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Endocrinology/Hormones Glucocorticoid Receptor

Glucocorticoid Receptor

The glucocorticoid receptor (GR, or GCR) also known as NR3C1 (nuclear receptor subfamily 3, group C, member 1) is the receptor to which cortisol and other glucocorticoids bind. The GR is expressed in almost every cell in the body and regulates genes controlling the development, metabolism, and immune response.
Cat No. product name
T1076 DexamethasoneHOT Dexamethasone is a glucocorticoid receptor agonist and an IL receptor modulator.Dexamethasone inhibits production of exosomes containing inflammatory microRNA-15...
T9022 AZD 9977 AZD 9977 is a novel, selective modulator of mineralocorticoid receptor .
T0107 Halcinonide Halcinonide, a high-efficiency corticosteroid, is served as an anti-inflammatory agent used in topical preparations.
T0261 Amcinonide Amcinonide is a Corticosteroid. The mechanism of action of amcinonide is as a Corticosteroid Hormone Receptor Agonist.
T1560 Prednisolone Prednisolone is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.
T1614 Hydrocortisone Hydrocortisone, a glucocorticoid receptor agonist, promotes protein catabolism, gluconeogenesis, capillary wall stability, renal excretion of calcium, and suppre...
T0948L Corticosterone Corticosterone is a sensitive inhibitor of monoamine transport.
T0034 Cortisone acetate Cortisone Acetate is the acetate salt form of cortisone, a synthetic or semisynthetic analog of the naturally occurring cortisone hormone produced by the adr...
T0034 Cortisone acetate Cortisone Acetate is the acetate salt form of cortisone, a synthetic or semisynthetic analog of the naturally occurring cortisone hormone produced by the adr...
T1243 Hydrocortisone acetate Hydrocortisone acetate is the synthetic acetate salt form of hydrocortisone, a corticosteroid with anti-inflammatory and immunosuppressive properties.
T3316 Fluoromethalone Fluorometholone is a corticosteroid, most often used after laser-based refractive surgery. It is marketed under the brand names FML (Allergan) and Flarex (Alcon)...
T6503 Fluorometholone Acetate Fluorometholone Acetate is a synthetic corticosteroid, used in the treatment of steroid responsive inflammatory conditions of the eye.
T1652 Betamethasone Betamethasone, a glucocorticoid steroid, has immunosuppressive and anti-inflammatory properties.
T6502 Fluocinonide Fluocinonide (Vanos) is an effective glucocorticoid steroid, utilized in the treatment as the skin disorders anti-inflammatory agent.
T2810 (20S)-Protopanaxatriol (20S)-Protopanaxatriol(g-PPT), a metabolite of ginsenoside, could regulate endothelial cell functions through the estrogen receptor and glucocorticoid receptor.
T1573 Flunisolide Flunisolide is a synthetic corticosteroid with anti-inflammatory and antiallergic properties.
T0977 Medrysone Medrysone is a topical, synthetic glucocorticoid with metabolic, anti-inflammatory and anti-allergic properties. Medrysone exerts its effect by interacting with ...
T1666 Fludrocortisone acetate Fludrocortisone, a glucocorticoid-receptor agonist, binds to cytoplasmic receptors, translocates to the nucleus, and subsequently initiates the transcription of ...
T1749 AL082D06 AL 082D06(D-06), a selective nonsteroidal glucocorticoid receptor (GR) antagonist (Ki: 210 nM), exhibits outstanding selectivity against AR, ER, MR and PR(Ki > 1...
T2548 Diflorasone Diflorasone is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive properties. Like other glucocorticoids, diflorasone enters the cell by dif...
T1561 Clobetasol propionate Clobetasol propionate exerts its effect by binding to cytoplasmic glucocorticoid receptors and subsequently activates glucocorticoid receptor-mediated gene expre...
T3096 Potassium canrenoate Potassium canrenoate is a synthetic pregnadiene derivative with anti-aldosterone activity.
T1163 Betamethasone 17-valerate Betamethasone Valerate is a synthetic glucocorticoid with metabolic, immunosuppressive and anti-inflammatory actions.
