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Search Result

Search Results for " estrogen receptor-err "

Targets

Estrogen Receptor/ERR Estrogen/progestogen Receptor

64

Compounds

31

Natural Products

Cat No. Product Name Synonyms Targets
T4388 PHTPP Estrogen Receptor/ERR , Estrogen/progestogen Receptor
PHTPP is a selective ERβ antagonist.
T15249 Estrogen receptor modulator 1 Estrogen Receptor/ERR
Estrogen receptor modulator 1 causes regression of Tamoxifen-resistant, hormone-independent xenograft tumors. Estrogen receptor modulator 1 is an orally active and selective estrogen receptor modulator (SERM) (pIC50: 0.4...
T16566 Propyl pyrazole triol PPT Estrogen Receptor/ERR , Estrogen/progestogen Receptor
Propyl pyrazole triol (PPT) is a selective agonist of estrogen receptor alpha. The relative binding affinity of Propyl pyrazole triol for ERα (ERα: 49%) around 410 times higher compared with estrogen receptor beta (ERβ: ...
T7904 SR 19881 Estrogen/progestogen Receptor
SR 19881 is a full agonist of ERRγ(EC50 value of 0.39 μM in a binding assay and an EC50 value of 4.7 μM in a cell-based assay).
T8984 FLTX1 Estrogen Receptor/ERR , Estrogen/progestogen Receptor
FLTX1 is a fluorescent derivative of Tamoxifen, designed to efficiently target and label intracellular Tamoxifen-binding sites (estrogen receptors) both under permeabilized and non-permeabilized conditions. Additionally,...
T0593 XCT790 Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Autophagy
XCT790 is a potent, selective and inverse agonist of estrogen-related receptor alpha(ERRα).
T7389 G15 Estrogen Receptor/ERR
G15 is a cell-permeable non-steroidal antagonist of GPER (Ki = 20 nM)
T15364 G-1 Estrogen Receptor/ERR , GPR
G-1 is a nonsteroidal, high-affinity and selective GPR30 agonist (Ki: 11 nM).
T3975 AZD9496 Estrogen Receptor/ERR , Estrogen/progestogen Receptor
AZD9496 is an orally available selective estrogen receptor(ERα) antagonist, with potential antineoplastic activity.
T14987 CMP8 Estrogen Receptor/ERR , Estrogen/progestogen Receptor
CMP8 is a selective ligand for estrogen receptor. CMP8 binds to the mutant estrogen receptor ligand binding domain (ERLBD). CMP8 has IC50 values of 29 nM , 41 nM, 1100 nM and 2200 nM for MGERα, MGRERα, hERα and hERβ, res...
T5531 GSK-4716 Estrogen Receptor/ERR
GSK4716 is an ERRβ/γ agonist (IC50 = 2 µM) that can activate the receptor with similar potency as the protein ligand
T3958 WAY-200070 WAY 200070 Estrogen Receptor/ERR , Estrogen/progestogen Receptor
WAY-200070 is a specific agonist of estrogen receptor β (ERRβ, IC50: 2.3 nM).
T1216 Diethylstilbestrol Stilbestrol,DES Estrogen Receptor/ERR , Estrogen/progestogen Receptor
Diethylstilbestrol (DES) is used in the treatment of menopausal and postmenopausal disorders.
T13443 (R)-Equol (+)-Equol Estrogen/progestogen Receptor
(R)-Equol ((+)-Equol) is an ERα and ERβ agonist with Kis of 27.4 and 15.4 nM, respectively.
T8370 GSK5182 Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Reactive Oxygen Species
GSK5182 is a highly selective inverse estrogen-related receptor γ agonist (IC50 : 79 nM)
T39710 ARV-471 Vepdegestrant Estrogen Receptor/ERR
ARV-471 (Vepdegestrant) is a orally active Cereblon -based estrogen receptor (ER) PROTAC degrader. ARV-471 is developed for the research of breast cancer.
T6306 Erteberel LY500307 Estrogen Receptor/ERR , Estrogen/progestogen Receptor
Erteberel (LY500307) is a potent, selective estrogen receptor β agonist with EC50 of 0.66 nM, 32-fold selectivity against estrogen receptor α. Phase 2.
