.3/197.8 nM).
T6019 Volasertib BI 6727 Apoptosis , PLK
Volasertib (BI 6727) (BI-6727) is a potent inhibitor of PLK1 (IC50: 0.87 nM), inducing mitotic arrest and apoptosis. It also inhibits PLK2/PLK3 (IC50s: 5/56 nM).
T9975 GPR183 3-(3,4-difluorophenyl)-N-[3-fluoro-5-(morpholin-4-yl)phenyl]propanamide Others
GPR183 is a chemotactic receptor known for its role in the maturation of B cells, and the endogenous ligand is the oxysterol 7α,25-dihydroxycholesterol (7α,25-OHC). GPR183 can be used in research on inflammatory bowel di...
T67899 Topoisomerase II inhibitor 13 Topoisomerase
Topoisomerase II inhibitor 13 inhibits topoisomerase II (Topo II) that shows strong anti-proliferation activity against HL-60/MX2 cancer cells derived from HL-60 against Topo II toxicity.
T14982 Clofilium tosylate Potassium Channel
Clofilium tosylate is a potassium channel blocker. It induces apoptosis of human promyelocytic leukemia (HL-60) cells via Bcl-2-insensitive activation of caspase-3.
T41231 GP 1a Cannabinoid Receptor , PERK , Arrestin
GP 1a is a potent agonist of cannabinoid receptor 2 (CB2) (EC50=7.1), as shown in cAMP, GTPγS and β-arrestin recruitment assays. GP 1a is approximately 30-fold more selective for CB2 receptors than CB1 receptors and incr...
T73588 8-(4-iodophenyl)-1,3,5,7-tetramethyl BODIPY
8-(4-iodophenyl)-1,3,5,7-tetramethyl BODIPY is a novel BODIPY fluorescent dye for the treatment of cytotoxicity.
T34694 Spicamycin
Spicamycin can be used as a potent inducer of differentiation of human myeloid leukemia cells (HL-60) and murine myeloid leukemia cells (M1).
T36693 FD-211
FD-211 is a δ lactone originally isolated from M. lutea with anticancer activity.1 It is cytotoxic to adriamycin-susceptible P388, T-24, HeLa, A549, and HL-60 cancer cells (IC50s = 4, 0.5, 1, 1, and 0.2 μg/ml, respective...
T78978 Antitrypanosomal agent 13 Parasite
Compound 4b (antitrypanosomal agent 13) is a potent antitrypanosomal with notable trypanocidal and cytotoxic activities, exhibiting GI50 values of 0.18 μM against T. brucei and 8.4 μM for HL-60 [1].
T41133 Ursonic acid methyl ester
Ursonic acid methyl ester, an esterified derivative of Ursolic acid, exhibits growth inhibitory activity against four tumor cell lines: HL-60, BGC, Bel-7402, and Hela, and the ED50 values for inhibition are >100 μg/ml.
T36593 TEI-9648
TEI-9648, a Vitamin D3 Lactone analogue, is a potent and specific vitamin D receptor (VDR) antagonist. TEI-9648 inhibits VDR/VDRE-mediated genomic actions of 1α,25(OH)2D3. TEI-9648 also inhibits HL-60 cell differentiatio...
T82774 Caspase-3 activator 3 Caspase
Caspase-3 activator 3 (compound 2h) effectively induces apoptosis in HL-60 and K562 cells by substantially activating caspase-3, demonstrating antileukemic activity with IC50 values of 42.89 μM and 33.61 μM, respectively...
T82775 Caspase-3 activator 2 Caspase
Caspase-3 Activator 2 (Compound 2f) is a caspase 3 activator with cytotoxic effects on HL-60 and K562 cells, exhibiting IC 50 values of 33.52 μM and 76.90 μM, respectively [1]. It facilitates apoptosis, rendering it usef...
T13643 Demethoxydeacetoxypseudolaric acid B analog Others
Demethoxydeacetoxypseudolaric acid B analog has potent activities against HMEC-1, HL-60, A-549, MB-MDA-468, BEL-7402, HCT116, and Hela cells with IC50s ranging from 0.136 to 1.162 μM. and is semi-synthesized by efficient...
T36418 O-Desmethyl-N-deschlorobenzoyl Indomethacin
O-Desmethyl-N-deschlorobenzoyl indomethacin is a metabolite of the non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor indomethacin .1It is formed from indomethacin in isolated rabbit hepatocytes. O-Desmethyl-...
T36894 5-Bromouridine
5-Bromouridine is a brominated analog of the nucleoside uridine .1It can be incorporated into RNA and subsequently detected by antibodies against bromodeoxyuridine .25-Bromouridine decreases the viability of HL-60 and MO...
T78815 MOZ-IN-3 Histone Acetyltransferase
MOZ-IN-3 (Compound 6j), a potent KAT6A (MOZ) acetyltransferase inhibitor with an IC50 of 30 nM, exhibits antitumor activity against multiple myeloid leukemia cell lines, including HL-60, U937, SKNO-1, and K562. This comp...
T36399 PAO-Nap
PAO-Nap is a chemically modified version of PAO, in which a naphthalimide fluorophore is attached to the compound using a linker called aminocaproic acid. This modified compound, PAO-Nap, exhibits a selective targeting o...
T69066 Forphenicine
Forphenicine is a bacterial metabolite that has been found in S. fulvoviridis and an inhibitor of alkaline phosphatase (IC50 = 0.036 µg/ml for the chicken intestine enzyme). It inhibits the growth of HL-60 leukemia cells...
T61828 DNA-PK-IN-8
DNA-PK-IN-8 is a highly potent, selective and orally active DNA-dependent protein kinase (DNA-PK) inhibitor with an IC 50 value of 0.8 nM. DNA-PK-IN-8 exhibits synergistic antiproliferative activity against a series of c...
T69629 M‑89 MLL inhibitor
M‑89 is a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein−Protein Interaction (Kd = 1.4 nM; IC50 = 25nM). M-89 binds to menin with a Kd value of 1.4 nM and effectively engages cellular men...
T83724 TPP-1 hydrochloride Targeting PD-L1 Peptide
TPP-1, a peptide inhibitor, targets the interaction between programmed cell death protein 1 (PD-1) and its ligand (PD-L1), binding specifically to PD-L1 with a dissociation constant (Kd) of 94.67 nM. At a concentration o...
T76379 Myelopeptide-2
Myelopeptide-2 is a peptide originally isolated from the supernatant of porcine bone marrow cell cultures, can restore mitogenic reactivity of human T lymphocytes inhibited by HL-60 leukemia cells or measles virus condit...
T77629 FD274 FD 274,FD-274 PI3K , mTOR
FD274 is a potent dual PI3K/mTOR inhibitor with inhibitory effects on PI3Kα/β/γ/δ and mTOR, with IC50s of 0.65 nM, 1.57 nM, 0.65 nM, 0.42 nM, and 2.03 nM, respectively. FD274 showed significant antiproliferative activity...
T19228 Calcitriol Impurities D 24-Homo Calcitriol,24-Homo-1,25-dihydroxyvitamin D3 Antiviral
Calcitriol Impurities D (24-Homo Calcitriol) is a hormonal form of the vitamin that promotes the differentiation of HL-60 human promyelocytic leukemia cells into monocytes.Calcitriol Impurities D has bone resorption acti...
T37068 NR-160
NR-160 is an inhibitor of histone deacetylase 6 (HDAC6; IC50= 0.03 μM).1It is selective for HDAC6 over HDAC1, -2, -3, -4, and -8 (IC50s = 5.18, 2.26, 8.48, 55.4, and 14.7 μM, respectively). NR-160 is cytotoxic against a ...
T37056 D-erythro-MAPP
D-erythro-MAPP is a derivative of ceramide and an inhibitor of alkaline ceramidase (Ki = 2-13 μM; IC50 = 1-5 μM). It is selective for alkaline ceramidase over acid ceramidase (IC50 = >500 μM) as well as the serine/threon...
