Home Tools
Log in
Cart

Search Result

Search Results for " dna alkylator-crosslinker "

Targets

31

Compounds

2

Natural Products

Cat No. Product Name Synonyms Targets
T0707L Cyclophosphamide DNA Alkylator/Crosslinker , DNA , MRP
Cyclophosphamide is an alkylating agent used in the treatment of several forms of cancer including leukemias, lymphomas and breast cancer.
T4368 Miriplatin SM-11355 DNA Alkylator/Crosslinker
Miriplatin (SM-11355) (SM-11355) is a platinum complex used in TACE that has promise for the therapy of hepatocellular carcinoma (HCC).
T1564 Cisplatin cis-Diaminodichloroplatinum,CDDP DNA Alkylator/Crosslinker , Ferroptosis , DNA/RNA Synthesis , Autophagy
Cisplatin (CDDP) is a DNA cross-linking agent. Cisplatin has antitumor activity and inhibits DNA synthesis by forming DNA adducts in cancer cells. Cisplatin also activates iron death and induces autophagy.
T0164 Oxaliplatin L-OHP DNA Alkylator/Crosslinker , DNA/RNA Synthesis , Autophagy
Oxaliplatin (L-OHP) is a DNA alkylating agent, an inhibitor of DNA synthesis. Oxaliplatin causes DNA cross-linking damage, preventing DNA replication and transcription and leading to cell death. Oxaliplatin induces autop...
T11120 Duocarmycin TM DNA Alkylation , Antibiotic
Duocarmycin TM is a DNA alkylator. Duocarmycin TM is an exceptionally potent antitumor antibiotic.
T0923 Busulfan Myleran,Sulphabutin,Busulphan Apoptosis , DNA Alkylator/Crosslinker , DNA Alkylation
Busulfan (Busulphan) is a synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully understood, busulfan appears to act through the alkylation...
T15793 Lurbinectedin PM01183 Others
Lurbinectedin (PM01183) is a DNA minor groove covalent binder. Lurbinectedin also shows effective anti-tumor activity.
T5017 Nimustine Hydrochloride Nidran hydrochloride Apoptosis , Others , DNA Alkylator/Crosslinker , DNA/RNA Synthesis
Nimustine Hydrochloride (Nidran hydrochloride) has been used in trials studying the treatment of Glioblastoma.
T1058 Carboplatin NSC 241240,CBDCA,JM-8 DNA Alkylator/Crosslinker , DNA/RNA Synthesis , Autophagy
Carboplatin (JM-8) is a cisplatin derivative, a DNA synthesis inhibitor. Carboplatin binds to DNA, inhibits replication and transcription, and induces cell death. Carboplatin has antitumor activity.
T1055 Ifosfamide NSC109724,Isophosphamide DNA Alkylator/Crosslinker , DNA/RNA Synthesis
Ifosfamide (NSC-109724) alkylates and forms DNA crosslinks, thereby preventing DNA strand separation and DNA replication. Ifosfamide is a synthetic analog of the nitrogen mustard cyclophosphamide with antineoplastic acti...
T8380 Bendamustine SDX105 Apoptosis , Others , DNA Alkylator/Crosslinker
Bendamustine (SDX105) for the treatment of Non-Hodgkin Lymphomas and Chronic Lymphocytic Leukemia
T8554 KCC-07 DNA Alkylator/Crosslinker
KCC-07 is a selective, potent and brain-penetrant inhibitor of methyl-CpG-binding domain protein 2(MBD2) with anticancer activity. KCC-07 prevents binding of MBD2 to methylated DNA and activates brain specific angiogenes...
T0975 Chlorambucil CB-1348,Chloroambucil,WR-139013 DNA Alkylator/Crosslinker , DNA Alkylation
Chlorambucil (CB-1348) is an orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arr...
T17159 Treosulfan NSC 39069,Treosulphan DNA Alkylator/Crosslinker , DNA Alkylation
Treosulfan (Treosulphan) is a bifunctional alkylating agent. It also has activity in ovarian cancer and other solid tumor types.
T1601 Lomustine CCNU,NSC 79037 Apoptosis , Others , DNA Alkylator/Crosslinker , DNA Alkylation , Autophagy
Lomustine (NSC-79037) is an alkylating agent of value against both hematologic malignancies and solid tumors.
T1798 RITA NSC 652287,RITA (NSC 652287) Mdm2 , DNA Alkylator/Crosslinker , p53 , Autophagy
RITA (NSC-652287)(NSC-652287) induced cross-links of both DNA-DNA and DNA-protein with no detectable DNA single-strand breaks. RITA, like nutlin-3, can disrupt the p53/Mdm2 interaction.
