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Metabolism Factor Xa

Factor Xa

Factor X, also known by the eponym Stuart–Prower factor, is an enzyme  of the coagulation cascade. It is a serine endopeptidase (protease group S1, PA clan). Factor X is synthesized in the liver and requires vitamin K for its synthesis.Factor X is activated, by hydrolysis, into factor Xa by both factor IX (with its cofactor, factor VIII in a complex known as intrinsic Tenase) and factor VII with its cofactor, tissue factor (a complex known as extrinsic Tenase ). It is therefore the first member of the final common pathway or thrombin pathway.
Cat No. product name
T20454 4-Chlorophenylurea 4-Chlorophenylurea is a novel orally bioavailable inhibitor of factor Xa.
T12782 RWJ-445167 RWJ-445167 is a thrombin and factor Xa dual inhibitor(Ki of 4.0 nM and 230 nM, respectively), with potent antithrombotic activity.
T12736 Rivaroxaban D4 Rivaroxaban D4 is a deuterium labeled Rivaroxaban. Rivaroxaban is a highly potent,selective and direct inhibitor of Factor Xa (FXa)(IC50:0.7 nM; Ki:0.4 nM).
T10174 5-R-Rivaroxaban 5-R-Rivaroxaban is (R)-enantiomer of Rivaroxaban. Rivaroxaban (BAY 59-7939) is a highly potent and selective, direct Factor Xa (FXa) inhibitor (IC50 0.7 nM; Ki 0...
T19488 O-Desmethyl apixaban sulfate sodium (503612-76-8 free base) O-Desmethyl apixaban sulfate sodium inhibits factor X (FXa) with a Ki of 58 μM,and is a major circulating metabolite of Apixaban in humans.
T4980 Betrixaban maleate Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa [1]. It was selected among ...
T4341 Betrixaban Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa [1]. It was selected among ...
T4690 Betrixaban hydrochloride(330942-05-7(free base)) Betrixaban is a potent, selective, and orally efficacious factor Xa (fXa) inhibitor (IC50: 1.5 nM).
T4076 Fondaparinux sodium Fondaparinux Sodium is an antithrombin-dependent factor Xa inhibitor with antithrombotic activity.
T0775 Coumarin Coumarin is a chemical compound/poison found in many plants, notably in high concentration in the tonka bean, woodruff, and bison grass. It has clinical value as...
T2368L Edoxaban Edoxaban(DU-176) is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention.
T1736 Apixaban Apixaban is an orally active inhibitor of coagulation factor Xa with anticoagulant activity. Apixaban directly inhibits factor Xa, thereby interfering with the c...
T1184 Rivaroxaban Rivaroxaban is an orally bioavailable oxazolidinone derivative and direct inhibitor of the coagulation factor Xa with anticoagulant activity. Upon oral administr...
T0642 2-Methoxyphenothiazine 2-Methoxy Phenothiazine is light yellow or light gray solid.
T2368 Edoxaban Tosylate Monohydrate Edoxaban(DU-176) is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention.
4-Chlorophenylurea
T20454CAS 140-38-5
4-Chlorophenylurea is a novel orally bioavailable inhibitor of factor Xa.
RWJ-445167
T12782CAS 226566-43-4
RWJ-445167 is a thrombin and factor Xa dual inhibitor(Ki of 4.0 nM and 230 nM, respectively), with potent antithrombotic activity.
Rivaroxaban D4
T12736CAS 1132681-38-9
Rivaroxaban D4 is a deuterium labeled Rivaroxaban. Rivaroxaban is a highly potent,selective and direct inhibitor of Factor Xa (FXa)(IC50:0.7 nM; Ki:0.4 nM).
5-R-Rivaroxaban
T10174CAS 865479-71-6
5-R-Rivaroxaban is (R)-enantiomer of Rivaroxaban. Rivaroxaban (BAY 59-7939) is a highly potent and selective, direct Factor Xa (FXa) inhibitor (IC50 0.7 nM; Ki 0...
O-Desmethyl apixaban sulfate sodium (503612-76-8 free base)
T19488CAS T19488
O-Desmethyl apixaban sulfate sodium inhibits factor X (FXa) with a Ki of 58 μM,and is a major circulating metabolite of Apixaban in humans.
Betrixaban maleate
T4980CAS 936539-80-9
Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa [1]. It was selected among ...
Betrixaban
T4341CAS 330942-05-7
Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa [1]. It was selected among ...
Betrixaban hydrochloride(330942-05-7(free base))
T4690CAS T4690
Betrixaban is a potent, selective, and orally efficacious factor Xa (fXa) inhibitor (IC50: 1.5 nM).
Fondaparinux sodium
T4076CAS 114870-03-0
Fondaparinux Sodium is an antithrombin-dependent factor Xa inhibitor with antithrombotic activity.
Coumarin
T0775CAS 91-64-5
Coumarin is a chemical compound/poison found in many plants, notably in high concentration in the tonka bean, woodruff, and bison grass. It has clinical value as...
Edoxaban
T2368LCAS 912273-65-5
Edoxaban(DU-176) is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention.
Apixaban
T1736CAS 503612-47-3
Apixaban is an orally active inhibitor of coagulation factor Xa with anticoagulant activity. Apixaban directly inhibits factor Xa, thereby interfering with the c...
Rivaroxaban
T1184CAS 366789-02-8
Rivaroxaban is an orally bioavailable oxazolidinone derivative and direct inhibitor of the coagulation factor Xa with anticoagulant activity. Upon oral administr...
2-Methoxyphenothiazine
T0642CAS 1771-18-2
2-Methoxy Phenothiazine is light yellow or light gray solid.
Edoxaban Tosylate Monohydrate
T2368CAS 1229194-11-9
Edoxaban(DU-176) is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention.