HCV Protease

NS2-3 protease (of hepatitis C virus, HCV) is an enzyme responsible for proteolytic cleavage between NS2 and NS3, which are non-structural proteins that form part of the HCV virus particle. NS3 protease of hepatitis C virus, on the other hand, is responsible for the cleavage of non-structural protein downstream. Both of these proteases are directly involved in HCV genome replication, that is, during the viral life-cycle that leads to virus multiplication in the host that has been infected by the virus.

Cat No.	product name
TQ0122L	VCH-916 free acid(1200133-34-1 free base)	VCH-916 is a novel nonnucleoside HCV NS5B polymerase inhibitor.
T4203	Ledipasvir acetone	Ledipasvir (GS5885) is an HCV NS5A polymerase inhibitor, used for the treatment of hepatitis C virus infection.
TQ0090	Nesbuvir	Nesbuvir (HCV-796) is a nonnucleoside inhibitor of the HCV nonstructural protein 5B (NS5B) polymerase.
TQ0064	Peretinoin	Peretinoin is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as RXR and RAR.
TQ0030	Tomeglovir	Tomeglovir is a potent anti-CMV agent, inhibiting the processing of viral DNA-concatemers (IC50s: 0.34/0.039 μM for HCMV and MCMV).
T7215	NM107	NM107 is a ribonucleoside with broad-spectrum antiviral activity, is an nucleoside inhibitor of the hepatitis C virus (HCV) NS5B polymerase, NM 107 in the wild-t...
T7158	Ombitasvir	Ombitasvir is an orally bioavailable and potent inhibitor of the hepatitis C virus (HCV) non-structural protein 5A (NS5A).with EC50s of 0.82 to 19.3 pM against H...
T5938	4-Phenoxybenzylamine	4-Phenoxybenzylamine inhibits the function of the NS3 protein by stabilizing an inactive conformation with an IC50 of about 500 μM against HCV NS3/4a .
T5396	Letermovir	Letermovir (AIC246) is a novel anti-CMV compound (EC50: about 5 nM in fibroblast cells). It targets the pUL56 subunit of the viral terminase complex.
T5126	Glecaprevir	Glecaprevir is an HCV NS3/4A protease inhibitor, (IC50s: 3.5-11.3 nM).
T5127	ABT530	ABT-530 (Pibrentasvir) is an HCV NS5A inhibitor with EC50s ranging from 1.4-5.0 pM against HCV replicons containing NS5A from genotypes 1-6.
T4988	Boceprevir	Boceprevir is a novel, potent, highly selective, orally bioavailable HCV NS3 protease inhibitor with Ki of 14 nM in both enzyme assay and EC90 of 350 nM in cell-...
T4686	Simeprevir	Simeprevir is a potent HCV NS3/4A protease inhibitor, and inhibits HCV replication with EC50 of 8 nM.
T4474	Asunaprevir	Asunaprevir is an effective hepatitis C virus (HCV) NS3 protease inhibitor.
T4544	Elbasvir	Elbasvir is an inhibitor of nonstructural protein 5A (NS5A) of hepatitis C virus (HCV) being developed as a component of treatment regimens for chronic HCV infec...
T4547	Grazoprevir	MK-5172 is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with Ki of 0.01 nM (gt1a), 0.0...
T4197	HZ1157	HZ-1157 is a hepatitis C virus (HCV) inhibitor with inhibitory activities toward HCV NS3/4A protease.
TQ0162	R-1479	R-1479 is an HCV replication inhibitor in the HCV subgenomic replicon system (IC50: 1.28 μM).
T3334	Velpatasvir	Velpatasvir, also known as GS-5816, is a potent and selective Hepatitis C virus NS5A inhibitor. GS-5816 has demonstrated pan-genotypic activity and a high barrie...
T1786	Daclatasvir dihydrochloride	Daclatasvir is an orally available antiviral agent that inhibits the NS5A region of the hepatitis C virus (HCV) and is used in combination with other oral antivi...
T6729	Lomibuvir	VX-222 (VCH-222) is a novel, potent and selective inhibitor of HCV polymerase with IC50 of 0.94-1.2 μM.
