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GPCR/G Protein Dopamine Receptor

Dopamine Receptor

Dopamine receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS). Dopamine receptors activate different effectors through not only G-protein coupling, but also signaling through different protein (dopamine receptor-interacting proteins) interactions. The neurotransmitter dopamine is the primary endogenous ligand for dopamine receptors.
Cat No. product name
T0025 Haloperidol Haloperidol is a highly potent neuroleptic by relieving nervous through the depression of nerve function. In addition, haloperidol has shown about 50-fold effic...
T0031 Ziprasidone hydrochloride monohydrate Ziprasidone(CP88059) is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of the antipsychotic activity.
T0031L Ziprasidone hydrochloride Ziprasidone (hydrochloride) is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of antipsychotic activity.
T0031L2 Ziprasidone Ziprasidone is an a typical antipsychotic used in the treatment of schizophrenia and bipolar disorder. Use of ziprasidone has not been consistently associate...
T0068 Fluphenazine hydrochloride Fluphenazine dihydrochloride is an inhibitor of phenothiazine-class D1DR and D2DR; In studies, Fluphenazine can be used to probe the effects and metabolic proc...
T0074 Chlorprothixene Chlorprothixene is a typical antipsychotic drug of the thioxanthene class,which was the first of the series to be synthesized.
T0074L Chlorprothixene hydrochloride Chlorprothixene brings strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors. Chlorprothixene is a ...
T0076 Paliperidone Paliperidone(Invega) is used as an atypical antipsychotic. It applies to the acute and maintenance treatment of schizophrenia. Chemically, paliperidone is the p...
T0082 Domperidone Domperidone(Motilium) is a dopamine blocker and an antidopaminergic reagent. It blocks the action of. It has strong affinities for the D2 and D3 dopamine recept...
T0136 Citicoline Citicoline is an intermediate in the synthesis of phosphatidylcholine, a component of cell membranes. Citicoline exerts neuroprotective effects.
T0137 Mirtazapine Mirtazapine is a tetracyclic antidepressant with a somewhat unique mechanism of action. Mirtazapine therapy can be associated with transient asymptomatic elevat...
T0162 Quetiapin Quetiapine is used for the therapy of schizophrenia, and for the treatment of acute manic episodes associated with bipolar I disorder. The mechanism of quetiapi...
T0255 Clomipramine hydrochloride Clomipramine hydrochloride is a tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily abs...
T0280 Spiperone Spiperone is a spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA.
T0287 Hexamethonium Bromide Hexamethonium Bromide, a specific antagonist of neuronal-type nicotinic AChR in ganglia, is poorly absorbed from the gastrointestinal tract and does not cross t...
T0302 Triflupromazine hydrochloride Triflupromazine hydrochloride, an antipsychotic medication, is Dopamine D1/D2 receptor antagonists.
T0322 Fipexide Fipexide (Attentil, Vigilor), a psychoactive drug of the piperazine chemical class, was developed in Italy in 1983. It was served as a nootropic drug in France ...
T0333 Aniracetam Aniracetam(Ro 13-5057), a nootropic and neuroprotective drug, selectively modulates the AMPA receptor and nAChR.
T0338 Minaprine dihydrochloride Minaprine is a reversible inhibitor of MAO-A, used in the treatment of various depressive states.
T0351 Risperidal Risperidone is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that act as an atypical antipsychotic agent.
T0365 Thioridazine hydrochloride Thioridazine, an antipsychotic drug, is used in the therapy of psychosis and schizophrenia and shows serotonin antagonism or D4 selectivity.
T0385 Prochlorperazine Maleate Prochlorperazine maleate is a phenothiazine antipsychotic used principally in the treatment of NAUSEA; VOMITING; and VERTIGO. It is more likely than CHLORPROMAZ...
T0445 Promethazine Tafluprost(AFP-168) is an analogue of anti-glaucoma prostaglandin (PG) .
T0455 Clozapine Clozapine is a tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and display...
T0469 Octopamine hydrochloride Octopamine (OA) is a biogenic monoamine structurally associated with noradrenaline. It can serve as a neurohormone, a neurotransmitter, and a neuromodulator in ...
T0505 L-(-)-α-Methyldopa Methyldopa, an alpha-adrenergic agonist (selective for α2-adrenergic receptors) psychoactive medicine, is served as an antihypertensive or sympatholytic.
T0716 Molindone hydrochloride Molindone hydrochloride is an indole derivative effective in schizophrenia and other psychoses by blocking the effects of dopamine in the brain.
T0719 Tetrabenazine Tetrabenazine is a drug formerly used as an antipsychotic and treatment of various movement disorders. Tetrabenazine blocks neurotransmitter uptake into adrener...
T0766 Promazine hydrochloride Promazine hydrochloride is a phenothiazine with actions similar to CHLORPROMAZINE but with less antipsychotic activity. It is primarily used in short-term treat...
T0776 Phenothiazine Phenothiazine is a class of agents exhibiting antiemetic, antipsychotic, antihistaminic, and anticholinergic activities. Phenothiazines antagonize the dopamine ...
T0783 Mianserin hydrochloride Mianserin hydrochloride is a tetracyclic compound with antidepressant effects. it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin ...
T0785 Dexchlorpheniramine Maleate Dexchlorpheniramine (trade name Polaramine) is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria...
T0811 Amisulpride Amisulpride (trade name Solian) is an antipsychotic drug sold by Sanofi-Aventis. It is not approved for use in the United States, but is approved for use in E...
T0848 Levodopa Levodopa is an amino acid precursor of dopamine with antiparkinsonian properties. Levodopa is a prodrug that is converted to dopamine by DOPA decarboxy...
T0869 Atomoxetine hydrochloride Atomoxetine Hydrochloride is the hydrochloride salt of atomoxetine, a phenoxy-3-propylamine derivative and selective non-stimulant, norepinephrine reuptake ...
T0990 Droperidol Droperidol is a Dopamine-2 Receptor Antagonist. The mechanism of action of droperidol is as a Dopamine D2 Antagonist.
T10213 A-437203 A-437203 is a selective D3 receptor antagonist (Kis: 71, 1.6, and 6220 nM for D2, D3, and D4 receptors).
T1045 Trimipramine maleate Trimipramine maleate appears to inhibit serotonin transport and norepinephrine uptake by nerve terminals. This increases available norepinephrine or serotonin a...
T10611 Brexpiprazole S-oxide D8 Brexpiprazole S-oxide D8 (DM-3411 D8) is a deuterium labeled Brexpiprazole S-oxide. Brexpiprazole S-oxide is a main metabolite of Brexpiprazole. Brexpiprazole i...
T10612 Brexpiprazole S-oxide Brexpiprazole S-oxide (DM-3411) is a main metabolite of Brexpiprazole. Brexpiprazole is a partial agonist of human 5-HT1A and dopamine receptors (Kis: 0.12 nM a...
T10681 Cariprazine D6 Cariprazine D6 (RGH-188 D6) is a deuterium-labeled Cariprazine. Cariprazine is an antipsychotic agent (D3 receptors, Ki: 0.085 nM; D2 receptors, Ki: 0.49 nM).
T10683 Carmoxirole hydrochloride Carmoxirole (EMD 45609) hydrochloride is a selective, peripherally acting agonist of dopamine D2 receptor with antihypertensive activities in vivo.
T1069 Metoclopramide hydrochloride Metoclopramide hydrochloride is a selective dopamine D2 receptor antagonist, used as an antiemetic.
T10837L Clocapramine Clocapramine is a D2 and 5-HT2A receptors antagonist.
T1090 Perphenazine Perphenazine is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties.
T10908 CY 208-243 CY 208-243 is a selective dopamine D1 receptor agonist with anti-Parkinson disease activity.
T1105 Penfluridol Penfluridol is a highly potent antipsychotic.
T11078 Deschloroclozapine Deschloroclozapine is an effective selective chemical generation actuator. Decloclopine is a dual antagonist of dopamine and serotonin receptors. The Kis of dop...
T11463 GR 103691 GR 103691 shows more than 100-fold selectivity for human dopamine human (h)D3 over hD4 and hD1 sites. GR 103691 is a potent, selective dopamine D3 receptor ant...
