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Search Result

Search Results for " endothelin-receptor "

Targets

Endothelin Receptor

81

Compounds

4

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T5458 Darusentan Lu-135252 Endothelin Receptor
Darusentan (Lu-135252) is a potent inhibitor of endothelin signaling and function in both large and small arteries
T3194 Ro 46-2005 Endothelin Receptor
Ro 46-2005 is a synthetic non-peptide endothelin receptor antagonist, inhibits the specific binding of 125I-ET-1 to human vascular smooth muscle cells (ETA receptor, IC50: 220 nM).
T2561 Macitentan ACT-064992 Apoptosis , Endothelin Receptor
Macitentan (ACT-064992) is an endothelin receptor antagonist that is used in the therapy of pulmonary arterial hypertension (PAH).
T3474 RO 46-8443 Endothelin Receptor
RO 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. RO 46-8443 displays up to 2000-fold selectivity for ETB receptors both in terms of binding inhibitory potency and functional inhibition.
T5355 Sparsentan RE-021,DARA-a RAAS , Endothelin Receptor
Sparsentan (DARA-a) is a first-in-class orally active and highly potent dual endothelin A and angiotensin II receptor antagonist(Ki of 9.3 and 0.8 nM, respectively)
T2026 CYM5442 S1P Receptor , LPL Receptor
CYM5442 is an S1P agonist, targeting to Sphingosine.
T6792 BQ-123 BQ123 Endothelin Receptor
BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2.
T6264 Bosentan Actelion,Ro 47-0203,Benzenesulfonamide Endothelin Receptor
Bosentan (Benzenesulfonamide) is a sulfonamide-derived, competitive and specific endothelin receptor antagonist with a slightly higher affinity for the endothelin A receptor than endothelin B receptor. Bosentan blocks th...
TQ0282 Avosentan SPP-301,Ro 67-0565 Endothelin Receptor
Avosentan (Ro 67-0565) is an effective and selective antagonist of the endothelin receptor (ETA receptor).
T0750 Sulfisoxazole NU-445,Sulfafurazole Endothelin Receptor , Antibacterial , Antibiotic , Autophagy
Sulfisoxazole (Sulfafurazole) is a short-acting sulfonamide antibacterial with activity against a wide range of gram-negative and gram-positive organisms.Sulfisoxazole inhibits breast cancer exosome release by targeting ...
T6258 Zibotentan ZD4054 Apoptosis , Endothelin Receptor
Zibotentan (ZD4054) (ZD4054) is a specific Endothelin (ET)A antagonist with IC50 of 21 nM, exhibiting no activity at ETB. Phase 3.
T1655 Ambrisentan BSF-208075,BSF 208075,LU 208075 Endothelin Receptor
Ambrisentan (BSF 208075) is an endothelin receptor antagonist used in the therapy of pulmonary arterial hypertension (PAH). Ambrisentan has been associated with a low rate of serum enzyme elevations during therapy but ha...
T6265 Bosentan (hydrate) Bosentan Hydrate,Benzenesulfonamide,Actelion,Ro 47-0203 Endothelin Receptor
Bosentan hydrate (Ro 47-0203) is a competitive and dual antagonist of endothelin-1 at the endothelin-A (ET-A) and endothelin-B (ET-B) receptors.
