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Search Result

Search Results for " dopamine d2 receptor "

Targets

Dopamine Receptor

159

Compounds

4

Natural Products

1

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T60075 Dopamine D2 receptor agonist-2 Dopamine D2 Receptor Dopamine Receptor
Dopamine D2 receptor agonist-2 (Dopamine D2 Receptor) is a ligand targeting the dopamine D2 receptor.
T11077 Dopamine D2 receptor antagonist-1 Others
Dopamine D2 Receptor Antagonist-1 functions as a negative allosteric modulator (NAM) of the dopamine D2 receptor (D2R), demonstrating sub-millimolar affinity.
T7635 Raclopride Dopamine Receptor
Raclopride is a selective antagonist of dopamine D2/D3 receptor.
T4007 Eticlopride hydrochloride Dopamine Receptor
Eticlopride, an antipsychotic, is a Selective dopamine D2/D3 receptor antagonist (Ki: 0.5/0.16 nM).
TQ0084 Lumateperone Tosylate ITI-007 Dopamine Receptor , 5-HT Receptor
lumateperone Tosylate (ITI-007) is a 5-HT2A receptor antagonist (Ki: 0.54 nM), a SERT blocker (Ki: 61 nM), a partial agonist of presynaptic D2 receptors and an antagonist of postsynaptic D2 receptors (Ki: 32 nM).
T16392 ONC206 Dopamine Receptor
ONC206, an analogue of the TRAIL inducer ONC201, acts as a selective antagonist of the D2-like dopamine receptors (DRD2/3/4) at nanomolar concentrations and possesses broad-spectrum anti-tumor activity.
T0280 Spiperone Spiroperidol,Spiropitan Dopamine Receptor
Spiperone (Spiropitan) is a spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA.
T21069 Lumateperone ITI 722,ITI722,ITI-007,ITI007 5-HT Receptor
Lumateperone (ITI 722) is a 5HT2A receptor antagonist and a dopamine receptor phosphoprotein modulator (DPPM).
T7943 Fluphenazine decanoate Dopamine Receptor
Fluphenazine decanoate is dopamine D2 receptor blocke,and is a long-acting phenothiazine neuroleptic that used to treat schizophrenia.
T8136 Perospirone hydrochloride Perospirone HCl,SM-9018 hydrochloride Dopamine Receptor , 5-HT Receptor
Perospirone hydrochloride (Perospirone HCl) is an atypical antipsychotic agent for the treatment of schizophrenia. It also displays affinity towards 5HT1A receptors as a partial agonist.
T2226 Pergolide mesylate Pergolide mesylate salt,LY127809,Pergolide methanesulfonate Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor
Pergolide mesylate salt(LY127809) is a long-acting dopamine agonist which has been used to treat PARKINSON DISEASE and HYPERPROLACTINEMIA but withdrawn from some markets due to potential for HEART VALVE DISEASES.
T10683 Carmoxirole hydrochloride EMD 45609 hydrochloride Dopamine Receptor
Carmoxirole hydrochloride (EMD 45609 hydrochloride) is a selective dopamine D2 receptor agonist with antihypertensive activity in vivo.
T9228 Propionylpromazine hydrochloride Propiopromazine hydrochloride Dopamine Receptor
Propionylpromazine hydrochloride (Propiopromazine hydrochloride) is a dopamine receptor D2 (DRD2) antagonist.
T70302 Fallypride Dopamine Receptor
Fallypride is a potent and selective dopamine D2/D3 receptor antagonist.
T6142 PD128907 HCl Dopamine Receptor
PD128907 HCl is a potent and selective dopamine D3 receptor agonist, with EC50 of 0.64 nM, exhibits 53-fold selectivity over dopamine D2 receptor.
T7180 Sultopride hydrochloride LIN-1418 hydrochloride Dopamine Receptor
Sultopride hydrochloride (LIN-1418 hydrochloride) is a selective dopamine D2 and D3 receptor antagonist.
T22817 GSK 789472 hydrochloride GSK-789472 HCl,1-phenyl-3-(piperidin-2-ylmethyl)imidazolidin-2-one hydrochloride,4,5-Dihydro-1-phenyl-3-(2-piperidinyl)methylimidazol-2(1H)-one Dopamine Receptor
GSK 789472 hydrochloride is both a dopamine D3 receptor antagonist and a D2 partial agonist.
T0302 Triflupromazine hydrochloride Neoprin,Fluopromazine hydrochloride,Fluorofen,Flumazin Dopamine Receptor , 5-HT Receptor , AChR , Autophagy
Triflupromazine hydrochloride (Fluopromazine hydrochloride), an antipsychotic medication, is Dopamine D1/D2 receptor antagonists.