T5633 H3B-5942 Estrogen Receptor/ERR , Estrogen/progestogen Receptor
H3B-5942 belongs to a class of ERα antagonists referred to as selective estrogen receptor covalent antagonists (SERCA).
T6620 Ospemifene FC-1271a Estrogen Receptor/ERR , Estrogen/progestogen Receptor
Ospemifene (FC-1271a) is a new selective non-hormonal estrogen receptor modulator (SERM) that is used for the treatment of moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy, due to menopause. FDA ap...
T7644 DPN Diarylpropionitrile Apoptosis , Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Autophagy
DPN (Diarylpropionitrile) is an selective agonist of estrogen receptor β (ERβ) .
T20625 Prochloraz Sporgon,Prelude Estrogen Receptor/ERR , AhR , Androgen Receptor , Antifungal
Prochloraz (Prelude) is a broad-spectrum contact imidazole fungicide. Prochloraz inhibits human placental microsomal aromatase in vitro (IC50 = 40 nM). Prochloraz also acts as an estrogen receptor (IC50s = 25 μM) and and...
T13674 Elacestrant RAD1901 Estrogen Receptor/ERR , Estrogen/progestogen Receptor
Elacestrant (RAD1901) with IC50s of 48 and 870 nM for ERα and ERβ, respectively.Elacestrant  is an orally available selective estrogen receptor degrader .
T0384 Estradiol benzoate Benzoestrofol,Benzhormovarine,Benovocylin Estrogen Receptor/ERR , Estrogen/progestogen Receptor
Estradiol benzoate (Benzhormovarine) is the synthetic benzoate ester of estradiol, a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females.
T0168 Estradiol (cypionate) Depofemin,Estradiol cypionate Estrogen Receptor/ERR , Estrogen/progestogen Receptor
Estradiol cypionate (Depofemin), the 17 β-cyclopentylpropinate ester of estradiol, inhibits ET-1 synthesis via estrogen receptor.
T0035 Dienestrol Restrol,Dehydrostilbestrol,Dienoestrol,Cycladiene Estrogen Receptor/ERR , Estrogen/progestogen Receptor
Dienestrol (Restrol) is a synthetic and nonsteroidal estrogen, which is an estrogen receptor agonist. Estrogens can increase a normal clear discharge from the vagina and make the vulva and urethra healthy.
T13507 4,4'-Iminodiphenol Leucoindophenol Estrogen/progestogen Receptor
4,4'-Iminodiphenol (Leucoindophenol) is an inactive estrogen receptor ligand with a diphenylamine backbone.
T6533 Hexestrol Bibenzyl,Hexanoestrol,meso-Hexestrol,Hexestrofen Estrogen Receptor/ERR , Estrogen/progestogen Receptor
Hexestrol (Hexanoestrol) binds to ERα and ERβ with EC50 of 0.07 nM and 0.175 nM, respectively.
T8981 WAY-169916 WAY 169916,WAY169916 NF-κB
WAY-169916 is a pathway-selective inhibitor of estrogen receptor (ER). It acts by inhibiting NF-kB transcriptional activity but being devoid of conventional estrogenic activity.
T11399 Giredestrant GDC-9545 Estrogen Receptor/ERR , Estrogen/progestogen Receptor
Giredestrant (GDC-9545) potently competes with estradiol for binding and induces a conformational change within the ER ligand binding domain. Giredestrant has anti-tumor activity. Giredestrant, a non-steroidal ER ligand,...
T12832 Amcenestrant SAR439859 Estrogen Receptor/ERR , Estrogen/progestogen Receptor
Amcenestrant (SAR439859) is an orally active, nonsteroidal and selective degrader of estrogen receptor (SERD). SAR439859 is a potent antagonist of ER (with an EC50 of 0.2 nM for ERα degradation).
T15191 PROTAC ERRα ligand 1 Estrogen Receptor/ERR , Estrogen/progestogen Receptor
PROTAC ERRα ligand 1 is an α (ERRα) antagonist of estrogen-related receptor (IC50s of 0.04 and 2.8 μM for ERRα and ERRγ, respectively).
T5835 PROTAC ERRα ligand 2 Estrogen Receptor/ERR , Estrogen/progestogen Receptor
PROTAC ERRα ligand 2 is an estrogen-related receptor α (ERRα) inverse agonist( IC50 : 5.67 nM)
T0695 Avobenzone Butyl methoxydibenzoylmethane,BF2AVB Apoptosis , Estrogen Receptor/ERR , Others
Avobenzone (Butyl methoxydibenzoylmethane), an oil-soluble ingredient, is a dibenzoylmethane derivative used in sunscreen products to absorb the full spectrum of UVA rays.
T2567 Etonogestrel 3-Oxodesogestrel,3-keto-Desogestrel,Nexplanon,Implanon Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Progesterone Receptor , Endogenous Metabolite
Etonogestrel (Implanon) is a steroidal progestin used as hormonal contraceptives.
T1579 Mestranol Devocin,Norquen,Menophase Estrogen Receptor/ERR , Estrogen/progestogen Receptor
Mestranol (Devocin), a semisynthetic estrogen, is used as an estrogen receptor agonist and must be demethylated to be biologically active.
T12148 N-Desmethyltamoxifen hydrochloride Estrogen Receptor/ERR , Endogenous Metabolite , PKC
N-Desmethyltamoxifen hydrochloride is the major tamoxifen metabolite in humans.
T1193 Clomiphene citrate NSC 35770,Clomifene citrate Estrogen Receptor/ERR , Estrogen/progestogen Receptor
Clomiphene citrate (NSC 35770) is a selective estrogen receptor modulator.
T7839 Lasofoxifene Tartrate CP-336156 Estrogen Receptor/ERR
Lasofoxifene Tartrate (CP-336156) is a third-generation, non-steroidal selective estrogen receptor modulator.
T13675 Elacestrant dihydrochloride RAD1901 dihydrochloride Estrogen/progestogen Receptor
Elacestrant dihydrochloride (DA-DKRAD1901 dihydrochloride) is an orally available selective estrogen receptor degrader with IC50s of 48 for ERα and 870 nM for ERβ, respectively.
T7313 Enclomiphene citrate Enclomifene citrate,(E)-Clomiphene citrate,trans-Clomiphene citrate Estrogen Receptor/ERR
Enclomiphene citrate (trans-Clomiphene citrate) is a non-steroidal estrogen receptor antagonist,with antioestrogenic property
T4420 4-Hydroxytamoxifen ICI 79280,(Z)-4-hydroxy Tamoxifen,trans-4-Hydroxytamoxifen Estrogen Receptor/ERR , Estrogen/progestogen Receptor
4-Hydroxytamoxifen (ICI 79280) is the active metabolite of Tamoxifen, an estrogen receptor modulator (SERM) with selective and oral potency. 4-Hydroxytamoxifen has antitumor activity and may be used in breast cancer rese...
T2250 DY131 DY 131,GSK 9089,DY-131 Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Smo
DY131 (DY-131) is a novel selective agonist of ERRβ and ERRγ.
T1536 Promestriene 3-propyl ethyl,17B-methyl estradiol,Promestriano Estrogen/progestogen Receptor
Promestriene (3-propyl ethyl) (INN) is a synthetic estrogen and glucocorticoid used topically in a 1% cream formulation. It is described as a tropic agent and antiseborrheic.
T2544 Bazedoxifene acetate WAY-TES 424,TSE 424,WAY-140424 Estrogen Receptor/ERR , Estrogen/progestogen Receptor
Bazedoxifene acetate (WAY-TES 424) is a novel selective estrogen receptor modulator (SERM).
T0040 Quinestrol W-3566,Ethinylestradiol 3-cyclopentyl ether,EE2CPE Estrogen Receptor/ERR , Estrogen/progestogen Receptor
Quinestrol (Ethinylestradiol 3-cyclopentyl ether) is a synthetic estrogen, applied in hormone replacement therapy, and occasionally to use in cancer and prostate cancer treatment.
T6743 (E/Z)-4-Hydroxytamoxifen Afimoxifene,4-Hydroxytamoxifen Estrogen Receptor/ERR , Estrogen/progestogen Receptor
(E/Z)-4-Hydroxytamoxifen (Afimoxifene) is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer.
