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Endocrinology/Hormones Estrogen/progestogen Receptor

Estrogen/progestogen Receptor

Estrogen receptors are a group of proteins found inside cells. They are receptors that are activated by the hormone estrogen (17β-estradiol). Two classes of estrogen receptor exist: ER, which is a member of the nuclear hormone family of intracellular receptors, and GPER (GPR30), which is a member of the rhodopsin-like family of G protein-coupled receptors.The progesterone receptor (PR), also known as NR3C3 or nuclear receptor subfamily 3, group C, member 3, is a protein found inside cells. It is activated by the steroid hormone progesterone.
Cat No. product name
T2146 FulvestrantHOT Fulvestrant is a potent Estrogen Receptor antagonist (IC50: 9.4 nM).
T8984 FLTX1 FLTX1, a fluorescent Tamoxifen derivative that can specifically label intracellular Tamoxifen-binding sites (estrogen receptors) under permeabilized and non-perm...
T3325 Liquiritigenin Liquiritigenin, a flavonoid aglycone from licorice, is a highly selective estrogen receptor β (ERβ) agonist.
T2177 Kaempferol Kaempferol is a natural flavonoid which has been isolated from Delphinium, Witch-hazel, grapefruit, and other plant sources.
T1009 Aquacrine Estrone is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE directly, or from ...
T6491 Equol S-equol is an orally bioavailable, non-steroidal estrogen naturally produced by the metabolism of the isoflavonoid daidzein by human intestinal microflora, with ...
T6306 Erteberel LY500307 is a potent, selective estrogen receptor β agonist with EC50 of 0.66 nM, 32-fold selectivity against estrogen receptor α. Phase 2.
T6819 Desogestrel Desogestrel is a synthetic progestational hormone used often as the progestogenic component of combined oral contraceptive agents.
T2567 Etonogestrel Etonogestrel is a steroidal progestin used as hormonal contraceptives.
T0835 Tamoxifen Z-isomer citrate Tamoxifen is an antineoplastic nonsteroidal selective estrogen receptor modulator (SERM).
T1216 Diethylstilbestrol Diethylstilbestrol is used in the treatment of menopausal and postmenopausal disorders.
T2569 Chlorotrianisene Chlorotrianisene is an orally bioavailable, highly lipophilic, synthetic triphenylethylene (TPE) derivative and selective estrogen receptor modulator (SERM), wit...
T1424 Ethynyl estradiol Ethinyl estradiol is a semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is of...
T0478 Progesterone Progesterone is the major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY G...
T1284 Megestrol acetate Megestrol acetate is a progestogen with actions and uses similar to those of the progestogens in general. Megestrol acetate also has anti-androgenic properties. ...
T3378 17α-Estradiol Endogenous estrogen receptor ligand (Ki values are 0.2 and 1.2 nM for ERα and ERβ receptors respectively).
T0384 Estradiol benzoate Estradiol Benzoate is the synthetic benzoate ester of estradiol, a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics...
T1490 Gestodene Gestodene is a progestogen hormonal contraceptive.
T1438 Butoconazole nitrate Butoconazole Nitrate is the nitrate salt form of butoconazole, a synthetic imidazole derivative with fungistatic properties. Butoconazole nitrate interferes with...
T2597 Norgestrel Norgestrel is a synthetic progestin commonly used alone or in combination with an estrogen for contraception. Norgestrel suppresses the secretion of luteinizing ...
T2577 Dienogest Dienogest is an orally-active, semisynthetic, fourth generation, nonethinylated progestogen with antiproliferative, antiandrogenic, anti-inflammatory and antiang...
T1541 Drospirenone Drospirenone is a synthetic spironolactone analogue and progestin with progestational and anti-mineralocorticoid activity.
T1514 Norethindrone Norethindrone is a synthetic progestational hormone with actions similar to those of PROGESTERONE but functioning as a more potent inhibitor of ovulation. It has...
T0171 Norethynodrel Norethynodrel is a synthetic progestational hormone with actions and uses similar to those of PROGESTERONE. It has been used in the treatment of functional uteri...
T6743 4-Hydroxytamoxifen 4-Hydroxytamoxifen is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemoprevent...
T1429 Hydroxyprogesterone Hydroxyprogesterone is a physiological progestin that is produced during glucocorticoid and steroid hormone synthesis and is increased during the third trimester...
T2598 Thymopentin Synthetic pentapeptide corresponding to the amino acids 32-36 of thymopoietin and exhibiting the full biological activity of the natural hormone. THYMOPENTIN is ...
T1261 Medroxyprogesterone Acetate Medroxyprogesterone acetate is a synthetic progestin that is derived from 17-hydroxyprogesterone. It is a long-acting contraceptive that is effective both orally...
T1377 Methyldienedione Methyldienedione is an anabolic steroid and a precursor to dienolone.
T1048 Estradiol Estradiol is an Estrogen. The mechanism of action of estradiol is as an Estrogen Receptor Agonist.