T4057 Hoechst 33258 trihydrochloride Hoechst 33258,Pibenzimol,Bisbenzimide,H 33258 trihydrochloride,bisBenzimide H 33258 trihydrochloride,HOE 33258 Parasite
Hoechst 33258 trihydrochloride (Bisbenzimide) is a benzimidazole anti-filarial agent. it is fluorescent when it binds to certain nucleotides in DNA, thus providing a tool for the study of DNA replication. it also interfe...
T35927 C2 L-threo Ceramide (d18:1/2:0) C2 L-threo Ceramide (d18:1/2:0)
C2 L-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It stimulates cholesterol efflux in CHO cells expressing the human ABCA1 receptor when used at a concentration o...
T36035 CAY10784
CAY10784 is a STAT3 inhibitor (IC50= 0.74 μM in a reporter assay) and a derivative of WP1066 .1It inhibits proliferation of HeLa, Caco-2, A549, A375, U87MG, and HL-60 cancer cells (IC50s = 1.8, 1.8, 3, 2.8, 2.3, and 1.2 ...
TP2193 Myelopeptide-2 (MP-2) Others
Myelopeptide-2 (MP-2) with the sequence Leu-Val-Val-Tyr-Pro-Trp is originally isolated from the supernatant of porcine bone marrow cell culture and is able to restore the mitogen responsiveness of human T lymphocytes inh...
T38377 ADTL-EI1712 ADTL-EI1712
ADTL-EI1712 is a dual inhibitor of ERK1 and ERK5 (IC50s = 40.43 and 64.5 nM, respectively).1It reduces ERK1 and ERK5 activity by 93.5% and 89.4%, respectively, but also inhibits ERK2 activity by 92.7%, in a panel of 100 ...
T35772 Emestrin
Emestrin is a mycotoxin originally isolated from E. striata that has antimicrobial, immunomodulatory, and cytotoxic activities.1,2,3,4,5 It is active against the fungi C. albicans and C. neoformans, as well as the bacter...
T35884 Sialyl-Lewis X
Sialyl-Lewis X (sLeX) is a sialylated fucosylated tetrasaccharide, an endogenous antigen. Sialyl-Lewis X is a high-affinity ligand for selectins (E-, P-, and L-selectin)[1]. Sialyl-Lewis X binds to ELAM-1 and CD62 and ha...
T35536 Tpl2 Kinase Inhibitor (hydrochloride)
Tpl2 kinase inhibitor is an inhibitor of tumor progression locus 2 (Tpl2; IC50= 0.05 μM).1It is selective for Tpl2 over MEK, p38 MAPK, Src, MK2, and PKC (IC50s = >40, 180, >400, 110, and >400 μM, respectively). Tpl2 kina...
T36199 AZD 1152 (hydrochloride)
AZD 1152 is an orally bioavailable prodrug of AZD 1152-HQPA, a selective inhibitor of Aurora kinase B (IC50= 0.36 nM).1AZD 1152 is converted to AZD 1152-HQPA in plasma. Inhibition of Aurora B results in disruption of spi...

