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Glucosidase

Glucosidase belongs to the glycoside hydrolase family of enzymes and plays a crucial role in breaking down glucosidic bonds to release glucose. Glucosidase is essential for sugar metabolism in organisms, found across a wide range of sources and present in almost all cellular structures that utilize carbohydrates for energy. This enzyme comes in two main types: β-glucosidase, involved in cellulose metabolism and various physiological pathways, and α-glucosidase, which directly participates in starch and glycogen metabolism. Dysfunctions in these enzymes can lead to metabolic disorders. Moreover, glucosidase serves as a target for various drugs and inhibitors aimed at regulating sugar metabolism in the human body.

Conduritol B epoxide
TQ03006090-95-5
Conduritol B epoxide is an irreversible inhibitor of β-glucosidase (GCase).
  • $41
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Gcase activator 1
T42801919820-28-2
Gcase activator 1 (LTI-291) is a glucocerebrosidase (Gcase) activator.
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Celgosivir
T10755L121104-96-9In house
Celgosivir (6 O-butanoyl castanospermine) is an inhibitor of α-glucosidase I. In vitro assay, it inhibits bovine viral diarrhoea virus (BVDV) ( IC50: 1.27 μM ).
  • $77
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Acarbose
T024756180-94-0
Acarbose (BAY g 5421) is an inhibitor of α-Glucosidases with antihyperglycemic activity.
  • $35
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Bisabolone oxide A
T3979422567-38-0
Bisabolone oxide A is a terpenoid isolated from Matricaria chamomilla L. It reduces neuronal excitability.Bisabolone oxide A inhibits α glucokinase and has been shown to inhibit α glucokinase in Helicoverpa armigera, Aedes vittatus, and Anopheles subpictus larvae and showed biotoxicity in Helicoverpa armigera, Aedes vittatus and Anopheles subpictus larvae experiments.
  • $397
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Mulberrofuran G
TN195687085-00-5
Mulberrofuran G, isolated from Morus alba L., has anti-hepatitis B virus activity and protects against ischemic injury-induced cell death. Mulberrofuran G is a dual inhibitor of PTP1B and alpha-glucosidase for use in the study of Alzheimer's disease.
  • $263
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Daucosterol
T3871474-58-8
Daucosterol (Sitogluside) has proliferation-enhancing activity, may be involved in the IGF1-AKT pathway. Daucosterol(β-Sitosterol β-D-glucoside) has efficient and inexpensive neuroprotectant effect, to contribute to IGF1-like activity, could be potentially developed as a medicine for ischemic stroke treatment.
  • $41
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Jionoside B1
TQ0226120406-37-3
Jionoside B1 is isolated from the roots of Jionoside (Gaertn.) and inhibits α-glucosidase.
  • $81
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Pinoresinol diglucoside
T6S053563902-38-5
1. Pinoresinol diglucoside (Pinoresinol Diglucopyranoside) is a putative α-glucosidase inhibiting compound. 2. Pinoresinol diglucoside is a important antihypertensive compound.
  • $45
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1-Deoxynojirimycin
T367519130-96-2
1-Deoxynojirimycin (Moranoline) is a potent α-glucosidase inhibitor, suppressing postprandial blood glucose, thereby possibly preventing diabetes mellitus.
  • $38
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Manghaslin
TN213055696-57-6
Manghaslin (Quercetin 3-O-rutinoside-(1->2)-O-rhamnoside) has considerable α-glucosidase inhibitory activity, illustrating the anti-diabetic potential of phenolic-rich litchi pulp extracts. Manghaslin also shows inhibitory activity against AChE
  • $113
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Kaempferol-3,7-di-O-β-glucoside
TN436825615-14-9
Kaempferol-3,7-di-O-β-glucoside (Kaempferol 3,7-diglucoside) is a flavonol from Morettia philaena that inhibits α-amylase, α-glucosidase, and acetylcholinesterase. It exhibits neuroprotective activity, slowing amyloid β peptide-induced damage in differentiated neuronal cells SH-SY5Y, and can be used in the study of neurological disorders such as Alzheimer's disease.
  • $178
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Castanospermine
TQ030879831-76-8
Castanospermine (1,6,7,8-Tetrahydroxyoctahydroindolizine) is a natural compound that inhibits α- and β-glucosidases, especially glucosidase l.
  • $32
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Isovitexin
T6S137138953-85-4
1. Isovitexin (Apigenin-6-C-Glucoside) exhibits a potential antioxidant activity. 2. Isovitexin shows a strong antihyperglycemic action, inhibits α-glucosidase in vivo.
  • $44
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IHVR-17028
T388941428247-78-2In house
IHVR-17028 is a potent broad-spectrum ERα-glucosidase I (α-glucosidase? I) inhibitor with IC50 of 0.24 μM and antiviral activity. IHVR-17028 inhibited BVDV, TCRV and DENV, and EC50 values were 0.4 μM, 0.26 μM and 0.3 μM, respectively. IHVR-17028 can be used to study infectious diseases.