T1193 Clomifene citrate Clomifene Citrate is a selective estrogen receptor modulator.
T2544 Bazedoxifene acetate Bazedoxifene acetate is a novel selective estrogen receptor modulator (SERM).
T6906 Tamoxifen Tamoxifen is an antagonist of the estrogen receptor in breast tissue.
T2280 Endoxifen Z-isomer Endoxifen (EDX) is a key active metabolite of tamoxifen (TAM) with higher affinity and specificity to estrogen receptors that also inhibits aromatase activity.
T2231 17-Beta-Estradiol-3,17-Dipropionate Estradiol dipropionate is a synthetic ester, specifically the 3, 17-dipropanoyl ester, of the natural estrogen, estradiol.
T3645 Endoxifen E-isomer hydrochloride Endoxifen, a tamoxifen metabolite, is effective specific Estrogen Response Modifier (SERM).
T2527 Ulipristal acetate Ulipristal Acetate is an orally bioavailable, acetate salt of ulipristal, a selective progesterone receptor modulator with anti-progesterone activity. Ulipristal...
T6620 Ospemifene Ospemifene is a new selective non-hormonal estrogen receptor modulator (SERM) that is used for the treatment of moderate to severe dyspareunia, a symptom of vulv...
T0040 Quinestrol Quinestrol  is a synthetic estrogen, applied in hormone replacement therapy, and occasionally to use in cancer and prostate cancer treatment.
T6713 Ulipristal Ulipristal is a selective SPRM for emergency contraception after an unprotected intercourse or contraceptive failure.
T3975 AZD9496 AZD9496 is an orally available selective estrogen receptor(ERα) antagonist, with potential antineoplastic activity.
T1480 Danazol Danazol is a synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary ou...
T3399 Psoralidin Psoralidin inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation and transcriptionally. Psoralidin possesses anticancer and chemopreventive p...
T6404 Bazedoxifene HCl Bazedoxifene HCl is a novel, non-steroidal, indole-based estrogen receptor modulator (SERM) binding to both ERα and ERβ with IC50 of 23 nM and 89 nM, respectiv...
T3846 Bavachin Bavachin is a phytoestrogen that activates the estrogen receptors ERα and ERβ.
T0593 XCT790 XCT790 is a potent, selective and inverse agonist of estrogen-related receptor alpha(ERRα).
T0996 Ethynodiol diacetate Ethynodiol diacetate is a synthetic progestational hormone used alone or in combination with estrogens as an oral contraceptive.
T0168 Depofemin Estradiol cypionate, the 17 β-cyclopentylpropinate ester of estradiol, inhibits ET-1 synthesis via estrogen receptor.
T6683 STF62247 STF-62247 is TGN inhibitor with IC50 of 0.625 μM and 16 μM in RCC4 and RCC4/VHL cells, respectively.
T2810 (20S)-Protopanaxatriol (20S)-Protopanaxatriol(g-PPT), a metabolite of ginsenoside, could regulate endothelial cell functions through the estrogen receptor and glucocorticoid receptor.
T1536 Promestriene Promestriene (INN) is a synthetic estrogen and glucocorticoid used topically in a 1% cream formulation. It is described as a tropic agent and antiseborrheic.
T2559 Allylestrenol Allylestrenol is a synthetic steroid with progestational activity.
T0301 Ethisterone Ethisterone is a progestogen hormone.
T3958 WAY 200070 WAY-200070 is a specific agonist of estrogen receptor β (ERRβ, IC50: 2.3 nM).
T2195 Epiandrosterone Epiandrosterone is a dehydroepiandrosterone metabolite and a precursor of testosterone and estradiol with hypolipidemic and anabolic property.
T3806 Kaempferide Kaempferide triglycoside inhibits the proliferation of native and estrogen receptor beta overexpressing colon cancer cells through a mechanism not mediated by li...
T3717 β-thujaplicin β-thujaplicin can inhibit ultraviolet B-induced apoptosis in keratinocytes and strongly suggest that the inhibitory mechanism is due to the antioxidant activity...
T1571 Estriol Estriol is a hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen...
T1579 Mestranol Mestranol, a semisynthetic estrogen, is used as an estrogen receptor agonist and must be demethylated to be biologically active.
T0345 Estropipate Estropipate is a natural estrogenic substance composed of estrone sulfate and piperazine.
T13768 (+)-Medicarpin (+)-Medicarpin potently inhibits osteoclastogenesis and promotes bone healing and increases bone mass by osteoblast differentiation with estrogen receptor (ER) ...
T12312 OP-1074 OP-1074 is a pure antiestrogen and a selective degrader of ER, shows specific antiestrogenic activity for ERα and ERβ.
TN1052 Lindleyin Lindleyin is a novel phytoestrogen and might trigger many of the biological responses evoked by the physiological estrogens.
TN1148 Isopsoralenoside Isopsoralenoside shows estrogen-like, osteoblastic proliferation accelerating, antitumor, and antibacterial effects.
