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Search Results for " guanylate cyclase "

Targets

45

Compounds

10

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T38770 Guanylate cyclase-IN-1
Guanylate cyclase-IN-1 (Example 46) is a specific inhibitor of guanylate cyclase, employed in research related to cardiovascular diseases.
T9080 Plecanatide Guanylate cyclase
Plecanatide acetate is an analogue of Uroguanylin. It is an orally active guanylate cyclase-C (GC-C) receptor agonist.
T11852 Linaclotide Guanylate cyclase
Linaclotide developed for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation, and is a potent and selective guanylate cyclase C agonist.
T16808 Runcaciguat Others , Guanylate cyclase
Runcaciguat is a soluble guanylate cyclase stimulator. Runcaciguat combines with selective partial adenosine A1 receptor agonists and can be used in studies about cardiovascular and renal diseases.
T21607 Ataciguat HMR-1766 Others , Guanylate cyclase
Ataciguat (HMR-1766) (HMR-1766) is a potent and specific soluble guanylate cyclase (sGC) activator.
T19777 ODQ Apoptosis , Others , Guanylate cyclase
ODQ is an effective and selective soluble guanylyl cyclase (sGC) inhibitor.
T16344 NS-2028 Others , Guanylate cyclase
NS-2028 is a highly selective soluble Guanylyl Cyclase (sGC) inhibitor (IC50: 30 nM and 200 nM for basal and NO-stimulated enzyme activity). It is commonly used in the research of nitric oxide signaling pathways. NS-2028...
T6775 BAY 41-2272 Guanylate cyclase
BAY 41-2272 is a direct and NO-independent soluble guanylate cyclase (sGC) stimulator.
T1984 Cinaciguat BAY 58-2667 Guanylate cyclase
Cinaciguat (BAY 58-2667) (BAY 58-2667) is the first of a new class of soluble guanylate cyclase (sGC) activators in Clinicalal development for acute decompensated heart failure.
T16569 Praliciguat IW-1973 Others , Guanylate cyclase
Praliciguat (IW-1973) stimulates sGC in HEK-293 cells (EC50: 197 nM). Praliciguat is an effective and orally active soluble guanylate cyclase stimulator. It also enhances NO signaling and acts as a vasodilator.
T16383 Olinciguat IW-1701 Guanylate cyclase
Olinciguat (IW-1701) is an oral guanylate cyclase (sGC) stimulator. It also has concentration-dependent stimulation of sGC in purified rat and human enzyme assays and a whole-cell assay.
T6968 Riociguat BAY 632521 Guanylate cyclase
Riociguat (BAY 632521) is a stimulator of guanylate cyclase which causes relaxation of vascular smooth muscle and is used to treat severe pulmonary arterial hypertension.
T4381 Lificiguat YC-1 Others , Guanylate cyclase , HIF
Lificiguat (YC-1) is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase(sGC) and an inhibitor of Hypoxia-inducible factor-1alpha (HIF-1alpha).
T21712 BAY 41-8543 Others , Guanylate cyclase
BAY 41-8543 is a nitric oxide (NO)-independent stimulator of soluble guanylyl cyclase (sGC).
T12670 (Rac)-MGV354 MGV354 Others
(Rac)-MGV354 (MGV354) is the racemate of MGV354. MGV354 is a soluble activator of guanylate cyclase (sGC)(EC50s of <0.5 nM, and 5 nM in CHO and GTM-3 E cells, respectively).
T6888 Methylene Blue methylthioninium chloride,CI-52015,Tetramethylthionine chloride,Basic Blue 9 Guanylate cyclase , Microtubule Associated , NO Synthase , Parasite , Monoamine Oxidase
Methylene Blue (Tetramethylthionine chloride) (IC50 of 1.9 μM) inhibits tau filament formation. And it inhibits soluble guanylyl cyclase. It is also used as a dye in chromoendoscopy.
T17226 Vericiguat BAY1021189 Guanylate cyclase
Vericiguat (BAY1021189) is a potent and orally available guanylate cyclase stimulator.
T0006 Methylene Blue trihydrate Methylthionine chloride,Basic blue 9,Methylene Blue Guanylate cyclase , Microtubule Associated , NO Synthase , Parasite , Monoamine Oxidase
Methylene Blue trihydrate (Basic blue 9) is a compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water or alcohol have a deep blue color. Methylene Blue trihydrate...
T7201 Nelociguat BAY60-4552 Guanylate cyclase
Nelociguat (BAY60-4552)(BAY60-4552) is a soluble guanylate cyclase stimulator (sGC stimulator). Soluble guanylate cyclase (sGC) is a key enzyme in the nitric oxide (NO) signalling pathway.
T21576 LY83583 6-Anilino-5,8-quinolinedione,6-anilinoquinoline-5,8-dione Guanylate cyclase
LY83583 is a soluble guanylate cyclase competitive inhibitor with IC50 of 2 µM.
T76769 Indusatumab Guanylate cyclase
Indusatumab (5F9 Monoclonal antibody) is an anti-human GUCY2C (Guanylate cyclase 2C) monoclonal antibody that can be used to synthesize antibody-drug conjugate.
T34648 Sinitrodil ITF296,ITF-296,ITF 296 Guanylate cyclase
Sinitrodil (ITF-296) is a guanylate cyclase stimulant that may be used in the treatment of myocardial ischemia and angina pectoris.
T0075 Nicorandil SG-75 Potassium Channel
