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Search Result

Search Results for " gaba-receptor "

Targets

Others

129

Compounds

40

Natural Products

15

Recombinant Proteins

1

Libraries

Cat No. Product Name Synonyms Targets
T3290 Pikamilone Picamilon,Nicotinoyl-GABA Others
Pikamilone (Picamilon) is an intelligent medicine.
T14571 Bifenazate GABA Receptor
Bifenazate is a positive allosteric modulator of GABA receptor. Bifenazate is an acaricide that controls 100% of mites at a concentration of 25 ppm.
T4440 Saclofen GABA Receptor
Saclofen is a sulfonic analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) that acts as a competitive antagonist of the GABAB receptor (IC50: 7.8 μM).1 This compound can be used to determine the function...
T10618 Broflanilide GABA Receptor
Broflanilide is metabolized to desmethyl-broflanilide, which is a potent antagonist at the insect resistant-to-dieldrin GABA receptor and inhibits S. litura RDL GABAR (IC50: 1.3 nM).
TQ0023 Lorediplon GABA Receptor
Lorediplon is a novel hypnotic drug acting as a GABAA receptor modulator, differentially active at the α1-subunit, associated with promoting sleep.
T7794 Zuranolone GABA Receptor
Zuranolone is an agonist of GABAA receptor.
T15775 Lotilaner GABA Receptor , Parasite
Lotilaner is a parasiticide. It is used as a potent non-competitive antagonist of insects GABACl receptors (IC50 of 23.84 nM for Drosophila melanogaster GABA receptor). It also has no effect on a dog GABAA receptor.
T4176 Rac-BHFF (R,S)-BHFF GABA Receptor
rac-BHFF ((R,S)-BHFF) is potent and selective GABA B receptor positive allosteric modulator that increases the potency and efficacy of GABA ( > 15-fold and > 149% respectively). It exhibits anxiolytic activity in vivo an...
T82357 GABA receptor Antagonist 1 GABA Receptor
GABA receptor Antagonist 1 (compound 7w) effectively inhibits the Px RDL1 GABAR at an IC50 of 7.08 nmol/L and demonstrates insecticidal efficacy against P. xylostella, S. frugiperda, S. exigua, and S. litura with respect...
T1065 Baclofen Lioresal GABA Receptor
Baclofen (Lioresal) is a synthetic chlorophenyl-butanoic acid derivative used to treat spasms due to spinal cord damage and multiple sclerosis, muscle-relaxing Baclofen acts as a gamma-aminobutyric acid (GABA) agonist sp...
T16539 Piperazine citrate GABA Receptor
Piperazine citrate, an organic compound, consists of a six-membered ring, containing two nitrogen atoms at opposite positions in the ring. It used as an Anthelmintic.
T5375 Loreclezole GABA Receptor
Loreclezole is a selective GABAA receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit-containing receptors.
T26600 Alpidem Ananxyl GABA Receptor
Alpidem (Ananxyl) is an anxiolytic drug from the imidazopyridine family. Alpidem does not produce sedative effects at normal doses, and is instead used specifically for the treatment of anxiety. Alpidem has nanomolar bin...
T9424 Temgicoluril Tetramethylglycoluril,mebikar GABA Receptor
Temgicoluril (mebikar) acts on GABA Receptor.
T11822 LAU159 GABA Receptor
LAU159 is a functionally selective positive α1β3 GABA(A) receptor modulator(EC50 : 2.2 μM).
T3644 U93631 GABA Receptor
GABAA receptor antagonist that binds the picrotoxin site and stabilizes the inactive form of the channel via allosteric interaction. Accelerates the decay of GABA-induced Cl- currents with little effect on peak amplitude...
T7136 AZD-6280 GABA Receptor
AZD6280 is a novel, subtype-selective GABAAα2/3 receptor positive modulators, used for treatment of generalized anxiety disorder.
T8572 CL 218872 GABA Receptor