T11200 Endoxifen (E-isomer) E-Endoxifen,Endoxifen E-isomer Estrogen Receptor/ERR
Endoxifen E-isomer (E-Endoxifen) is the E-isomer of (Z)-Endoxifen. Endoxifen E-isomer has antiestrogenic effects.
T5118 Brilanestrant GDC0810,GDC 0810,GDC-0810,ARN-810,RG 6046 Estrogen Receptor/ERR , Estrogen/progestogen Receptor
Brilanestrant (GDC-0810) is a selective estrogen receptor degrader (IC50: 0.7 nM).
T2231 Estradiol dipropionate 17-Beta-Estradiol-3,17-Dipropionate Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Progesterone Receptor
Estradiol dipropionate (17-Beta-Estradiol-3,17-Dipropionate) is a synthetic ester, specifically the 3, 17-dipropanoyl ester, of the natural estrogen, estradiol.
T2146 Fulvestrant ZM 182780,ZD 9238,ICI 182780 Apoptosis , Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Autophagy
Fulvestrant (ZM 182780) is an estrogen receptor (ER) antagonist (IC50=9.4 nM) and an agonist of GPR30. Fulvestrant has antitumor activity, inhibiting cell proliferation and inducing apoptosis and autophagy.

Compounds

PHTPP
T4388
Synonym:
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
Estrogen receptor modulator 1
T15249
Synonym:
Target: Estrogen Receptor/ERR
Propyl pyrazole triol
T16566
Synonym: PPT
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
SR 19881
T7904
Synonym:
Target: Estrogen/progestogen Receptor
FLTX1
T8984
Synonym:
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
XCT790
T0593
Synonym:
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Autophagy
G15
T7389
Synonym:
Target: Estrogen Receptor/ERR
G-1
T15364
Synonym:
Target: Estrogen Receptor/ERR, GPR
AZD9496
T3975
Synonym:
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
CMP8
T14987
Synonym:
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
GSK-4716
T5531
Synonym:
Target: Estrogen Receptor/ERR
WAY-200070
T3958
Synonym: WAY 200070
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
Diethylstilbestrol
T1216
Synonym: Stilbestrol,DES
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
(R)-Equol
T13443
Synonym: (+)-Equol
Target: Estrogen/progestogen Receptor
GSK5182
T8370
Synonym:
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Reactive Oxygen Species
ARV-471
T39710
Synonym: Vepdegestrant
Target: Estrogen Receptor/ERR
Erteberel
T6306
Synonym: LY500307
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
H3B-5942
T5633
Synonym:
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
Ospemifene
T6620
Synonym: FC-1271a
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
DPN
T7644
Synonym: Diarylpropionitrile
Target: Apoptosis, Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Autophagy
Prochloraz
T20625
Synonym: Sporgon,Prelude
Target: Estrogen Receptor/ERR, AhR, Androgen Receptor, Antifungal
Elacestrant
T13674
Synonym: RAD1901
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
Estradiol benzoate
T0384
Synonym: Benzoestrofol,Benzhormovarine,Benovocylin
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
Estradiol (cypionate)
T0168
Synonym: Depofemin,Estradiol cypionate
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
Dienestrol
T0035
Synonym: Restrol,Dehydrostilbestrol,Dienoestrol,Cycladiene
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
4,4'-Iminodiphenol
T13507
Synonym: Leucoindophenol
Target: Estrogen/progestogen Receptor
Hexestrol
T6533
Synonym: Bibenzyl,Hexanoestrol,meso-Hexestrol,Hexestrofen
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
WAY-169916
T8981
Synonym: WAY 169916,WAY169916
Target: NF-κB
Giredestrant
T11399
Synonym: GDC-9545
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
Amcenestrant
T12832
Synonym: SAR439859
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
PROTAC ERRα ligand 1
T15191
Synonym:
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
PROTAC ERRα ligand 2
T5835
Synonym:
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