TN1370 Allura Red AC Allura Red AC and amaranth are very important food azo dyes used in food, drug, paper, cosmetic and textile industries.
TN1679 Genistein 7,4'-di-O-beta-D-glucopyranoside Genistein 7,4'-di-O-beta-D-glucopyranoside shows significant estrogenic proliferative effect in MCF-7 cell in sub-cytotoxic concentration range.
TN1690 Glabrene Glabrene, Liquiritin apioside, neolicuroside, and 18α²-glycyrrhetic acid are the predominant phenolic derivatives partitioning at the interface and most likely...
TN1768 Iriflophenone Standard reference
TN2045 Pelargonidin-3-O-glucoside chloride Pelargonidin-3-O-glucopyranoside is the glucoside of Pelargonidin, an potential antidiabetic agent. Pelargonidin-3-O-glucopyranoside has antioxidant, anti-inflam...
TN2200 Segetalin A Segetalin A has estrogen-like activity.
TN2288 Uralenol Uralenol significantly shows the inhibitory activities against the PTP1B enzyme; it also shows inhibitory activities on mushroom tyrosinase using l-tyrosine as s...
T8370 GSK5182 GSK5182 is a highly selective inverse estrogen-related receptor γ agonist (IC50 : 79 nM)
T7904 SR 19881 SR 19881 is a full agonist of ERRγ(EC50 value of 0.39 μM in a binding assay and an EC50 value of 4.7 μM in a cell-based assay).
T12278 NXT629 NXT629 is a selective and competitive antagonist of PPAR-α(human PPARα with an IC50 of 77 nM).
T12329 Ospemifene D4 Ospemifene D4 is a deuterium labeled Ospemifene. Ospemifene is a selective and orally active modulator of estrogen receptor.
TQ0274 25(R)-27-hydroxy Cholesterol 27-Hydroxycholesterol is a selective modulator of estrogen receptor and an agonist of the liver X receptor.
T14987 CMP8 CMP8 is a selective ligand for the estrogen receptor which binds to the mutant estrogen receptor ligand-binding domain (ERLBD) (IC50s: 29 nM, 41 nM, 1100 nM and ...
T15191 PROTAC ERRα ligand 1 PROTAC ERRα ligand 1 is an antagonist of the estrogen-related receptor (ERRα; IC50s: 0.04 and 2.8 μM for ERRα and ERRγ).
T12832 SAR439859 SAR439859 is an orally active, nonsteroidal and selective degrader of estrogen receptor (SERD). SAR439859 is a potent antagonist of ER (with an EC50 of 0.2 nM fo...
T13674 Elacestrant Elacestrant with IC50s of 48 and 870 nM for ERα and ERβ, respectively.Elacestrant  is an orally available selective estrogen receptor degrader .
T13675 Elacestrant dihydrochloride Elacestrant dihydrochloride is an orally available selective estrogen receptor degrader with IC50s of 48 and 870 nM for ERα and ERβ, respectively.
T11222 ERB-196 Erb-196 is an estrogen receptor-receptor agonist with non-steroidal selectivity.
T11230 ERRα antagonist-1 ERRα antagonist-1 does not inhibit the interaction of either ERRβ or ERRγ with PGC-1α and PGC-1β coactivator, and also does not inhibit interaction of ERα ...
T11231 ERRγ Inverse Agonist 1 ERRγ Inverse Agonist 1  is a potent, selective and orally bioavailable Estrogen-related Receptor grammar  inverse agonist, with an IC50 of 40 nM.
T11399 Giredestrant Giredestrant potently competes with estradiol for binding and induces a conformational change within the ER ligand binding domain. Giredestrant has anti-tumor a...
T7709 (E/Z)-GSK5182 (E/Z)-GSK5182 is a racemic compound of (E)-GSK5182 and (Z)-GSK5182 isomers. GSK5182 is a highly selective and orally active estrogen-related receptor γ (ERRγ) ...
T13447 (R)-Zanubrutinib (R)-Zanubrutinib is the R enantiomer of Zanubrutinib. Zanubrutinib is a selective inhibitor of Bruton tyrosine kinase (BTK).
T16351 NSC16168 NSC16168 inhibits DNA repair and potentiates CDDP efficacy in cancer. NSC16168 is a specific ERCC1-XPF inhibitor (IC50: 0.42 μM).
T7974 Lynestrenol Lynestrenol is a synthetic progestational hormone, is the progesterone receptor agonist
T7839 Lasofoxifene Tartrate Lasofoxifene Tartrate is a third-generation, non-steroidal selective estrogen receptor modulator.
T1659 Melatonine Melatonin is a biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness and...
T4000 (±)-Equol Equol is a non-steroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzen by human intestinal microflora. The estrogen receptor (...
T0709 Pimaricin Natamycin is a Polyene Antimicrobial.
T1263 Levonorgestrel Levonorgestrel is a Progestin and Progestin-containing Intrauterine Device. The physiologic effect of levonorgestrel is by means of Inhibit Ovum Fertilization.