T0707 Cyclophosphamide hydrate Cyclophosphamide monohydrate DNA Alkylator/Crosslinker , DNA , MRP
Cyclophosphamide hydrate is a DNA alkylating agent, an inhibitor of DNA synthesis. Cyclophosphamide hydrate has antitumor and immunosuppressive activities.
T3091 Carmustine bis-chloroethylnitrosourea,Nitrumon,Gliadel,BCNU,BiCNU,Carmubris DNA Alkylator/Crosslinker , DNA Alkylation
Carmustine (bis-chloroethylnitrosourea) is a cell-cycle phase nonspecific alkylating antineoplastic agent.
T1250 Thio-TEPA Tiofosyl,Triethylenethiophosphoramide,Tiofosfamid DNA Alkylator/Crosslinker , DNA Alkylation , Antibacterial , Antibiotic
Thio-TEPA (Tiofosyl) is a polyfunctional, organophosphorus alkylating agent with antineoplastic activity.
T17212 VAL-083 Dianhydrogalactitol,Dianhydrodulcitol DNA Alkylator/Crosslinker , DNA Alkylation
VAL-083 (Dianhydrogalactitol) is an alkylating compound that creates N7 methylation on DNA. It also has antitumor activity.
T14858 Calicheamicin Calicheamicin γ1 Others
Calicheamicin (Calicheamicin γ1) is an antitumor antibiotic and is a DNA synthesis inhibitor. It also is a cytotoxic agent that causes double-strand DNA breaks.
T1488 Procarbazine hydrochloride NSC-77213 HCl,Procarbazine HCl DNA Alkylator/Crosslinker , DNA/RNA Synthesis
Procarbazine hydrochloride (NSC-77213 HCl) is the hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cytotoxicity has not been elucidated, procarba...
T4570 Pipobroman Vercyte,A-8103,Amedel Others , DNA Alkylator/Crosslinker
Pipobroman (Vercyte) is an anti-cancer drug that probably acts as an alkylating agent. Pipobroman has well documented clinical activity in polycythemia vera (PV) and essential thrombocythemia (ET). Pipobroman allows, wit...
T4350 Palifosfamide ZIO-201,Isophosphamide mustard,Isophosphoramide mustard DNA Alkylator/Crosslinker , DNA Alkylation , Drug Metabolite
Palifosfamide (Isophosphamide mustard) lysine (ZIO-201) is a stable form of palifosfamide. Palifosfamide lysine has broad activity in sarcoma lines in vitro. The IC50 ranges from 2.25 to 6.75 μM for most cell lines excep...
T6798 Tretazicar 5-Aziridino-2,4-dinitrobenzamide,CB1954,NSC 115829 DNA Alkylator/Crosslinker , DNA Alkylation
CB1954(Tretazicar (NSC-115829)), an anticancer prodrug, is activated by NAD(P)H quinone oxidoreductase 2. It is converted in the presence of the enzyme NQO2 and co-substrate caricotamide ( EP-0152R) (EP) into a potent cy...
T7221 Satraplatin BMS182751,JM216,BMY45594 DNA Alkylator/Crosslinker , DNA Alkylation
Satraplatin (BMS182751) is an orally available antineoplastic platinum(IV) complex.Satraplatin has a favorable toxicity profile and appears to have clinical activity against a variety of malignancies.
T1178 Temozolomide NSC 362856,TZM,CCRG 81045,TMZ Apoptosis , DNA Alkylator/Crosslinker , DNA/RNA Synthesis , Autophagy
Temozolomide (TMZ) is a DNA alkylating agent with blood-brain barrier permeability and oral activity. Temozolomide has antitumor activity and antiangiogenic activity, and also induces apoptosis and autophagy.
T0095 Bendamustine hydrochloride SDX-105,SDX-105 (Cytostasane) HCl,Bendamustine HCl,EP-3101 Apoptosis , DNA Alkylator/Crosslinker , DNA/RNA Synthesis
Bendamustine hydrochloride (EP-3101) (IC50 of 50 μM) is an alkylating agent associated with DNA damage.
T4459 PK11000 DNA Alkylator/Crosslinker
PK11000 is a p53 targeting compound, has anti-tumor activities through activation of unstable p53.
T1241 Altretamine Hexamethylmelamine,NSC13875,RB-1515,ENT-50852,WR-95704 DNA Alkylator/Crosslinker , DNA Alkylation
Altretamine (ENT-50852) is an alkylating agent with antineoplastic activity.
T4169 N-Nitroso-N-methylurea 1-Methyl-1-nitrosourea,N-Methyl-N-nitrosourea,Methylnitrosourea Others , DNA Alkylator/Crosslinker
N-Nitroso-N-methylurea (Methylnitrosourea) is a nitrosourea compound with alkylating, carcinogenic, and mutagenic properties.