  • $297
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Brevifolincarboxylic acid
TN145118490-95-4
Brevifolincarboxylic acid is a natural product isolated from Polygonum capitatum, it has inhibitory effect on the aryl hydrocarbon receptor (AhR). Brevifolincarboxylic acid is an α-glucosidase inhibitor with an IC50 of 323.46 μM.
  • $77
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Terphenyllin
T1313052452-60-5
Terphenyllin has α-glucosidase inhibitory activity, and is a natural product isolated from the coral derived fungus Aspergillus candidus.
  • $113
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ethyl rosmarinate
TN6784174591-47-0
ethyl rosmarinate inhibit the activity of tyrosinase, α-glucosidase, and matrix metalloproteinase-1 (MMP-1).
  • $66
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4',5-Dihydroxyflavone
T82606665-67-4
4',5-Dihydroxyflavone is a soybean LOX-1 inhibitor (Ki: 102.6 μM) and a yeast α-Glucosidase inhibitor (IC50: 66 μM).
  • $34
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N-Caffeoyl O-methyltyramine
T12142189307-47-9
N-Caffeoyl O-methyltyramine is isolated from Cuscuta reflexa with strong inhibitory activity against α-glucosidase with IC50 of 103.58 μM.
  • $60
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kuwanon G
T3S161275629-19-5
1. Kuwanon G (Moracenin B) as dual inhibitors of PTP1B and α-glucosidase enzymes, as well as insulin sensitizers, it may potentially be utilized as an effective treatment for Type II diabetes mellitus. 2. Kuwanon G has anti-inflammatory activity, it can attenuate atherosclerosis through inhibiting foam cell formation and inflammatory response. 3. Kuwanon G is a potent inhibitor of Mycobacterium tuberculosis protein tyrosine phosphatase B. 4. Kuwanon G shows acetylcholinesterase (AChE) and butyrylcholinesterase(BChE) inhibitory activities, it may be a promising candidate for preventive and therapeutic agents for Alzheimer's disease. 5. Kuwanon G prevents the pathological progression of allergic asthma through the inhibition of lung destruction by inflammation and immune stimulation. 6. Kuwanon G has antibacterial activity against oral pathogens. 7. Kuwanon G is a specific antagonist for the GRP-preferring receptor and can be useful for studying the physiological and pathological role of GRP.
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AMP-Deoxynojirimycin
T35626216758-20-2
AMP-Deoxynojirimycin (AMP-DNM) is a potent inhibitor of ceramide glucosyltransferase and GCase 2, as well as GlcCer biosynthesis, and is utilized in the study of Parkinson's disease and diabetes.
  • $98
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Butyl isobutyl phthalate
T831917851-53-5
Butyl isobutyl phthalate (ButylIsobutylPhthalate) is a non-competitive α-glucosidase inhibitor(IC50 :38 μM),it shows a hypoglycemic effect
  • $31
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Ginkgolic Acid (C13:0)
T6S212220261-38-5
Ginkgolic Acid (C13:0) (6-Tridecylsalicylic acid): 0exhibits the highest α-glucosidase inhibitory activity.
  • $37
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Viscidulin III
TN230292519-91-0
Viscidulin III (Ganhuangenin) is present in Scutellaria baicalensis and acts as an α-glucosidase inhibitor.
  • $73
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Ceftezole sodium
T785841136-22-5
Ceftezole sodium (Falomesin) is a broad-spectrum cephalosporin antibiotic active gram-negative and gram-positive bacteria except for Proteus vulgaris, Pseudomonas aeruginosa, and Serratia marcescens. It has the inhibition of cell wall synthesis via affinity for penicillin-binding proteins. It also inhibits alpha-glucosidase.
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Tryptophan, N-indol-3-ylacetyl- (6CI)
T548957105-53-0
Tryptophan, N-indol-3-ylacetyl- (6CI) (Indole-3-acetyl-L-tryptophan) is involved in regulatory mechanisms for the control of auxin activity during physiological and pathophysiological responses. It may also be used in the synthesis of β-D-galactosidase and β-D-glucosidase inhibitors.
  • $30
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β-Glucosidase
T761109001-22-3
β-Glucosidase is a glucoside bond hydrolase widely found in organisms and is involved in glucose metabolism, which can be used to study diseases caused by abnormal glucose metabolism.
  • $36
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Kaempferol 3-O-gentiobioside
T820222149-35-5
Kaempferol 3-O-gentiobioside, a flavonoid isolated from C. alata leaves, exhibits antidiabetic activity and α-glucosidase inhibition, demonstrating a carbohydrate enzyme inhibitory effect (IC50: 50 μM).
  • $197
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NCGC00092410
T40544442898-34-2In house
NCGC00092410 (ML008) is a glucocerebrosidase (GC) inhibitor with IC50 value of 31 nM. It can be used for the study of Gaucher disease caused by mutation of glucocerebrase gene.
  • $58
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1-Deoxynojirimycin hydrochloride
T2134473285-50-4
1-Deoxynojirimycin hydrochloride (Moranoline) is a potent and selective inhibitor of alpha-glucosidase, most commonly found in mulberry leaves. Duvoglustat is used to suppress the elevation of postprandial hyperglycemia.