T0188 Fluticasone propionate Fluticasone propionate, derived from fluticasone used to remedy asthma and allergic rhinitis, is a high affinity, selective GR (glucocorticoid receptor) agonist....
T1688 5Beta-Pregnane-3Alpha,20alpha-Diol 5Beta-Pregnane-3Alpha, 20alpha-Diol is an inactive metabolite of PROGESTERONE by reduction at C5, C3, and C20 position. Pregnanediol has two hydroxyl groups, at ...
T1549 Raloxifene hydrochloride Raloxifene hydrochloride is a second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women. It has estroge...
T6533 Hexestrol Hexestrol binds to ERα and ERβ with EC50 of 0.07 nM and 0.175 nM, respectively.
T0035 Dienestrol Dienestrol is a synthetic and nonsteroidal estrogen, which is an estrogen receptor agonist. Estrogens can increase a normal clear discharge from the vagina and m...
T1102 Mifepristone Mifepristone is a Progestin Antagonist. The mechanism of action of mifepristone is as a Progestational Hormone Receptor Antagonist.
T2973 Astragaloside IV Astragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteas...
T0870 Altrenogest Altrenogest(A35957; RU2267), a progestogen, has structural relation with veterinary steroid trenbolone.
T0139 Toremifene Toremifene is a selective estrogen-receptor modulator (SERM).
T1464 Toremifene citrate Toremifene citrate is a selective estrogen receptor modulator (SERM). It is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on...
T2250 DY131 DY131 is a novel selective agonist of ERRβ and ERRγ.
TQ0163 Sagittatoside A Sagittatoside A selectively activates estrogen response element (ERE)-luciferase activity via ERα.
T4281 (E/Z)-Endoxifen (E/Z)-Endoxifen is an active metabolite of tamoxifen produced by the sequential action of cytochrome P450 (CYP) isoforms, including CYP2D6. It is a strong anti-e...
T4420 (Z)-4-hydroxy Tamoxifen 4-Hydroxytamoxifen is a selective estrogen receptor modulator (SERM).
T4388 PHTPP PHTPP is a selective ERβ antagonist.
T4505 Ferrous Bisglycinate Ferrous Bisglycinate is used in the fortification of infant formulations and foods.
T5118 GDC0810 GDC-0810 is a selective estrogen receptor degrader (IC50: 0.7 nM).
T5040 Medroxyprogesterone Medroxyprogesterone is used in the treatment of renal carcinoma. It is a synthetic progestational hormone used in veterinary practice as an estrus regulator.
T5174 Nestoron Nestoron, a synthetic progestin, is a high-affinity agonist of the progesterone receptor (EC50: 10.3 nM).
T5531 GSK-4716 GSK4716 is an ERRβ/γ agonist (IC50 = 2 µM) that can activate the receptor with similar potency as the protein ligand
T5633 H3B-5942 H3B-5942 belongs to a class of ERα antagonists referred to as selective estrogen receptor covalent antagonists (SERCA).
T5835 PROTAC ERRα ligand 2 PROTAC ERRα ligand 2 is an estrogen-related receptor α (ERRα) inverse agonist( IC50 : 5.67 nM)
T7223 Gestrinone Gestrinone is a synthetic androgen receptor agonist and ER and progesterone receptor antagonist used to treat endometriosis. It inhibits leiomyoma cells with an ...
T7644 DPN DPN is an selective agonist of estrogen receptor β (ERβ) .
TQ0149 Prinaberel Prinaberel (ERB-041) is an effective and selective ERβ agonist and >200-fold selective for ERβ.
T6827 Endoxifen HCl Endoxifen HCl is the active metabolite of Tamoxifen, which is an effective and selective estrogen receptor antagonist.
Fulvestrant HOT
T2146CAS 129453-61-8
Fulvestrant is a potent Estrogen Receptor antagonist (IC50: 9.4 nM).
FLTX1
T8984CAS 1481401-71-1
FLTX1, a fluorescent Tamoxifen derivative that can specifically label intracellular Tamoxifen-binding sites (estrogen receptors) under permeabilized and non-perm...
Liquiritigenin
T3325CAS 578-86-9
Liquiritigenin, a flavonoid aglycone from licorice, is a highly selective estrogen receptor β (ERβ) agonist.
Kaempferol
T2177CAS 520-18-3
Kaempferol is a natural flavonoid which has been isolated from Delphinium, Witch-hazel, grapefruit, and other plant sources.
Aquacrine
T1009CAS 53-16-7
Estrone is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE directly, or from ...
Equol
T6491CAS 531-95-3
S-equol is an orally bioavailable, non-steroidal estrogen naturally produced by the metabolism of the isoflavonoid daidzein by human intestinal microflora, with ...
Erteberel
T6306CAS 533884-09-2
LY500307 is a potent, selective estrogen receptor β agonist with EC50 of 0.66 nM, 32-fold selectivity against estrogen receptor α. Phase 2.