CL 218872 is a benzodiazepine agonist displaying selectivity for α1 subunit-containing GABAA receptors (Ki values are 130, 1820, 1530, > 10000, 490 and > 10000 nM for α1, α2, α3, α4, α5 and α6-subunit containing receptor...
T17144 TPA 023 GABA Receptor
TPA 023 is a selective agonist of GABAA α2/α3 subtype (Kis = 0.19 - 0.41 nM).
T0715 Chlormezanone Trancopal Others , GABA Receptor
Chlormezanone (Trancopal) is a non-benzodiazepine that is used in the management of anxiety. It has been suggested for use in the treatment of muscle spasm.
T11349 GABAA receptor agent 1 GABA Receptor
GABAA receptor agent 1 has strong anticonvulsant activity and is a high affinity ligand of GABAA receptor.
T36520 COR659 Cannabinoid Receptor , GABA Receptor
COR659 is a GABAB positive allosteric modulator (PAM) . COR659 suppresses alcohol and chocolate self-administration in rats[1]. COR659 apparently exerts its effects via a composite mechanism, including positive allosteri...
T2196 Fipronil Fluocyanobenpyrazole,Termidor P450 , GluCls , GABA Receptor
Fipronil (Fluocyanobenpyrazole) is a broad-use insecticide that belongs to the phenylpyrazole chemical family. Fipronil is a broad-spectrum insecticide that disrupts the insect central nervous system by blocking GABA-gat...
T1240 Flumazenil Ro 15-1788 GABA Receptor
Flumazenil (Ro 15-1788) antagonizes the benzodiazepine binding site of the gamma-aminobutyric acid (GABA)/benzodiazepine receptor complex in the central nervous system (CNS), thereby preventing the chloride channel openi...
T8630 Baclofen hydrochloride 4-amino-3-(4-chlorophenyl)butanoic acid hydron chloride GABA Receptor
Baclofen hydrochloride (4-amino-3-(4-chlorophenyl)butanoic acid hydron chloride) is a GAMMA-AMINOBUTYRIC ACID derivative that is a specific GABA-B RECEPTORS agonist. It is used in the treatment of MUSCLE SPASTICITY, espe...
T13536 Afoxolaner Chloride channel , GABA Receptor , Parasite
Afoxolaner is an isoxazoline insecticide/acaricide against Ixodes scapularis in dogs. Afoxolaner acts on the insect GABA and glutamate receptors, inhibiting GABA & glutamate-regulated uptake of chloride ions, resulting i...
T7622 Gabazine SR95531 GABA Receptor
Gabazine (SR95531) is an antagonist of GABAA receptors (Ki : 74-150 nM)
T1128 Oxiracetam ISF2522 GABA Receptor
Oxiracetam (ISF2522), a cyclic derivative of gamma-aminobutyric acid (GABA), is utilized for the treatment of cognitive impairments.
T23104 Ocinaplon DOV 273547 GABA Receptor
Ocinaplon (DOV 273547) is a GABAA receptors modulator.
T12207 NEO 376 SPI-376 Dopamine Receptor , 5-HT Receptor , GABA Receptor
NEO 376 (SPI-376) is a selective 5-HT1 receptor, GABA receptor and dopamine receptor modulator, showing anti-psychotic actively.
T8887 2'MeO6MF GABA Receptor
2'MeO6MF is a brain-penetrant positive allosteric modulator at α2β1γ2L and all α1-containing GABAA receptors.It offers neuroprotection and improved functional recovery and dampens the stroke-induced inflammatory response...
TQ0040 ONO-8590580 CS-2894 GABA Receptor
ONO-8590580 (CS-2894) is a negative allosteric modulator of GABAA α5.
T21793 CGP 35348 GABA Receptor
CGP 35348 is a selective antagonist of GABAB receptor (EC50 = 34 μM). CGP 35348 can be used in studies of neuromuscular coordination and spatial learning after neonatal brain damage in albino mice.
T2067 NS11394 NS 11394 GABA Receptor
NS11394 is a effective and subtype-selective GABA(A) receptor-positive modulator; possesses a functional efficacy selectivity profile of α(5) > α(3) > α(2) > α(1) at GABA(A) alpha subunit-containing receptors.
T11684 Isoguvacine hydrochloride 1,2,3,6-tetrahydro-4-pyridinecarboxylic acid hydrochloride GABA Receptor