T11728 JR-AB2-011 JR-AB2-011 inhibits mTORC2 activity by blocking Rictor-mTOR association (Ki: 0.19 μM). JR-AB2-011 has anti-glioblastoma multiforme (GBM) properties. JR-AB2-011...
T1175 Bromopride Bromopride is a dopamine antagonist with prokinetic properties closely related to metoclopramide, and is widely used as an antiemetic. It is not available in th...
T11799 L-745870 hydrochloride L-745870 hydrochloride has excellent brain penetration. L-745870 hydrochloride is a high-affinity, selective and orally active human dopamine D4 receptor antag...
T11799L L-745870 L-745870 is a high-affinity and selective human dopamine D4 receptor antagonist (Ki: 0.43 nM). L-745870 has excellent brain penetration. It considerably weaker ...
T1180 Blonanserin Blonanserin is an atypical antipsychotic approved in Japan in January, 2008. Relative to many other antipsychotics, blonanserin has an improved tolerability pro...
T1201 Sulpiride Sulpiride is a dopamine D2-receptor antagonist, used therapeutically as an antidepressant, antipsychotic, and as a digestive aid.
T1211 Levosulpiride Levosulpiride is the (S)-enantiomer of sulpiride, which is a D2 receptor antagonist, an atypical antipsychotic drug of the benzamide class.
T1222 Trifluoperazine dihydrochloride Trifluoperazine Dihydrochloride is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic.
T12252 NRA-0160 NRA-0160 is a selective antagonist of dopamine D4 receptor(Ki of 0.48 nM)
T12288 Odapipam Odapipam is a selective and high affinity antagonist of benzazepine dopamine D1 receptor (Kd of 0.18 nM).
T1233 Oxolinic acid Oxolinic acid is a synthetic antimicrobial related to NALIDIXIC ACID and used in URINARY TRACT INFECTIONS.
T12352 Oxidopamine hydrochloride Oxidopamine hydrochloride is an neurotransmitter dopamine antagonist.
T12383 PD 168568 dihydrochloride PD 168568 dihydrochloride is an orally active and selective antagonist of D4 dopamine receptor(Ki of 8.8 nM).
T12405 Pentiapine Pentiapine is a novel inhibitor of dopamine release.
T12476 Pimozide D4 Pimozide D4 is a deuterium labeled Pimozide.
T12510 PNU-177864 hydrochloride PNU-177864 hydrochloride is a selective and orally active antagonist of dopamine D3 receptor,with antischizophrenic activity.
T12606 Quinpirole Hydrochloride Quinpirole Hydrochloride is a high-affinity dopamine D2/D3 receptor agonist.
T12676 (Rac)-Rotigotine hydrochloride (Rac)-Rotigotine hydrochloride is a racemate of Rotigotine. Rotigotine is a full agonist of dopamine receptor, a partial the 5-HT1A receptor agonist.
T12761 Ro 10-5824 dihydrochloride Ro 10-5824 dihydrochloride is a selective agonist of dopamine D4 receptor partial, (Ki of 5.2 nM).
T12861L SB-277011 dihydrochloride SB-277011 dihydrochloride is a potent, selective, orally bioavailable and brain penetrate antagonist of dopamine D3 receptor(pKis of 8.0, 6.0, <5.2 and 5.9 for ...
T12865 SCH-23390 maleate SCH-23390 maleate is a potent and selective antagonist of dopamine D1-like receptor (1 and D5 receptor with Kis of 0.2 nM and 0.3 nM, respectively).
T1292 Tiapride hydrochloride Tiapride is a selective blocker of D2/3 dopamine receptors in the brain. It is used in the therapy of various psychiatric and neurological disorders containing ...
T13164 Tipepidine hydrochloride Tipepidine hydrochloride ia a reversible inhibitor of dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK))(IC50 : 7.0 μM), with antidepressant-like eff...
T1322 Bendazol Bendazol is always used as the drug for hypertension and cerebral Angiospasm.
T13240 U91356 U91356 is an agonist of dopamine receptor.
T13245 UCSF924 UCSF924 is a potent and specific agonist of dopamine D4 receptor (DRD4) partial (EC50 of 4.2 nM,Ki value of 3 nM)
T1327 Nortriptyline hydrochloride Nortriptyline hydrochloride is a metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia,...
T1336 Benztropine mesylate Benztropine mesylate is a centrally active muscarinic antagonist that has been used in the symptomatic treatment of PARKINSON DISEASE. Benztropine also inhibits...
T13387 Zatebradine Zatebradine is a potent hyperpolarization-activated cyclic nucleotide-gated (HCN) channels inhibitor(IC50 of 1.96 µM).
T13463L Dihydrexidine Dihydrexidine is a full efficacy D1-like dopamine receptor (D1/D5) agonist (IC50: 10 nM for D1 receptor). It also shows potent antiparkinsonian activity.
T13463L2 Dihydrexidine hydrochloride Dihydrexidine hydrochloride is a full efficacy D1-like dopamine receptor (D1/D5) agonist (IC50: 10 nM for D1 receptor). It also shows potent antiparkinsonian ac...
T13468 (±)-Epibatidine (±)-Epibatidine is an agonist of nicotinic. (±)-Epibatidine is an agonist of neuronal nAChR.
T13570 Benzamide Derivative 1 Benzamide Derivative 1, extracted from patent EP0213775A1 (compound 18), may be useful in the treatment of gastrointestinal disorders.
T13652 Dicarbine Double carbene can be used for the study of schizophrenia and alcoholism. It can block dopamine receptors in various parts of the brain and prevent the reductio...
T1384 Chlorpromazine hydrochloride Chlorpromazine hydrochloride is the prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are...
T13898 SPD-473 citrate SPD-473 citrate is an inhibitior of serotonin/dopamine/norepinephrine reuptake.
T1406 Amantadine hydrochloride Amantadine hydrochloride is an antiviral that is used in the prophylactic or symptomatic treatment of influenza A and Parkinson disease.
T14088 ABT-670 ABT-670 is a selective agonist of dopamine D4 receptor. For human D4, ferret D4, and rat D4, the EC50 values are 89 nM, 160 nM, and 93 nM , respectively.
T1412 Loxapine succinate salt Loxapine succinate, a D2DR and D4DR inhibitor, is utilized in schizophrenia.
T1471 Duloxetine hydrochloride Duloxetine hydrochloride is a thiophene derivative and selective neurotransmitter uptake inhibitor for SEROTONIN and NORADRENALINE (SNRI). It is an ANTIDEPRESSI...
T1476 Pramipexole Pramipexole is a selective dopamine receptor agonist used in the therapy of Parkinson disease. Pramipexole therapy is associated with a low rate of transient se...
T14767 BP 897 BP 897 is a potent and selective agonist of dopamine D3 receptor(Kis of 0.92 nM and 61 nM for D3 and D2 receptors), and shows low affinities at D1 and D4 recept...
T1476L Pramipexole dihydrochloride Pramipexole dihydrochloride could be used to treat Parkinson disease.
T14782 Brilaroxazine Brilaroxazine (RP5603) is a partial agonist of dopamine (DA) D2, D3, and D4 receptors, 5-HT1A (Ki: 1.5 nM) and 5-HT2A (Ki: 2.5 nM), and has antagonist activity ...
T14853 Cabergoline Cabergoline is an ergot derived-dopamine D2-like receptor agonist (Ki: 0.7, 1.5, and 1.2 for D2, D3, and 5-HT2B receptors).
T15100 Desmethyl cariprazine Desmethyl cariprazine is a Cariprazine active metabolite. Cariprazine, an antipsychotic drug candidate, shows a high affinity for the D3 (Ki: 0.085 nM) and D2 (...
T15117 Didesmethyl cariprazine Cariprazine is an antipsychotic drug candidate. It shows high affinity for the D3 and D2 receptors, and moderate affinity for the 5-HT1A receptor. Didesmethyl c...
T1517 Benserazide hydrochloride Benserazide Hydrochloride is a peripherally-acting L-amino acid decarboxylase (AAAD) or DOPA decarboxylase inhibitor.