  • $33
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α-Glucosidase-IN-23
T67728161187-57-1In house
α-Glucosidase-IN-23 is an orally active inhibitor of α-glucosidase that can decrease blood glucose levels by inhibiting α-glucosidase (IC50 = 4.48 μM).
  • $118
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(Z)-Butylidenephthalide
TN232672917-31-8
(Z)-Butylidenephthalide ((Z)-3-Butylidenephthalide) has antitumor and hypoglycemic effects, and can effectively inhibit the tumor growth of glioma and inhibit R-glucosidase activity.
  • $123
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α-Glucosidase-IN-4
T607152410538-67-7
α-Glucosidase-IN-4 is a potent α-glucosidase inhibitor exhibiting antihypertensive and hypoglycemic activity.
  • $350
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Magnoloside B
TN7134116872-05-0
Magnoloside B, a phenylethanol glycoside from the fruit of Magnolia officinalis, is an α-glucosidase inhibitor with protective effects against free radical-induced oxidative damage and can be used in cancer research.
  • $195
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α-Glucosidase-IN-22
T678982870693-28-8
α-Glucosidase-IN-22 is a selective inhibitor of α-glucosidase (IC50=0.64 μM). α-Glucosidase-IN-22 has antidiabetic activity and has potential in type 2 diabetes (T2DM) studies.
  • $53
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(E)-3-(4-Methoxyphenyl)acrylic acid
T41095943-89-5
(E)-3-(4-Methoxyphenyl)acrylic acid is a small molecule compound isolated from the rhizome of Etlingera pavieana (Pierre ex Gagnep.) R. M. Sm. It is a novel α-glucosidase inhibitor with hepatoprotective, antiamnesic, and cognitive enhancement activities, and it can be used to lower blood pressure sugar.
  • $29
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N1,N10-Bis(p-coumaroyl)spermidine
TN4621114916-05-1
N1,N10-Bis(p-coumaroyl)spermidine, which can be extracted from the herb of alfalfa, exhibits inhibitory effects on alpha-glucosidase.
  • $1,980
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Naringinase
T410449068-31-9
Naringinase is a hydrolytic enzymatic complex that exhibits α-L-rhamnosidase and β-D-glucosidase activities. It is widely found in nature and is primarily utilized for the biotransformation of steroids, antibiotics, and glycosides.
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Erythro-Guaiacylglycerol beta-coniferyl ether
TN4003890317-92-7
Erythro-Guaiacylglycerol beta-coniferyl ether is a compound that can be extracted from the stems and leaves of mung beans and has inhibitory effects on alpha-glucosidase with an EC50 value of 18.71 μM.
  • $899
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α-Glucosidase-IN-26
T78731
α-Glucosidase-IN-26 (Compound 7i), with an IC50 value of 4.63 µM, functions as an α-glucosidase inhibitor and is utilized in type 2 diabetes mellitus (T2DM) research [1].
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α-Amylase/α-Glucosidase-IN-4
T79402
α-Amylase α-Glucosidase-IN-4 (compound 5), a dual inhibitor targeting α-amylase (Amylases) and α-glucosidase (Glucosidase), exhibits potent inhibition with IC50 values of 1.10 μM and 0.15 μM respectively, and is noted for its potential antidiabetic activity [1].
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Antidiabetic agent 2
T79644
Compound 56 (Antidiabetic agent 2) is a glucose-uptake promoter that inhibits DPP-4, PTP-1B, α-amylase, and α-glucosidase, with IC50 values of 0.036, 0.042, 0.241, and 0.185 μM, respectively. This agent effectively decreases blood glucose levels [1].
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α-Glucosidase-IN-42
T80708
α-Glucosidase-IN-42 (Compound 26), a 9-O-berberrubine carboxylate derivative, exhibits potent α-glucosidase inhibitory activity with an IC50 of 1.61 μM and has potential for use in antidiabetic research [1].
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α-Glucosidase-IN-27
T79237
α-Glucosidase-IN-27 (compound 8l), an α-glucosidase inhibitor with an IC50 of 25.78 μM, demonstrates potential for type 2 diabetes (D2M) research [1].
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Oroxin A
TWS078731567-75-6
Oroxin A (Baicalin-7-glucoside) is a partial PPARγ agonist that can activate PPARγ transcriptional activation in vitro and in vivo. Oroxin A also exhibited inhibitory activity against α-glucosidase and antioxidant capacity.
  • $121
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α-Glucosidase-IN-40
T80710
α-Glucosidase-IN-40 (compound 5) is a noncompetitive inhibitor of the α-glucosidase enzyme, with an inhibitory concentration (IC50) of 24.62 μM [1].
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α-Glucosidase-IN-74
T200727
α-Glucosidase-IN-74, a nicotinamide-thiazole derivative, functions as an α-glucosidase (α-glucosidase) inhibitor. It demonstrates antidiabetic activity by reducing blood glucose and triglyceride levels in Streptozotocin-induced diabetic animals.
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