Isoguvacine hydrochloride (1,2,3,6-tetrahydro-4-pyridinecarboxylic acid hydrochloride) is a GABA receptor agonist. Isoguvacine hydrochloride binds to rat synaptic cortical membranes and activates α1β2γ2S, α2β2γ2S, α3β2γ2...
T7699 AZD7325 AZD-7325 P450 , GABA Receptor
AZD7325 (AZD-7325) is a GABA-Aα2,3 -selective receptor modulator.
T4363 CGP52432 CGP 52432 GABA Receptor
CGP52432 is a very potent antagonist of GABAB receptors (IC50 = 85 nM).
T12930 SKF89976A hydrochloride d,l-SKF89976A hydrochloride GABA Receptor
SKF89976A hydrochloride (d,l-SKF89976A hydrochloride) is a selective inhibitor GABA transporter such as GAT-1 (IC50s = 0.28 μM), GAT-2 (IC50s = 137.34 μM) and GAT-3(IC50s = 202.8 μM) in CHO cells.
T1860 Imepitoin AWD 131-138,ELB-138 GABA Receptor
Imepitoin (AWD 131-138) is a new low-affinity partial benzodiazepine receptor agonist. It shows potent anticonvulsant and anxiolytic properties in rodent models.
T4993 Afloqualone HQ-495 GABA Receptor
Afloqualone (HQ-495) is a agonist of GABA Receptor . Target: GABA Receptor in vitro: Afloqualone is a quinazolinone family GABAergic drug. It has sedative and muscle-relaxant effects, resulting from its agonist activity ...
T6355 (R)-baclofen STX209,Arbaclofen GABA Receptor
(R)-baclofen (STX209), a derivative of gamma-aminobutyric acid, is commonly utilized for the treatment of spasticity.
T4688 Pipequaline hydrochloride PK-8165 hydrochloride GABA Receptor
Pipequaline hydrochloride (PK-8165 hydrochloride) is an anticonflict & anticonvulsant quinoline derivative. It is an anxiolytic drug that was never marketed. It possesses a novel chemical structure that is not closely re...
T0169 Nefiracetam DM9384,DZL-221 GABA Receptor
Nefiracetam (DM9384) are underway in Phase 2 trials. Nefiracetam, a GABAergic、 cholinergic、and monoaminergic neuronal system enhancer, is used for Ro 5-4864-induced convulsions.
T12492 Pivagabine CXB-722 GABA Receptor
Pivagabine (CXB-722), a hydrophobic 4-aminobutyric acid derivative, exhibits neuromodulatory activity and successfully penetrates the blood-brain barrier in rats. It counteracts the impact of foot shock on GABAA receptor...
T13690 Etifoxine hydrochloride HOE 36-801 hydrochloride GABA Receptor
Etifoxine hydrochloride (HOE 36-801 hydrochloride) is an anxiolytic and anticonvulsant drug. Unlike benzodiazepines, Etifoxine hydrochloride appears to produce its anxiolytic effects by binding to β2 and β3 subunits of t...
T2407 Tiagabine TGB,NO050328,Gabitril,NO328 GABA Receptor
Tiagabine (NO050328) is an Anti-epileptic Agent. The physiologic effect of tiagabine is by means of Decreased Central Nervous System Disorganized Electrical Activity.
T0349 Riluzole PK 26124,RP-54274 GABA Receptor , Sodium Channel , NMDAR
Riluzole (RP-54274) is a glutamate antagonist (RECEPTORS, GLUTAMATE) used as an anticonvulsant (ANTICONVULSANTS) and to prolong the survival of patients with AMYOTROPHIC LATERAL SCLEROSIS.
T5880 Aminooxyacetic acid hemihydrochloride Carboxymethoxylamine Hemihydrochloride Others , GABA Receptor
Aminooxyacetic acid hemihydrochloride (Carboxymethoxylamine Hemihydrochloride) is a malate-aspartate shuttle (MAS) inhibitor which also inhibits the GABA degradating enzyme GABA-T.
T14983 Clomethiazole Distraneurin,Chlormethiazole,5-(2-CHLOROETHYL)-4-METHYLTHIAZOLE P450 , GABA Receptor
Clomethiazole (Distraneurin) is an orally active GABAA agonist and it is an anticonvulsant agent. It also has the potential for treating convulsive status epilepticus. Chlormethiazole inhibits cytochrome P450 isoforms: C...
T11277 FG 7142 ZK 39106,LSU-65 GABA Receptor
FG 7142 (LSU-65) also modulates GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50= 137 nM). FG 7142 can increase tyrosine hydroxylation and cause upregulation of β-adrenoceptors in mouse cereb...