T1124 Flumethasone Flumethasone is a glucocorticoid receptor agonist, with anti-inflammatory, antipruritic and vasoconstrictive properties.
T2748 Cortodoxone Cortodoxone is a glucocorticoid steroid hormone that is an intermediate in the biosynthesis of cortisol in the adrenal gland.
T0485 Deflazacort Deflazacort is a glucocorticoid served as an immunosuppressant and anti-inflammatory. It can be used to treat autoimmune diseases due to inhibiting the immune sy...
T0270 Hydrocortisone butyrate Hydrocortisone Butyrate is a synthetic glucocorticoid receptor agonist with antiinflammatory, antipruritic and vasoconstrictive effects.
T2526 Ciclesonide Ciclesonide(RPR251526) is a glucocorticoid used for the treatment of obstructive airway diseases.
T0208 Prednisolone phosphate sodium Prednisolone disodium phosphate, a synthetic glucocorticoid, has immunomodulating and anti-inflammatory properties.
T0798 Triamcinolone Triamcinolone is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. Upon cell entry,  triamcinolone binds to and activates the...
T6580 Meprednisone Betapar(Meprednisone) is a glucocorticoid and a methylated derivative of prednisone.
T0947 Dexamethason acetate Dexamethasone Acetate is the acetate salt form of Dexamethasone, a synthetic adrenal corticosteroid with potent anti-inflammatory properties. In addition to bind...
T0094 Budesonide Budesonide, an anti-inflammatory corticosteroid, has shown the effective glucocorticoid activitie and few mineralocorticoid activities. According to reports, Bud...
T0337 Prednisolone-21-acetate Prednisolone Acetate is the acetate salt form of prednisolone, a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.
T21395 Finerenone Finerenone is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist with IC50 of 18 nM for the treatment o...
T0354 Canrenone Canrenone is an aldosterone antagonist with potassium-sparing diuretic activity.
T8777 BecloMethasone BecloMethasone is a prototype glucocorticoid receptor agonist. It is used topically as an anti-inflammatory agent and in aerosol form for the treatment of asthm...
T17217 Vamorolone Vamorolone is an orally active dissociative steroidal anti-inflammatory drug and membrane-stabilizer. Vamorolone improves muscular dystrophy without side effects...
T16727 Relacorilant Relacorilant is a selective and orally bioavailable antagonist of glucocorticoid receptor(Ki of 7.2 nM in HepG2 TAT assay, and also shows Kis of 12, 81.2, 210 nM...
T16727 Relacorilant Relacorilant is a selective and orally bioavailable antagonist of glucocorticoid receptor(Ki of 7.2 nM in HepG2 TAT assay, and also shows Kis of 12, 81.2, 210 nM...
T16727 Relacorilant Relacorilant is a selective and orally bioavailable antagonist of glucocorticoid receptor(Ki of 7.2 nM in HepG2 TAT assay, and also shows Kis of 12, 81.2, 210 nM...
T15389L Glucagon hydrochloride (16941-32-5 free base) Glucagon hydrochloride is a peptide hormone, produced by pancreatic α-cells. It activates HNF4α and increases HNF4α phosphorylation. Glucagon hydrochloride st...
T15389L Glucagon hydrochloride (16941-32-5 free base) Glucagon hydrochloride is a peptide hormone, produced by pancreatic α-cells. It activates HNF4α and increases HNF4α phosphorylation. Glucagon hydrochloride st...
T15451 GW-870086 GW-870086 is an effective anti-inflammatory agent. GW-870086 also plays a role in a glucocorticoid receptor agonist (pIC50: 10.1 in A549 cells expressing NF-κB)...
T15246 Esaxerenone Esaxerenone is a highly potent and selective non-steroidal antagonist of the mineralocorticoid receptor.
T14377 AZD5423 AZD5423 is an inhaled, potent, selective, and non-steroidal modulator of glucocorticoid receptor (GR) and it effectively reduces allergen-induced responses in su...