TQ0259 Atrasentan A-147627,(+)-A 127722,ABT-627 Endothelin Receptor
Atrasentan (ABT-627) (ABT-627) is an endothelin receptor antagonist (IC50: 0.0551 nM for ETA).
T6672 Sitaxsentan sodium TBC11251 sodium salt,TBC11251,Thelin,Sitaxentan sodium Endothelin Receptor
Sitaxsentan sodium (TBC11251 sodium salt) is a highly selective antagonist of endothelin A receptors.
T7817 Aprocitentan ACT-132577 Endothelin Receptor
Aprocitentan (ACT-132577) is ETA and ETB antagonist .
TQ0270 Atrasentan hydrochloride (+)-A 127722 hydrochloride,ABT-627 hydrochloride,A-147627 hydrochloride Endothelin Receptor
Atrasentan hydrochloride (ABT-627 hydrochloride) is an antagonist of the endothelin receptor(IC50 = 55.1 μM for ETA).
T15596 IRL 2500 Endothelin Receptor
IRL 2500 is an antagonist of Endothelin receptor with IC50s of 1.3 and 94 nM for Endothelin A receptor and Endothelin B receptor.
T12924 Sitaxsentan TBC-11251,IPI 1040 Endothelin Receptor
Sitaxsentan (TBC-11251) is A selective endothelin A (ETA) receptor antagonist. Endothelin is an effective vasoconstrictor. Sitaxsentan blocks the binding of endothelin to its receptors, thereby eliminating the harmful ef...
T31605 Edonentan BMS207940,BMS-207940,BMS 207940 Endothelin Receptor
Edonentan is A potent endothelin A (ETA) receptor antagonist that can be used to study heart failure.
T36008 Nebentan potassium
Nebentan potassium (YM598) is a potent, selective and orally active non-peptide endothelin ETA receptor antagonist through the modification of Bosentan . Nebentan potassium inhibits [125I] endothelin-1 binding to cloned ...
TP2262L IRL-1038 acetate IRL-1038 acetate(144602-02-8 Free base) Endothelin Receptor
IRL-1038 acetate is a potent ETB endothelin receptor antagonist.
T21790 BMS 182874 hydrochloride Endothelin Receptor
BMS 182874 hydrochloride is a nonpeptide endothelin (El) receptor antagonist.
T34541 SB-209670 SB 209670 Endothelin Receptor
SB-209670 is a selective endothelin receptor antagonist that inhibits the activity of ET(B) receptors in rat vascular endothelium and vascular smooth muscle.
T15595L IRL-1620 acetate IRL-1620 acetate（142569-99-1 free base） Endothelin Receptor
IRL-1620 acetate is an effective and selective agonist of Endothelin B receptor (ETB) with a Ki of 16 pM which is more selective than ETA with a Ki of 19 μM.
T22540L Ac-Endothelin-1 (16-21), human acetate Others
Ac-Endothelin-1 (16-21), human acetate, the principal peptide of the endothelin family, has been shown to have a variety of biological activities in both vascular and nonvascular tissues. The C-terminal fragment, which i...
T26841 BMS 182874 BMS182874,BMS-182874 Endothelin Receptor
BMS 182874 is an orally effective and highly selective endothelin receptor ETA antagonist with an IC50 value of 0.150 μM for ETA and a Ki value of 0.055 μM for ETA.BMS 182874 is able to reduce arterial pressure in a rat ...
TP2106L Urantide acetate(669089-53-6 free base) Neurotensin Receptor
Urantide acetate is a selective and competitive urotensin-II (UT) receptor antagonist (pKB = 8.3). Blocks hU-II induced contractions in thoracic aorta ex vivo. Exhibits no effect on noradrenaline or endothelin 1-induced ...
T4200 Sacubitril hemicalcium salt AHU-377 (hemicalcium salt),AHU377 calcium salt Neprilysin
Sacubitril hemicalcium salt (AHU377 calcium salt) is a potent NEP inhibitor with an IC50 of 5 nM. Sacubitril hemicalcium salt is a component of the heart failure medicine LCZ696. Sacubitril hemicalcium salt is a prodrug ...
T22663 CI 1020 Others
endothelin-A receptor (ETA) antagonist
TP1512 [Ala1,​3,​11,​15]​-​Endothelin TFA
[Ala1,3,11,15]-Endothelin (TFA) is a highly selective for endothelin A (ETA) and endothelin B (ETB) receptor.[Ala1,3,11,15]-Endothelin is a selective ETB endothelin receptor agonist (IC50 values are 0.33 and 2200 nM for ...
T10225 ABT-546 A-216546 Others
ABT-546 (A-216546) is a potent, highly selective, and active endothelin ETA receptor antagonist with a Ki of 0.46 nM for [125I]endothelin-1 binding to cloned human endothelin ETA.
T69791 Fandosentan
Fandosentan is an endothelin receptor antagonist.
T30572 BQ 485 BQ485,BQ-485
BQ 484 is an endothelin (ET) receptor antagonist.
T69816 ATZ-1993
ATZ-1993 is an Endothelin Receptor Antagonist.
T70454 Cgs 27830
Cgs 27830 is an Endothelin Receptor Antagonist.
T15232 TBC3711 Endothelin Mordulator 1 Others
TBC3711 is an endothelin receptor modulator. It is used for the research of endothelin-mediated disorders.
T22791 FR 139317 Others
highly potent and selective ETA endothelin receptor antagonist
T28683 SB234551 SB 234551,SB-234551
SB234551 is a selective antagonist of endothelin ETA receptor.
T24053 WS 009A WS009 A,FR 901366,WS009A,WS-009A
WS 009A is an antagonist of the endothelin receptor.
T24081 WS 009B WS-009B,FR 901367,WS009B
WS 009B is an antagonist of the endothelin receptor.
T28343 PD-156707 PD156707
PD-156707 is a selective antagonist of endothelin A receptor.
T69338 TBC 3711
TBC 3711 is an endothelin a receptor antagonist.
T70727 BQ-610
BQ-610 is an Endothelin A receptor antagonist.
T61498 Sulfisoxazole diethanolamine
Sulfisoxazole diethanolamine, also known as Sulfafurazole diethanolamine, is a sulfonamide antibacterial compound with an oxazole substituent. It acts as an endothelin receptor antagonist, specifically targeting endothel...
T27776 L-749329 L749329,L 749329
L-749329 is a ligand of ET(A) and ET(B) endothelin receptor.
T70452 PD 151242
PD 151242 is an endothelin receptor antagonist.
T30515 BMS-346567 BMS346567,BMS 346567
BMS-346567 is a potent and selective dual angiotensin II and endothelin receptor antagonist.
T27725 Kendomycin TAN-2162,TAN 2162,TAN2162
Kendomycin is a proteasome inhibitor and endothelin receptor antagonist. It induces apoptosis in lymphoma.
T17064 Tezosentan RO 610612 Others
Tezosentan is an antagonist of the endothelin receptor (pA2s: 9.5, 7.7 for ETA and ETB receptors, respectively).