Compounds

Pikamilone
T3290
Synonym: Picamilon,Nicotinoyl-GABA
Target: Others
Bifenazate
T14571
Synonym:
Target: GABA Receptor
Saclofen
T4440
Synonym:
Target: GABA Receptor
Broflanilide
T10618
Synonym:
Target: GABA Receptor
Lorediplon
TQ0023
Synonym:
Target: GABA Receptor
Zuranolone
T7794
Synonym:
Target: GABA Receptor
Lotilaner
T15775
Synonym:
Target: GABA Receptor, Parasite
rac-BHFF
T4176
Synonym: (R,S)-BHFF
Target: GABA Receptor
GABA receptor Antagonist 1
T82357
Synonym:
Target: GABA Receptor
Baclofen
T1065
Synonym: Lioresal
Target: GABA Receptor
Piperazine citrate
T16539
Synonym:
Target: GABA Receptor
Loreclezole
T5375
Synonym:
Target: GABA Receptor
Alpidem
T26600
Synonym: Ananxyl
Target: GABA Receptor
Temgicoluril
T9424
Synonym: Tetramethylglycoluril,mebikar
Target: GABA Receptor
LAU159
T11822
Synonym:
Target: GABA Receptor
U93631
T3644
Synonym:
Target: GABA Receptor
AZD-6280
T7136
Synonym:
Target: GABA Receptor
CL 218872
T8572
Synonym:
Target: GABA Receptor
TPA 023
T17144
Synonym:
Target: GABA Receptor
Chlormezanone
T0715
Synonym: Trancopal
Target: Others, GABA Receptor
GABAA receptor agent 1
T11349
Synonym:
Target: GABA Receptor
COR659
T36520
Synonym:
Target: Cannabinoid Receptor, GABA Receptor
Fipronil
T2196
Synonym: Fluocyanobenpyrazole,Termidor
Target: P450, GluCls, GABA Receptor
Flumazenil
T1240
Synonym: Ro 15-1788
Target: GABA Receptor
Baclofen hydrochloride
T8630
Synonym: 4-amino-3-(4-chlorophenyl)butanoic acid hydron chloride
Target: GABA Receptor
Afoxolaner
T13536
Synonym:
Target: Chloride channel, GABA Receptor, Parasite
Gabazine
T7622
Synonym: SR95531
Target: GABA Receptor
Oxiracetam
T1128
Synonym: ISF2522
Target: GABA Receptor
Ocinaplon
T23104
Synonym: DOV 273547
Target: GABA Receptor
NEO 376
T12207
Synonym: SPI-376
Target: Dopamine Receptor, 5-HT Receptor, GABA Receptor
2'MeO6MF
T8887
Synonym:
Target: GABA Receptor
ONO-8590580
TQ0040
Synonym: CS-2894
Target: GABA Receptor
CGP 35348
T21793
Synonym:
Target: GABA Receptor
NS11394
T2067
Synonym: NS 11394
Target: GABA Receptor
Isoguvacine hydrochloride
T11684
Synonym: 1,2,3,6-tetrahydro-4-pyridinecarboxylic acid hydrochloride
Target: GABA Receptor
AZD7325
T7699
Synonym: AZD-7325
Target: P450, GABA Receptor
CGP52432
T4363
Synonym: CGP 52432
Target: GABA Receptor
SKF89976A hydrochloride
T12930
Synonym: d,l-SKF89976A hydrochloride
Target: GABA Receptor
Imepitoin
T1860
Synonym: AWD 131-138,ELB-138
Target: GABA Receptor
Afloqualone
T4993
Synonym: HQ-495
Target: GABA Receptor
(R)-baclofen
T6355
Synonym: STX209,Arbaclofen
Target: GABA Receptor
Pipequaline hydrochloride
T4688
Synonym: PK-8165 hydrochloride
Target: GABA Receptor
Nefiracetam
T0169
Synonym: DM9384,DZL-221
Target: GABA Receptor
Pivagabine
T12492
Synonym: CXB-722
Target: GABA Receptor
Etifoxine hydrochloride
T13690
Synonym: HOE 36-801 hydrochloride
Target: GABA Receptor
Tiagabine
T2407
Synonym: TGB,NO050328,Gabitril,NO328
Target: GABA Receptor
Riluzole
T0349
Synonym: PK 26124,RP-54274
Target: GABA Receptor, Sodium Channel, NMDAR
Aminooxyacetic acid hemihydrochloride
T5880
Synonym: Carboxymethoxylamine Hemihydrochloride
Target: Others, GABA Receptor
Clomethiazole
T14983
Synonym: Distraneurin,Chlormethiazole,5-(2-CHLOROETHYL)-4-METHYLTHIAZOLE
Target: P450, GABA Receptor
FG 7142
T11277
Synonym: ZK 39106,LSU-65
Target: GABA Receptor
1 2 3
Cat No. Product Name Synonyms Targets
TN1023 Miltirone P450 , GABA Receptor
Miltirone is a CYPs inhibitor, it has been characterized as a low-affinity ligand for central benzodiazepine receptors.
TQ0119 Cirsimaritin GABA Receptor
Cirsimaritin exhibits antibacterial, anti-inflammation, anti-tumor, antioxidant properties and renal protection. Cirsimaritin binds weakly to the benzodiazepine site on GABAA receptors.
T5754 Kavain NF-κB , GABA Receptor
Kavain, a compound extracted from the Kava plant, Piper methysticum, is found to be involved in TNF-α expression in human and mouse cells via regulation of transcriptional factors such as NF-kB and LITAF.
T4728 4-Acetamidobutanoic acid N-acetyl GABA,4-ACETAMIDOBUTYRIC ACID GABA Receptor , Endogenous Metabolite , Antibacterial
4-Acetamidobutanoic acid (4-ACETAMIDOBUTYRIC ACID) can be found in blood, feces, and urine, as well as in human prostate tissue. 4-Acetamidobutanoic acid exists in all eukaryotes, ranging from yeast to humans. 4-Acetamid...
T3782 Jujuboside A transporter , GABA Receptor