Desogestrel
T6819CAS 54024-22-5
Desogestrel is a synthetic progestational hormone used often as the progestogenic component of combined oral contraceptive agents.
Etonogestrel
T2567CAS 54048-10-1
Etonogestrel is a steroidal progestin used as hormonal contraceptives.
Tamoxifen Z-isomer citrate
T0835CAS 54965-24-1
Tamoxifen is an antineoplastic nonsteroidal selective estrogen receptor modulator (SERM).
Diethylstilbestrol
T1216CAS 56-53-1
Diethylstilbestrol is used in the treatment of menopausal and postmenopausal disorders.
Chlorotrianisene
T2569CAS 569-57-3
Chlorotrianisene is an orally bioavailable, highly lipophilic, synthetic triphenylethylene (TPE) derivative and selective estrogen receptor modulator (SERM), wit...
Ethynyl estradiol
T1424CAS 57-63-6
Ethinyl estradiol is a semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is of...
Progesterone
T0478CAS 57-83-0
Progesterone is the major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY G...
Megestrol acetate
T1284CAS 595-33-5
Megestrol acetate is a progestogen with actions and uses similar to those of the progestogens in general. Megestrol acetate also has anti-androgenic properties. ...
17α-Estradiol
T3378CAS 57-91-0
Endogenous estrogen receptor ligand (Ki values are 0.2 and 1.2 nM for ERα and ERβ receptors respectively).
Estradiol benzoate
T0384CAS 50-50-0
Estradiol Benzoate is the synthetic benzoate ester of estradiol, a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics...
Gestodene
T1490CAS 60282-87-3
Gestodene is a progestogen hormonal contraceptive.
Butoconazole nitrate
T1438CAS 64872-77-1
Butoconazole Nitrate is the nitrate salt form of butoconazole, a synthetic imidazole derivative with fungistatic properties. Butoconazole nitrate interferes with...
Norgestrel
T2597CAS 6533-00-2
Norgestrel is a synthetic progestin commonly used alone or in combination with an estrogen for contraception. Norgestrel suppresses the secretion of luteinizing ...
Dienogest
T2577CAS 65928-58-7
Dienogest is an orally-active, semisynthetic, fourth generation, nonethinylated progestogen with antiproliferative, antiandrogenic, anti-inflammatory and antiang...
Drospirenone
T1541CAS 67392-87-4
Drospirenone is a synthetic spironolactone analogue and progestin with progestational and anti-mineralocorticoid activity.
Norethindrone
T1514CAS 68-22-4
Norethindrone is a synthetic progestational hormone with actions similar to those of PROGESTERONE but functioning as a more potent inhibitor of ovulation. It has...
Norethynodrel
T0171CAS 68-23-5
Norethynodrel is a synthetic progestational hormone with actions and uses similar to those of PROGESTERONE. It has been used in the treatment of functional uteri...
4-Hydroxytamoxifen
T6743CAS 68392-35-8
4-Hydroxytamoxifen is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemoprevent...
Hydroxyprogesterone
T1429CAS 68-96-2
Hydroxyprogesterone is a physiological progestin that is produced during glucocorticoid and steroid hormone synthesis and is increased during the third trimester...
Thymopentin
T2598CAS 69558-55-0
Synthetic pentapeptide corresponding to the amino acids 32-36 of thymopoietin and exhibiting the full biological activity of the natural hormone. THYMOPENTIN is ...
Medroxyprogesterone Acetate
T1261CAS 71-58-9
Medroxyprogesterone acetate is a synthetic progestin that is derived from 17-hydroxyprogesterone. It is a long-acting contraceptive that is effective both orally...
Methyldienedione
T1377CAS 5173-46-6
Methyldienedione is an anabolic steroid and a precursor to dienolone.
Estradiol
T1048CAS 50-28-2
Estradiol is an Estrogen. The mechanism of action of estradiol is as an Estrogen Receptor Agonist.
Clomifene citrate
T1193CAS 50-41-9
Clomifene Citrate is a selective estrogen receptor modulator.
Bazedoxifene acetate
T2544CAS 198481-33-3
Bazedoxifene acetate is a novel selective estrogen receptor modulator (SERM).
Tamoxifen
T6906CAS 10540-29-1
Tamoxifen is an antagonist of the estrogen receptor in breast tissue.
Endoxifen Z-isomer
T2280CAS 112093-28-4
Endoxifen (EDX) is a key active metabolite of tamoxifen (TAM) with higher affinity and specificity to estrogen receptors that also inhibits aromatase activity.
17-Beta-Estradiol-3,17-Dipropionate
T2231CAS 113-38-2
Estradiol dipropionate is a synthetic ester, specifically the 3, 17-dipropanoyl ester, of the natural estrogen, estradiol.
Endoxifen E-isomer hydrochloride
T3645CAS 1197194-61-8
Endoxifen, a tamoxifen metabolite, is effective specific Estrogen Response Modifier (SERM).