T3489	Dasabuvir	Dasabuvir is a non-nucleoside inhibitor of the hepatitis C virus (HCV) non-structural protein 5B (NS5B), an RNA-dependent RNA polymerase, with potential activity...
T6676	Sofosbuvir	Sofosbuvir is a uridine monophosphate analog inhibitor of hepatitis C virus (HCV) polymerase NS5B that is used as an antiviral agent in the treatment of chronic ...
T3226	Paritaprevir	Paritaprevir is an orally bioavailable, synthetic acylsulfonamide inhibitor of the hepatitis C virus (HCV) protease complex comprised of non-structural protein 3...
T6200	Ledipasvir	Ledipasvir is a Hepatitis C Virus NS5A Inhibitor. The mechanism of action of ledipasvir is as a P-Glycoprotein Inhibitor, and Breast Cancer Resistance Protein In...
T0013	Mecarbinate	Mecarbinate is arbidol hydrochloride's chemical intermediate.
T2117	PSI6206	PSI-6206 (RO2433) is a selective HCV RNA polymerase inhibitor.
T2162	Maribavir	Maribavir is an orally available benzimidazole riboside compound with activity against cytomegalovirus (CMV). Maribavir is a selective ATP competitor of the vira...
T2774	Lycorine chloride	Lycorine (hydrochloride) is VE-cadherin inhibitor,and has IC50 of 1.2μM in Hey1B cell.It is an HCV inhibitor with strong activity.
T1643	Penciclovir	Penciclovir is a Herpesvirus Nucleoside Analog DNA Polymerase Inhibitor. In HSV infected cells, penciclovir is phosphorylated by viral thymidine kinase and subse...
T6190	Telaprevir	Telaprevir (VX-950) is an effective inhibitor of HCV NS3-4A serine protease (IC50: 0.35 μM).
T0392	Artemisinin	Artemisinin is an ancient Chinese herbal therapy for malarial fevers which has been recently found to have potent activity against many forms of malarial organis...
T6025	Danoprevir	Danoprevir is a peptidomimetic inhibitor of the NS3/4A protease(IC50=0.2-3.5 nM) of hepatitis C virus (HCV).
TQ0122	VCH-916	VCH-916 is a new nonnucleoside inhibitor of HCV NS5B polymerase.
TN1138	Gamma-Fagarine	gamma-Fagarine possesses moderate levels of anti-HCV activities with IC50 values being 20.4 ± 0.4 ug/ml, respectively. It has sister chromatid exchanges (SCEs)-...
T7607	PSI-6130	PSI-6130 is a potent and selective HCV NS5B polymerase inhibitor. PSI-6130 inhibits HCV replication with a mean IC50 of 0.6 μM.
T17029	Tegobuvir	Tegobuvir is a specific and covalent HCV NS5B polymerase inhibitor.
T15573	Inarigivir soproxil	Inarigivir soproxil is an agonist of innate immunity. It also displays effective antiviral activity against resistant hepatitis C virus (HCV) variants (EC50s of ...
T16088	MK-0608	MK-0608 is an orally bioavailable HCV replication inhibitor in vitro(EC50 = 0.3 μM and EC90=1.3 μM in the subgenomic-replicon assay).
T19073	Tris(4-aminophenyl)methane	Tris(4-aminophenyl)methane, a triphenylmethane dye, is a weak HCV helicase inhibitor.
T16675	PSI-352938	PSI-352938 is an inhibitor of hepatitis C virus nucleotide.
T16710	Mericitabine	Mericitabine is a nucleoside HCV NS5B polymerase inhibitor. It acts as an RNA chain terminator and prevents the elongation of RNA transcripts during replication....
T16774	RO-9187	RO-9187 is an effective HCV virus replication inhibitor(IC50: 171 nM).
T17190	U18666A	U18666A is a cell-permeable drug and is a cholesterol synthesis and transport inhibitor. It inhibits replication of Ebola virus, dengue virus, and human hepatiti...
T12969	Sofosbuvir impurity N	Sofosbuvir impurity N is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.