Compounds

Darusentan
T5458
Synonym: Lu-135252
Target: Endothelin Receptor
Ro 46-2005
T3194
Synonym:
Target: Endothelin Receptor
Macitentan
T2561
Synonym: ACT-064992
Target: Apoptosis, Endothelin Receptor
RO 46-8443
T3474
Synonym:
Target: Endothelin Receptor
Sparsentan
T5355
Synonym: RE-021,DARA-a
Target: RAAS, Endothelin Receptor
CYM5442
T2026
Synonym:
Target: S1P Receptor, LPL Receptor
BQ-123
T6792
Synonym: BQ123
Target: Endothelin Receptor
Bosentan
T6264
Synonym: Actelion,Ro 47-0203,Benzenesulfonamide
Target: Endothelin Receptor
Avosentan
TQ0282
Synonym: SPP-301,Ro 67-0565
Target: Endothelin Receptor
Sulfisoxazole
T0750
Synonym: NU-445,Sulfafurazole
Target: Endothelin Receptor, Antibacterial, Antibiotic, Autophagy
Zibotentan
T6258
Synonym: ZD4054
Target: Apoptosis, Endothelin Receptor
Ambrisentan
T1655
Synonym: BSF-208075,BSF 208075,LU 208075
Target: Endothelin Receptor
Bosentan (hydrate)
T6265
Synonym: Bosentan Hydrate,Benzenesulfonamide,Actelion,Ro 47-0203
Target: Endothelin Receptor
Atrasentan
TQ0259
Synonym: A-147627,(+)-A 127722,ABT-627
Target: Endothelin Receptor
Sitaxsentan sodium
T6672
Synonym: TBC11251 sodium salt,TBC11251,Thelin,Sitaxentan sodium
Target: Endothelin Receptor
Aprocitentan
T7817
Synonym: ACT-132577
Target: Endothelin Receptor
Atrasentan hydrochloride
TQ0270
Synonym: (+)-A 127722 hydrochloride,ABT-627 hydrochloride,A-147627 hydrochloride
Target: Endothelin Receptor
IRL 2500
T15596
Synonym:
Target: Endothelin Receptor
Sitaxsentan
T12924
Synonym: TBC-11251,IPI 1040
Target: Endothelin Receptor
Edonentan
T31605
Synonym: BMS207940,BMS-207940,BMS 207940
Target: Endothelin Receptor
Nebentan potassium
T36008
Synonym:
Target:
IRL-1038 acetate
TP2262L
Synonym: IRL-1038 acetate(144602-02-8 Free base)
Target: Endothelin Receptor
BMS 182874 hydrochloride
T21790
Synonym:
Target: Endothelin Receptor
SB-209670
T34541
Synonym: SB 209670
Target: Endothelin Receptor
IRL-1620 acetate
T15595L
Synonym: IRL-1620 acetate（142569-99-1 free base）
Target: Endothelin Receptor
Ac-Endothelin-1 (16-21), human acetate
T22540L
Synonym:
Target: Others
BMS 182874
T26841
Synonym: BMS182874,BMS-182874
Target: Endothelin Receptor
Urantide acetate(669089-53-6 free base)
TP2106L
Synonym:
Target: Neurotensin Receptor
Sacubitril hemicalcium salt
T4200
Synonym: AHU-377 (hemicalcium salt),AHU377 calcium salt
Target: Neprilysin
CI 1020
T22663
Synonym:
Target: Others
[Ala1,​3,​11,​15]​-​Endothelin TFA
TP1512
Synonym:
Target:
ABT-546
T10225
Synonym: A-216546
Target: Others
Fandosentan
T69791
Synonym:
Target:
BQ 485
T30572
Synonym: BQ485,BQ-485
Target:
ATZ-1993
T69816
Synonym:
Target:
Cgs 27830
T70454
Synonym:
Target:
TBC3711
T15232
Synonym: Endothelin Mordulator 1
Target: Others
FR 139317
T22791
Synonym:
Target: Others
SB234551
T28683
Synonym: SB 234551,SB-234551
Target:
WS 009A
T24053
Synonym: WS009 A,FR 901366,WS009A,WS-009A
Target:
WS 009B
T24081
Synonym: WS-009B,FR 901367,WS009B
Target:
PD-156707
T28343
Synonym: PD156707
Target:
TBC 3711
T69338
Synonym:
Target:
BQ-610
T70727
Synonym:
Target:
Sulfisoxazole diethanolamine
T61498
Synonym:
Target:
L-749329
T27776
Synonym: L749329,L 749329
Target:
PD 151242
T70452
Synonym:
Target:
BMS-346567
T30515
Synonym: BMS346567,BMS 346567
Target:
Kendomycin
T27725
Synonym: TAN-2162,TAN 2162,TAN2162
Target:
Tezosentan
T17064
Synonym: RO 610612
Target: Others
1 2

Recombinant Proteins

Species：
Human (4)
Expression System：
HEK293 (3)
Yeast (1)
Tag：
His (2)
N-terminal 6xHis-tagged (1)
mFc (1)
Cat No. Product Name Species Expression System
TMPY-00181 Endothelin B Receptor Protein, Human, Recombinant (His) Human HEK293
The hypermethylation of EDNRB gene was remarkably related to infiltration and metastasis of gastric cancer and may attribute to the tumor progression. EDNRB is a new candidate tumor suppressor gene which is often down-re...
TMPY-03860 Endothelin B Receptor Protein, Human, Recombinant (mFc) Human HEK293
The hypermethylation of EDNRB gene was remarkably related to infiltration and metastasis of gastric cancer and may attribute to the tumor progression. EDNRB is a new candidate tumor suppressor gene which is often down-re...
TMPY-02717 GPR37 Protein, Human, Recombinant (His) Human HEK293
GPR37 (cathepsin Z) is an orphan receptor that belongs to the G-protein coupled receptor 1 family. G protein-coupled receptors are a large protein family comprised of transmembrane receptors that sense molecules outside ...
TMPH-01294 EDNRA Protein, Human, Recombinant (His) Human Yeast
Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.
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