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Search Result

Search Results for " estrogen receptor alpha "

Targets

Estrogen Receptor/ERR Estrogen/progestogen Receptor Autophagy

21

Compounds

2

Natural Products

8

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T0593 XCT790 Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Autophagy
XCT790 is a potent, selective and inverse agonist of estrogen-related receptor alpha(ERRα).
T16566 Propyl pyrazole triol PPT Estrogen Receptor/ERR , Estrogen/progestogen Receptor
Propyl pyrazole triol (PPT) is a selective agonist of estrogen receptor alpha. The relative binding affinity of Propyl pyrazole triol for ERα (ERα: 49%) around 410 times higher compared with estrogen receptor beta (ERβ: ...
T18609 PROTAC ERRα Degrader-2 Others
PROTAC ERRα Degrader-2 is a compound consisting of an MDM2 ligand binding group, a linker, and an estrogen-related receptor alpha (ERRα) binding group. This compound is designed to specifically degrade estrogen-related r...
T12101 MPP dihydrochloride (289726-02-9 Free base) Others
MPP dihydrochloride is a highly selective antagonist of estrogen receptor alpha (ERα).
T63277 Estrogen receptor antagonist 2
Estrogen receptor antagonist 2 is a selective down-regulator of estrogen receptor. Estrogen (E2) and estrogen alpha receptor (ERα) are important drivers of breast cancer development. estrogen receptor antagonist 2 has re...
T39118 AZD9496 maleate
AZD9496 maleate is a highly potent and selective antagonist of the estrogen receptor alpha (ERα), exhibiting an IC50 value of 0.28 nM. This compound, AZD9496 maleate, is an orally bioavailable selective estrogen receptor...
T62490 OBHS
OBHS is an inhibitor of estrogen receptor alpha (ERα).
T18651 (rel)-PROTAC ERRα Degrader-1 Others
(rel)-PROTAC ERRα Degrader-1 is a relative configuration of PROTAC ERRα Degrader-1, which is an estrogen-related receptor alpha (ERRa) degrader. PROTAC ERRα Degrader-1 consists of an MDM2 ligand binding moiety, a linker ...
T18636 PROTAC ERα Degrader-1 Others
PROTAC ERα Degrader-1 is a chemical compound. It consists of a ubiquitin E3 ligase binding group, a linker, and a protein binding group. This compound serves as a degrader of estrogen receptor-alpha (ERα).
T18514 PAC Others
PAC is a chemical conjugate consisting of an ADCs linker and PROTACs linked to an antibody. When PAC is conjugated to an antibody, it exhibits enhanced degradation of estrogen receptor-alpha (ERα) in comparison to PROTAC...
T60441 DK3
DK3 is a potent and selective agonist of estrogen-related receptor alpha (ERRα). ERRα is a potential drug target for cancer and metabolic diseases [1].
T18606 PROTAC ER Degrader-2 Others
PROTAC ER Degrader-2 serves as a synthesis intermediate for the production of PAC, a compound that incorporates the ADCs linker and PROTACs, which are subsequently conjugated to an antibody. PAC, exhibits a greater capab...
T18607 PROTAC ER Degrader-3 Others
PROTAC ER Degrader-3, an intermediate for the synthesis of PAC, specifically compound LP2. PAC serves as the linker for ADCs and PROTACs that are conjugated to an antibody. Notably, when PAC is conjugated to an antibody,...
T69696 TAS-108 citrate
TAS-108, also known as SR16234, is a synthetic, antiestrogenic steroidal compound with potential antitumor activity. TAS-108 binds to and inhibits estrogenic receptor alpha (ERa), mainly expressed in the mammary gland an...
T74375 PROTAC ERα Y537S degrader-1
PROTAC ERα Y537S degrader-1 comprises a ubiquitin E3 ligase binding group, a linker and a protein binding group. PROTAC ERα Y537S degrader-1 is an estrogen receptor-alpha (ERα) Y537S degrader [1] .
T64026 ERα antagonist 1
ERα antagonist 1 is a selective, potent, covalent estrogen receptor alpha (ERα) antagonist that blocks the cell cycle of MCF-7 cells in G0/G1 phase and induces apoptosis.
T70399 TTC-352
TTC-352 is an orally bioavailable selective human estrogen receptor alpha (ERalpha; ESR1; ERa) partial agonist (ShERPA), with potential antineoplastic activity. Upon administration, TTC-352 mimics the naturally-occurring...
T17941 ERRα Ligand-Linker Conjugates 1 Others
ERRα Ligand-Linker Conjugates 1 refers to a chemical compound that consists of a ligand targeting estrogen-related receptor alpha (ERRα), and a PROTAC linker that facilitates the recruitment of E3 ligases MDM2. It finds ...
T62106 (Rac)-ErSO-DFP
(Rac)-ErSO-DFP is a derivative of ErSO-DFP and a selective small molecule Erα biomodulator. (Rac)-ErSO-DFP overactivates ERα+-dependent anticipatory unfolded protein responses and exhibits anti-estrogen receptor alpha-po...
T74060 AZ'6421
AZ'6421, functioning as a Proteolysis Targeting Chimera (PROTAC), selectively degrades estrogen receptor alpha, demonstrating potent anti-tumor activity by inhibiting uncontrolled cellular proliferation characteristic of...
T68292 GTX-758
GTX-758, also known as Capesaris, is a n orally available, nonsteroidal selective estrogen receptor (ER) alpha agonist with potential antineoplastic activity. Upon administration of GTx-758, this agent suppresses the sec...
Cat No. Product Name Synonyms Targets
T13542 α-Zearalenol Estrogen Receptor/ERR
α-Zearalenol is one of the major metabolites of Zearalenone. α-Zearalenol has structural analogy to estrogen, thus α-Zearalenol can bind to estrogen receptors (ERs).
T6491 (-)-(S)-Equol (−)-Equol,Equol,4',7-Dihydroxyisoflavan,4',7-Isoflavandiol Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Endogenous Metabolite
(-)-(S)-Equol (4',7-Dihydroxyisoflavan) is an orally bioavailable, non-steroidal estrogen naturally produced by the metabolism of the isoflavonoid daidzein by human intestinal microflora, with potential chemoprotective a...