T24613 PF-00217830 PF-217830 Dopamine Receptor , Serotonin Transporter
PF-00217830 is a serotonin 1A receptor agonist, dopamine D2 receptor agonist, and serotonin 2A receptor antagonist.PF-00217830 may be used in the study of schizophrenia.
T3187 Fluoroclebopride Dopamine Receptor
Fluoroclebopride is a dopamine (DA) D2 receptor ligand.
T14083 Abaperidone Dopamine Receptor , 5-HT Receptor
Abaperidone is a potent 5-HT2A receptor and dopamine D2 receptor antagonist with an IC50 of 6.2 for 5-HT2A receptors and 17 nM for dopamine D2 receptors.Abaperidone is a potentially atypical anti-psychotropic compound th...
T38754 Trazpiroben TAK-906 Dopamine Receptor
Trazpiroben (TAK-906) is a selective dopamine D2/D3 receptor antagonist used in the study of gastroparesis.
T2564 Cis-(Z)-Flupentixol dihydrochloride Emergil,Flupenthixol dihydrochloride Dopamine Receptor , 5-HT Receptor
cis-(Z)-Flupentixol dihydrochloride (Emergil) is a dopamine receptor antagonist.
T3431 Pardoprunox hydrochloride SLV-308 hydrochloride,DU-126891 hydrochloride Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor
Pardoprunox hydrochloride (SLV-308 hydrochloride) is a novel partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist, D2 (pKi = 8.1) and D3 receptor (pKi = 8.6) partial agonist and 5-HT1A recept...
T0990 Droperidol NSC 169874,Dehydrobenzperidol Dopamine Receptor
Droperidol (Dehydrobenzperidol) is a Dopamine-2 Receptor Antagonist. The mechanism of action of droperidol is as a Dopamine D2 Antagonist.
T27677 JNJ-37822681 JNJ37822681,JNJ 37822681 Dopamine Receptor
JNJ-37822681 is a novel, highly selective dopamine D₂ receptor antagonist characterized by a rapid dissociation rate from the dopamine D₂ receptor.
T14767 BP 897 hydrochloride Dopamine Receptor
BP 897 is a potent and selective agonist of dopamine D3 receptor and it is a weak dopamine D2 receptor antagonist, with Kis of 0.92 nM and 61 nM for D3 and D2 receptors. Which shows low affinities at D1 and D4 receptors ...
T30098 Aplindore Fumarate Aplindore,DAB-452 Fumarate,DAB-452 Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor
Aplindore Fumarate (DAB-452) is a small molecule dopamine D2 receptor partial agonist.Aplindore Fumarate exhibits high affinity for dopamine D2 and D3 receptors, and low affinity for dopamine D4, 5-hydroxytryptophan (5-H...
T1201 Sulpiride Aiglonyl,Dogmatil,Sulpyrid,Dolmatil,Dobren Dopamine Receptor
Sulpiride (Aiglonyl) is a dopamine D2-receptor antagonist, used therapeutically as an antidepressant, antipsychotic, and as a digestive aid.
T21782 A 77636 hydrochloride A77636 hydrochloride Dopamine Receptor
A 77636 hydrochloride is a potent, orally active, selective and long acting dopamine D1 receptor agonist (pKi=7.40; Ki=39.8 nM). A 77636 hydrochloride shows antiparkinsonian activity. A 77636 hydrochloride is functionall...
T28809 SLV-310 SLV 310,SLV310 Dopamine Receptor , 5-HT Receptor
SLV-310 is a potent dopamine D2 receptor antagonist and 5-HT reuptake receptor inhibitor used in the study of neurological disorders such as bipolar disorder and schizophrenia.
T1069 Metoclopramide hydrochloride Maxolon,Metoclopramide HCl Dopamine Receptor , 5-HT Receptor , AChR
Metoclopramide hydrochloride (Metoclopramide HCl) is a selective dopamine D2 receptor antagonist, used as an antiemetic.
T5842 Bromocriptine mesylate CB-154 Dopamine Receptor , Autophagy
Bromocriptine mesylate (CB-154) is a potent dopamine receptor agonist that binds the D2 receptor with highest affinity (Ki = 2.5 nM)
T12861 SB-277011 SB-277011A Dopamine Receptor
SB-277011 (SB-277011A) is a specific antagonist of the dopamine D3 receptor with pKi values of 8.0, 6.0, 5.0, and <5.2 for D3 receptor, D2 receptor, 5-HT1D, and 5-HT1B respectively.
T10232 Acetophenazine dimaleate Dopamine Receptor
Acetophenazine dimaleate is an antipsychotic agent, effective in anxious depression. Acetophenazine dimaleate primarily targets the dopamine D2 receptor.
T9100 BP 897 2-Naphthalenecarboxamide, N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]- Dopamine Receptor