T14301 Apararenone Apararenone is a novel antagonist of non-steroidal mineralocorticoid receptor, and for the treatment of diabetic nephropathies and non-alcoholic steatohepatitis....
T8396 Prednisone acetate Prednisone acetate is a glucocorticoid receptor agonist with immunomodulating properties and anti-inflammatory.
TQ0225 AZD7594 AZD7594 is an effective and selective nonsteroidal glucocorticoid receptor modulator (IC50: 0.9 nM).
T4602 Hydrocortisone 21-hemisuccinate Hydrocortisone 21-hemisuccinate is a corticosteroid used as an analytical and chromatography reagent.
T1102 Mifepristone Mifepristone is a Progestin Antagonist. The mechanism of action of mifepristone is as a Progestational Hormone Receptor Antagonist.
T1018 Prednisone Prednisone is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.
T0343 Nimodipine Nimodipine, a 1, 4-dihydropyridine calcium channel blocker, acts primarily on vascular smooth muscle cells.
T2884 Cortisone Cortisone is a corticosteroid with potent glucocorticoid activity.
T1127 Beclomethasone dipropionate Beclomethasone Dipropionate is the dipropionate ester of a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. After cell surface re...
T1559 Betamethasone dipropionate Betamethasone Dipropionate is the 17, 21-dipropionate ester of betamethasone, a synthetic glucocorticoid with metabolic, immunosuppressive and anti-inflammatory ...
T1284 Megestrol acetate Megestrol acetate is a progestogen with actions and uses similar to those of the progestogens in general. Megestrol acetate also has anti-androgenic properties. ...
T6022 LY404039 LY404039 is an effective agonist of recombinant human mGlu2(Ki =149 nM)/mGlu3(Ki =92 nM).
T1168 Desonide Desonide is a synthetic glucocorticosteroid for topical use, with anti-inflammatory activity. Desonide binds to glucocorticoid receptors in the cytoplasm, and th...
T1541 Drospirenone Drospirenone is a synthetic spironolactone analogue and progestin with progestational and anti-mineralocorticoid activity.
T1531 Mometasone furoate Mometasone furoate is a pregnadienediol derivative ANTI-ALLERGIC AGENT and ANTI-INFLAMMATORY AGENT that is used in the management of ASTHMA and ALLERGIC RHINITIS...
T0367 Fluocinolone acetonide Fluocinolone acetonide is a glucocorticoid derivative used topically in the treatment of various skin disorders. It is usually employed as a cream, gel, lotion, ...
T0820 Triamcinolone acetonide Triamcinolone acetonide is a Corticosteroid. The mechanism of action of triamcinolone acetonide is as a Corticosteroid Hormone Receptor Agonist. It is an anti-in...
T3962 TPI1 TPI-1 is a SHP-1 inhibitor.
T0188 Fluticasone propionate Fluticasone propionate, derived from fluticasone used to remedy asthma and allergic rhinitis, is a high affinity, selective GR (glucocorticoid receptor) agonist....
T0181 Loteprednol etabonate Loteprednol Etabonate is an ophthalmic analog of the corticosteroid prednisolone with anti-inflammatory activity.
T1171 Methylprednisolone Methylprednisolone is a PREDNISOLONE derivative with similar anti-inflammatory action.
T0083 Eplerenone Eplerenone is an aldosterone receptor antagonist and potassium-sparing diuretic used in the therapy of hypertension. Eplerenone therapy has been associated with ...
Dexamethasone HOT
T1076CAS 50-02-2
Dexamethasone is a glucocorticoid receptor agonist and an IL receptor modulator.Dexamethasone inhibits production of exosomes containing inflammatory microRNA-15...
AZD 9977
T9022CAS 1850385-64-6
AZD 9977 is a novel, selective modulator of mineralocorticoid receptor .
Halcinonide
T0107CAS 3093-35-4
Halcinonide, a high-efficiency corticosteroid, is served as an anti-inflammatory agent used in topical preparations.
Amcinonide
T0261CAS 51022-69-6
Amcinonide is a Corticosteroid. The mechanism of action of amcinonide is as a Corticosteroid Hormone Receptor Agonist.