Ulipristal acetate
T2527CAS 126784-99-4
Ulipristal Acetate is an orally bioavailable, acetate salt of ulipristal, a selective progesterone receptor modulator with anti-progesterone activity. Ulipristal...
Ospemifene
T6620CAS 128607-22-7
Ospemifene is a new selective non-hormonal estrogen receptor modulator (SERM) that is used for the treatment of moderate to severe dyspareunia, a symptom of vulv...
Quinestrol
T0040CAS 152-43-2
Quinestrol  is a synthetic estrogen, applied in hormone replacement therapy, and occasionally to use in cancer and prostate cancer treatment.
Ulipristal
T6713CAS 159811-51-5
Ulipristal is a selective SPRM for emergency contraception after an unprotected intercourse or contraceptive failure.
AZD9496
T3975CAS 1639042-08-2
AZD9496 is an orally available selective estrogen receptor(ERα) antagonist, with potential antineoplastic activity.
Danazol
T1480CAS 17230-88-5
Danazol is a synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary ou...
Psoralidin
T3399CAS 18642-23-4
Psoralidin inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation and transcriptionally. Psoralidin possesses anticancer and chemopreventive p...
Bazedoxifene HCl
T6404CAS 198480-56-7
Bazedoxifene HCl is a novel, non-steroidal, indole-based estrogen receptor modulator (SERM) binding to both ERα and ERβ with IC50 of 23 nM and 89 nM, respectiv...
Bavachin
T3846CAS 19879-32-4
Bavachin is a phytoestrogen that activates the estrogen receptors ERα and ERβ.
XCT790
T0593CAS 725247-18-7
XCT790 is a potent, selective and inverse agonist of estrogen-related receptor alpha(ERRα).
Ethynodiol diacetate
T0996CAS 297-76-7
Ethynodiol diacetate is a synthetic progestational hormone used alone or in combination with estrogens as an oral contraceptive.
Depofemin
T0168CAS 313-06-4
Estradiol cypionate, the 17 β-cyclopentylpropinate ester of estradiol, inhibits ET-1 synthesis via estrogen receptor.
STF62247
T6683CAS 315702-99-9
STF-62247 is TGN inhibitor with IC50 of 0.625 μM and 16 μM in RCC4 and RCC4/VHL cells, respectively.
(20S)-Protopanaxatriol
T2810CAS 34080-08-5
(20S)-Protopanaxatriol(g-PPT), a metabolite of ginsenoside, could regulate endothelial cell functions through the estrogen receptor and glucocorticoid receptor.
Promestriene
T1536CAS 39219-28-8
Promestriene (INN) is a synthetic estrogen and glucocorticoid used topically in a 1% cream formulation. It is described as a tropic agent and antiseborrheic.
Allylestrenol
T2559CAS 432-60-0
Allylestrenol is a synthetic steroid with progestational activity.
Ethisterone
T0301CAS 434-03-7
Ethisterone is a progestogen hormone.
WAY 200070
T3958CAS 440122-66-7
WAY-200070 is a specific agonist of estrogen receptor β (ERRβ, IC50: 2.3 nM).
Epiandrosterone
T2195CAS 481-29-8
Epiandrosterone is a dehydroepiandrosterone metabolite and a precursor of testosterone and estradiol with hypolipidemic and anabolic property.
kaempferide
T3806CAS 491-54-3
Kaempferide triglycoside inhibits the proliferation of native and estrogen receptor beta overexpressing colon cancer cells through a mechanism not mediated by li...
β-thujaplicin
T3717CAS 499-44-5
β-thujaplicin can inhibit ultraviolet B-induced apoptosis in keratinocytes and strongly suggest that the inhibitory mechanism is due to the antioxidant activity...
Estriol
T1571CAS 50-27-1
Estriol is a hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen...
Mestranol
T1579CAS 72-33-3
Mestranol, a semisynthetic estrogen, is used as an estrogen receptor agonist and must be demethylated to be biologically active.
Estropipate
T0345CAS 7280-37-7
Estropipate is a natural estrogenic substance composed of estrone sulfate and piperazine.
(+)-Medicarpin
T13768CAS 33983-39-0
(+)-Medicarpin potently inhibits osteoclastogenesis and promotes bone healing and increases bone mass by osteoblast differentiation with estrogen receptor (ER) ...
OP-1074
T12312CAS 1443752-76-8
OP-1074 is a pure antiestrogen and a selective degrader of ER, shows specific antiestrogenic activity for ERα and ERβ.
Lindleyin
TN1052CAS 59282-56-3
Lindleyin is a novel phytoestrogen and might trigger many of the biological responses evoked by the physiological estrogens.
Isopsoralenoside
TN1148CAS 905954-18-9
Isopsoralenoside shows estrogen-like, osteoblastic proliferation accelerating, antitumor, and antibacterial effects.
Allura Red AC
TN1370CAS 25956-17-6
Allura Red AC and amaranth are very important food azo dyes used in food, drug, paper, cosmetic and textile industries.