BP 897 (2-Naphthalenecarboxamide, N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-) is a potent and selective dopamine D3 receptor agonist, and a weak dopamine D2 receptor antagonist, with Kis of 0.92 nM and 61 nM for D3 ...
T7352 Pridopidine ACR16,ASP2314,FR310826 Dopamine Receptor
Pridopidine (FR310826), a dopamine (DA) stabilizer, acts as a low affinity dopamine D2 receptor (D2R) antagonist, improves motor performance and shows neuroprotective effects in Huntington disease R6/2 mouse model.
T28073 MLS1547 MLS000051547,MLS 1547,MLS-1547 Dopamine Receptor
MLS1547 (MLS000051547) is a highly efficacious agonist of G protein-biased dopamine D2 receptor with a Ki of 1.2 μM. MLS1547 stimulates D2R G protein-mediated signaling with EC50 of 0.37 μM in a calcium mobilization assa...
T16472 Pericyazine Propericiazine,RP 8909 Dopamine Receptor
Pericyazine (Propericiazine) is a selective D2-dopamine receptor antagonist. Pericyazine is a first-generation antipsychotic drug that is used as an adjunct to the short-term management of severe anxiety states and psych...
T7553 (+)-PD 128907 hydrochloride Dopamine Receptor
(+)-PD 128907 hydrochloride is an agonist of D3 dopamine receptor .
T26360 Benperidol R4584,R-4584,Anquil,McN-JR-4584,R 4584
Benperidol (Anquil) is a butanone analog with antipsychotic and stabilizing properties, and has been shown to be effective in blocking D2 receptors.Benperidol can be used in positron emission tomography (PET) scanning to...
T8389 Trifluoperazine trifluoroperazine CaMK , Dopamine Receptor , Influenza Virus , Adrenergic Receptor , P-gp , Autophagy
Trifluoperazine (trifluoroperazine) is a Dopamine D2 receptor inhibitor(IC50 : 1.2 nM), and Treatment of schizophrenia.
T21337 Lurasidone SM-13496 Dopamine Receptor , 5-HT Receptor
Lurasidone (SM-13496) is an antagonist of both dopamine D2 and 5-HT7(IC50=1.68 and 0.495 nM, respectively).It also a partial agonist of 5-HT1A receptor(IC50 : 6.75 nM).
T13164 Tipepidine hydrochloride Potassium Channel , Dopamine Receptor
Tipepidine hydrochloride is a reversible inhibitor of dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK)) (IC50: 7.0 μM), with antidepressant-like effect.
T33816 Ordopidine ACR-325,ACR 325,ACR325 Dopamine Receptor
Ordopidine (ACR325) is a dopaminergic stabilizer that suppresses psychostimulant-induced hyperactivity disorder and stimulates behavior during inactivity. Ordopidine acts as a dopamine D2 receptor antagonist in vitro and...
T14490 Talipexole dihydrochloride Domnin,B-HT 920 dihydrochloride Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor
Talipexole dihydrochloride (Domnin) is a dopamine D2 receptor agonist, α2-adrenoceptor agonist, and 5-HT3 receptor antagonist in both rat cortical and intestinal membrane fractions with Ki values of 0.35 μM and 0.22 μM, ...
T26375 (S)-Amisulpride Esamisulpride,(S) Amisulpride,SEP-4199 Dopamine Receptor , 5-HT Receptor
(S)-Amisulpride ((S) Amisulpride) (Esamisulpride) is a potent dopamine D2/D3 receptor antagonist. (S)-Amisulpride is an antagonist at the 5-HT7 receptor with a Ki of 900 nM. (S)-Amisulpride has antipsychotic and antidepr...
T13510 Sigma-LIGAND-1 Sigma receptor
Sigma-LIGAND-1 is a selective Sigma Receptor ligand with an IC50s of 16 nM, 19 nM at the DTG site and the PPP site, respectively. Sigma-LIGAND-1 has a Ki of 4000 nM at the dopamine D2 receptor.
T11722 JNJ-37822681 dihydrochloride Dopamine Receptor
JNJ-37822681 has potential for the treatment of schizophrenia and bipolar disorder.JNJ-37822681 dihydrochloride is a potent, specific, centrally active, fast-dissociating dopamine D2 receptor antagonist with a moderate b...
T26834 BL-1020 Mesylate CYP-1020 Mesylate Dopamine Receptor , GABA Receptor
BL-1020 Mesylate (CYP-1020 Mesylate) is an orally available GABA A receptor agonist and D2 antagonist that decreases dopamine activity and enhances GABAA activity.BL-1020 Mesylate has been used in the study of schizophre...