Compounds

ABT-737
T2099
Synonym:
Target: Mitophagy, BCL, Autophagy
Volasertib
T6019
Synonym: BI 6727
Target: Apoptosis, PLK
GPR183
T9975
Synonym: 3-(3,4-difluorophenyl)-N-[3-fluoro-5-(morpholin-4-yl)phenyl]propanamide
Target: Others
Topoisomerase II inhibitor 13
T67899
Synonym:
Target: Topoisomerase
Clofilium tosylate
T14982
Synonym:
Target: Potassium Channel
GP 1a
T41231
Synonym:
Target: Cannabinoid Receptor, PERK, Arrestin
8-(4-iodophenyl)-1,3,5,7-tetramethyl BODIPY
T73588
Synonym:
Target:
Spicamycin
T34694
Synonym:
Target:
FD-211
T36693
Synonym:
Target:
Antitrypanosomal agent 13
T78978
Synonym:
Target: Parasite
Ursonic acid methyl ester
T41133
Synonym:
Target:
TEI-9648
T36593
Synonym:
Target:
Caspase-3 activator 3
T82774
Synonym:
Target: Caspase
Caspase-3 activator 2
T82775
Synonym:
Target: Caspase
Demethoxydeacetoxypseudolaric acid B analog
T13643
Synonym:
Target: Others
O-Desmethyl-N-deschlorobenzoyl Indomethacin
T36418
Synonym:
Target:
5-Bromouridine
T36894
Synonym:
Target:
MOZ-IN-3
T78815
Synonym:
Target: Histone Acetyltransferase
PAO-Nap
T36399
Synonym:
Target:
Forphenicine
T69066
Synonym:
Target:
DNA-PK-IN-8
T61828
Synonym:
Target:
M‑89 MLL inhibitor
T69629
Synonym:
Target:
TPP-1 hydrochloride
T83724
Synonym: Targeting PD-L1 Peptide
Target:
Myelopeptide-2
T76379
Synonym:
Target:
FD274
T77629
Synonym: FD 274,FD-274
Target: PI3K, mTOR
Calcitriol Impurities D
T19228
Synonym: 24-Homo Calcitriol,24-Homo-1,25-dihydroxyvitamin D3
Target: Antiviral
NR-160
T37068
Synonym:
Target:
D-erythro-MAPP
T37056
Synonym:
Target:
Hoechst 33258 trihydrochloride
T4057
Synonym: Hoechst 33258,Pibenzimol,Bisbenzimide,H 33258 trihydrochloride,bisBenzimide H 33258 trihydrochloride,HOE 33258
Target: Parasite
C2 L-threo Ceramide (d18:1/2:0)
T35927
Synonym: C2 L-threo Ceramide (d18:1/2:0)
Target:
CAY10784
T36035
Synonym:
Target:
Myelopeptide-2 (MP-2)
TP2193
Synonym:
Target: Others
ADTL-EI1712
T38377
Synonym: ADTL-EI1712
Target:
Emestrin
T35772
Synonym:
Target:
Sialyl-Lewis X
T35884
Synonym:
Target:
Tpl2 Kinase Inhibitor (hydrochloride)
T35536
Synonym:
Target:
AZD 1152 (hydrochloride)
T36199
Synonym:
Target:
Cat No. Product Name Synonyms Targets
TN1121 Evocarpine Apoptosis , cAMP , Anti-infection , Calcium Channel , Antibacterial
Evocarpine shows antimycobacterial, and vasorelaxant effects, it can inhibit Ca2+ influx through voltage-dependent calcium channels.
TN1684 Ginsenoside F5 Apoptosis
Ginsenoside F5 is a natural product from Panax ginseng C. A. Mey, remarkably inhibits the growth of HL-60 cells by the apoptosis pathway
TJS0328 Nordalbergin 6,7-dihydroxy-4-phenylcoumarin,6,7-Dihydroxy-4-Phenylchromen-2-One Others
Nordalbergin is a natural product for research related to life sciences. The catalog number is TJS0328 and the CAS number is 482-82-6.
T1882 Meisoindigo N-Methylisoindigotin,Methylisoindigotin,Natura-α,Dian III Apoptosis
Meisoindigo (Natura-α) is a derivative of indigo natural, might induces apoptosis and myeloid differentiation of acute myeloid leukemia (AML).
TQ0309 Glaucocalyxin B Autophagy
Glaucocalyxin B is a diterpenoid isolated from Rabdosia japonica with anticancer and antitumor activity. It decreases the growth of HL-60 cells (IC50: 5.86 μM).
T1166 Ellipticine NSC 71795,Elliptisine Topoisomerase
Ellipticine (Elliptisine) is a potent antineoplastic agent exhibiting multiple mechanisms of action, IC50 of 0.67±0.06, 1.25±0.13, 1.25±0.13, 0.67±0.06, 0.27±0.02, 0.49±0.04, 0.44±0.03, and 1.48±0.62 μM for Leukemia HL-6...
TN7043 Neolancerin Others
Neolancerin is a natural product isolated from adventitious roots of St. John’s wort (Hypericum perforatum L.).