T15270 Fananserin Fananserin is an orally bioavailable and selective antagonist of the 5-HT2 receptor (Ki: 0.37 nM for the rat 5-HT2A receptor). It also is an antagonist of dopam...
T15339 Foscarbidopa Foscarbidopa is a prodrug of Carbidopa. It acts as a dopamine receptor agonist.
T1539 Iloperidone Iloperidone is an atypical antipsychotic agent that is used for treatment of schizophrenia.
T1540 Doxepin hydrochloride Doxepin Hydrochloride is a dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mec...
T1567 Olanzapine Olanzapine is an atypical antipsychotic that is used currently in the treatment of schizophrenia and bipolar illness.
T15686 L-741626 L-741626 is a selective antagonist of D2 dopamine receptor (Ki: 2.4, 100, and 220 nM for human D2, D3 and D4 receptors respectively).
T15744 Levophacetoperane hydrochloride Levophacetoperane inhibits in vitro in a competitive manner. It also can norepinephrine uptake and dopamine uptake.
T1644 Dopamine hydrochloride Dopamine is a naturally occurring catecholamine formed by decarboxylation of dihydroxyphenylalanine and a precursor of norepinephrine and epinephrine. Dopamine ...
T16472 Pericyazine Pericyazine is a selective D2-dopamine receptor antagonist. Pericyazine is a first-generation antipsychotic drug that is used as an adjunct to the short-term ma...
T16511 PF2562 PF2562 is a dopamine D1 ligand. It is used as a dopamine D1 agonist or partial agonist. PF2562 binds to human D1 receptor (Ki: 113 nM). PF2562 shows activity ag...
T16759 Ritanserin Ritanserin is a highly effective, relatively selective, long-acting antagonist of 5-HT2 receptor (IC50: 0.9 nM).
T16999 Tavapadon Tavapadon is an orally active and highly selective dopamine D1/D5 receptor partial agonist.
T17072 Thiethylperazine dimaleate Thiethylperazine maleate is a selective ABCC1 activator. Thiethylperazine maleate is also a phenothiazine derivate, and an orally active dopamine D2-receptor an...
T1735 Lurasidone hydrochloride Lurasidone hydrochloride is a thiazole derivative and atypical antipsychotic agent that functions as a dopamine D2 receptor antagonist; serotonin 5-HT2 receptor...
T1769 Pardoprunox Pardoprunox is a partial dopamine D2 agonist and noradrenergic agonist with serotonin 5-HT1A agonist properties. Pardoprunox has been used in trials studying th...
T1871 GBR-12935 GBR 12935 can induce the increase of the extracellular levels of dopamine to basal levels.
T2092 Amitifadine hydrochloride Amitifadine hydrochloride is a triple reuptake inhibitor (TRI) or serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI).
T2132 Buspirone hydrochloride Buspirone is a 5HT(1A) receptor agonist, used to treat generalized anxiety disorder (GAD).
T2190 Methiothepin mesylate Methiothepin mesylate is a potent and non-selective 5-HT2 receptor antagonist,used as an antipsychotic.
T2226 Pergolide mesylate salt PERGOLIDE MESYLATE is a long-acting dopamine agonist which has been used to treat PARKINSON DISEASE and HYPERPROLACTINEMIA but withdrawn from some markets due t...
T2306 Brexpiprazole Brexpiprazole is a partial agonist of human 5-hydroxytryptamine (5-HT) 5-HT1A and dopamine D2 receptors.
T2546 Pimozide Pimozide is a diphenylbutylpiperidine derivative and a dopamine antagonist with the antipsychotic property. Pimozide selectively inhibits type 2 dopaminergic re...
T2564 Flupenthixol dihydrochloride Flupenthixol dihydrochloride is a dopamine receptor antagonist.
T2574 Alizapride hydrochloride Alizapride hydrochloride is a dopamine receptor antagonist used for the treatment of nausea and vomiting.
T2592 Ropinirole hydrochloride Ropinirole a selective dopamine D2 receptors agonist (Ki: 29 nM). Ropinirole Hydrochloride is the hydrochloride salt form of ropinirole, a non-ergot dopamine ag...
T2714 Rotundine Rotundine is extracted from Corydalis yanhusuo W. T. Wang.
T2874 Tetrahydroberberine THB Tetrahydroberberine is an isoquinoline alkaloid isolated from corydalis tuber, has a micromolar affinity for dopamine D(2) receptors.
T2S1397 L-Stepholidine L-Stepholidine, which has dual actions on dopamine D1 and D2 receptors, attenuates heroin self-administration and cue-induced reinstatement. It also elicits ant...
T3046 BMY 7378 dihydrochloride BMY-7378, α1D-adrenergic receptor antagonist, is a weak partial agonist/antagonist of 5-HT1A receptor.
T3085 Piperacetazine Piperacetazine, an antipsychotic prodrug, is used forschizophrenia.
T3187 Fluoroclebopride Fluoroclebopride is a dopamine (DA) D2 receptor ligand.
T3278 Piribedil Piribedil is a dopamine D2 agonist, used in the treatment of Parkinson's disease.
T3337 Ddr1-In-1 DDR1-IN-1 is an effective and specific DDR1 receptor tyrosine kinase inhibitor (IC50: 105 nM), about 3-fold selectivity over DDR2.
T3369 Nuciferine Nuciferine is an alkaloid found within the plants Nymphaea caerulea and Nelumbo nucifera. It has a profile of action associated with dopamine receptor blockade.
T3431 Pardoprunox hydrochloride Pardoprunox hydrochloride is a novel partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist, D2 (pKi = 8.1) and D3 receptor (pKi = 8....
T3497 Ocaperidona Ocaperidona (Ocaperidone), a very high affinity dopamine D2 antagonist.
T3526 Dasotraline hydrochloride Dasotraline hydrochloride (SEP-225289 hydrochloride) is a triple reuptake inhibitor  that inhibits dopamine, norepinephrine, and serotonin transporters with IC...
T4081 MPTP-hydrochloride MPTP-hydrochloride is a precusor of MPP+ which is toxic to dopaminergic neurons and causes Parkinsonism.
T4117 Zuclopenthixol Zuclopenthixol is a thioxanthene with therapeutic actions similar to the phenothiazine antipsychotics. It is an antagonist at D1 and D2 dopamine receptors.
T4262 BisfluoroModafinil CRL-40940 is a selective dopaminergic reuptake inhibitor
T4274 Melitracen hydrochloride Melitracen Hydrochloride, an antidepressant, is used as potential dopamine D1/2 receptor antagonist to treat depression.
T4297 Flibanserin Flibanserin is a serotonergic antidepressant used to treat hypoactive sexual desire disorder. Flibanserin has been associated with a low rate of minor serum ami...
T4369 SCH 23390 hydrochloride SCH 23390 hydrochloride is an effective dopamine receptor antagonist, and for the D1(Ki=0.2 nM) and D5(Ki=0.3 nM).
T4576 Perospirone Perospirone is an antagonist of serotonin 5HT2A receptors and dopamine D2 receptors. It also displays affinity towards 5HT1A receptors as a partial agonist.
T4577 Cariprazine Cariprazine is a novel antipsychotic drug candidate that exhibits high affinity for the D3 (Ki=0.085 nM) and D2 (Ki=0.49 nM) receptors, and moderate affinity fo...
T4616 5-Chloro-2-methoxyprocainamide Metoclopramide is a dopamine D2 antagonist which has been used for treatment of a variety of gastrointestinal symptoms over the last thirty years. In various co...
T5009 Tribenzagan Hydrochloride Trimethobenzamide hydrochloride is a blocker of the D2 receptor. Trimethobenzamide is an antiemetic used to prevent nausea and vomiting.
T5135 Flupentixol Dihydrochloride Flupentixol is used in therapy of schizophrenia as well as in anxiolytic and depressive disorders.
T5158 N-Desmethylclozapine N-Desmethylclozapine is an antagonist of serotonin (5-HT) receptor subtype 5-HT2C (IC50: 7.1 nM). It also is an antagonist at dopamine D4 receptors, an agonist ...
T5380 Ansofaxine hydrochloride Ansofaxine (LY03005; LPM570065) is a serotonin-norepinephrine-dopamine reuptake inhibitor (IC50s: 723, 763 and 491 nM, respectively).
T5387 LP-211 LP-211 is a brain penetrant selective agonist for a 5-HT7 receptor (Ki: 0.58 nM), and >300-fold selectivity over the 5-HT1A receptor.
T5397 A-381393 A-381393 is a selective and brain penetrate dopamine D4 receptor antagonist (Kis: 1.9/1.5/1.6 nM for human dopamine D4.2/D4.4/D4.7 receptor).
T5842 Bromocriptine mesylate Bromocriptine is a potent dopamine receptor agonist that binds the D2 receptor with highest affinity (Ki = 2.5 nM)
T5858 Sertindole Sertindole is an atypical antipsychotic that binds to dopamine D2 receptors and the serotonin (5-HT) receptor subtypes 5-HT1D, 5-HT2A, and 5-HT2C (Kds = 2.7, 20...
T5954 Alpha-Methyldopa Sesquihydrate Alpha-Methyldopa Sesquihydrate is a DOPA decarboxylase inhibitor and indirect α2-adrenergic receptor agonist used to treat hypertension. It inhibits the sympat...
T6241 Quetiapine Fumarate Quetiapine Fumarate, an atypical antipsychotic, is used in the treatment of bipolar I mania, schizophrenia, bipolar II depression, bipolar I depression.
T6647 Rotigotine Rotigotine is a non-ergot dopamine receptor agonist used in the therapy of Parkinson disease and restless leg syndrome. Administered as a once-daily transdermal...
T6835 Fenoldopam mesylate Fenoldopam is a selective dopamine-1 receptor (DA1) agonist with natriuretic/diuretic properties. It lowers blood pressure through arteriolar vasodilation.
T6951 Pramipexole 2HCl Monohydrate Pramipexole Dihydrochloride is the hydrochloride salt of pramipexole, a benzothiazole derivative. As a nonergot dopamine agonist, pramipexole binds to D2 and D3...
T6988 SKF38393 HCl SKF38393 HCl is a selective dopamine D1/D5 receptor agonist.
T7070 Nomifensine (maleate) Nomifensine maleate is a selective inhibitor of dopamine uptake, used in adult attention deficit disorder.
T7153 Vanoxerine dihydrochloride Vanoxerine dihydrochloride is a potent inhibitor that blocks dopamine uptake (IC50 : 1-51 nM)
T7180 Sultopride hydrochloride Sultopride Hydrochloride is a selective dopamine D2 and D3 receptor antagonist.
T7308 Nomifensine Nomifensine is a norepinephrine-dopamine reuptake inhibitor that prevents dopamine reuptake into synaptosomes.
T7352 Pridopidine Pridopidine, a dopamine (DA) stabilizer, acts as a low affinity dopamine D2 receptor (D2R) antagonist, improves motor performance and shows neuroprotective effe...
T7553 (+)-PD 128907 hydrochloride (+)-PD 128907 hydrochloride is an agonist of D3 dopamine receptor .
T7569 Clebopride malate Clebopride malate is a dopamine antagonist drug Used to treat functional gastrointestinal disorders such as nausea or vomiting.
T7632 Veralipride Veralipride is an antagonist of D2 receptor.
T7635 Raclopride Raclopride is a selective antagonist of dopamine D2/D3 receptor.
T7654 L-DOPA methyl ester (hydrochloride) L-DOPA methyl ester (LDME) is an agonist of dopamine D1 receptor.
T7728 ACEPROMAZINE MALEATE ACEPROMAZINE MALEATE is a dopamine receptor antagonist
T7834 ABT-724 ABT-724 is an agonist of dopamine D4 receptor(EC50: 12.4 nM)
T7943 Fluphenazine decanoate Fluphenazine decanoate is dopamine D2 receptor blocke,and is a long-acting phenothiazine neuroleptic that used to treat schizophrenia.
T8382 Cariprazine HCl Cariprazine HCl is an antipsychotic drug, is a D3 and D2 receptor partial agonist((Ki of 0.085 nM and 0.49 nM, respectively)
T8385 Metoclopramide hydrochloride hydrate Metoclopramide hydrochloride hydrate is a dopamine D2 antagonist that is a drug used for digestive dysfunction. It acts as an anti-emetic
T8389 Trifluoperazine Trifluoperazine is a Dopamine D2 receptor inhibitor(IC50 : 1.2 nM), and Treatment of schizophrenia.
T8423 ML417 ML417 is a selective and brain penetrant agonist of D3 Dopamine (EC50 : 38 nM).
T8633 9-FLUORENOL 9-FLUORENOL is a dopamine reuptake inhibitor with IC50 of 9 µM, and a major metabolite of a compound developed as a wakefulness-promoting agent.
T8653 DOPEXAMINE Dopexamine is a dopaminergic agonist
T8702 SKF-83566 SKF-83566 is a blood-brain permeable and orally active antagonist of D1-like dopamine receptor and a weaker competitive 5-HT2 receptor antagonist with Ki of 11 ...
TN1081 Hirsuteine Hirsuteine exhibits potent neuroprotective effects against glutamate-induced HT22 cell death.
TN1424 Bacopaside X Bacopaside X (9.06 μM) showed binding affinity towards the D1 receptor.
TN2856 Delta3,2-Hydroxylbakuchiol Delta3,2-Hydroxylbakuchiol, a monoamine transporter inhibitor involved in regulating dopaminergic and noradrenergic neurotransmission and may have represented p...
TQ0140 Sumanirole maleate Sumanirole maleate (U-95666E) is a highly selective full agonist of the D2 receptor (ED50: 46 nM).
TQ0175 Dexpramipexole Dexpramipexole (KNS-760704, R-(+)-Pramipexole) is a neuroprotective agent and weak non-ergoline dopamine agonist.
Haloperidol
T0025CAS 52-86-8
Haloperidol is a highly potent neuroleptic by relieving nervous through the depression of nerve function. In addition, haloperidol has shown about 50-fold effic...
Ziprasidone hydrochloride monohydrate
T0031CAS 138982-67-9
Ziprasidone(CP88059) is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of the antipsychotic activity.
Ziprasidone hydrochloride
T0031LCAS 122883-93-6
Ziprasidone (hydrochloride) is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of antipsychotic activity.
Ziprasidone
T0031L2CAS 146939-27-7
Ziprasidone is an a typical antipsychotic used in the treatment of schizophrenia and bipolar disorder. Use of ziprasidone has not been consistently associate...
Fluphenazine hydrochloride
T0068CAS 146-56-5
Fluphenazine dihydrochloride is an inhibitor of phenothiazine-class D1DR and D2DR; In studies, Fluphenazine can be used to probe the effects and metabolic proc...
Chlorprothixene
T0074CAS 113-59-7
Chlorprothixene is a typical antipsychotic drug of the thioxanthene class,which was the first of the series to be synthesized.
Chlorprothixene hydrochloride
T0074LCAS 6469-93-8
Chlorprothixene brings strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors. Chlorprothixene is a ...
Paliperidone
T0076CAS 144598-75-4
Paliperidone(Invega) is used as an atypical antipsychotic. It applies to the acute and maintenance treatment of schizophrenia. Chemically, paliperidone is the p...
Domperidone
T0082CAS 57808-66-9
Domperidone(Motilium) is a dopamine blocker and an antidopaminergic reagent. It blocks the action of. It has strong affinities for the D2 and D3 dopamine recept...
Citicoline
T0136CAS 987-78-0
Citicoline is an intermediate in the synthesis of phosphatidylcholine, a component of cell membranes. Citicoline exerts neuroprotective effects.
Mirtazapine
T0137CAS 85650-52-8
Mirtazapine is a tetracyclic antidepressant with a somewhat unique mechanism of action. Mirtazapine therapy can be associated with transient asymptomatic elevat...
Quetiapin
T0162CAS 111974-69-7
Quetiapine is used for the therapy of schizophrenia, and for the treatment of acute manic episodes associated with bipolar I disorder. The mechanism of quetiapi...