Compounds

Dopamine D2 receptor agonist-2
T60075
Synonym: Dopamine D2 Receptor
Target: Dopamine Receptor
Dopamine D2 receptor antagonist-1
T11077
Synonym:
Target: Others
Raclopride
T7635
Synonym:
Target: Dopamine Receptor
Eticlopride hydrochloride
T4007
Synonym:
Target: Dopamine Receptor
lumateperone Tosylate
TQ0084
Synonym: ITI-007
Target: Dopamine Receptor, 5-HT Receptor
ONC206
T16392
Synonym:
Target: Dopamine Receptor
Spiperone
T0280
Synonym: Spiroperidol,Spiropitan
Target: Dopamine Receptor
Lumateperone
T21069
Synonym: ITI 722,ITI722,ITI-007,ITI007
Target: 5-HT Receptor
Fluphenazine decanoate
T7943
Synonym:
Target: Dopamine Receptor
Perospirone hydrochloride
T8136
Synonym: Perospirone HCl,SM-9018 hydrochloride
Target: Dopamine Receptor, 5-HT Receptor
Pergolide mesylate
T2226
Synonym: Pergolide mesylate salt,LY127809,Pergolide methanesulfonate
Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor
Carmoxirole hydrochloride
T10683
Synonym: EMD 45609 hydrochloride
Target: Dopamine Receptor
Propionylpromazine hydrochloride
T9228
Synonym: Propiopromazine hydrochloride
Target: Dopamine Receptor
Fallypride
T70302
Synonym:
Target: Dopamine Receptor
PD128907 HCl
T6142
Synonym:
Target: Dopamine Receptor
Sultopride hydrochloride
T7180
Synonym: LIN-1418 hydrochloride
Target: Dopamine Receptor
GSK 789472 hydrochloride
T22817
Synonym: GSK-789472 HCl,1-phenyl-3-(piperidin-2-ylmethyl)imidazolidin-2-one hydrochloride,4,5-Dihydro-1-phenyl-3-(2-piperidinyl)methylimidazol-2(1H)-one
Target: Dopamine Receptor
Triflupromazine hydrochloride
T0302
Synonym: Neoprin,Fluopromazine hydrochloride,Fluorofen,Flumazin
Target: Dopamine Receptor, 5-HT Receptor, AChR, Autophagy
PF-00217830
T24613
Synonym: PF-217830
Target: Dopamine Receptor, Serotonin Transporter
Fluoroclebopride
T3187
Synonym:
Target: Dopamine Receptor
Abaperidone
T14083
Synonym:
Target: Dopamine Receptor, 5-HT Receptor
Trazpiroben
T38754
Synonym: TAK-906
Target: Dopamine Receptor
cis-(Z)-Flupentixol dihydrochloride
T2564
Synonym: Emergil,Flupenthixol dihydrochloride
Target: Dopamine Receptor, 5-HT Receptor
Pardoprunox hydrochloride
T3431
Synonym: SLV-308 hydrochloride,DU-126891 hydrochloride
Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor
Droperidol
T0990
Synonym: NSC 169874,Dehydrobenzperidol
Target: Dopamine Receptor
JNJ-37822681
T27677
Synonym: JNJ37822681,JNJ 37822681
Target: Dopamine Receptor
BP 897 hydrochloride
T14767
Synonym:
Target: Dopamine Receptor
Aplindore Fumarate
T30098
Synonym: Aplindore,DAB-452 Fumarate,DAB-452
Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor
Sulpiride
T1201
Synonym: Aiglonyl,Dogmatil,Sulpyrid,Dolmatil,Dobren
Target: Dopamine Receptor
A 77636 hydrochloride
T21782
Synonym: A77636 hydrochloride
Target: Dopamine Receptor
SLV-310
T28809
Synonym: SLV 310,SLV310
Target: Dopamine Receptor, 5-HT Receptor
Metoclopramide hydrochloride
T1069
Synonym: Maxolon,Metoclopramide HCl
Target: Dopamine Receptor, 5-HT Receptor, AChR
Bromocriptine mesylate
T5842
Synonym: CB-154
Target: Dopamine Receptor, Autophagy
SB-277011
T12861
Synonym: SB-277011A
Target: Dopamine Receptor
Acetophenazine dimaleate
T10232
Synonym:
Target: Dopamine Receptor
BP 897
T9100
Synonym: 2-Naphthalenecarboxamide, N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-
Target: Dopamine Receptor
Pridopidine
T7352
