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Cat No. | Product Name | Synonyms | Targets |
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T38770 | Guanylate cyclase-IN-1 | ||
Guanylate cyclase-IN-1 (Example 46) is a specific inhibitor of guanylate cyclase, employed in research related to cardiovascular diseases. | |||
T9080 | Plecanatide | Guanylate cyclase | |
Plecanatide acetate is an analogue of Uroguanylin. It is an orally active guanylate cyclase-C (GC-C) receptor agonist. | |||
T11852 | Linaclotide | Guanylate cyclase | |
Linaclotide developed for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation, and is a potent and selective guanylate cyclase C agonist. | |||
T16808 | Runcaciguat | Others , Guanylate cyclase | |
Runcaciguat is a soluble guanylate cyclase stimulator. Runcaciguat combines with selective partial adenosine A1 receptor agonists and can be used in studies about cardiovascular and renal diseases. | |||
T21607 | Ataciguat | HMR-1766 | Others , Guanylate cyclase |
Ataciguat (HMR-1766) (HMR-1766) is a potent and specific soluble guanylate cyclase (sGC) activator. | |||
T19777 | ODQ | Apoptosis , Others , Guanylate cyclase | |
ODQ is an effective and selective soluble guanylyl cyclase (sGC) inhibitor. | |||
T16344 | NS-2028 | Others , Guanylate cyclase | |
NS-2028 is a highly selective soluble Guanylyl Cyclase (sGC) inhibitor (IC50: 30 nM and 200 nM for basal and NO-stimulated enzyme activity). It is commonly used in the research of nitric oxide signaling pathways. NS-2028... | |||
T6775 | BAY 41-2272 | Guanylate cyclase | |
BAY 41-2272 is a direct and NO-independent soluble guanylate cyclase (sGC) stimulator. | |||
T1984 | Cinaciguat | BAY 58-2667 | Guanylate cyclase |
Cinaciguat (BAY 58-2667) (BAY 58-2667) is the first of a new class of soluble guanylate cyclase (sGC) activators in Clinicalal development for acute decompensated heart failure. | |||
T16569 | Praliciguat | IW-1973 | Others , Guanylate cyclase |
Praliciguat (IW-1973) stimulates sGC in HEK-293 cells (EC50: 197 nM). Praliciguat is an effective and orally active soluble guanylate cyclase stimulator. It also enhances NO signaling and acts as a vasodilator. | |||
T16383 | Olinciguat | IW-1701 | Guanylate cyclase |
Olinciguat (IW-1701) is an oral guanylate cyclase (sGC) stimulator. It also has concentration-dependent stimulation of sGC in purified rat and human enzyme assays and a whole-cell assay. | |||
T6968 | Riociguat | BAY 632521 | Guanylate cyclase |
Riociguat (BAY 632521) is a stimulator of guanylate cyclase which causes relaxation of vascular smooth muscle and is used to treat severe pulmonary arterial hypertension. | |||
T4381 | Lificiguat | YC-1 | Others , Guanylate cyclase , HIF |
Lificiguat (YC-1) is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase(sGC) and an inhibitor of Hypoxia-inducible factor-1alpha (HIF-1alpha). | |||
T21712 | BAY 41-8543 | Others , Guanylate cyclase | |
BAY 41-8543 is a nitric oxide (NO)-independent stimulator of soluble guanylyl cyclase (sGC). | |||
T12670 | (Rac)-MGV354 | MGV354 | Others |
(Rac)-MGV354 (MGV354) is the racemate of MGV354. MGV354 is a soluble activator of guanylate cyclase (sGC)(EC50s of <0.5 nM, and 5 nM in CHO and GTM-3 E cells, respectively). | |||
T6888 | Methylene Blue | methylthioninium chloride,CI-52015,Tetramethylthionine chloride,Basic Blue 9 | Guanylate cyclase , Microtubule Associated , NO Synthase , Parasite , Monoamine Oxidase |
Methylene Blue (Tetramethylthionine chloride) (IC50 of 1.9 μM) inhibits tau filament formation. And it inhibits soluble guanylyl cyclase. It is also used as a dye in chromoendoscopy. | |||
T17226 | Vericiguat | BAY1021189 | Guanylate cyclase |
Vericiguat (BAY1021189) is a potent and orally available guanylate cyclase stimulator. | |||
T0006 | Methylene Blue trihydrate | Methylthionine chloride,Basic blue 9,Methylene Blue | Guanylate cyclase , Microtubule Associated , NO Synthase , Parasite , Monoamine Oxidase |
Methylene Blue trihydrate (Basic blue 9) is a compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water or alcohol have a deep blue color. Methylene Blue trihydrate... | |||
T7201 | Nelociguat | BAY60-4552 | Guanylate cyclase |