Clomipramine hydrochloride
T0255CAS 17321-77-6
Clomipramine hydrochloride is a tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily abs...
Spiperone
T0280CAS 749-02-0
Spiperone is a spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA.
Hexamethonium Bromide
T0287CAS 55-97-0
Hexamethonium Bromide, a specific antagonist of neuronal-type nicotinic AChR in ganglia, is poorly absorbed from the gastrointestinal tract and does not cross t...
Triflupromazine hydrochloride
T0302CAS 1098-60-8
Triflupromazine hydrochloride, an antipsychotic medication, is Dopamine D1/D2 receptor antagonists.
Fipexide
T0322CAS 34161-24-5
Fipexide (Attentil, Vigilor), a psychoactive drug of the piperazine chemical class, was developed in Italy in 1983. It was served as a nootropic drug in France ...
Aniracetam
T0333CAS 72432-10-1
Aniracetam(Ro 13-5057), a nootropic and neuroprotective drug, selectively modulates the AMPA receptor and nAChR.
Minaprine dihydrochloride
T0338CAS 25905-77-5
Minaprine is a reversible inhibitor of MAO-A, used in the treatment of various depressive states.
Risperidal
T0351CAS 106266-06-2
Risperidone is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that act as an atypical antipsychotic agent.
Thioridazine hydrochloride
T0365CAS 130-61-0
Thioridazine, an antipsychotic drug, is used in the therapy of psychosis and schizophrenia and shows serotonin antagonism or D4 selectivity.
Prochlorperazine Maleate
T0385CAS 84-02-6
Prochlorperazine maleate is a phenothiazine antipsychotic used principally in the treatment of NAUSEA; VOMITING; and VERTIGO. It is more likely than CHLORPROMAZ...
Promethazine
T0445CAS 60-87-7
Tafluprost(AFP-168) is an analogue of anti-glaucoma prostaglandin (PG) .
Clozapine
T0455CAS 5786-21-0
Clozapine is a tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and display...
Octopamine hydrochloride
T0469CAS 770-05-8
Octopamine (OA) is a biogenic monoamine structurally associated with noradrenaline. It can serve as a neurohormone, a neurotransmitter, and a neuromodulator in ...
L-(-)-α-Methyldopa
T0505CAS 555-30-6
Methyldopa, an alpha-adrenergic agonist (selective for α2-adrenergic receptors) psychoactive medicine, is served as an antihypertensive or sympatholytic.
Molindone hydrochloride
T0716CAS 15622-65-8
Molindone hydrochloride is an indole derivative effective in schizophrenia and other psychoses by blocking the effects of dopamine in the brain.
Tetrabenazine
T0719CAS 58-46-8
Tetrabenazine is a drug formerly used as an antipsychotic and treatment of various movement disorders. Tetrabenazine blocks neurotransmitter uptake into adrener...
Promazine hydrochloride
T0766CAS 53-60-1
Promazine hydrochloride is a phenothiazine with actions similar to CHLORPROMAZINE but with less antipsychotic activity. It is primarily used in short-term treat...
Phenothiazine
T0776CAS 92-84-2
Phenothiazine is a class of agents exhibiting antiemetic, antipsychotic, antihistaminic, and anticholinergic activities. Phenothiazines antagonize the dopamine ...
Mianserin hydrochloride
T0783CAS 21535-47-7
Mianserin hydrochloride is a tetracyclic compound with antidepressant effects. it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin ...
Dexchlorpheniramine Maleate
T0785CAS 2438-32-6
Dexchlorpheniramine (trade name Polaramine) is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria...
Amisulpride
T0811CAS 71675-85-9
Amisulpride (trade name Solian) is an antipsychotic drug sold by Sanofi-Aventis. It is not approved for use in the United States, but is approved for use in E...
Levodopa
T0848CAS 59-92-7
Levodopa is an amino acid precursor of dopamine with antiparkinsonian properties. Levodopa is a prodrug that is converted to dopamine by DOPA decarboxy...
Atomoxetine hydrochloride
T0869CAS 82248-59-7
Atomoxetine Hydrochloride is the hydrochloride salt of atomoxetine, a phenoxy-3-propylamine derivative and selective non-stimulant, norepinephrine reuptake ...
Droperidol
T0990CAS 548-73-2
Droperidol is a Dopamine-2 Receptor Antagonist. The mechanism of action of droperidol is as a Dopamine D2 Antagonist.
A-437203
T10213CAS 220519-06-2
A-437203 is a selective D3 receptor antagonist (Kis: 71, 1.6, and 6220 nM for D2, D3, and D4 receptors).
Trimipramine maleate
T1045CAS 521-78-8
Trimipramine maleate appears to inhibit serotonin transport and norepinephrine uptake by nerve terminals. This increases available norepinephrine or serotonin a...
Brexpiprazole S-oxide D8
T10611CAS T10611
Brexpiprazole S-oxide D8 (DM-3411 D8) is a deuterium labeled Brexpiprazole S-oxide. Brexpiprazole S-oxide is a main metabolite of Brexpiprazole. Brexpiprazole i...
Brexpiprazole S-oxide
T10612CAS 1191900-51-2
Brexpiprazole S-oxide (DM-3411) is a main metabolite of Brexpiprazole. Brexpiprazole is a partial agonist of human 5-HT1A and dopamine receptors (Kis: 0.12 nM a...
Cariprazine D6
T10681CAS T10681
Cariprazine D6 (RGH-188 D6) is a deuterium-labeled Cariprazine. Cariprazine is an antipsychotic agent (D3 receptors, Ki: 0.085 nM; D2 receptors, Ki: 0.49 nM).
Carmoxirole hydrochloride
T10683CAS 115092-85-8
Carmoxirole (EMD 45609) hydrochloride is a selective, peripherally acting agonist of dopamine D2 receptor with antihypertensive activities in vivo.
Metoclopramide hydrochloride
T1069CAS 7232-21-5
Metoclopramide hydrochloride is a selective dopamine D2 receptor antagonist, used as an antiemetic.
Clocapramine
T10837LCAS 47739-98-0
Clocapramine is a D2 and 5-HT2A receptors antagonist.
Perphenazine
T1090CAS 58-39-9
Perphenazine is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties.
CY 208-243
T10908CAS 100999-26-6
CY 208-243 is a selective dopamine D1 receptor agonist with anti-Parkinson disease activity.
Penfluridol
T1105CAS 26864-56-2
Penfluridol is a highly potent antipsychotic.
Deschloroclozapine
T11078CAS 1977-07-7
Deschloroclozapine is an effective selective chemical generation actuator. Decloclopine is a dual antagonist of dopamine and serotonin receptors. The Kis of dop...
GR 103691
T11463CAS 162408-66-4
GR 103691 shows more than 100-fold selectivity for human dopamine human (h)D3 over hD4 and hD1 sites. GR 103691 is a potent, selective dopamine D3 receptor ant...
JR-AB2-011
T11728CAS 329182-61-8
JR-AB2-011 inhibits mTORC2 activity by blocking Rictor-mTOR association (Ki: 0.19 μM). JR-AB2-011 has anti-glioblastoma multiforme (GBM) properties. JR-AB2-011...
Bromopride
T1175CAS 4093-35-0
Bromopride is a dopamine antagonist with prokinetic properties closely related to metoclopramide, and is widely used as an antiemetic. It is not available in th...
L-745870 hydrochloride
T11799CAS 1173023-36-3
L-745870 hydrochloride has excellent brain penetration. L-745870 hydrochloride is a high-affinity, selective and orally active human dopamine D4 receptor antag...
L-745870
T11799LCAS 158985-00-3
L-745870 is a high-affinity and selective human dopamine D4 receptor antagonist (Ki: 0.43 nM). L-745870 has excellent brain penetration. It considerably weaker ...
Blonanserin
T1180CAS 132810-10-7
Blonanserin is an atypical antipsychotic approved in Japan in January, 2008. Relative to many other antipsychotics, blonanserin has an improved tolerability pro...
Sulpiride
T1201CAS 15676-16-1
Sulpiride is a dopamine D2-receptor antagonist, used therapeutically as an antidepressant, antipsychotic, and as a digestive aid.