TN3438	Arborinine	Arborinine shows mild in vitro antibacterial activity, it possesses moderate levels of anti-hepatitis C virus(HCV) activities with the IC50 values being 6.4 ± 0...
TN3809	Dehydrojuncusol	Dehydrojuncusol, a new inhibitor of hepatitis C virus RNA replication, it inhibits infection of different HCV genotypes by targeting the NS5A protein and is acti...
TN4404	Ladanein	Ladanein is a phytochemicals inhibitor that is known to disrupt the interactions of core and other hepatitis C virus (HCV) proteins.Ladanein possesses free radic...
TN5079	Sulochrin	Sulochrin shows antifungal and antibacterial activities, it can inhibit hepatitis C virus (HCV) infection in a dose-dependent manner without any apparent cytotox...
TN5263	1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one	Xanthohumol has anti-hepatitis C virus, anti-carcinogenic, free radical-scavenging, and anti-inflammatory activities, it can inhibit HIV-1 induced cytopathic eff...
T19862	Voxilaprevir	Voxilaprevir is an inhibitor of hepatitis C virus (HCV) nonstructural (NS) protein 3/4A protease.
T13281	Valopicitabine	Valopicitabine is an effective prodrug of the effective anti-HCV drug 2'-C-methylcytidine and can be used as a promising antiviral drug for the study of chronic ...
T12968	Sofosbuvir impurity M	Sofosbuvir impurity M is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.
TN1703	Glycyrin	Glycyrin, one of the main PPAR-gamma ligands of licorice, can significantly decrease the blood glucose levels of genetically diabetic KK-A(y) mice.
T14667	BLT-1	BLT-1 is a scavenger receptor BI (SR-BI)inhibitor.
TN2089	Platycodin D3	Platycodin D3 is a NF-κB inhibitor, it could as expectorants in diverse inflammatory pulmonary diseases, it can regulate the production and secretion of airway ...
T12033	Micrococcin P1	Micrococcin P1 is a macrocyclic peptide antibiotic and is a potent hepatitis C virus (HCV) inhibitor(EC50 range of 0.1-0.5 μM)
T10067	2',5-Difluoro-2'-deoxycytidine	2',5-Difluoro-2'-deoxycytidine has potent anti-HCV activity and toxicity to rRNA.
T14095	ACH-806	ACH-806 is an NS4A antagonist. It can inhibit Hepatitis C Virus (HCV) replication with an EC50 of 14 nM.
T14489	Azvudine	Azvudine is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV. Azvudine inhibits NRTI-resistant viral strai...
T14555	BI-1230	BI-1230 is potent and digit nanomolar inhibitor of HCV NS3 protease and of viral replication and it is also highly selective against other serine/cysteine protea...
T12956	Sofosbuvir impurity A	Sofosbuvir impurity A is an diastereoisomer of Sofosbuvir. Sofosbuvir is anHCV RNA replication inhibitor ,with potent anti-hepatitis C virus activity.
T12967	Sofosbuvir impurity L	Sofosbuvir impurity L is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.
T12961	Sofosbuvir impurity F	Sofosbuvir impurity F is a diastereoisomer of Sofosbuvir. Sofosbuvir is anHCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.
T12962	Sofosbuvir impurity G	Sofosbuvir impurity G is a diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.
T12963	Sofosbuvir impurity H	Sofosbuvir impurity H, an diastereoisomer of Sofosbuvir, is the impurity of Sofosbuvir. Sofosbuvir (PSI-7977) is a diastereoisomer of Sofosbuvir.Sofosbuvir is an...
T12964	Sofosbuvir impurity I	Sofosbuvir impurity I is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.
T12965	Sofosbuvir impurity J	Sofosbuvir impurity J is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.
T12966	Sofosbuvir impurity K	Sofosbuvir impurity K is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.
T6229	Daclatasvir	Daclatasvir (BMS-790052) is a highly selective inhibitor of HCV NS5A with EC50 of 9-50 pM, for a broad range of HCV replicon genotypes and the JFH-1 genotype 2a ...