Genistein 7,4'-di-O-beta-D-glucopyranoside
TN1679CAS 36190-98-4
Genistein 7,4'-di-O-beta-D-glucopyranoside shows significant estrogenic proliferative effect in MCF-7 cell in sub-cytotoxic concentration range.
Glabrene
TN1690CAS 60008-03-9
Glabrene, Liquiritin apioside, neolicuroside, and 18α²-glycyrrhetic acid are the predominant phenolic derivatives partitioning at the interface and most likely...
Iriflophenone
TN1768CAS 52591-10-3
Standard reference
Pelargonidin-3-O-glucoside chloride
TN2045CAS 18466-51-8
Pelargonidin-3-O-glucopyranoside is the glucoside of Pelargonidin, an potential antidiabetic agent. Pelargonidin-3-O-glucopyranoside has antioxidant, anti-inflam...
Segetalin A
TN2200CAS 161875-97-4
Segetalin A has estrogen-like activity.
Uralenol
TN2288CAS 139163-15-8
Uralenol significantly shows the inhibitory activities against the PTP1B enzyme; it also shows inhibitory activities on mushroom tyrosinase using l-tyrosine as s...
GSK5182
T8370CAS 877387-37-6
GSK5182 is a highly selective inverse estrogen-related receptor γ agonist (IC50 : 79 nM)
SR 19881
T7904CAS 2213490-89-0
SR 19881 is a full agonist of ERRγ(EC50 value of 0.39 μM in a binding assay and an EC50 value of 4.7 μM in a cell-based assay).
NXT629
T12278CAS 1454925-59-7
NXT629 is a selective and competitive antagonist of PPAR-α(human PPARα with an IC50 of 77 nM).
Ospemifene D4
T12329CAS T12329
Ospemifene D4 is a deuterium labeled Ospemifene. Ospemifene is a selective and orally active modulator of estrogen receptor.
25(R)-27-hydroxy Cholesterol
TQ0274CAS 20380-11-4
27-Hydroxycholesterol is a selective modulator of estrogen receptor and an agonist of the liver X receptor.
CMP8
T14987CAS 851107-28-3
CMP8 is a selective ligand for the estrogen receptor which binds to the mutant estrogen receptor ligand-binding domain (ERLBD) (IC50s: 29 nM, 41 nM, 1100 nM and ...
PROTAC ERRα ligand 1
T15191CAS 1264754-13-3
PROTAC ERRα ligand 1 is an antagonist of the estrogen-related receptor (ERRα; IC50s: 0.04 and 2.8 μM for ERRα and ERRγ).
SAR439859
T12832CAS 2114339-57-8
SAR439859 is an orally active, nonsteroidal and selective degrader of estrogen receptor (SERD). SAR439859 is a potent antagonist of ER (with an EC50 of 0.2 nM fo...
Elacestrant
T13674CAS 722533-56-4
Elacestrant with IC50s of 48 and 870 nM for ERα and ERβ, respectively.Elacestrant  is an orally available selective estrogen receptor degrader .
Elacestrant dihydrochloride
T13675CAS 1349723-93-8
Elacestrant dihydrochloride is an orally available selective estrogen receptor degrader with IC50s of 48 and 870 nM for ERα and ERβ, respectively.
ERB-196
T11222CAS 550997-55-2
Erb-196 is an estrogen receptor-receptor agonist with non-steroidal selectivity.
ERRα antagonist-1
T11230CAS 1072145-33-5
ERRα antagonist-1 does not inhibit the interaction of either ERRβ or ERRγ with PGC-1α and PGC-1β coactivator, and also does not inhibit interaction of ERα ...
ERRγ Inverse Agonist 1
T11231CAS T11231
ERRγ Inverse Agonist 1  is a potent, selective and orally bioavailable Estrogen-related Receptor grammar  inverse agonist, with an IC50 of 40 nM.
Giredestrant
T11399CAS 1953133-47-5
Giredestrant potently competes with estradiol for binding and induces a conformational change within the ER ligand binding domain. Giredestrant has anti-tumor a...
(E/Z)-GSK5182
T7709CAS T7709
(E/Z)-GSK5182 is a racemic compound of (E)-GSK5182 and (Z)-GSK5182 isomers. GSK5182 is a highly selective and orally active estrogen-related receptor γ (ERRγ) ...
(R)-Zanubrutinib
T13447CAS 1691249-44-1
(R)-Zanubrutinib is the R enantiomer of Zanubrutinib. Zanubrutinib is a selective inhibitor of Bruton tyrosine kinase (BTK).
NSC16168
T16351CAS 6837-93-0
NSC16168 inhibits DNA repair and potentiates CDDP efficacy in cancer. NSC16168 is a specific ERCC1-XPF inhibitor (IC50: 0.42 μM).
Lynestrenol
T7974CAS 52-76-6
Lynestrenol is a synthetic progestational hormone, is the progesterone receptor agonist
Lasofoxifene Tartrate
T7839CAS 190791-29-8
Lasofoxifene Tartrate is a third-generation, non-steroidal selective estrogen receptor modulator.