Levosulpiride
T1211CAS 23672-07-3
Levosulpiride is the (S)-enantiomer of sulpiride, which is a D2 receptor antagonist, an atypical antipsychotic drug of the benzamide class.
Trifluoperazine dihydrochloride
T1222CAS 440-17-5
Trifluoperazine Dihydrochloride is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic.
NRA-0160
T12252CAS 204718-47-8
NRA-0160 is a selective antagonist of dopamine D4 receptor(Ki of 0.48 nM)
Odapipam
T12288CAS 131796-63-9
Odapipam is a selective and high affinity antagonist of benzazepine dopamine D1 receptor (Kd of 0.18 nM).
Oxolinic acid
T1233CAS 14698-29-4
Oxolinic acid is a synthetic antimicrobial related to NALIDIXIC ACID and used in URINARY TRACT INFECTIONS.
Oxidopamine hydrochloride
T12352CAS 28094-15-7
Oxidopamine hydrochloride is an neurotransmitter dopamine antagonist.
PD 168568 dihydrochloride
T12383CAS 1782532-06-2
PD 168568 dihydrochloride is an orally active and selective antagonist of D4 dopamine receptor(Ki of 8.8 nM).
Pentiapine
T12405CAS 81382-51-6
Pentiapine is a novel inhibitor of dopamine release.
Pimozide D4
T12476CAS 1803193-57-8
Pimozide D4 is a deuterium labeled Pimozide.
PNU-177864 hydrochloride
T12510CAS 1783978-03-9
PNU-177864 hydrochloride is a selective and orally active antagonist of dopamine D3 receptor,with antischizophrenic activity.
Quinpirole Hydrochloride
T12606CAS 85798-08-9
Quinpirole Hydrochloride is a high-affinity dopamine D2/D3 receptor agonist.
(Rac)-Rotigotine hydrochloride
T12676CAS 102120-99-0
(Rac)-Rotigotine hydrochloride is a racemate of Rotigotine. Rotigotine is a full agonist of dopamine receptor, a partial the 5-HT1A receptor agonist.
Ro 10-5824 dihydrochloride
T12761CAS 189744-94-3
Ro 10-5824 dihydrochloride is a selective agonist of dopamine D4 receptor partial, (Ki of 5.2 nM).
SB-277011 dihydrochloride
T12861LCAS 1226917-67-4
SB-277011 dihydrochloride is a potent, selective, orally bioavailable and brain penetrate antagonist of dopamine D3 receptor(pKis of 8.0, 6.0, <5.2 and 5.9 for ...
SCH-23390 maleate
T12865CAS 87134-87-0
SCH-23390 maleate is a potent and selective antagonist of dopamine D1-like receptor (1 and D5 receptor with Kis of 0.2 nM and 0.3 nM, respectively).
Tiapride hydrochloride
T1292CAS 51012-33-0
Tiapride is a selective blocker of D2/3 dopamine receptors in the brain. It is used in the therapy of various psychiatric and neurological disorders containing ...
Tipepidine hydrochloride
T13164CAS 1449686-84-3
Tipepidine hydrochloride ia a reversible inhibitor of dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK))(IC50 : 7.0 μM), with antidepressant-like eff...
Bendazol
T1322CAS 621-72-7
Bendazol is always used as the drug for hypertension and cerebral Angiospasm.
U91356
T13240CAS 152886-85-6
U91356 is an agonist of dopamine receptor.
UCSF924
T13245CAS 1434515-70-4
UCSF924 is a potent and specific agonist of dopamine D4 receptor (DRD4) partial (EC50 of 4.2 nM,Ki value of 3 nM)
Nortriptyline hydrochloride
T1327CAS 894-71-3
Nortriptyline hydrochloride is a metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia,...
Benztropine mesylate
T1336CAS 132-17-2
Benztropine mesylate is a centrally active muscarinic antagonist that has been used in the symptomatic treatment of PARKINSON DISEASE. Benztropine also inhibits...
Zatebradine
T13387CAS 85175-67-3
Zatebradine is a potent hyperpolarization-activated cyclic nucleotide-gated (HCN) channels inhibitor(IC50 of 1.96 µM).
Dihydrexidine
T13463LCAS 123039-93-0
Dihydrexidine is a full efficacy D1-like dopamine receptor (D1/D5) agonist (IC50: 10 nM for D1 receptor). It also shows potent antiparkinsonian activity.
Dihydrexidine hydrochloride
T13463L2CAS 137417-08-4
Dihydrexidine hydrochloride is a full efficacy D1-like dopamine receptor (D1/D5) agonist (IC50: 10 nM for D1 receptor). It also shows potent antiparkinsonian ac...
(±)-Epibatidine
T13468CAS 148152-66-3
(±)-Epibatidine is an agonist of nicotinic. (±)-Epibatidine is an agonist of neuronal nAChR.
Benzamide Derivative 1
T13570CAS 108226-05-7
Benzamide Derivative 1, extracted from patent EP0213775A1 (compound 18), may be useful in the treatment of gastrointestinal disorders.
Dicarbine
T13652CAS 17411-19-7
Double carbene can be used for the study of schizophrenia and alcoholism. It can block dopamine receptors in various parts of the brain and prevent the reductio...
Chlorpromazine hydrochloride
T1384CAS 69-09-0
Chlorpromazine hydrochloride is the prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are...
SPD-473 citrate
T13898CAS 161190-26-7
SPD-473 citrate is an inhibitior of serotonin/dopamine/norepinephrine reuptake.
Amantadine hydrochloride
T1406CAS 665-66-7
Amantadine hydrochloride is an antiviral that is used in the prophylactic or symptomatic treatment of influenza A and Parkinson disease.
ABT-670
T14088CAS 630119-43-6
ABT-670 is a selective agonist of dopamine D4 receptor. For human D4, ferret D4, and rat D4, the EC50 values are 89 nM, 160 nM, and 93 nM , respectively.
Loxapine succinate salt
T1412CAS 27833-64-3
Loxapine succinate, a D2DR and D4DR inhibitor, is utilized in schizophrenia.
Duloxetine hydrochloride
T1471CAS 136434-34-9
Duloxetine hydrochloride is a thiophene derivative and selective neurotransmitter uptake inhibitor for SEROTONIN and NORADRENALINE (SNRI). It is an ANTIDEPRESSI...
Pramipexole
T1476CAS 104632-26-0
Pramipexole is a selective dopamine receptor agonist used in the therapy of Parkinson disease. Pramipexole therapy is associated with a low rate of transient se...
BP 897
T14767CAS 314776-92-6
BP 897 is a potent and selective agonist of dopamine D3 receptor(Kis of 0.92 nM and 61 nM for D3 and D2 receptors), and shows low affinities at D1 and D4 recept...
Pramipexole dihydrochloride
T1476LCAS 104632-25-9
Pramipexole dihydrochloride could be used to treat Parkinson disease.
Brilaroxazine
T14782CAS 1239729-06-6
Brilaroxazine (RP5603) is a partial agonist of dopamine (DA) D2, D3, and D4 receptors, 5-HT1A (Ki: 1.5 nM) and 5-HT2A (Ki: 2.5 nM), and has antagonist activity ...
Cabergoline
T14853CAS 81409-90-7
Cabergoline is an ergot derived-dopamine D2-like receptor agonist (Ki: 0.7, 1.5, and 1.2 for D2, D3, and 5-HT2B receptors).
Desmethyl cariprazine
T15100CAS 839712-15-1
Desmethyl cariprazine is a Cariprazine active metabolite. Cariprazine, an antipsychotic drug candidate, shows a high affinity for the D3 (Ki: 0.085 nM) and D2 (...
Didesmethyl cariprazine
T15117CAS 839712-25-3
Cariprazine is an antipsychotic drug candidate. It shows high affinity for the D3 and D2 receptors, and moderate affinity for the 5-HT1A receptor. Didesmethyl c...
Benserazide hydrochloride
T1517CAS 14919-77-8
Benserazide Hydrochloride is a peripherally-acting L-amino acid decarboxylase (AAAD) or DOPA decarboxylase inhibitor.