Synonym: ACR16,ASP2314,FR310826
Target: Dopamine Receptor
MLS1547
T28073
Synonym: MLS000051547,MLS 1547,MLS-1547
Target: Dopamine Receptor
Pericyazine
T16472
Synonym: Propericiazine,RP 8909
Target: Dopamine Receptor
(+)-PD 128907 hydrochloride
T7553
Synonym:
Target: Dopamine Receptor
Benperidol
T26360
Synonym: R4584,R-4584,Anquil,McN-JR-4584,R 4584
Target:
Trifluoperazine
T8389
Synonym: trifluoroperazine
Target: CaMK, Dopamine Receptor, Influenza Virus, Adrenergic Receptor, P-gp, Autophagy
Lurasidone
T21337
Synonym: SM-13496
Target: Dopamine Receptor, 5-HT Receptor
Tipepidine hydrochloride
T13164
Synonym:
Target: Potassium Channel, Dopamine Receptor
Ordopidine
T33816
Synonym: ACR-325,ACR 325,ACR325
Target: Dopamine Receptor
Talipexole dihydrochloride
T14490
Synonym: Domnin,B-HT 920 dihydrochloride
Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor
(S)-Amisulpride
T26375
Synonym: Esamisulpride,(S) Amisulpride,SEP-4199
Target: Dopamine Receptor, 5-HT Receptor
Sigma-LIGAND-1
T13510
Synonym:
Target: Sigma receptor
JNJ-37822681 dihydrochloride
T11722
Synonym:
Target: Dopamine Receptor
BL-1020 Mesylate
T26834
Synonym: CYP-1020 Mesylate
Target: Dopamine Receptor, GABA Receptor
1 2 3 4
Cat No. Product Name Synonyms Targets
T1045 Trimipramine maleate Surmontil maleate Dopamine Receptor , 5-HT Receptor , Antibacterial , Adrenergic Receptor , Norepinephrine , Histamine Receptor
Trimipramine maleate (Surmontil maleate) appears to inhibit serotonin transport and norepinephrine uptake by nerve terminals. This increases available norepinephrine or serotonin and prolongs its action. Trimipramine Mal...
T15686 L-741626 3-(4-(4-Chlorophenyl-4-hydroxypiperidino)methyl)indole Dopamine Receptor
L-741626 (3-(4-(4-Chlorophenyl-4-hydroxypiperidino)methyl)indole) is a selective antagonist of D2 dopamine receptor (Ki: 2.4, 100, and 220 nM for human D2, D3 and D4 receptors respectively).
T14853 Cabergoline FCE-21336 Dopamine Receptor , 5-HT Receptor , Autophagy
Cabergoline (FCE-21336) is an ergot derived-dopamine D2-like receptor agonist. It has high affinity for D2, D3, and 5-HT2B receptors (Ki=0.7, 1.5, and 1.2, respectively).Cabergoline permits rapid and effective hormonal a...
T6648 Rotundine Gindarine,L-Tetrahydropalmatine,Caseanine,(-)-Tetrahydropalmatine Dopamine Receptor , 5-HT Receptor
Rotundine (Gindarine) (L-tetrahydropalmatine, L-THP) is a selective dopamine D1 receptor antagonist with IC50 of 166 nM.

Natural Products

Trimipramine maleate
T1045
Synonym: Surmontil maleate
Target: Dopamine Receptor, 5-HT Receptor, Antibacterial, Adrenergic Receptor, Norepinephrine, Histamine Receptor
L-741626
T15686
Synonym: 3-(4-(4-Chlorophenyl-4-hydroxypiperidino)methyl)indole
Target: Dopamine Receptor
Cabergoline
T14853
Synonym: FCE-21336
Target: Dopamine Receptor, 5-HT Receptor, Autophagy
Rotundine
T6648
Synonym: Gindarine,L-Tetrahydropalmatine,Caseanine,(-)-Tetrahydropalmatine
Target: Dopamine Receptor, 5-HT Receptor

Recombinant Proteins

Species：
Human (1)
Expression System：
E. coli (1)
Tag：
N-terminal 10xHis-tagged and C-terminal Myc-tagged (1)
Cat No. Product Name Species Expression System
TMPH-01201 DRD2 Protein, Human, Recombinant (His & Myc) Human E. coli
Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5.
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