Compounds

Cyclophosphamide
T0707L
Synonym:
Target: DNA Alkylator/Crosslinker, DNA, MRP
Miriplatin
T4368
Synonym: SM-11355
Target: DNA Alkylator/Crosslinker
Cisplatin
T1564
Synonym: cis-Diaminodichloroplatinum,CDDP
Target: DNA Alkylator/Crosslinker, Ferroptosis, DNA/RNA Synthesis, Autophagy
Oxaliplatin
T0164
Synonym: L-OHP
Target: DNA Alkylator/Crosslinker, DNA/RNA Synthesis, Autophagy
Duocarmycin TM
T11120
Synonym:
Target: DNA Alkylation, Antibiotic
Busulfan
T0923
Synonym: Myleran,Sulphabutin,Busulphan
Target: Apoptosis, DNA Alkylator/Crosslinker, DNA Alkylation
Lurbinectedin
T15793
Synonym: PM01183
Target: Others
Nimustine Hydrochloride
T5017
Synonym: Nidran hydrochloride
Target: Apoptosis, Others, DNA Alkylator/Crosslinker, DNA/RNA Synthesis
Carboplatin
T1058
Synonym: NSC 241240,CBDCA,JM-8
Target: DNA Alkylator/Crosslinker, DNA/RNA Synthesis, Autophagy
Ifosfamide
T1055
Synonym: NSC109724,Isophosphamide
Target: DNA Alkylator/Crosslinker, DNA/RNA Synthesis
Bendamustine
T8380
Synonym: SDX105
Target: Apoptosis, Others, DNA Alkylator/Crosslinker
KCC-07
T8554
Synonym:
Target: DNA Alkylator/Crosslinker
Chlorambucil
T0975
Synonym: CB-1348,Chloroambucil,WR-139013
Target: DNA Alkylator/Crosslinker, DNA Alkylation
Treosulfan
T17159
Synonym: NSC 39069,Treosulphan
Target: DNA Alkylator/Crosslinker, DNA Alkylation
Lomustine
T1601
Synonym: CCNU,NSC 79037
Target: Apoptosis, Others, DNA Alkylator/Crosslinker, DNA Alkylation, Autophagy
RITA
T1798
Synonym: NSC 652287,RITA (NSC 652287)
Target: Mdm2, DNA Alkylator/Crosslinker, p53, Autophagy
Cyclophosphamide hydrate
T0707
Synonym: Cyclophosphamide monohydrate
Target: DNA Alkylator/Crosslinker, DNA, MRP
Carmustine
T3091
Synonym: bis-chloroethylnitrosourea,Nitrumon,Gliadel,BCNU,BiCNU,Carmubris
Target: DNA Alkylator/Crosslinker, DNA Alkylation
Thio-TEPA
T1250
Synonym: Tiofosyl,Triethylenethiophosphoramide,Tiofosfamid
Target: DNA Alkylator/Crosslinker, DNA Alkylation, Antibacterial, Antibiotic
VAL-083
T17212
Synonym: Dianhydrogalactitol,Dianhydrodulcitol
Target: DNA Alkylator/Crosslinker, DNA Alkylation
Calicheamicin
T14858
Synonym: Calicheamicin γ1
Target: Others
Procarbazine hydrochloride
T1488
Synonym: NSC-77213 HCl,Procarbazine HCl
Target: DNA Alkylator/Crosslinker, DNA/RNA Synthesis
Pipobroman
T4570
Synonym: Vercyte,A-8103,Amedel
Target: Others, DNA Alkylator/Crosslinker
Palifosfamide
T4350
Synonym: ZIO-201,Isophosphamide mustard,Isophosphoramide mustard
Target: DNA Alkylator/Crosslinker, DNA Alkylation, Drug Metabolite
Tretazicar
T6798
Synonym: 5-Aziridino-2,4-dinitrobenzamide,CB1954,NSC 115829
Target: DNA Alkylator/Crosslinker, DNA Alkylation
Satraplatin
T7221
Synonym: BMS182751,JM216,BMY45594
Target: DNA Alkylator/Crosslinker, DNA Alkylation
Temozolomide
T1178
Synonym: NSC 362856,TZM,CCRG 81045,TMZ
Target: Apoptosis, DNA Alkylator/Crosslinker, DNA/RNA Synthesis, Autophagy
Bendamustine hydrochloride
T0095
Synonym: SDX-105,SDX-105 (Cytostasane) HCl,Bendamustine HCl,EP-3101
Target: Apoptosis, DNA Alkylator/Crosslinker, DNA/RNA Synthesis
PK11000
T4459
Synonym:
Target: DNA Alkylator/Crosslinker
Altretamine
T1241
Synonym: Hexamethylmelamine,NSC13875,RB-1515,ENT-50852,WR-95704
Target: DNA Alkylator/Crosslinker, DNA Alkylation
N-Nitroso-N-methylurea
T4169
Synonym: 1-Methyl-1-nitrosourea,N-Methyl-N-nitrosourea,Methylnitrosourea
Target: Others, DNA Alkylator/Crosslinker
Cat No. Product Name Synonyms Targets
T4558 Trioxsalen Trimethylpsoralen,Trioxysalen,Trisoralen DNA Alkylator/Crosslinker , DHFR
Trioxsalen (Trioxysalen) is a furanocoumarin and a psoralen derivative, in conjunction with UV-A for phototherapy treatment of vitiligo and hand eczema. After photoactivation it creates interstrand cross-links in DNA, wh...
T1507 Streptozocin STZ,Streptozotocin,NSC-85998,U 9889 DNA Alkylator/Crosslinker , DNA Alkylation , DNA/RNA Synthesis , Antibacterial , Antibiotic , Autophagy
Streptozocin (NSC-85998) is an antibiotic that induces DNA methylation. Streptozocin is toxic to insulin-producing pancreatic islet B-cells and is commonly used in the construction of animal models of type 1 diabetes. Th...
TargetMol