Fananserin
T15270CAS 127625-29-0
Fananserin is an orally bioavailable and selective antagonist of the 5-HT2 receptor (Ki: 0.37 nM for the rat 5-HT2A receptor). It also is an antagonist of dopam...
Foscarbidopa
T15339CAS 1907685-81-7
Foscarbidopa is a prodrug of Carbidopa. It acts as a dopamine receptor agonist.
Iloperidone
T1539CAS 133454-47-4
Iloperidone is an atypical antipsychotic agent that is used for treatment of schizophrenia.
Doxepin hydrochloride
T1540CAS 1229-29-4
Doxepin Hydrochloride is a dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mec...
Olanzapine
T1567CAS 132539-06-1
Olanzapine is an atypical antipsychotic that is used currently in the treatment of schizophrenia and bipolar illness.
L-741626
T15686CAS 81226-60-0
L-741626 is a selective antagonist of D2 dopamine receptor (Ki: 2.4, 100, and 220 nM for human D2, D3 and D4 receptors respectively).
Levophacetoperane hydrochloride
T15744CAS 23257-56-9
Levophacetoperane inhibits in vitro in a competitive manner. It also can norepinephrine uptake and dopamine uptake.
Dopamine hydrochloride
T1644CAS 62-31-7
Dopamine is a naturally occurring catecholamine formed by decarboxylation of dihydroxyphenylalanine and a precursor of norepinephrine and epinephrine. Dopamine ...
Pericyazine
T16472CAS 2622-26-6
Pericyazine is a selective D2-dopamine receptor antagonist. Pericyazine is a first-generation antipsychotic drug that is used as an adjunct to the short-term ma...
PF2562
T16511CAS 1609258-91-4
PF2562 is a dopamine D1 ligand. It is used as a dopamine D1 agonist or partial agonist. PF2562 binds to human D1 receptor (Ki: 113 nM). PF2562 shows activity ag...
Ritanserin
T16759CAS 87051-43-2
Ritanserin is a highly effective, relatively selective, long-acting antagonist of 5-HT2 receptor (IC50: 0.9 nM).
Tavapadon
T16999CAS 1643489-24-0
Tavapadon is an orally active and highly selective dopamine D1/D5 receptor partial agonist.
Thiethylperazine dimaleate
T17072CAS 1179-69-7
Thiethylperazine maleate is a selective ABCC1 activator. Thiethylperazine maleate is also a phenothiazine derivate, and an orally active dopamine D2-receptor an...
Lurasidone hydrochloride
T1735CAS 367514-88-3
Lurasidone hydrochloride is a thiazole derivative and atypical antipsychotic agent that functions as a dopamine D2 receptor antagonist; serotonin 5-HT2 receptor...
Pardoprunox
T1769CAS 269718-84-5
Pardoprunox is a partial dopamine D2 agonist and noradrenergic agonist with serotonin 5-HT1A agonist properties. Pardoprunox has been used in trials studying th...
GBR-12935
T1871CAS 67469-81-2
GBR 12935 can induce the increase of the extracellular levels of dopamine to basal levels.
Amitifadine hydrochloride
T2092CAS 410074-74-7
Amitifadine hydrochloride is a triple reuptake inhibitor (TRI) or serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI).
Buspirone hydrochloride
T2132CAS 33386-08-2
Buspirone is a 5HT(1A) receptor agonist, used to treat generalized anxiety disorder (GAD).
Methiothepin mesylate
T2190CAS 74611-28-2
Methiothepin mesylate is a potent and non-selective 5-HT2 receptor antagonist,used as an antipsychotic.
Pergolide mesylate salt
T2226CAS 66104-23-2
PERGOLIDE MESYLATE is a long-acting dopamine agonist which has been used to treat PARKINSON DISEASE and HYPERPROLACTINEMIA but withdrawn from some markets due t...
Brexpiprazole
T2306CAS 913611-97-9
Brexpiprazole is a partial agonist of human 5-hydroxytryptamine (5-HT) 5-HT1A and dopamine D2 receptors.
Pimozide
T2546CAS 2062-78-4
Pimozide is a diphenylbutylpiperidine derivative and a dopamine antagonist with the antipsychotic property. Pimozide selectively inhibits type 2 dopaminergic re...
Flupenthixol dihydrochloride
T2564CAS 51529-01-2
Flupenthixol dihydrochloride is a dopamine receptor antagonist.
Alizapride hydrochloride
T2574CAS 59338-87-3
Alizapride hydrochloride is a dopamine receptor antagonist used for the treatment of nausea and vomiting.
Ropinirole hydrochloride
T2592CAS 91374-20-8
Ropinirole a selective dopamine D2 receptors agonist (Ki: 29 nM). Ropinirole Hydrochloride is the hydrochloride salt form of ropinirole, a non-ergot dopamine ag...
Rotundine
T2714CAS 10097-84-4
Rotundine is extracted from Corydalis yanhusuo W. T. Wang.
Tetrahydroberberine THB
T2874CAS 522-97-4
Tetrahydroberberine is an isoquinoline alkaloid isolated from corydalis tuber, has a micromolar affinity for dopamine D(2) receptors.
L-Stepholidine
T2S1397CAS 16562-13-3
L-Stepholidine, which has dual actions on dopamine D1 and D2 receptors, attenuates heroin self-administration and cue-induced reinstatement. It also elicits ant...
BMY 7378 dihydrochloride
T3046CAS 21102-95-4
BMY-7378, α1D-adrenergic receptor antagonist, is a weak partial agonist/antagonist of 5-HT1A receptor.
Piperacetazine
T3085CAS 3819-00-9
Piperacetazine, an antipsychotic prodrug, is used forschizophrenia.
Fluoroclebopride
T3187CAS 154540-49-5
Fluoroclebopride is a dopamine (DA) D2 receptor ligand.
Piribedil
T3278CAS 3605-01-4
Piribedil is a dopamine D2 agonist, used in the treatment of Parkinson's disease.
Ddr1-In-1
T3337CAS 1449685-96-4
DDR1-IN-1 is an effective and specific DDR1 receptor tyrosine kinase inhibitor (IC50: 105 nM), about 3-fold selectivity over DDR2.
Nuciferine
T3369CAS 475-83-2
Nuciferine is an alkaloid found within the plants Nymphaea caerulea and Nelumbo nucifera. It has a profile of action associated with dopamine receptor blockade.
Pardoprunox hydrochloride
T3431CAS 269718-83-4
Pardoprunox hydrochloride is a novel partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist, D2 (pKi = 8.1) and D3 receptor (pKi = 8....
Ocaperidona
T3497CAS 129029-23-8
Ocaperidona (Ocaperidone), a very high affinity dopamine D2 antagonist.
Dasotraline hydrochloride
T3526CAS 675126-08-6
Dasotraline hydrochloride (SEP-225289 hydrochloride) is a triple reuptake inhibitor  that inhibits dopamine, norepinephrine, and serotonin transporters with IC...
MPTP-hydrochloride
T4081CAS 23007-85-4
MPTP-hydrochloride is a precusor of MPP+ which is toxic to dopaminergic neurons and causes Parkinsonism.
Zuclopenthixol
T4117CAS 53772-83-1
Zuclopenthixol is a thioxanthene with therapeutic actions similar to the phenothiazine antipsychotics. It is an antagonist at D1 and D2 dopamine receptors.
BisfluoroModafinil
T4262CAS 90280-13-0
CRL-40940 is a selective dopaminergic reuptake inhibitor
Melitracen hydrochloride
T4274CAS 10563-70-9
Melitracen Hydrochloride, an antidepressant, is used as potential dopamine D1/2 receptor antagonist to treat depression.
Flibanserin
T4297CAS 167933-07-5
Flibanserin is a serotonergic antidepressant used to treat hypoactive sexual desire disorder. Flibanserin has been associated with a low rate of minor serum ami...
SCH 23390 hydrochloride
T4369CAS 125941-87-9
SCH 23390 hydrochloride is an effective dopamine receptor antagonist, and for the D1(Ki=0.2 nM) and D5(Ki=0.3 nM).