Prednisolone
T1560CAS 50-24-8
Prednisolone is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.
Hydrocortisone
T1614CAS 50-23-7
Hydrocortisone, a glucocorticoid receptor agonist, promotes protein catabolism, gluconeogenesis, capillary wall stability, renal excretion of calcium, and suppre...
Corticosterone
T0948LCAS 50-22-6
Corticosterone is a sensitive inhibitor of monoamine transport.
Cortisone acetate
T0034CAS 50-04-4
Cortisone Acetate is the acetate salt form of cortisone, a synthetic or semisynthetic analog of the naturally occurring cortisone hormone produced by the adr...
Cortisone acetate
T0034CAS 50-04-4
Cortisone Acetate is the acetate salt form of cortisone, a synthetic or semisynthetic analog of the naturally occurring cortisone hormone produced by the adr...
Hydrocortisone acetate
T1243CAS 50-03-3
Hydrocortisone acetate is the synthetic acetate salt form of hydrocortisone, a corticosteroid with anti-inflammatory and immunosuppressive properties.
Fluoromethalone
T3316CAS 426-13-1
Fluorometholone is a corticosteroid, most often used after laser-based refractive surgery. It is marketed under the brand names FML (Allergan) and Flarex (Alcon)...
Fluorometholone Acetate
T6503CAS 3801-06-7
Fluorometholone Acetate is a synthetic corticosteroid, used in the treatment of steroid responsive inflammatory conditions of the eye.
Betamethasone
T1652CAS 378-44-9
Betamethasone, a glucocorticoid steroid, has immunosuppressive and anti-inflammatory properties.
Fluocinonide
T6502CAS 356-12-7
Fluocinonide (Vanos) is an effective glucocorticoid steroid, utilized in the treatment as the skin disorders anti-inflammatory agent.
(20S)-Protopanaxatriol
T2810CAS 34080-08-5
(20S)-Protopanaxatriol(g-PPT), a metabolite of ginsenoside, could regulate endothelial cell functions through the estrogen receptor and glucocorticoid receptor.
Flunisolide
T1573CAS 3385-03-3
Flunisolide is a synthetic corticosteroid with anti-inflammatory and antiallergic properties.
Medrysone
T0977CAS 2668-66-8
Medrysone is a topical, synthetic glucocorticoid with metabolic, anti-inflammatory and anti-allergic properties. Medrysone exerts its effect by interacting with ...
Fludrocortisone acetate
T1666CAS 514-36-3
Fludrocortisone, a glucocorticoid-receptor agonist, binds to cytoplasmic receptors, translocates to the nucleus, and subsequently initiates the transcription of ...
AL082D06
T1749CAS 256925-03-8
AL 082D06(D-06), a selective nonsteroidal glucocorticoid receptor (GR) antagonist (Ki: 210 nM), exhibits outstanding selectivity against AR, ER, MR and PR(Ki > 1...
Diflorasone
T2548CAS 2557-49-5
Diflorasone is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive properties. Like other glucocorticoids, diflorasone enters the cell by dif...
Clobetasol propionate
T1561CAS 25122-46-7
Clobetasol propionate exerts its effect by binding to cytoplasmic glucocorticoid receptors and subsequently activates glucocorticoid receptor-mediated gene expre...
Potassium canrenoate
T3096CAS 2181-04-6
Potassium canrenoate is a synthetic pregnadiene derivative with anti-aldosterone activity.
Betamethasone 17-valerate
T1163CAS 2152-44-5
Betamethasone Valerate is a synthetic glucocorticoid with metabolic, immunosuppressive and anti-inflammatory actions.
Flumethasone
T1124CAS 2135-17-3
Flumethasone is a glucocorticoid receptor agonist, with anti-inflammatory, antipruritic and vasoconstrictive properties.
Cortodoxone
T2748CAS 152-58-9
Cortodoxone is a glucocorticoid steroid hormone that is an intermediate in the biosynthesis of cortisol in the adrenal gland.
Deflazacort
T0485CAS 14484-47-0
Deflazacort is a glucocorticoid served as an immunosuppressant and anti-inflammatory. It can be used to treat autoimmune diseases due to inhibiting the immune sy...