Jujuboside A is a glycoside extracted from Semen Ziziphi Spinosae, having neurophysiological inhibitory effects, used as a potential therapeutic agent for the treatment of Alzheimer s disease.
T7557 Guvacine hydrochloride GABA Receptor
Guvacine hydrochloride is an inhibits of GABA uptake (IC50 : 10 μM)
T8036 6-Methylflavone GABA Receptor
6-Methylflavone is an activator of α1β2γ2L and α1β2 GABAA receptors.
T3S2100 (-)-Securinine Securinine GABA Receptor
(-)-Securinine (Securinine) is plant-derived alkaloid and also a GABAA receptor antagonist.
TN1217 2'-O-Methylisoliquiritigenin Dopamine Receptor , 5-HT Receptor , GABA Receptor
2'-O-Methylisoliquiritigenin, a compound synthesized by enzymes specifically induced in NR.2'-O-Methylisoliquiritigenin, isolated from the Arachis species, up-regulates 5-HT, NE, DA and GABA pathways, but does not put a ...
T5799 Arecaidine hydrochloride Others
Arecaidine hydrochloride may have carcinogenesis.
T0508 γ-Aminobutyric acid Gamma-aminobutyric acid,4-Aminobutyric acid,GABA,4-Aminobutanoic acid,Piperidic acid GABA Receptor , Endogenous Metabolite
γ-Aminobutyric acid (4-Aminobutyric acid) is the most common inhibitory neurotransmitter in the central nervous system.
T8268 6,2'-Dihydroxyflavone GABA Receptor
6,2'-Dihydroxyflavone is a novel antagonist of GABAA receptor.
T2979 DL-Menthol Hexahydrothymol,(±)-Menthol GABA Receptor , AChE
DL-Menthol ((±)-Menthol) is a racemic mixture of the monoterpene alcohols (–)-menthol and (+)-menthod, which have been found in Cannabis. (–)-Menthol is more common than (+)-menthol in nature and exhibits analgesic, anti...
T2720 Ginsenoside Rc Panaxoside Rc Others , TNF , GABA Receptor , Interleukin
Ginsenoside Rc (Panaxoside Rc) is one of the ginsenosides from Panax ginseng, inhibits the expression of TNF-α and IL-1β.
T2850 Bicuculline (+)-Bicuculline,d-Bicuculline GABA Receptor
Bicuculline ((+)-Bicuculline) is a light-sensitive competitive antagonist of GABAA receptors. It was originally identified in 1932 in plant alkaloid extracts and has been isolated from Dicentra cucullaria, Adlumia fungos...
T2749 Ginkgolide A BN-52020 GABA Receptor , Endogenous Metabolite
Ginkgolide A (BN-52020) is a highly active PAF antagonist cage molecule that is isolated from the leaves of the Ginkgo biloba tree. Shows potential in a wide variety of inflammatory and immunological disorders.
T1396 Bemegride Bemegrid,3-Ethyl-3-methylglutarimide,Agipnon GABA Receptor
Bemegride (3-Ethyl-3-methylglutarimide), a central nervous system stimulant, serves as an antidote for barbiturate poisoning.
T3698 Alpha-Asarone α-Asarone,trans-Asarone P450 , GABA Receptor , HMG-CoA Reductase
alpha-Asarone (trans-Asarone) is a psychoactive compound with antidepressant-like activity in mice.
T5S1882 Songorine Napellonine,Zongorine,Bullatine G Others , GABA Receptor
Songorine (Napellonine) shows favorable anti-tumor activity in preliminary pharmacological verification trials including cell proliferation and molecular docking assays.
TMS0418 Dihydroergotoxine mesylate Ergoloid mesylates GABA Receptor
Dihydroergotoxine mesylate (Ergoloid mesylates) is mainly used to improve symptoms and physical symptoms of mental degeneration related to aging.
TN1202 (-)-α-Pinene (1S)-(-)-Alpha-Pinene Virus Protease , GABA Receptor , Endogenous Metabolite , Antibacterial
(-)-α-Pinene ((1S)-(-)-Alpha-Pinene) enhances the quantity of NREMS without affecting the intensity of NREMS by prolonging GABAergic synaptic transmission, acting as a partial modulator of GABAA-BZD receptors and directl...
T4590 (+)-Kavain Kavain,L-KAWAIN,(R)-KAWAIN Calcium Channel , GABA Receptor , Sodium Channel , Monoamine Transporter
(+)-Kavain ((R)-KAWAIN) is one of the six major kavalactones found in the Piper methysticum (kava) plant; reversible inhibitor of MAO-B.
TN1325 (2S)-6-Prenylnaringenin 6-Prenylnaringenin,6-PN GABA Receptor
(2S)-6-Prenylnaringenin (6-Prenylnaringenin) is an isomer of the potent phytoestrogen, 8-prenylnaringenin. (2S)-6-Prenylnaringenin is the most potent compound in the forebrain and acts as a positive allosteric modulator ...
T7595 L-DABA L-2,4-Diaminobutyric acid,L-DAB HBR GABA Receptor , Endogenous Metabolite
L-DABA (L-2,4-Diaminobutyric acid) is an inhibitor of GABA transaminase (IC50 > 500 μM).
T8040 Cholesterol myristate Cholesteryl myristate,Cholesteryl tetradecanoate Others , Potassium Channel , GABA Receptor , Endogenous Metabolite , AChR