Melatonine
T1659CAS 73-31-4
Melatonin is a biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness and...
(±)-Equol
T4000CAS 94105-90-5
Equol is a non-steroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzen by human intestinal microflora. The estrogen receptor (...
Pimaricin
T0709CAS 7681-93-8
Natamycin is a Polyene Antimicrobial.
Levonorgestrel
T1263CAS 797-63-7
Levonorgestrel is a Progestin and Progestin-containing Intrauterine Device. The physiologic effect of levonorgestrel is by means of Inhibit Ovum Fertilization.
Fluticasone propionate
T0188CAS 80474-14-2
Fluticasone propionate, derived from fluticasone used to remedy asthma and allergic rhinitis, is a high affinity, selective GR (glucocorticoid receptor) agonist....
5Beta-Pregnane-3Alpha,20alpha-Diol
T1688CAS 80-92-2
5Beta-Pregnane-3Alpha, 20alpha-Diol is an inactive metabolite of PROGESTERONE by reduction at C5, C3, and C20 position. Pregnanediol has two hydroxyl groups, at ...
Raloxifene hydrochloride
T1549CAS 82640-04-8
Raloxifene hydrochloride is a second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women. It has estroge...
Hexestrol
T6533CAS 84-16-2
Hexestrol binds to ERα and ERβ with EC50 of 0.07 nM and 0.175 nM, respectively.
Dienestrol
T0035CAS 84-17-3
Dienestrol is a synthetic and nonsteroidal estrogen, which is an estrogen receptor agonist. Estrogens can increase a normal clear discharge from the vagina and m...
Mifepristone
T1102CAS 84371-65-3
Mifepristone is a Progestin Antagonist. The mechanism of action of mifepristone is as a Progestational Hormone Receptor Antagonist.
Astragaloside IV
T2973CAS 84687-43-4
Astragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteas...
Altrenogest
T0870CAS 850-52-2
Altrenogest(A35957; RU2267), a progestogen, has structural relation with veterinary steroid trenbolone.
Toremifene
T0139CAS 89778-26-7
Toremifene is a selective estrogen-receptor modulator (SERM).
Toremifene citrate
T1464CAS 89778-27-8
Toremifene citrate is a selective estrogen receptor modulator (SERM). It is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on...
DY131
T2250CAS 95167-41-2
DY131 is a novel selective agonist of ERRβ and ERRγ.
Sagittatoside A
TQ0163CAS 118525-35-2
Sagittatoside A selectively activates estrogen response element (ERE)-luciferase activity via ERα.
(E/Z)-Endoxifen
T4281CAS 110025-28-0
(E/Z)-Endoxifen is an active metabolite of tamoxifen produced by the sequential action of cytochrome P450 (CYP) isoforms, including CYP2D6. It is a strong anti-e...
(Z)-4-hydroxy Tamoxifen
T4420CAS 68047-06-3
4-Hydroxytamoxifen is a selective estrogen receptor modulator (SERM).
PHTPP
T4388CAS 805239-56-9
PHTPP is a selective ERβ antagonist.
Ferrous Bisglycinate
T4505CAS 20150-34-9
Ferrous Bisglycinate is used in the fortification of infant formulations and foods.
GDC0810
T5118CAS 1365888-06-7
GDC-0810 is a selective estrogen receptor degrader (IC50: 0.7 nM).
Medroxyprogesterone
T5040CAS 520-85-4
Medroxyprogesterone is used in the treatment of renal carcinoma. It is a synthetic progestational hormone used in veterinary practice as an estrus regulator.
Nestoron
T5174CAS 7759-35-5
Nestoron, a synthetic progestin, is a high-affinity agonist of the progesterone receptor (EC50: 10.3 nM).
GSK-4716
T5531CAS 101574-65-6
GSK4716 is an ERRβ/γ agonist (IC50 = 2 µM) that can activate the receptor with similar potency as the protein ligand
H3B-5942
T5633CAS 2052128-15-9
H3B-5942 belongs to a class of ERα antagonists referred to as selective estrogen receptor covalent antagonists (SERCA).
PROTAC ERRα ligand 2
T5835CAS 2306388-57-6
PROTAC ERRα ligand 2 is an estrogen-related receptor α (ERRα) inverse agonist( IC50 : 5.67 nM)
Gestrinone
T7223CAS 16320-04-0
Gestrinone is a synthetic androgen receptor agonist and ER and progesterone receptor antagonist used to treat endometriosis. It inhibits leiomyoma cells with an ...
DPN
T7644CAS 1428-67-7
DPN is an selective agonist of estrogen receptor β (ERβ) .
Prinaberel
TQ0149CAS 524684-52-4
Prinaberel (ERB-041) is an effective and selective ERβ agonist and >200-fold selective for ERβ.
Endoxifen HCl
T6827CAS 1032008-74-4
Endoxifen HCl is the active metabolite of Tamoxifen, which is an effective and selective estrogen receptor antagonist.