Nicorandil (SG-75)(Ikorel) acts by relaxing the smooth muscle of the blood vessels, especially those of the venous system. It undertakes this through two methods. Firstly, by activating potassium channels, and secondly b...
T0096 Vardenafil Vivanza,Levitra,Vardenafil hydrochloride PDE
Vardenafil (Vivanza) is an oral therapy for the treatment of erectile dysfunction. It is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). Penile erection is a hemod...
TP1219 Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate ANP (1-28), human, porcineANP(1-28)
T39723 Mosliciguat
Mosliciguat is a guanylate cyclase activator.
T10562 (4-Acetamidocyclohexyl) nitrate BM121307 Others
(4-Acetamidocyclohexyl) nitrate (BM121307) is an activator of guanylate cyclase.
T11852L Linaclotide acetate MM 416775,MM416775 MD-1100 acetate,Linzess,MM-416775
Linaclotide acetate is used as an oral guanylate cyclase C agonist linaclotide; 14 amino acid peptide for the potential treatment of constipation-predominant irritable bowel syndrome and chronic idiopathic constipation.
T39673 Zagociguat
Zagociguat is a soluble guanylate cyclase stimulator that enhances nitric oxide (NO) signaling, resulting in increased production of cyclic guanosine monophosphate. This compound shows promise for investigating non-centr...
T22197 CFM 1571 hydrochloride
CFM 1571 hydrochloride is a chemical compound that acts as a stimulator of the nitric oxide receptor known as soluble guanylate cyclase (sGC). It demonstrates an EC50 value of 5.49 μM and an IC50 value of 2.84 μM. Solubl...
T12501 Plecanatide acetate Others
Plecanatide acetate is a agonist of guanylate cyclase-C (GC-C) receptor( EC50 of 190 nM in T84 cells), and shows anti-inflammatory activity in models of murine colitis.
T38482 MM 419447
MM 419447 is a guanylate cyclase-C agonist, and it is a metabolite of linaclotide. This compound, MM 419447, shows promise in the field of irritable bowel syndrome with constipation (IBS-C) research.
T76389 Prepro-ANF (56-92), human
Prepro-ANF (56-92), human, a precursor to the human atrial natriuretic factor, serves as an activator of guanylate cyclase, specifically enhancing particulate guanylate cyclase activity within the renal membrane and unit...
T12888 MGV354 Others
MGV354 is a soluble activator of guanylate cyclase(sGC) with EC 50 s of <0.5 nM, and 5 nM in CHO and GTM-3 E cells, respectively [1] [2].
T76274 Dolcanatide
Dolcanatide, an orally active guanylate cyclase-C (GC-C) agonist, exhibits laxative, anti-nociceptive, and anti-inflammatory properties. It is utilized in research concerning inflammatory bowel disease [1] [2].
T80150 Guanylin (mouse, rat) Guanylate cyclase
Guanylin (mouse, rat), a peptide consisting of 15 amino acids, acts as an activator of intestinal guanylate cyclase and is utilized in diarrhea research [1].
T10536 BI 703704 Others
BI 703704, a soluble guanylate cyclase (sGC) activator, inhibits the progression of diabetic nephropathy in the ZSF1 rat [1].
T37960 Guanylin(human) TFA
Guanylin (human) TFA is a 15-amino acid peptide that serves as an endogenous activator of intestinal guanylate cyclase. This compound is primarily located in the gastrointestinal tract, where it regulates electrolyte and...
T81407 Prepro-Atrial Natriuretic Factor (26-55) (human)
Prepro-Atrial Natriuretic Factor (26-55) (human) is a polypeptide that elevates cyclic GMP levels in the renal cortex and medulla and enhances renal guanylate cyclase activity [1].
T62471 SGC agonist 1
SGC agonist 1 is a potent soluble guanylate cyclase (SGC) agonist. SGC agonist 1 is able to increase solubility and has high cell permeability.
T62909 SGC agonist 2
SGC agonist 2 is a potent soluble guanylate cyclase (SGC) agonist. SGC agonist 2 has potential for cardiovascular disease (heart failure, angina, pulmonary hypertension, myocardial infarction) and fibrotic disease (renal...
T80890 Uroguanylin-15 (Rat)
Uroguanylin-15 (Rat) is a bioactive natriuretic peptide hormone that modulates sodium excretion in response to high NaCl intake by activating guanylate cyclase signaling pathways in the intestine and kidney. Initially is...
T75339 Methylene blue hydrate
Methylene Blue (Basic Blue 9) hydrate functions as an inhibitor of guanylyl cyclase (sGC), monoamine oxidase A (MAO-A), and NO synthase (NOS). This compound, known for its vasopressor activity, is widely utilized as a dy...
T75137 BAY-747
BAY-747 (BAY 1165747) is an orally administered, brain-penetrant compound that stimulates soluble guanylate cyclase (sGC). It effectively counteracts memory impairments induced by L-NAME and improves cognitive performanc...
T71402 Nicorandil-d4
Nicorandil-d4 is intended for use as an internal standard for the quantification of nicorandil by GC- or LC-MS. Nicorandil is an activator of sulfonylurea receptor 2B (SUR2B) linked to ATP-sensitive potassium channel Kir...