Avobenzone
T0695
Synonym: Butyl methoxydibenzoylmethane,BF2AVB
Target: Apoptosis, Estrogen Receptor/ERR, Others
Etonogestrel
T2567
Synonym: 3-Oxodesogestrel,3-keto-Desogestrel,Nexplanon,Implanon
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Progesterone Receptor, Endogenous Metabolite
Mestranol
T1579
Synonym: Devocin,Norquen,Menophase
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
N-Desmethyltamoxifen hydrochloride
T12148
Synonym:
Target: Estrogen Receptor/ERR, Endogenous Metabolite, PKC
Clomiphene citrate
T1193
Synonym: NSC 35770,Clomifene citrate
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
Lasofoxifene Tartrate
T7839
Synonym: CP-336156
Target: Estrogen Receptor/ERR
Elacestrant dihydrochloride
T13675
Synonym: RAD1901 dihydrochloride
Target: Estrogen/progestogen Receptor
Enclomiphene citrate
T7313
Synonym: Enclomifene citrate,(E)-Clomiphene citrate,trans-Clomiphene citrate
Target: Estrogen Receptor/ERR
4-Hydroxytamoxifen
T4420
Synonym: ICI 79280,(Z)-4-hydroxy Tamoxifen,trans-4-Hydroxytamoxifen
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
DY131
T2250
Synonym: DY 131,GSK 9089,DY-131
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Smo
Promestriene
T1536
Synonym: 3-propyl ethyl,17B-methyl estradiol,Promestriano
Target: Estrogen/progestogen Receptor
Bazedoxifene acetate
T2544
Synonym: WAY-TES 424,TSE 424,WAY-140424
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
Quinestrol
T0040
Synonym: W-3566,Ethinylestradiol 3-cyclopentyl ether,EE2CPE
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
(E/Z)-4-Hydroxytamoxifen
T6743
Synonym: Afimoxifene,4-Hydroxytamoxifen
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
Endoxifen (E-isomer)
T11200
Synonym: E-Endoxifen,Endoxifen E-isomer
Target: Estrogen Receptor/ERR
Brilanestrant
T5118
Synonym: GDC0810,GDC 0810,GDC-0810,ARN-810,RG 6046
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
Estradiol dipropionate
T2231
Synonym: 17-Beta-Estradiol-3,17-Dipropionate
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Progesterone Receptor
Fulvestrant
T2146
Synonym: ZM 182780,ZD 9238,ICI 182780
Target: Apoptosis, Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Autophagy
1 2
Cat No. Product Name Synonyms Targets
TN1052 Lindleyin Estrogen Receptor/ERR , Estrogen/progestogen Receptor
Lindleyin is a novel phytoestrogen and might trigger many of the biological responses evoked by the physiological estrogens.
T13768 (+)-Medicarpin Estrogen/progestogen Receptor
(+)-Medicarpin, a pterocarpan, is an isoflavonoid compound derived from multiple medicinal plant species such as Sophora japonica, Zollernia paraensis, Platymiscium yucatamun, Machaerium aristulatum, and Platymiscium flo...
T5S0543 Isocurcumenol Apoptosis , Estrogen Receptor/ERR , Reductase
1. Isocurcumenol inhibits 5α-reductase which converts testosterone to dihydrotestosterone (DHT).
T3665 Tectoridin Shekanin Estrogen Receptor/ERR , Reductase
Tectoridin (Shekanin) possesses an estrogenic and thyroid hormone-like agent by activating estrogen and thyroid hormone receptors. Tectoridin has anti-oxidant, anti-inflammatory and hypoglycemic activities; Tectoridin an...
T3855 Tracheloside Estrogen Receptor/ERR , Phosphorylase
Tracheloside significantly decreases the activity of alkaline phosphatase (IC50: 0.31 μg/ml), a level of inhibition comparable to that of tamoxifen (IC50: 0.43 μg/ml).
TQ0295 Coumestrol Estrogen Receptor/ERR
Coumestrol that existed in soybean products suppresses the proliferation of ES2 cells (IC50: 50 μM). It exhibits activities against neurological disorders, cancers and autoimmune diseases.
T13542 α-Zearalenol Estrogen Receptor/ERR
α-Zearalenol is one of the major metabolites of Zearalenone. α-Zearalenol has structural analogy to estrogen, thus α-Zearalenol can bind to estrogen receptors (ERs).