Cholesterol Myristate (Cholesteryl Myristate) is a natural steroid found in traditional Chinese medicine that interacts with various ion channels, including the GABAA receptor, nicotinic acetylcholine receptor, and the i...
T2983 3,4,5-Trimethoxycinnamic acid 3-(3,4,5-Trimethoxyphenyl)acrylic Acid,O-Methylsinapic acid GABA Receptor , Endogenous Metabolite
3,4,5-Trimethoxycinnamic acid (O-Methylsinapic acid) (TMCA) is one of the constituents of Polygalae Radix and may exert anti-seizure activity by acting at the GABAA/BZ receptor complex.
T2S1814 P-Hydroxybenzaldehyde 4-Formylphenol,4-hydroxybenzaldehyde,p-Oxybenzaldehyde Transaminase , GABA Receptor , Endogenous Metabolite
1. p-Hydroxybenzaldehyde (p-Oxybenzaldehyde) shows an inhibitory effect on the GABA transaminase to contribute to an antiepileptic and anticonvulsive activity, and its inhibitory activity was higher than that of valproic...
T2S1464 Thiocolchicoside Thiocolchicine 2-glucoside analog,Coltramyl Others , GABA Receptor
Thiocolchicoside (Thiocolchicine 2-glucoside analog) (Muscoril, Myoril, Neoflax) is a muscle relaxant with anti-inflammatory and analgesic effects. It acts as a competitive GABAA receptor antagonist and also glycine rece...
T8193 α-Thujone Thujone,ALPHA-(-)-THUJONE Apoptosis , Reactive Oxygen Species , GABA Receptor , AChR , Parasite , Autophagy
α-Thujone is an inhibitor of ACh with an IC50 value of 24.7μM.
T0710 L-Cycloserine Levcycloserine,Levcicloserina,(-)-Cycloserine,(S)-Cycloserine,Levcycloserinum,(S)-4-Amino-3-isoxazolidone HIV Protease , GABA Receptor
L-Cycloserine ((-)-Cycloserine) irreversibly inhibits GABA pyridoxal 5′-phosphate-dependent aminotransferase in E. coli, as well in the brains of various animals, results in increased levels of gamma-aminobutyric acid (G...
TN2865 (E)-3,4,5-Trimethoxycinnamic acid O-Methylsinapic acid,3,4,5-Trimethoxy-trans-cinnamic acid,3,4,5-Trimethoxyphenylacrylic acid Others
(E)-3,4,5-Trimethoxycinnamic acid (O-Methylsinapic acid) is a natural product from the roots and rhizomes of Notopterygium incisum.
T3417 Amentoflavone Didemethyl-ginkgetin,Amenthoflavone,3',8''-Biapigenin Apoptosis , P450 , Phospholipase , Reactive Oxygen Species , Opioid Receptor , COX , Antibacterial , RSV , Antifungal
Amentoflavone (3',8''-Biapigenin), as a potent inhibitor of CYP3A4 and CYP2C9, can interact with many other medications. CYP3A4 and CYP2C9 are proteins used for drug metabolism in the body. Amentoflavone also is an inhib...
TN3174 6-Methoxyflavanone NSC50184 GABA Receptor
6-Methoxyflavanone (6-MeOF) is A positive allosteric modulator of the GABA response of human recombinant GABA A receptor, with antianxiety and anti-inflammatory activity, and can be used to reduce cisplatin induced neuro...
T3741 (-)-borneol L-Borneol GABA Receptor
(-)-borneol (L-Borneol) has a highly efficacious positive modulating action at GABA receptor with an EC50 of 237 μM.
T5734 (+)-BORNEOL d-Borneol GABA Receptor
(+)-BORNEOL (d-Borneol) is a natural bicyclic monoterpene used for analgesia and anesthesia in traditional Chinese medicine; enhances GABA receptor activity with an EC50 of 248 μM.
T5776 Pimpinellin Apoptosis , Anti-infection
Pimpinellin is a natural product that acts as antagonist of proteins with GABA receptor activity.
T4881 Phosphorylethanolamine O-Phosphorylethanolamine Others , Endogenous Metabolite
Phosphorylethanolamine (O-Phosphorylethanolamine) is a phosphomonoester metabolite of the phospholipid metabolism. Phosphorylethanolamine is a precursor of phospholipid synthesis and a product of phospholipid breakdown. ...
T3S2259 Methyl eugenol 4-allylveratrole,eugenyl methyl ether,O-methyleugenol,Eugenol Methyl ether GABA Receptor
1. Methyl eugenol (4-allylveratrole) is a natural constituent of the essential oils of a number of plants widely used in foodstuffs as flavouring agents, in view of the carcinogenic potential of ME, the need to check its...
T75557 Withasomniferolide B
Withasomniferolide B, a withanolide, can be obtained through isolation from a methanol extract of Withania somnifera roots, which acts as a positive activator of the GABA(A) receptor [1].
TN3351 Aflatrem GABA Receptor
Aflatrem is a tremorgenic mycotoxin with acute neurotoxic effects, a single low dose of aflatrem is able to induce degeneration of neuronal processes in hippocampal neurotransmitter systems. Aflatrem potentiates the gamm...