T10390 Asperphenamate Others , Antifungal
Asperphenamate is a fungal metabolite of Aspergillus flatiipes. The IC50s for T47D cells, MDA-MB-231 cells, and HL-60 cells are 92.3 μM, 96.5 μM, and 97.9 μM. Asperphenamate shows an anticancer effect.
TJS0487 (-)-Syringaresinol DL-Syringaresinol,Lirioresinol b Others
(-)-Syringaresinol (DL-Syringaresinol) is derived from the stems of Annona Montana. (-)-Syringaresinol inhibits the proliferation of human promyelocytic HL-60 cells through G1 arrest and induction of apoptosis and posses...
T25664 Lepidiline A Macaline A Others
Lepidiline A (Macaline A) is a flavonoid lignin with anti-inflammatory activity. Lepidiline A showed cytotoxic activity against HL-60 cells with IC50 of 32.3 μM. It is the active ingredient of Lepidium meyenii Walpers, a...
T67922 Lepidiline C Others
Lepidiline C is a novel imidazoles alkaloids extracted from the root of Lepidium meenii Walpers of the brassaceae family. It has shown cytotoxic activity against HL-60 cells (IC50:27.7 μM).
T5S1000 Sophoraflavanone G Kushenol F,Vexibinol Apoptosis
Sophoraflavanone G (Kushenol F) (Kushenol F), isolated from Sophora flavescens, induces MDA-MB-231 and HL-60 cells apoptosis through suppression of MAPK-related pathways.
T5826 Eupalinolide A HSP
Eupalinolide B is a natural product ,and demonstrates potent cytotoxicity against A-549, BGC-823, SMMC-7721, and HL-60 tumour cell lines.
TN1215 (2S)-2'-Methoxykurarinone 2'-Methoxykurarinone,2'-O-Methylkurarinone Akt , Antifection
(2S)-2'-Methoxykurarinone is isolated from the roots of Sophora flavescens. (2S)-2'-Methoxykurarinone has anti-inflammatory, antipyretic, antidiabetic, and antineoplastic effects. (2S)-2'-Methoxykurarinone inhibits osteo...
T36528 Illudin M Apoptosis , DNA Alkylator/Crosslinker
Illudin M is a cytotoxic sesquiterpene from the fungus O. illudens that alkylates DNA. It has a cytotoxicity of 6-100 nM against HL-60 human leukemia cells.Illudin M has anticancer activity and is a pre-drug for the synt...
TN1258 3-Acetyl-beta-boswellic acid 3-O-Acetyl-beta-boswellic acid DNA/RNA Synthesis
3-Acetyl-beta-boswellic acid has antitumor activity, it inhibits synthesis of DNA, RNA and protein in human leukemia HL-60 cells in a dose dependent manner with IC50 values ranging from 0.6 to 7.1 microM.
T3864 Erianin BCL , Antibacterial
Erianin is a nature product extracted from Dendrobium chrysotoxum, has notable antitumour activity , can cause extensive tumour necrosis, growth delay. Erianin has antiangiogenic action by inhibiting endothelial metaboli...
T3405 [6]-Gingerol 6-Gingerol,gingerol,(S)-(+)-[6]Gingerol Apoptosis , AMPK
[6]-Gingerol ((S)-(+)-[6]Gingerol), an antioxidant, protects HL-60 cells from oxidative stress. It has protective effects for Yous tumors in the pancreas, ovaries, breast tissue, the bowel, among other tissues.
TN1369 Alloimperatorin Prangenidin Others
Alloimperatorin (Prangenidin) exhibits in vitro antitumor activity in HL-60 acute myeloid leukemia cancer cells via inducing apoptosis, cell cycle disruption and inhibition of cell migration. It photosensitizes efficient...
T4601 9-Methoxycanthin-6-one Others
9-Methoxycanthin-6-one has anti-tumour activity, exhibits cytotoxic activity towards KB, LU-1, LNCaP, HL-60 cancer cells and other human cancer cell lines with IC50 values around 1-4 μg/mL.
T3S2325 Ardisiacrispin A Saxifragifolin B,LTS-4,Deglucocyclamin HSV
Ardisiacrispin A (Deglucocyclamin) has cytotoxic activity toward HepG2 cancer cell with the GI(50) value of 1.56μM, it could inhibit the proliferation of Bel-7402 cells by inducing apoptosis and disassembling microtubule...
