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Metabolism GR

GR

A growth factor receptor is a receptor which binds to growth factor. Growth factor receptors are the first stop in cells where the signaling cascade for cell differentiation and proliferation begins. Growth factors, which are ligands that bind to the receptor are the initial step to activating the growth factor receptors and tells the cell to grow and/or divide. These receptors may use the JAK/STAT, MAP kinase, and PI3 kinase pathways.
Cat No. product name
T16404 ORIC-101 ORIC-101 is a highly effective and selective glucocorticoid receptor antagonist (EC50: 5.6 nM). It also has anti-cancer activity.
T15000 Cort108297 Cort108297 is a specific antagonist of the glucocorticoid receptor with a high affinity for GRs (Ki: 0.45 nM).
T14386 AZD9567 AZD9567 (compound 15) is a potent, oral active, non-steroidal and selective glucocorticoid receptor modulator (SGRM), with an IC50 of 3.8 nM. It shows excellent ...
T14374 AZD2906 AZD2906 shows IC50s of 2.2, 0.3, 41.6 and 7.5 nM at GR in human, rat PBMC and human, rat whole blood, respectively[1]. AZD2906 is a selective glucocorticoid rece...
T14154 Alclometasone Alclometasone (7a-Chloro-16a-methyl prednisolone) is a glucocorticoid and inhibits the release of pro-inflammatory mediators from leukocytes. Alclometasone can b...
T0276 Hydrocortisone Valerate Hydrocortisone Valerate has anti-inflammatory, antipruritic and vasoconstrictive properties.
T1683 Actriol Actriol is always used as Glucocorticoid Receptor agonist.
T0294 Methylprodnisolone Sodium Succinate METHYLPREDNISOLONE, a water-soluble ester, is used for allergic, cardiac, and hypoxic emergencies.
ORIC-101
T16404CAS 2222344-98-9
ORIC-101 is a highly effective and selective glucocorticoid receptor antagonist (EC50: 5.6 nM). It also has anti-cancer activity.
Cort108297
T15000CAS 1018679-79-2
Cort108297 is a specific antagonist of the glucocorticoid receptor with a high affinity for GRs (Ki: 0.45 nM).
AZD9567
T14386CAS 1893415-00-3
AZD9567 (compound 15) is a potent, oral active, non-steroidal and selective glucocorticoid receptor modulator (SGRM), with an IC50 of 3.8 nM. It shows excellent ...
AZD2906
T14374CAS 1034148-15-6
AZD2906 shows IC50s of 2.2, 0.3, 41.6 and 7.5 nM at GR in human, rat PBMC and human, rat whole blood, respectively[1]. AZD2906 is a selective glucocorticoid rece...
Alclometasone
T14154CAS 67452-97-5
Alclometasone (7a-Chloro-16a-methyl prednisolone) is a glucocorticoid and inhibits the release of pro-inflammatory mediators from leukocytes. Alclometasone can b...
Hydrocortisone Valerate
T0276CAS 57524-89-7
Hydrocortisone Valerate has anti-inflammatory, antipruritic and vasoconstrictive properties.
Actriol
T1683CAS 547-81-9
Actriol is always used as Glucocorticoid Receptor agonist.
Methylprodnisolone Sodium Succinate
T0294CAS 2375-03-3
METHYLPREDNISOLONE, a water-soluble ester, is used for allergic, cardiac, and hypoxic emergencies.