Hydrocortisone butyrate
T0270CAS 13609-67-1
Hydrocortisone Butyrate is a synthetic glucocorticoid receptor agonist with antiinflammatory, antipruritic and vasoconstrictive effects.
Ciclesonide
T2526CAS 126544-47-6
Ciclesonide(RPR251526) is a glucocorticoid used for the treatment of obstructive airway diseases.
Prednisolone phosphate sodium
T0208CAS 125-02-0
Prednisolone disodium phosphate, a synthetic glucocorticoid, has immunomodulating and anti-inflammatory properties.
Triamcinolone
T0798CAS 124-94-7
Triamcinolone is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. Upon cell entry,  triamcinolone binds to and activates the...
Meprednisone
T6580CAS 1247-42-3
Betapar(Meprednisone) is a glucocorticoid and a methylated derivative of prednisone.
Dexamethason acetate
T0947CAS 1177-87-3
Dexamethasone Acetate is the acetate salt form of Dexamethasone, a synthetic adrenal corticosteroid with potent anti-inflammatory properties. In addition to bind...
Budesonide
T0094CAS 51333-22-3
Budesonide, an anti-inflammatory corticosteroid, has shown the effective glucocorticoid activitie and few mineralocorticoid activities. According to reports, Bud...
Prednisolone-21-acetate
T0337CAS 52-21-1
Prednisolone Acetate is the acetate salt form of prednisolone, a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.
Finerenone
T21395CAS 1050477-31-0
Finerenone is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist with IC50 of 18 nM for the treatment o...
Canrenone
T0354CAS 976-71-6
Canrenone is an aldosterone antagonist with potassium-sparing diuretic activity.
BecloMethasone
T8777CAS 4419-39-0
BecloMethasone is a prototype glucocorticoid receptor agonist. It is used topically as an anti-inflammatory agent and in aerosol form for the treatment of asthm...
Vamorolone
T17217CAS 13209-41-1
Vamorolone is an orally active dissociative steroidal anti-inflammatory drug and membrane-stabilizer. Vamorolone improves muscular dystrophy without side effects...
Relacorilant
T16727CAS 1496510-51-0
Relacorilant is a selective and orally bioavailable antagonist of glucocorticoid receptor(Ki of 7.2 nM in HepG2 TAT assay, and also shows Kis of 12, 81.2, 210 nM...
Relacorilant
T16727CAS 1496510-51-0
Relacorilant is a selective and orally bioavailable antagonist of glucocorticoid receptor(Ki of 7.2 nM in HepG2 TAT assay, and also shows Kis of 12, 81.2, 210 nM...
Relacorilant
T16727CAS 1496510-51-0
Relacorilant is a selective and orally bioavailable antagonist of glucocorticoid receptor(Ki of 7.2 nM in HepG2 TAT assay, and also shows Kis of 12, 81.2, 210 nM...
Glucagon hydrochloride (16941-32-5 free base)
T15389LCAS 28270-04-4
Glucagon hydrochloride is a peptide hormone, produced by pancreatic α-cells. It activates HNF4α and increases HNF4α phosphorylation. Glucagon hydrochloride st...
Glucagon hydrochloride (16941-32-5 free base)
T15389LCAS 28270-04-4
Glucagon hydrochloride is a peptide hormone, produced by pancreatic α-cells. It activates HNF4α and increases HNF4α phosphorylation. Glucagon hydrochloride st...
GW-870086
T15451CAS 827319-43-7
GW-870086 is an effective anti-inflammatory agent. GW-870086 also plays a role in a glucocorticoid receptor agonist (pIC50: 10.1 in A549 cells expressing NF-κB)...
Esaxerenone
T15246CAS 1632006-28-0
Esaxerenone is a highly potent and selective non-steroidal antagonist of the mineralocorticoid receptor.
AZD5423
T14377CAS 1034148-04-3
AZD5423 is an inhaled, potent, selective, and non-steroidal modulator of glucocorticoid receptor (GR) and it effectively reduces allergen-induced responses in su...