T6S2238 Eupalinolide B Others
Eupalinolide A has the effects of relieving phlegm and relieving cough, clearing away heat and detoxification, diuretic swelling and reducing blood pressure.
TN2318 Yadanziolide C Others
Yadanziolide C induces differentiation with cultured HL-60 promyelocytic leukemia cells.
TN4245 Icariside D2 Akt
Icariside D2 shows significant cytotoxic activity on the HL-60 cell line with the IC50 value of 9.0 ± 1.0 uM, it induces apoptosis via alteration of expression of apoptosis-related proteins and decreased phosphorylation ...
TN5456 Isoerysenegalensein E
Isoerysenegalensein E shows anti-estrogenic activity comparable to that of 4-hydroxytamoxifen, a typical estrogen receptor antagonist. It shows significant cytotoxicity against HL-60 cells, it induces apoptosis in HL-60 ...
TN2837 29-Nor-20-oxolupeol Others
29-Nor-20-oxolupeol(3 beta-Hydroxy-30-norlupan-20-one) has growth inhibitory effects on HL-60 cells.
TN3371 Albatrelin G Others
Albatrelin G shows weak cytotoxic activity to cell lines HL-60, SMMC-7721, A-549, and MCF-7, in vitro.
TN5373 Ustusolate A
1. Ustusolate A shows weak cytotoxicity against HL-60 and A549 cells with IC50 values of 20.6 and 30.0 microM, respectively.
TN6054 Norglaucine hydrochloride
(+)-Norglaucine shows cytotoxic activity toward the tumor cell lines B16-F10 (mouse melanoma), HepG2 (human hepatocellular carcinoma), K562 (human chronic myelocytic leukemia) and HL-60 (human promyelocytic leukemia) and...
TN5676 Musellarin B
Musellarin B is cytotoxic toward several of the human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW480).
T19960 Hinesol (-)-Hinesol
Hinesol is a unique sesquiterpenoid isolated from Atractylodes lancea rhizome. Hinesol has been found to induce apoptosis through the JNK signaling pathway in HL-60 cells.
TN4375 Kamebanin Antifection
Kamebanin, a natural diterpenoid, has antibacterial activity. It also shows efficient cytotoxic activity against HeLa and HL-60 cells.
TN4373 Kaempferol tetraacetate Antifection
Kaempferol tetraacetate is a potent antiplatelet agent. It exhibits significant cytotoxicity in vitro against three human cell lines HL-60, U937 and SK-MEL-1.
TN5212 Uvedalin Others
Uvedalin shows cytotoxicity against HeLa, HL-60, and Murine B16-F10 melanoma cell lines.
T61955 Aspochalasin M
Aspochalasin M shows moderate activity on HL-60 cells (IC50=20.0 μ M). Aspochalasin M has research potential in leukemia diseases.
T72795 (S)-Erypoegin K
(S)-Erypoegin K is a potent anticancer agent. (S)-Erypoegin K shows potent anti-proliferative activity against HL-60 cells. (S)-Erypoegin K induces apoptosis .
TN3561 Cabraleone Others
The mixture of cabraleone and ocotillone shows cytotoxicity against HL-60 leukaemia cell line.
TN4799 Piptocarphin F Others
Piptocarphin F shows strong cytotoxic activities against mouse lymphoid tumor cell line P388. It also shows cytotoxic activity (IC50 3.87-12.5 umol/L) against the human leukemic cell line HL-60.
T81937 Lewis a trisaccharide Lewis a
Lewis a trisaccharide (Lewis a) constitutes a significant component of the glycan structures on spermatozoa and is also a major constituent of the glycans on the surface of HL-60 cells [1].
TN5211 Ustusolate E Others
Ustusolate E exhibits moderate cytotoxicity against A549 and HL-60 cells with the IC50 value of 9.0 microM.