Compounds

Guanylate cyclase-IN-1
T38770
Synonym:
Target:
Plecanatide
T9080
Synonym:
Target: Guanylate cyclase
Linaclotide
T11852
Synonym:
Target: Guanylate cyclase
Runcaciguat
T16808
Synonym:
Target: Others, Guanylate cyclase
Ataciguat
T21607
Synonym: HMR-1766
Target: Others, Guanylate cyclase
ODQ
T19777
Synonym:
Target: Apoptosis, Others, Guanylate cyclase
NS-2028
T16344
Synonym:
Target: Others, Guanylate cyclase
BAY 41-2272
T6775
Synonym:
Target: Guanylate cyclase
Cinaciguat
T1984
Synonym: BAY 58-2667
Target: Guanylate cyclase
Praliciguat
T16569
Synonym: IW-1973
Target: Others, Guanylate cyclase
Olinciguat
T16383
Synonym: IW-1701
Target: Guanylate cyclase
Riociguat
T6968
Synonym: BAY 632521
Target: Guanylate cyclase
Lificiguat
T4381
Synonym: YC-1
Target: Others, Guanylate cyclase, HIF
BAY 41-8543
T21712
Synonym:
Target: Others, Guanylate cyclase
(Rac)-MGV354
T12670
Synonym: MGV354
Target: Others
Methylene Blue
T6888
Synonym: methylthioninium chloride,CI-52015,Tetramethylthionine chloride,Basic Blue 9
Target: Guanylate cyclase, Microtubule Associated, NO Synthase, Parasite, Monoamine Oxidase
Vericiguat
T17226
Synonym: BAY1021189
Target: Guanylate cyclase
Methylene Blue trihydrate
T0006
Synonym: Methylthionine chloride,Basic blue 9,Methylene Blue
Target: Guanylate cyclase, Microtubule Associated, NO Synthase, Parasite, Monoamine Oxidase
Nelociguat
T7201
Synonym: BAY60-4552
Target: Guanylate cyclase
LY83583
T21576
Synonym: 6-Anilino-5,8-quinolinedione,6-anilinoquinoline-5,8-dione
Target: Guanylate cyclase
Indusatumab
T76769
Synonym:
Target: Guanylate cyclase
Sinitrodil
T34648
Synonym: ITF296,ITF-296,ITF 296
Target: Guanylate cyclase
Nicorandil
T0075
Synonym: SG-75
Target: Potassium Channel
Vardenafil
T0096
Synonym: Vivanza,Levitra,Vardenafil hydrochloride
Target: PDE
Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate
TP1219
Synonym: ANP (1-28), human, porcineANP(1-28)
Target:
Mosliciguat
T39723
Synonym:
Target:
(4-Acetamidocyclohexyl) nitrate
T10562
Synonym: BM121307
Target: Others
Linaclotide acetate
T11852L
Synonym: MM 416775,MM416775 MD-1100 acetate,Linzess,MM-416775
Target:
Zagociguat
T39673
Synonym:
Target:
CFM 1571 hydrochloride
T22197
Synonym:
Target:
Plecanatide acetate
T12501
Synonym:
Target: Others
MM 419447
T38482
Synonym:
Target:
Prepro-ANF (56-92), human
T76389
Synonym:
Target:
MGV354
T12888
Synonym:
Target: Others
Dolcanatide
T76274
Synonym:
Target:
Guanylin (mouse, rat)
T80150
Synonym:
Target: Guanylate cyclase
BI 703704
T10536
Synonym:
Target: Others
Guanylin(human) TFA
T37960
Synonym:
Target:
Prepro-Atrial Natriuretic Factor (26-55) (human)
T81407
Synonym:
Target:
SGC agonist 1
T62471
Synonym:
Target:
SGC agonist 2
T62909
Synonym:
Target:
Uroguanylin-15 (Rat)
T80890
Synonym:
Target:
Methylene blue hydrate
T75339
Synonym:
Target:
BAY-747
T75137
Synonym:
Target:
Nicorandil-d4
T71402
Synonym:
Target:

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-06353 GUCA2B Protein, Mouse, Recombinant (His) Mouse HEK293
TMPJ-00911 GUCY2C Protein, Human, Recombinant (hFc) Human Human Cells
GUCY2C (Guanylyl Cyclase C), also known as heat-stable enterotoxin receptor, is a type I transmembrane protein of the guanylate cyclase (gc) family. GUCY2C cell surface expression is confined to luminal surfaces of the i...
TMPJ-00910 GUCY2C Protein, Human, Recombinant (His & Avi), Biotinylated Human Human Cells
GUCY2C (Guanylyl Cyclase C), also known as heat-stable enterotoxin receptor, is a type I transmembrane protein of the guanylate cyclase (gc) family. GUCY2C cell surface expression is confined to luminal surfaces of the i...
TMPY-03554 GCAP1 Protein, Human, Recombinant Human Baculovirus-Insect Cells
GCAP 1 gene plays a role in the recovery of retinal photoreceptors from photobleaching. In the recovery phase, the phototransduction messenger cGMP is replenished by retinal guanylyl cyclase-1 (GC1). GC1 is activated by ...
TMPY-03463 GCAP1 Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
GCAP 1 gene plays a role in the recovery of retinal photoreceptors from photobleaching. In the recovery phase, the phototransduction messenger cGMP is replenished by retinal guanylyl cyclase-1 (GC1). GC1 is activated by ...
TMPH-00581 ATP-dependent Clp protease adapter protein ClpS Protein, E. coli, Recombinant (His) E. coli E. coli
Toxin which activates the particulate form of guanylate cyclase and increases cyclic GMP levels within the host intestinal epithelial cells.
TMPH-00580 Aquaporin Z Protein, E. coli, Recombinant (His) E. coli in vitro E. coli expression system
Toxin which activates the particulate form of guanylate cyclase and increases cyclic GMP levels within the host intestinal epithelial cells.
TMPH-00579 Antitoxin RelB Protein, E. coli, Recombinant (His & Myc) E. coli E. coli
Toxin which activates the particulate form of guanylate cyclase and increases cyclic GMP levels within the host intestinal epithelial cells.
TMPH-03715 Y-STB Protein, Yersinia enterocolitica, Recombinant (His & SUMO) Yersinia enterocolitica E. coli
Toxin which activates the particulate form of guanylate cyclase and increases cyclic GMP levels within the host intestinal epithelial cells. Could play an important role in pathogenesis.
TMPH-01284 EEF1A1 Protein, Human, Recombinant Human E. coli
Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and el...
TargetMol