Apararenone
T14301CAS 945966-46-1
Apararenone is a novel antagonist of non-steroidal mineralocorticoid receptor, and for the treatment of diabetic nephropathies and non-alcoholic steatohepatitis....
Prednisone acetate
T8396CAS 125-10-0
Prednisone acetate is a glucocorticoid receptor agonist with immunomodulating properties and anti-inflammatory.
AZD7594
TQ0225CAS 1196509-60-0
AZD7594 is an effective and selective nonsteroidal glucocorticoid receptor modulator (IC50: 0.9 nM).
Hydrocortisone 21-hemisuccinate
T4602CAS 2203-97-6
Hydrocortisone 21-hemisuccinate is a corticosteroid used as an analytical and chromatography reagent.
Mifepristone
T1102CAS 84371-65-3
Mifepristone is a Progestin Antagonist. The mechanism of action of mifepristone is as a Progestational Hormone Receptor Antagonist.
Prednisone
T1018CAS 53-03-2
Prednisone is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.
Nimodipine
T0343CAS 66085-59-4
Nimodipine, a 1, 4-dihydropyridine calcium channel blocker, acts primarily on vascular smooth muscle cells.
Cortisone
T2884CAS 53-06-5
Cortisone is a corticosteroid with potent glucocorticoid activity.
Beclomethasone dipropionate
T1127CAS 5534-09-8
Beclomethasone Dipropionate is the dipropionate ester of a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. After cell surface re...
Betamethasone dipropionate
T1559CAS 5593-20-4
Betamethasone Dipropionate is the 17, 21-dipropionate ester of betamethasone, a synthetic glucocorticoid with metabolic, immunosuppressive and anti-inflammatory ...
Megestrol acetate
T1284CAS 595-33-5
Megestrol acetate is a progestogen with actions and uses similar to those of the progestogens in general. Megestrol acetate also has anti-androgenic properties. ...
LY404039
T6022CAS 635318-11-5
LY404039 is an effective agonist of recombinant human mGlu2(Ki =149 nM)/mGlu3(Ki =92 nM).
Desonide
T1168CAS 638-94-8
Desonide is a synthetic glucocorticosteroid for topical use, with anti-inflammatory activity. Desonide binds to glucocorticoid receptors in the cytoplasm, and th...
Drospirenone
T1541CAS 67392-87-4
Drospirenone is a synthetic spironolactone analogue and progestin with progestational and anti-mineralocorticoid activity.
Mometasone furoate
T1531CAS 83919-23-7
Mometasone furoate is a pregnadienediol derivative ANTI-ALLERGIC AGENT and ANTI-INFLAMMATORY AGENT that is used in the management of ASTHMA and ALLERGIC RHINITIS...
Fluocinolone acetonide
T0367CAS 67-73-2
Fluocinolone acetonide is a glucocorticoid derivative used topically in the treatment of various skin disorders. It is usually employed as a cream, gel, lotion, ...
Triamcinolone acetonide
T0820CAS 76-25-5
Triamcinolone acetonide is a Corticosteroid. The mechanism of action of triamcinolone acetonide is as a Corticosteroid Hormone Receptor Agonist. It is an anti-in...
TPI1
T3962CAS 79756-69-7
TPI-1 is a SHP-1 inhibitor.
Fluticasone propionate
T0188CAS 80474-14-2
Fluticasone propionate, derived from fluticasone used to remedy asthma and allergic rhinitis, is a high affinity, selective GR (glucocorticoid receptor) agonist....
Loteprednol etabonate
T0181CAS 82034-46-6
Loteprednol Etabonate is an ophthalmic analog of the corticosteroid prednisolone with anti-inflammatory activity.
Methylprednisolone
T1171CAS 83-43-2
Methylprednisolone is a PREDNISOLONE derivative with similar anti-inflammatory action.
Eplerenone
T0083CAS 107724-20-9
Eplerenone is an aldosterone receptor antagonist and potassium-sparing diuretic used in the therapy of hypertension. Eplerenone therapy has been associated with ...