Natural Products

α-Zearalenol
T13542
Synonym:
Target: Estrogen Receptor/ERR
(-)-(S)-Equol
T6491
Synonym: (−)-Equol,Equol,4',7-Dihydroxyisoflavan,4',7-Isoflavandiol
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Endogenous Metabolite

Recombinant Proteins

Species：
Human (6)
Bovine (2)
Expression System：
E. coli (5)
Yeast (2)
Baculovirus-Insect Cells (1)
Tag：
N-terminal 6xHis-tagged (4)
His (2)
C-6His,N-T7 tag (1)
N-6His (1)
Cat No. Product Name Species Expression System
TMPJ-00762 ER alpha Protein, Human, Recombinant (His) Human E. coli
Estrogen Receptor is a major ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily. Estrogen Receptor is composed of several domains important for hormone binding, DNA binding, and a...
TMPH-01304 ER beta Protein, Human, Recombinant (E. coli, His) Human E. coli
Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner.; Lacks ...
TMPH-01305 ER beta Protein, Human, Recombinant (His) Human Yeast
Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner.; Lacks ...
TMPH-00279 Interferon tau-1/IFNT1 Protein, Bovine, Recombinant (His) Bovine Yeast
Paracrine hormone primarily responsible for maternal recognition of pregnancy. Interacts with endometrial receptors, probably type I interferon receptors, and blocks estrogen receptor expression, preventing the estrogen-...
TMPJ-00705 BCAS2 Protein, Human, Recombinant (His, T7) Human E. coli
Breast Carcinoma-Amplified Sequence 2 (BCAS2) is a member of the SPF27 family. BCAS2 is a nuclear protein and widely expressed in many rtissues. BCAS2 is identified as being overexpressed in various breast cancer cell li...
TMPH-00278 Interferon tau-1/IFNT1 Protein, Bovine, Recombinant (E. coli, His) Bovine E. coli
Paracrine hormone primarily responsible for maternal recognition of pregnancy. Interacts with endometrial receptors, probably type I interferon receptors, and blocks estrogen receptor expression, preventing the estrogen-...
TMPY-04422 Casein Kinase 1 gamma 2 Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
Casein kinase I gamma 2 isoform (CSNK1G2), a member of the large casein kinase I (CKI) subfamily, protein kinase superfamily. It may affect the development of brain, and associate with vesicular trafficking and neurotran...
TMPY-02214 OTUB1 Protein, Human, Recombinant (His) Human E. coli
Ubiquitin thioesterase OTUB1, also known as Deubiquitinating enzyme OTUB1, OTU domain-containing ubiquitin aldehyde-binding protein 1, Otubain-1, Ubiquitin-specific-processing protease OTUB1, OTUB1 and OTB1, is a cytopla...
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