T0301 Ethisterone 17α-Ethynyltestosterone,Pregneninolone Estrogen Receptor/ERR , Estrogen/progestogen Receptor
Ethisterone (17α-Ethynyltestosterone) is a progestogen hormone.
T3325 Liquiritigenin 4',7-Dihydroxyflavanone Estrogen Receptor/ERR , Estrogen/progestogen Receptor
Liquiritigenin (4',7-Dihydroxyflavanone), a flavonoid aglycone from licorice, is a highly selective estrogen receptor β (ERβ) agonist.
T3913 Saikosaponin D Estrogen Receptor/ERR , NF-κB , Antibacterial , STAT
Saikosaponin D is a novel SERCA inhibitor by inhibiting NF-κB and STAT3 signaling to protect against acetaminophen-induced hepatotoxicity.
T4000 (±)-Equol Equol,(R,S)-Equol Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Drug Metabolite
(±)-Equol ((R,S)-Equol) is a non-steroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzen by human intestinal microflora. The estrogen receptor (ER) agonist activity of the naturally occu...
T3846 Bavachin Corylifolin Estrogen Receptor/ERR , Estrogen/progestogen Receptor
Bavachin (Corylifolin) is a phytoestrogen that activates the estrogen receptors ERα and ERβ.
TMA1644 Segetalin B Estrogen Receptor/ERR
Segetalin B is a natural product from Vaccaria segetalis (Neck.) Garcke, has estrogen-like activity.
T1009 Estrone Oestrone,Fluoroethyl,Aquacrine Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Endogenous Metabolite
Estrone (Aquacrine) is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE directly, or from TESTOSTERONE via ESTRADIOL. In humans, it is pr...
T1571 Estriol NSC-12169,Oestriol Estrogen Receptor/ERR , Estrogen/progestogen Receptor , MRP , Endogenous Metabolite
Estriol (Oestriol) is a hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During PREGNANCY, a large amount of estriol is...
T3840 Dihydroresveratrol 3,4',5-Trihydroxybibenzyl Estrogen Receptor/ERR , Others
Dihydroresveratrol (3,4',5-Trihydroxybibenzyl) is a major metabolite of resveratrol that is produced by animal-associated bacteria, including the gut microbiota. Dihydroresveratrol and dihydroresveratrol monosulfate are ...
T3385 Gypenoside XVII GP-17,Gynosaponin S Estrogen Receptor/ERR , GSK-3 , Endogenous Metabolite
Gypenoside XVII (Gynosaponin S) confers protection against Aβ25-35-induced neurotoxicity through estrogen receptor-dependent activation of PI3K/Akt pathways, activation of Nrf2/ARE/HO-1 and inactivation of GSK-3β pathway...
T2177 Kaempferol Kempferol,Robigenin Apoptosis , Estrogen Receptor/ERR , Mitophagy , Estrogen/progestogen Receptor , HIV Protease , Endogenous Metabolite , Parasite , Autophagy
Kaempferol (Robigenin) is a natural flavonoid and an inverse agonist of ERRα and ERRγ. Kaempferol has a wide range of antitumor, anti-inflammatory, antioxidant, antibacterial and antiviral activities.
T2837 Chrysin 5, 7-Dihydroxyflavone,NSC 407436,5,7-Dihydroxyflavone Estrogen Receptor/ERR , Antioxidant
Chrysin (5,7-Dihydroxyflavone) exhibits many biological activities and pharmacological effects, including antioxidant, anti-inflammatory, anticancer, and antiviral activities.
T0760 Cholesterol Cholesterin,Cholesteryl alcohol Estrogen Receptor/ERR , MRP , Endogenous Metabolite , ROR
Cholesterol (cholesteryl alcohol) is a natural product that is the major sterol in mammals and an agonist of estrogen-related receptor α (ERRα). Cholesterol is widely found in the cell membranes of animals and is also us...
T2810 (20S)-Protopanaxatriol 20(S)-APPT,g-PPT Apoptosis , Estrogen Receptor/ERR , Glucocorticoid Receptor , Estrogen/progestogen Receptor , Liver X Receptor
(20S)-Protopanaxatriol (g-PPT)(g-PPT), a metabolite of ginsenoside, could regulate endothelial cell functions through the estrogen receptor and glucocorticoid receptor.