Nelociguat (BAY60-4552)(BAY60-4552) is a soluble guanylate cyclase stimulator (sGC stimulator). Soluble guanylate cyclase (sGC) is a key enzyme in the nitric oxide (NO) signalling pathway. | |||
T21576 | LY83583 | 6-Anilino-5,8-quinolinedione,6-anilinoquinoline-5,8-dione | Guanylate cyclase |
LY83583 is a soluble guanylate cyclase competitive inhibitor with IC50 of 2 µM. | |||
T76769 | Indusatumab | Guanylate cyclase | |
Indusatumab (5F9 Monoclonal antibody) is an anti-human GUCY2C (Guanylate cyclase 2C) monoclonal antibody that can be used to synthesize antibody-drug conjugate. | |||
T34648 | Sinitrodil | ITF296,ITF-296,ITF 296 | Guanylate cyclase |
Sinitrodil (ITF-296) is a guanylate cyclase stimulant that may be used in the treatment of myocardial ischemia and angina pectoris. | |||
T0075 | Nicorandil | SG-75 | Potassium Channel |
Nicorandil (SG-75)(Ikorel) acts by relaxing the smooth muscle of the blood vessels, especially those of the venous system. It undertakes this through two methods. Firstly, by activating potassium channels, and secondly b... | |||
T0096 | Vardenafil | Vivanza,Levitra,Vardenafil hydrochloride | PDE |
Vardenafil (Vivanza) is an oral therapy for the treatment of erectile dysfunction. It is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). Penile erection is a hemod... | |||
TP1219 | Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate | ANP (1-28), human, porcineANP(1-28) | |
T39723 | Mosliciguat | ||
Mosliciguat is a guanylate cyclase activator. | |||
T10562 | (4-Acetamidocyclohexyl) nitrate | BM121307 | Others |
(4-Acetamidocyclohexyl) nitrate (BM121307) is an activator of guanylate cyclase. | |||
T11852L | Linaclotide acetate | MM 416775,MM416775 MD-1100 acetate,Linzess,MM-416775 | |
Linaclotide acetate is used as an oral guanylate cyclase C agonist linaclotide; 14 amino acid peptide for the potential treatment of constipation-predominant irritable bowel syndrome and chronic idiopathic constipation. | |||
T39673 | Zagociguat | ||
Zagociguat is a soluble guanylate cyclase stimulator that enhances nitric oxide (NO) signaling, resulting in increased production of cyclic guanosine monophosphate. This compound shows promise for investigating non-centr... | |||
T22197 | CFM 1571 hydrochloride | ||
CFM 1571 hydrochloride is a chemical compound that acts as a stimulator of the nitric oxide receptor known as soluble guanylate cyclase (sGC). It demonstrates an EC50 value of 5.49 μM and an IC50 value of 2.84 μM. Solubl... | |||
T12501 | Plecanatide acetate | Others | |
Plecanatide acetate is a agonist of guanylate cyclase-C (GC-C) receptor( EC50 of 190 nM in T84 cells), and shows anti-inflammatory activity in models of murine colitis. | |||
T38482 | MM 419447 | ||
MM 419447 is a guanylate cyclase-C agonist, and it is a metabolite of linaclotide. This compound, MM 419447, shows promise in the field of irritable bowel syndrome with constipation (IBS-C) research. | |||
T76389 | Prepro-ANF (56-92), human | ||
Prepro-ANF (56-92), human, a precursor to the human atrial natriuretic factor, serves as an activator of guanylate cyclase, specifically enhancing particulate guanylate cyclase activity within the renal membrane and unit... | |||
T12888 | MGV354 | Others | |
MGV354 is a soluble activator of guanylate cyclase(sGC) with EC 50 s of <0.5 nM, and 5 nM in CHO and GTM-3 E cells, respectively [1] [2]. | |||
T76274 | Dolcanatide | ||
Dolcanatide, an orally active guanylate cyclase-C (GC-C) agonist, exhibits laxative, anti-nociceptive, and anti-inflammatory properties. It is utilized in research concerning inflammatory bowel disease [1] [2]. | |||
T80150 | Guanylin (mouse, rat) | Guanylate cyclase | |
Guanylin (mouse, rat), a peptide consisting of 15 amino acids, acts as an activator of intestinal guanylate cyclase and is utilized in diarrhea research [1]. | |||
T10536 | BI 703704 | Others | |
BI 703704, a soluble guanylate cyclase (sGC) activator, inhibits the progression of diabetic nephropathy in the ZSF1 rat [1]. | |||
T37960 | Guanylin(human) TFA | ||
Guanylin (human) TFA is a 15-amino acid peptide that serves as an endogenous activator of intestinal guanylate cyclase. This compound is primarily located in the gastrointestinal tract, where it regulates electrolyte and... | |||
T81407 | Prepro-Atrial Natriuretic Factor (26-55) (human) | ||