T27305 Fascaplysin chloride NSC622398,NSC 622398,Fascaplysin,NSC-622398
Fascaplysin is a cyclin D kinase 4/ cyclin D1 inhibitor (IC50 = 0.35 μM). Fascaplysin induces caspase mediated crosstalk between autophagy and apoptosis through the inhibition of PI3K/AKT/mTOR signaling cascade in human ...
TN3477 Baccatin VIII Others
Baccatin VIII exhibits inhibitory effects on HL-60 and MCF-7, with IC50 values of 3.44 and 9.67 uM, respectively.
TN3992 Erysubin A Others
Erysubin A , wighteone, and lupalbigenin show promising cytotoxic effects toward HL-60 cells (IC50 4.3 ± 0.7 to 18.0 ± 1.7 uM).
TN3250 7-Prenyljacareubin Others
7-Prenyljacareubin shows moderate cytotoxic activity against HL-60, SMMC-7721, A549, MCF-7, and SW480 cell lines.
T83260 6β,7β-Epoxyasteriscunolide A
6β,7β-Epoxyasteriscunolide A, a sesquiterpenoid, exhibits cytotoxicity against HL-60 and MOLT-3 leukemia cell lines, demonstrating half maximal inhibitory concentrations (IC50s) ranging from 4.1 to 5.4 μM [1].
TN1572 Desacetylcinobufotalin Others
Desacetylcinobufotalin has significant antitumor activity through induction apoptosis via mitochondria pathway, it also shows potent cytotoxic activities against HL-60 cell lines.
TN4087 Furowanin A Caspase
Furowanin A shows significant cytotoxicity against HL-60 cells, it induces that Caspase-9 and caspase-3 inhibitors suppresses apoptosis.
TN5210 Ustusolate C Others
Ustusolate C and ustusolate E exhibit moderate cytotoxicity against A549 and HL-60 cells with IC50 values of 10.5 and 9.0 microM, respectively.
TN2184 Schisanlactone E Others
Schisanlactone E may show moderate cytotoxic activity against the human tumor cell lines Bel-7402, BGC-823, MCF-7 and HL-60.
TN2591 11beta-Hydroxycedrelone Others
11β-Hydroxycedrelone has cytotoxic activity, it exhibits moderate inhibitory activity against HL-60 cell line with the IC50 values of 8.9 uM.
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Natural Products

Evocarpine
TN1121
Synonym:
Target: Apoptosis, cAMP, Anti-infection, Calcium Channel, Antibacterial
Ginsenoside F5
TN1684
Synonym:
Target: Apoptosis
Nordalbergin
TJS0328
Synonym: 6,7-dihydroxy-4-phenylcoumarin,6,7-Dihydroxy-4-Phenylchromen-2-One
Target: Others
Meisoindigo
T1882
Synonym: N-Methylisoindigotin,Methylisoindigotin,Natura-α,Dian III
Target: Apoptosis
Glaucocalyxin B
TQ0309
Synonym:
Target: Autophagy
Ellipticine
T1166
Synonym: NSC 71795,Elliptisine
Target: Topoisomerase
Neolancerin
TN7043
Synonym:
Target: Others
Asperphenamate
T10390
Synonym:
Target: Others, Antifungal
(-)-Syringaresinol
TJS0487
Synonym: DL-Syringaresinol,Lirioresinol b
Target: Others
Lepidiline A
T25664
Synonym: Macaline A
Target: Others
Lepidiline C
T67922
Synonym:
Target: Others
Sophoraflavanone G
T5S1000
Synonym: Kushenol F,Vexibinol
Target: Apoptosis
Eupalinolide A
T5826
Synonym:
Target: HSP
(2S)-2'-Methoxykurarinone
TN1215
Synonym: 2'-Methoxykurarinone,2'-O-Methylkurarinone
Target: Akt, Antifection
Illudin M
T36528
Synonym:
Target: Apoptosis, DNA Alkylator/Crosslinker
3-Acetyl-beta-boswellic acid
TN1258
Synonym: 3-O-Acetyl-beta-boswellic acid
Target: DNA/RNA Synthesis
Erianin
T3864
Synonym:
Target: BCL, Antibacterial
[6]-Gingerol
T3405
Synonym: 6-Gingerol,gingerol,(S)-(+)-[6]Gingerol