TQ0274 27-Hydroxycholesterol 25(R)-27-hydroxy Cholesterol Estrogen/progestogen Receptor , Liver X Receptor
27-Hydroxycholesterol (25(R)-27-hydroxy Cholesterol) is a selective modulator of estrogen receptor and an agonist of the liver X receptor.
T6491 (-)-(S)-Equol (−)-Equol,Equol,4',7-Dihydroxyisoflavan,4',7-Isoflavandiol Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Endogenous Metabolite
(-)-(S)-Equol (4',7-Dihydroxyisoflavan) is an orally bioavailable, non-steroidal estrogen naturally produced by the metabolism of the isoflavonoid daidzein by human intestinal microflora, with potential chemoprotective a...
T1424 Ethynyl estradiol 17α-Ethynylestradiol,Ethinyl Estradiol Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Endogenous Metabolite
Ethynyl estradiol is a semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is often used as the estrogenic component in ORAL CONTRACEPTIVES...
T0345 Estropipate Piperazine estrone sulfate,Pipestrone,Estrone sulfate piperazine salt Estrogen Receptor/ERR , Estrogen/progestogen Receptor
Estropipate (Piperazine estrone sulfate) is a natural estrogenic substance composed of estrone sulfate and piperazine.
T1048 Estradiol E2,17β-Estradiol,17β-Oestradiol,β-Estradiol Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Endogenous Metabolite
Estradiol (E2) is a naturally occurring steroidal sex hormone that is essential for female fertility and maintenance of secondary sexual characteristics. Estradiol upregulates IL-6 expression through estrogen receptor be...
T36857 Estrone sulfate sodium Estrone 3-sulfate (sodium salt),17β-Estrone 3-sulfate Endogenous Metabolite
Estrone sulfate sodium (17β-Estrone 3-sulfate) is an endogenous steroid and an estrogen ester that is biologically inactive. It is converted by steroid sulfatase into estrone . Estrone sulfate sodium has been investigate...
T3806 Kaempferide Kaempferol 4'-O-methyl ether,Kaempferol 4'-methyl ether,4'-Methylkaempferol,4'-O-Methylkaempferol Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Influenza Virus , Antibacterial , Autophagy
kaempferide (4'-Methylkaempferol) inhibits the proliferation of native and estrogen receptor beta overexpressing colon cancer cells through a mechanism not mediated by ligand binding dependent estrogen receptor activatio...
T1549 Raloxifene hydrochloride LY156758 hydrochloride,Raloxifene HCl,LY139481 hydrochloride,Keoxifene hydrochloride,LY156758 (Keoxifene) HCl Estrogen Receptor/ERR , Others , MAO , Estrogen/progestogen Receptor , Autophagy
Raloxifene hydrochloride (LY156758 hydrochloride) is a second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women. It has estrogen agonist effects on bone and chol...
T2882 Genistin Genistoside,Genistein glucoside,Genistein 7-glucoside,Genistine,Genistein 7-O-β-D-glucopyranoside Apoptosis , Estrogen Receptor/ERR , Others
Genistin (Genistoside) is the major isoflavonoid of soybeans and soy products.It has been reported to possess various therapeutic effects, including anti-inflammatory and anticancer activities
T7299 β-Estradiol 17-acetate beta-estradiol 17-acetate,1,3,5(10)-Estratriene-3,17β-diol 17-acetate Estrogen Receptor/ERR , Others
β-Estradiol 17-acetate (1,3,5(10)-Estratriene-3,17β-diol 17-acetate) is a metabolite of estradiol.