Prepro-Atrial Natriuretic Factor (26-55) (human) is a polypeptide that elevates cyclic GMP levels in the renal cortex and medulla and enhances renal guanylate cyclase activity [1]. | |||
T62471 | SGC agonist 1 | ||
SGC agonist 1 is a potent soluble guanylate cyclase (SGC) agonist. SGC agonist 1 is able to increase solubility and has high cell permeability. | |||
T62909 | SGC agonist 2 | ||
SGC agonist 2 is a potent soluble guanylate cyclase (SGC) agonist. SGC agonist 2 has potential for cardiovascular disease (heart failure, angina, pulmonary hypertension, myocardial infarction) and fibrotic disease (renal... | |||
T80890 | Uroguanylin-15 (Rat) | ||
Uroguanylin-15 (Rat) is a bioactive natriuretic peptide hormone that modulates sodium excretion in response to high NaCl intake by activating guanylate cyclase signaling pathways in the intestine and kidney. Initially is... | |||
T75339 | Methylene blue hydrate | ||
Methylene Blue (Basic Blue 9) hydrate functions as an inhibitor of guanylyl cyclase (sGC), monoamine oxidase A (MAO-A), and NO synthase (NOS). This compound, known for its vasopressor activity, is widely utilized as a dy... | |||
T75137 | BAY-747 | ||
BAY-747 (BAY 1165747) is an orally administered, brain-penetrant compound that stimulates soluble guanylate cyclase (sGC). It effectively counteracts memory impairments induced by L-NAME and improves cognitive performanc... | |||
T71402 | Nicorandil-d4 | ||
Nicorandil-d4 is intended for use as an internal standard for the quantification of nicorandil by GC- or LC-MS. Nicorandil is an activator of sulfonylurea receptor 2B (SUR2B) linked to ATP-sensitive potassium channel Kir... |
Cat No. | Product Name | Species | Expression System |
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TMPY-06353 | GUCA2B Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
TMPJ-00911 | GUCY2C Protein, Human, Recombinant (hFc) | Human | Human Cells |
GUCY2C (Guanylyl Cyclase C), also known as heat-stable enterotoxin receptor, is a type I transmembrane protein of the guanylate cyclase (gc) family. GUCY2C cell surface expression is confined to luminal surfaces of the i... | |||
TMPJ-00910 | GUCY2C Protein, Human, Recombinant (His & Avi), Biotinylated | Human | Human Cells |
GUCY2C (Guanylyl Cyclase C), also known as heat-stable enterotoxin receptor, is a type I transmembrane protein of the guanylate cyclase (gc) family. GUCY2C cell surface expression is confined to luminal surfaces of the i... | |||
TMPY-03554 | GCAP1 Protein, Human, Recombinant | Human | Baculovirus-Insect Cells |
GCAP 1 gene plays a role in the recovery of retinal photoreceptors from photobleaching. In the recovery phase, the phototransduction messenger cGMP is replenished by retinal guanylyl cyclase-1 (GC1). GC1 is activated by ... | |||
TMPY-03463 | GCAP1 Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
GCAP 1 gene plays a role in the recovery of retinal photoreceptors from photobleaching. In the recovery phase, the phototransduction messenger cGMP is replenished by retinal guanylyl cyclase-1 (GC1). GC1 is activated by ... | |||
TMPH-00581 | ATP-dependent Clp protease adapter protein ClpS Protein, E. coli, Recombinant (His) | E. coli | E. coli |
Toxin which activates the particulate form of guanylate cyclase and increases cyclic GMP levels within the host intestinal epithelial cells. | |||
TMPH-00580 | Aquaporin Z Protein, E. coli, Recombinant (His) | E. coli | in vitro E. coli expression system |
Toxin which activates the particulate form of guanylate cyclase and increases cyclic GMP levels within the host intestinal epithelial cells. | |||
TMPH-00579 | Antitoxin RelB Protein, E. coli, Recombinant (His & Myc) | E. coli | E. coli |
Toxin which activates the particulate form of guanylate cyclase and increases cyclic GMP levels within the host intestinal epithelial cells. | |||
TMPH-03715 | Y-STB Protein, Yersinia enterocolitica, Recombinant (His & SUMO) | Yersinia enterocolitica | E. coli |
Toxin which activates the particulate form of guanylate cyclase and increases cyclic GMP levels within the host intestinal epithelial cells. Could play an important role in pathogenesis. | |||
TMPH-01284 | EEF1A1 Protein, Human, Recombinant | Human | E. coli |
Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and el... |