Natural Products

Miltirone
TN1023
Synonym:
Target: P450, GABA Receptor
Cirsimaritin
TQ0119
Synonym:
Target: GABA Receptor
Kavain
T5754
Synonym:
Target: NF-κB, GABA Receptor
4-Acetamidobutanoic acid
T4728
Synonym: N-acetyl GABA,4-ACETAMIDOBUTYRIC ACID
Target: GABA Receptor, Endogenous Metabolite, Antibacterial
Jujuboside A
T3782
Synonym:
Target: transporter, GABA Receptor
Guvacine hydrochloride
T7557
Synonym:
Target: GABA Receptor
6-Methylflavone
T8036
Synonym:
Target: GABA Receptor
(-)-Securinine
T3S2100
Synonym: Securinine
Target: GABA Receptor
2'-O-Methylisoliquiritigenin
TN1217
Synonym:
Target: Dopamine Receptor, 5-HT Receptor, GABA Receptor
Arecaidine hydrochloride
T5799
Synonym:
Target: Others
γ-Aminobutyric acid
T0508
Synonym: Gamma-aminobutyric acid,4-Aminobutyric acid,GABA,4-Aminobutanoic acid,Piperidic acid
Target: GABA Receptor, Endogenous Metabolite
6,2'-Dihydroxyflavone
T8268
Synonym:
Target: GABA Receptor
DL-Menthol
T2979
Synonym: Hexahydrothymol,(±)-Menthol
Target: GABA Receptor, AChE
Ginsenoside Rc
T2720
Synonym: Panaxoside Rc
Target: Others, TNF, GABA Receptor, Interleukin
Bicuculline
T2850
Synonym: (+)-Bicuculline,d-Bicuculline
Target: GABA Receptor
Ginkgolide A
T2749
Synonym: BN-52020
Target: GABA Receptor, Endogenous Metabolite
Bemegride
T1396
Synonym: Bemegrid,3-Ethyl-3-methylglutarimide,Agipnon
Target: GABA Receptor
alpha-Asarone
T3698
Synonym: α-Asarone,trans-Asarone
Target: P450, GABA Receptor, HMG-CoA Reductase
Songorine
T5S1882
Synonym: Napellonine,Zongorine,Bullatine G
Target: Others, GABA Receptor
Dihydroergotoxine mesylate
TMS0418
Synonym: Ergoloid mesylates
Target: GABA Receptor
(-)-α-Pinene
TN1202
Synonym: (1S)-(-)-Alpha-Pinene
Target: Virus Protease, GABA Receptor, Endogenous Metabolite, Antibacterial
(+)-Kavain
T4590
Synonym: Kavain,L-KAWAIN,(R)-KAWAIN
Target: Calcium Channel, GABA Receptor, Sodium Channel, Monoamine Transporter
(2S)-6-Prenylnaringenin
TN1325
Synonym: 6-Prenylnaringenin,6-PN
Target: GABA Receptor
L-DABA
T7595
Synonym: L-2,4-Diaminobutyric acid,L-DAB HBR
Target: GABA Receptor, Endogenous Metabolite
Cholesterol myristate
T8040
Synonym: Cholesteryl myristate,Cholesteryl tetradecanoate
Target: Others, Potassium Channel, GABA Receptor, Endogenous Metabolite, AChR
3,4,5-Trimethoxycinnamic acid
T2983
Synonym: 3-(3,4,5-Trimethoxyphenyl)acrylic Acid,O-Methylsinapic acid
Target: GABA Receptor, Endogenous Metabolite
p-Hydroxybenzaldehyde
T2S1814
Synonym: 4-Formylphenol,4-hydroxybenzaldehyde,p-Oxybenzaldehyde
Target: Transaminase, GABA Receptor, Endogenous Metabolite
Thiocolchicoside
T2S1464
Synonym: Thiocolchicine 2-glucoside analog,Coltramyl
Target: Others, GABA Receptor
α-Thujone
T8193
Synonym: Thujone,ALPHA-(-)-THUJONE
Target: Apoptosis, Reactive Oxygen Species, GABA Receptor, AChR, Parasite, Autophagy
L-Cycloserine
T0710
Synonym: Levcycloserine,Levcicloserina,(-)-Cycloserine,(S)-Cycloserine,Levcycloserinum,(S)-4-Amino-3-isoxazolidone
Target: HIV Protease, GABA Receptor
(E)-3,4,5-Trimethoxycinnamic acid
TN2865
Synonym: O-Methylsinapic acid,3,4,5-Trimethoxy-trans-cinnamic acid,3,4,5-Trimethoxyphenylacrylic acid
Target: Others
Amentoflavone
T3417
Synonym: Didemethyl-ginkgetin,Amenthoflavone,3',8''-Biapigenin
Target: Apoptosis, P450, Phospholipase, Reactive Oxygen Species, Opioid Receptor, COX, Antibacterial, RSV, Antifungal
6-Methoxyflavanone
TN3174
Synonym: NSC50184
Target: GABA Receptor
(-)-borneol
T3741
Synonym: L-Borneol
Target: GABA Receptor
(+)-BORNEOL
T5734
Synonym: d-Borneol
Target: GABA Receptor
pimpinellin
T5776
Synonym:
Target: Apoptosis, Anti-infection
Phosphorylethanolamine
T4881
Synonym: O-Phosphorylethanolamine
Target: Others, Endogenous Metabolite
Methyl eugenol
T3S2259
Synonym: 4-allylveratrole,eugenyl methyl ether,O-methyleugenol,Eugenol Methyl ether
Target: GABA Receptor
Withasomniferolide B
T75557
Synonym:
Target:
Aflatrem
TN3351
Synonym:
Target: GABA Receptor