Perospirone
T4576CAS 150915-41-6
Perospirone is an antagonist of serotonin 5HT2A receptors and dopamine D2 receptors. It also displays affinity towards 5HT1A receptors as a partial agonist.
Cariprazine
T4577CAS 839712-12-8
Cariprazine is a novel antipsychotic drug candidate that exhibits high affinity for the D3 (Ki=0.085 nM) and D2 (Ki=0.49 nM) receptors, and moderate affinity fo...
5-Chloro-2-methoxyprocainamide
T4616CAS 364-62-5
Metoclopramide is a dopamine D2 antagonist which has been used for treatment of a variety of gastrointestinal symptoms over the last thirty years. In various co...
Tribenzagan Hydrochloride
T5009CAS 554-92-7
Trimethobenzamide hydrochloride is a blocker of the D2 receptor. Trimethobenzamide is an antiemetic used to prevent nausea and vomiting.
Flupentixol Dihydrochloride
T5135CAS 2413-38-9
Flupentixol is used in therapy of schizophrenia as well as in anxiolytic and depressive disorders.
N-Desmethylclozapine
T5158CAS 6104-71-8
N-Desmethylclozapine is an antagonist of serotonin (5-HT) receptor subtype 5-HT2C (IC50: 7.1 nM). It also is an antagonist at dopamine D4 receptors, an agonist ...
Ansofaxine hydrochloride
T5380CAS 916918-84-8
Ansofaxine (LY03005; LPM570065) is a serotonin-norepinephrine-dopamine reuptake inhibitor (IC50s: 723, 763 and 491 nM, respectively).
LP-211
T5387CAS 1052147-86-0
LP-211 is a brain penetrant selective agonist for a 5-HT7 receptor (Ki: 0.58 nM), and >300-fold selectivity over the 5-HT1A receptor.
A-381393
T5397CAS 726174-00-1
A-381393 is a selective and brain penetrate dopamine D4 receptor antagonist (Kis: 1.9/1.5/1.6 nM for human dopamine D4.2/D4.4/D4.7 receptor).
Bromocriptine mesylate
T5842CAS 22260-51-1
Bromocriptine is a potent dopamine receptor agonist that binds the D2 receptor with highest affinity (Ki = 2.5 nM)
Sertindole
T5858CAS 106516-24-9
Sertindole is an atypical antipsychotic that binds to dopamine D2 receptors and the serotonin (5-HT) receptor subtypes 5-HT1D, 5-HT2A, and 5-HT2C (Kds = 2.7, 20...
Alpha-Methyldopa Sesquihydrate
T5954CAS 41372-08-1
Alpha-Methyldopa Sesquihydrate is a DOPA decarboxylase inhibitor and indirect α2-adrenergic receptor agonist used to treat hypertension. It inhibits the sympat...
Quetiapine Fumarate
T6241CAS 111974-72-2
Quetiapine Fumarate, an atypical antipsychotic, is used in the treatment of bipolar I mania, schizophrenia, bipolar II depression, bipolar I depression.
Rotigotine
T6647CAS 99755-59-6
Rotigotine is a non-ergot dopamine receptor agonist used in the therapy of Parkinson disease and restless leg syndrome. Administered as a once-daily transdermal...
Fenoldopam mesylate
T6835CAS 67227-57-0
Fenoldopam is a selective dopamine-1 receptor (DA1) agonist with natriuretic/diuretic properties. It lowers blood pressure through arteriolar vasodilation.
Pramipexole 2HCl Monohydrate
T6951CAS 191217-81-9
Pramipexole Dihydrochloride is the hydrochloride salt of pramipexole, a benzothiazole derivative. As a nonergot dopamine agonist, pramipexole binds to D2 and D3...
SKF38393 HCl
T6988CAS 62717-42-4
SKF38393 HCl is a selective dopamine D1/D5 receptor agonist.
Nomifensine (maleate)
T7070CAS 32795-47-4
Nomifensine maleate is a selective inhibitor of dopamine uptake, used in adult attention deficit disorder.
Vanoxerine dihydrochloride
T7153CAS 67469-78-7
Vanoxerine dihydrochloride is a potent inhibitor that blocks dopamine uptake (IC50 : 1-51 nM)
Sultopride hydrochloride
T7180CAS 23694-17-9
Sultopride Hydrochloride is a selective dopamine D2 and D3 receptor antagonist.
Nomifensine
T7308CAS 24526-64-5
Nomifensine is a norepinephrine-dopamine reuptake inhibitor that prevents dopamine reuptake into synaptosomes.
Pridopidine
T7352CAS 346688-38-8
Pridopidine, a dopamine (DA) stabilizer, acts as a low affinity dopamine D2 receptor (D2R) antagonist, improves motor performance and shows neuroprotective effe...
(+)-PD 128907 hydrochloride
T7553CAS 300576-59-4
(+)-PD 128907 hydrochloride is an agonist of D3 dopamine receptor .
Clebopride malate
T7569CAS 57645-91-7
Clebopride malate is a dopamine antagonist drug Used to treat functional gastrointestinal disorders such as nausea or vomiting.
Veralipride
T7632CAS 66644-81-3
Veralipride is an antagonist of D2 receptor.
Raclopride
T7635CAS 84225-95-6
Raclopride is a selective antagonist of dopamine D2/D3 receptor.
L-DOPA methyl ester (hydrochloride)
T7654CAS 1421-65-4
L-DOPA methyl ester (LDME) is an agonist of dopamine D1 receptor.
ACEPROMAZINE MALEATE
T7728CAS 3598-37-6
ACEPROMAZINE MALEATE is a dopamine receptor antagonist
ABT-724
T7834CAS 70006-24-5
ABT-724 is an agonist of dopamine D4 receptor(EC50: 12.4 nM)
Fluphenazine decanoate
T7943CAS 5002-47-1
Fluphenazine decanoate is dopamine D2 receptor blocke,and is a long-acting phenothiazine neuroleptic that used to treat schizophrenia.
Cariprazine HCl
T8382CAS 1083076-69-0
Cariprazine HCl is an antipsychotic drug, is a D3 and D2 receptor partial agonist((Ki of 0.085 nM and 0.49 nM, respectively)
Metoclopramide hydrochloride hydrate
T8385CAS 54143-57-6
Metoclopramide hydrochloride hydrate is a dopamine D2 antagonist that is a drug used for digestive dysfunction. It acts as an anti-emetic
Trifluoperazine
T8389CAS 117-89-5
Trifluoperazine is a Dopamine D2 receptor inhibitor(IC50 : 1.2 nM), and Treatment of schizophrenia.
ML417
T8423CAS 1386162-69-1
ML417 is a selective and brain penetrant agonist of D3 Dopamine (EC50 : 38 nM).
9-FLUORENOL
T8633CAS 1689-64-1
9-FLUORENOL is a dopamine reuptake inhibitor with IC50 of 9 µM, and a major metabolite of a compound developed as a wakefulness-promoting agent.
DOPEXAMINE
T8653CAS 86197-47-9
Dopexamine is a dopaminergic agonist
SKF-83566
T8702CAS 99295-33-7
SKF-83566 is a blood-brain permeable and orally active antagonist of D1-like dopamine receptor and a weaker competitive 5-HT2 receptor antagonist with Ki of 11 ...
Hirsuteine
TN1081CAS 35467-43-7
Hirsuteine exhibits potent neuroprotective effects against glutamate-induced HT22 cell death.
Bacopaside X
TN1424CAS 94443-88-6
Bacopaside X (9.06 μM) showed binding affinity towards the D1 receptor.
Delta3,2-Hydroxylbakuchiol
TN2856CAS 178765-49-6
Delta3,2-Hydroxylbakuchiol, a monoamine transporter inhibitor involved in regulating dopaminergic and noradrenergic neurotransmission and may have represented p...
Sumanirole maleate
TQ0140CAS 179386-44-8
Sumanirole maleate (U-95666E) is a highly selective full agonist of the D2 receptor (ED50: 46 nM).
Dexpramipexole
TQ0175CAS 104632-28-2
Dexpramipexole (KNS-760704, R-(+)-Pramipexole) is a neuroprotective agent and weak non-ergoline dopamine agonist.