Target: Apoptosis, AMPK
Alloimperatorin
TN1369
Synonym: Prangenidin
Target: Others
9-Methoxycanthin-6-one
T4601
Synonym:
Target: Others
Ardisiacrispin A
T3S2325
Synonym: Saxifragifolin B,LTS-4,Deglucocyclamin
Target: HSV
Eupalinolide B
T6S2238
Synonym:
Target: Others
Yadanziolide C
TN2318
Synonym:
Target: Others
Icariside D2
TN4245
Synonym:
Target: Akt
Isoerysenegalensein E
TN5456
Synonym:
Target:
29-Nor-20-oxolupeol
TN2837
Synonym:
Target: Others
Albatrelin G
TN3371
Synonym:
Target: Others
Ustusolate A
TN5373
Synonym:
Target:
Norglaucine hydrochloride
TN6054
Synonym:
Target:
Musellarin B
TN5676
Synonym:
Target:
Hinesol
T19960
Synonym: (-)-Hinesol
Target:
Kamebanin
TN4375
Synonym:
Target: Antifection
Kaempferol tetraacetate
TN4373
Synonym:
Target: Antifection
Uvedalin
TN5212
Synonym:
Target: Others
Aspochalasin M
T61955
Synonym:
Target:
(S)-Erypoegin K
T72795
Synonym:
Target:
Cabraleone
TN3561
Synonym:
Target: Others
Piptocarphin F
TN4799
Synonym:
Target: Others
Lewis a trisaccharide
T81937
Synonym: Lewis a
Target:
Ustusolate E
TN5211
Synonym:
Target: Others
Fascaplysin chloride
T27305
Synonym: NSC622398,NSC 622398,Fascaplysin,NSC-622398
Target:
Baccatin VIII
TN3477
Synonym:
Target: Others
Erysubin A
TN3992
Synonym:
Target: Others
7-Prenyljacareubin
TN3250
Synonym:
Target: Others
6β,7β-Epoxyasteriscunolide A
T83260
Synonym:
Target:
Desacetylcinobufotalin
TN1572
Synonym:
Target: Others
Furowanin A
TN4087
Synonym:
Target: Caspase
Ustusolate C
TN5210
Synonym:
Target: Others
Schisanlactone E
TN2184
Synonym:
Target: Others
11beta-Hydroxycedrelone
TN2591
Synonym:
Target: Others

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPK-00501 PADI4 Protein, Cynomolgus, Recombinant (His) Cynomolgus E. coli
Peptidylarginine deiminase type4 (PADI4) was firstly identified as a non-MHC RA genetic risk factor. Furthermore, PADI4 risk allele possessed the association with bone damage regardless of anti citrullinated peptide anti...
TMPK-01238 PADI4 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated Human E. coli
Peptidylarginine deiminase type4 (PADI4) was firstly identified as a non-MHC RA genetic risk factor. Furthermore, PADI4 risk allele possessed the association with bone damage regardless of anti citrullinated peptide anti...
TMPK-00502 PADI4 Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His), Biotinylated Cynomolgus E. coli
Peptidylarginine deiminase type4 (PADI4) was firstly identified as a non-MHC RA genetic risk factor. Furthermore, PADI4 risk allele possessed the association with bone damage regardless of anti citrullinated peptide anti...
TMPJ-00532 PADI4 Protein, Human, Recombinant (E. coli, His) Human E. coli
Protein-Arginine Deiminase Type-4 (PADI4) belongs to the Protein Arginine Deiminase family. PADI4 is expressed in eosinophils and neutrophils, but it is not expressed in peripheral monocytes or lymphocytes. PADI4 catalyz...
TMPY-03051 B3GNT2 Protein, Human, Recombinant (hFc) Human HEK293
B3GNT2 belongs to the beta-1,3-N-acetylglucosaminyltransferase family. It is a type II transmembrane protein that prefers the substrate of lacto-N-neotetraose. Alternative splicing produced 2 isoforms of the human protei...
TargetMol