Recombinant Proteins

Species：
Human (13)
Mouse (1)
Rat (1)
Expression System：
E. coli (14)
HEK293 (1)
Tag：
N-terminal 6xHis-tagged (4)
His (3)
N-terminal 10xHis-tagged and C-terminal Myc-tagged (2)
His,MBP (1)
N-6His,C-Fc (1)
N-GST (1)
N-terminal 6xHis-SUMO-tagged (1)
N-terminal GST-tagged (1)
hFc (1)
Cat No. Product Name Species Expression System
TMPY-00587 GABARAP Protein, Human, Recombinant (His & MBP) Human E. coli
The Atg8/LC3/GABARAP family of proteins, a group that has structural homology with ubiquitin, connects with a large set of binding partners to function in macroautophagy (hereafter autophagy). GABARAP in tumorigenesis in...
TMPJ-00015 GABARAP Protein, Human, Recombinant (His & hFc) Human E. coli
Gamma-Aminobutyric Acid Receptor-Associated Protein (GABARAP) is a ligand-gated chloride channel protein that mediates inhibitory neurotransmission and belongs to the MAP1 LC3 family. GABARAP is highly positively charged...
TMPJ-00016 GABARAP Protein, Human, Recombinant (GST) Human E. coli
Gamma-Aminobutyric Acid Receptor-Associated Protein (GABARAP) is a ligand-gated chloride channel protein that mediates inhibitory neurotransmission and belongs to the MAP1 LC3 family. GABARAP is highly positively charged...
TMPY-03991 DBI Protein, Human, Recombinant (His) Human E. coli
The diazepam binding inhibitor (DBI), alternatively known as the acyl-CoA binding protein (ACBP), is involved in multiple biological actions. The polypeptide binds to the peripheral, or mitochondrial, benzodiazepine rece...
TMPY-03268 GABARAPL1 Protein, Human, Recombinant (His) Human E. coli
ATG8, also known as GABARAPL1, is a ubiquitin-like protein that has a crystal structure. ATG8 consists of a 5-stranded β-sheet, which is enclosed by two α-helices at one side and one α-helix at the other side and exhibit...
TMPY-03461 GABARAPL2 Protein, Human, Recombinant (His) Human E. coli
GATE-16, also known as ATG8, belongs to the MAP1 LC3 family. It is expressed at high levels in the brain, heart, prostate, ovary, spleen and skeletal muscle. GATE-16 is expressed at very low levels in lung, thymus and...
TMPH-01368 GABRP Protein, Human, Recombinant (His) Human E. coli
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. In the uterus, the function of th...
TMPH-02492 DBI Protein, Mouse, Recombinant (His & Myc) Mouse E. coli
Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site lo...
TMPH-03235 DBI Protein, Rat, Recombinant (His & Myc) Rat E. coli
Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site lo...
TMPH-00890 DBI Protein, Human, Recombinant (aa 2-104, His) Human E. coli
Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site lo...
TMPH-01367 GABRB2 Protein, Human, Recombinant (His) Human E. coli
Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain. Plays an important role in the formation of functional inhibitory GABAergi...
TMPH-01366 GABRA1 Protein, Human, Recombinant (His) Human E. coli
Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain. Plays an important role in the formation of functional inhibitory GABAergi...
TMPY-00186 GHRH Protein, Human, Recombinant (hFc) Human HEK293
The role of hypothalamic growth hormone-releasing hormone (GHRH) in the release of growth hormone (GH) from the pituitary is well established. Extra-hypothalamic growth hormone-releasing hormone (GHRH) plays an important...
TMPH-01249 ADAR Protein, Human, Recombinant (GST) Human E. coli
Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translatio...
TMPH-01248 ADAR Protein, Human, Recombinant (His & SUMO) Human E. coli
Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translatio...
Cat No. Product Name
L2610 Neurotransmitter Receptor Compound Library

1513 compounds
A unique collection of 1513 neurotransmitter receptor compounds, can be used for HTS and HCS screening；

Libraries

Neurotransmitter Receptor Compound Library
L2610
Compounds: 1513
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