Natural Products

Lindleyin
TN1052
Synonym:
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
(+)-Medicarpin
T13768
Synonym:
Target: Estrogen/progestogen Receptor
Isocurcumenol
T5S0543
Synonym:
Target: Apoptosis, Estrogen Receptor/ERR, Reductase
Tectoridin
T3665
Synonym: Shekanin
Target: Estrogen Receptor/ERR, Reductase
Tracheloside
T3855
Synonym:
Target: Estrogen Receptor/ERR, Phosphorylase
Coumestrol
TQ0295
Synonym:
Target: Estrogen Receptor/ERR
α-Zearalenol
T13542
Synonym:
Target: Estrogen Receptor/ERR
Ethisterone
T0301
Synonym: 17α-Ethynyltestosterone,Pregneninolone
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
Liquiritigenin
T3325
Synonym: 4',7-Dihydroxyflavanone
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
Saikosaponin D
T3913
Synonym:
Target: Estrogen Receptor/ERR, NF-κB, Antibacterial, STAT
(±)-Equol
T4000
Synonym: Equol,(R,S)-Equol
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Drug Metabolite
Bavachin
T3846
Synonym: Corylifolin
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
Segetalin B
TMA1644
Synonym:
Target: Estrogen Receptor/ERR
Estrone
T1009
Synonym: Oestrone,Fluoroethyl,Aquacrine
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Endogenous Metabolite
Estriol
T1571
Synonym: NSC-12169,Oestriol
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, MRP, Endogenous Metabolite
Dihydroresveratrol
T3840
Synonym: 3,4',5-Trihydroxybibenzyl
Target: Estrogen Receptor/ERR, Others
Gypenoside XVII
T3385
Synonym: GP-17,Gynosaponin S
Target: Estrogen Receptor/ERR, GSK-3, Endogenous Metabolite
Kaempferol
T2177
Synonym: Kempferol,Robigenin
Target: Apoptosis, Estrogen Receptor/ERR, Mitophagy, Estrogen/progestogen Receptor, HIV Protease, Endogenous Metabolite, Parasite, Autophagy
Chrysin
T2837
Synonym: 5, 7-Dihydroxyflavone,NSC 407436,5,7-Dihydroxyflavone
Target: Estrogen Receptor/ERR, Antioxidant
Cholesterol
T0760
Synonym: Cholesterin,Cholesteryl alcohol
Target: Estrogen Receptor/ERR, MRP, Endogenous Metabolite, ROR
(20S)-Protopanaxatriol
T2810
Synonym: 20(S)-APPT,g-PPT
Target: Apoptosis, Estrogen Receptor/ERR, Glucocorticoid Receptor, Estrogen/progestogen Receptor, Liver X Receptor
27-Hydroxycholesterol
TQ0274
Synonym: 25(R)-27-hydroxy Cholesterol
Target: Estrogen/progestogen Receptor, Liver X Receptor
(-)-(S)-Equol
T6491
Synonym: (−)-Equol,Equol,4',7-Dihydroxyisoflavan,4',7-Isoflavandiol
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Endogenous Metabolite
Ethynyl estradiol
T1424
Synonym: 17α-Ethynylestradiol,Ethinyl Estradiol
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Endogenous Metabolite
Estropipate
T0345
Synonym: Piperazine estrone sulfate,Pipestrone,Estrone sulfate piperazine salt
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
Estradiol
T1048
Synonym: E2,17β-Estradiol,17β-Oestradiol,β-Estradiol
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Endogenous Metabolite
Estrone sulfate sodium
T36857
Synonym: Estrone 3-sulfate (sodium salt),17β-Estrone 3-sulfate
Target: Endogenous Metabolite
kaempferide
T3806
Synonym: Kaempferol 4'-O-methyl ether,Kaempferol 4'-methyl ether,4'-Methylkaempferol,4'-O-Methylkaempferol
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Influenza Virus, Antibacterial, Autophagy
Raloxifene hydrochloride
T1549
Synonym: LY156758 hydrochloride,Raloxifene HCl,LY139481 hydrochloride,Keoxifene hydrochloride,LY156758 (Keoxifene) HCl
Target: Estrogen Receptor/ERR, Others, MAO, Estrogen/progestogen Receptor, Autophagy
Genistin
T2882
Synonym: Genistoside,Genistein glucoside,Genistein 7-glucoside,Genistine,Genistein 7-O-β-D-glucopyranoside
Target: Apoptosis, Estrogen Receptor/ERR, Others
β-Estradiol 17-acetate
T7299
Synonym: beta-estradiol 17-acetate,1,3,5(10)-Estratriene-3,17β-diol 17-acetate
Target: Estrogen Receptor/ERR, Others
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