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Cat No. | Product Name | Synonyms | Targets |
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T0707L | Cyclophosphamide | DNA Alkylator/Crosslinker , DNA , MRP | |
Cyclophosphamide is an alkylating agent used in the treatment of several forms of cancer including leukemias, lymphomas and breast cancer. | |||
T4368 | Miriplatin | SM-11355 | DNA Alkylator/Crosslinker |
Miriplatin (SM-11355) (SM-11355) is a platinum complex used in TACE that has promise for the therapy of hepatocellular carcinoma (HCC). | |||
T1564 | Cisplatin | cis-Diaminodichloroplatinum,CDDP | DNA Alkylator/Crosslinker , Ferroptosis , DNA/RNA Synthesis , Autophagy |
Cisplatin (CDDP) is a DNA cross-linking agent. Cisplatin has antitumor activity and inhibits DNA synthesis by forming DNA adducts in cancer cells. Cisplatin also activates iron death and induces autophagy. | |||
T0164 | Oxaliplatin | L-OHP | DNA Alkylator/Crosslinker , DNA/RNA Synthesis , Autophagy |
Oxaliplatin (L-OHP) is a DNA alkylating agent, an inhibitor of DNA synthesis. Oxaliplatin causes DNA cross-linking damage, preventing DNA replication and transcription and leading to cell death. Oxaliplatin induces autop... | |||
T11120 | Duocarmycin TM | DNA Alkylation , Antibiotic | |
Duocarmycin TM is a DNA alkylator. Duocarmycin TM is an exceptionally potent antitumor antibiotic. | |||
T0923 | Busulfan | Myleran,Sulphabutin,Busulphan | Apoptosis , DNA Alkylator/Crosslinker , DNA Alkylation |
Busulfan (Busulphan) is a synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully understood, busulfan appears to act through the alkylation... | |||
T15793 | Lurbinectedin | PM01183 | Others |
Lurbinectedin (PM01183) is a DNA minor groove covalent binder. Lurbinectedin also shows effective anti-tumor activity. | |||
T5017 | Nimustine Hydrochloride | Nidran hydrochloride | Apoptosis , Others , DNA Alkylator/Crosslinker , DNA/RNA Synthesis |
Nimustine Hydrochloride (Nidran hydrochloride) has been used in trials studying the treatment of Glioblastoma. | |||
T1058 | Carboplatin | NSC 241240,CBDCA,JM-8 | DNA Alkylator/Crosslinker , DNA/RNA Synthesis , Autophagy |
Carboplatin (JM-8) is a cisplatin derivative, a DNA synthesis inhibitor. Carboplatin binds to DNA, inhibits replication and transcription, and induces cell death. Carboplatin has antitumor activity. | |||
T1055 | Ifosfamide | NSC109724,Isophosphamide | DNA Alkylator/Crosslinker , DNA/RNA Synthesis |
Ifosfamide (NSC-109724) alkylates and forms DNA crosslinks, thereby preventing DNA strand separation and DNA replication. Ifosfamide is a synthetic analog of the nitrogen mustard cyclophosphamide with antineoplastic acti... | |||
T8380 | Bendamustine | SDX105 | Apoptosis , Others , DNA Alkylator/Crosslinker |
Bendamustine (SDX105) for the treatment of Non-Hodgkin Lymphomas and Chronic Lymphocytic Leukemia | |||
T8554 | KCC-07 | DNA Alkylator/Crosslinker | |
KCC-07 is a selective, potent and brain-penetrant inhibitor of methyl-CpG-binding domain protein 2(MBD2) with anticancer activity. KCC-07 prevents binding of MBD2 to methylated DNA and activates brain specific angiogenes... | |||
T0975 | Chlorambucil | CB-1348,Chloroambucil,WR-139013 | DNA Alkylator/Crosslinker , DNA Alkylation |
Chlorambucil (CB-1348) is an orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arr... | |||
T17159 | Treosulfan | NSC 39069,Treosulphan | DNA Alkylator/Crosslinker , DNA Alkylation |
Treosulfan (Treosulphan) is a bifunctional alkylating agent. It also has activity in ovarian cancer and other solid tumor types. | |||
T1601 | Lomustine | CCNU,NSC 79037 | Apoptosis , Others , DNA Alkylator/Crosslinker , DNA Alkylation , Autophagy |
Lomustine (NSC-79037) is an alkylating agent of value against both hematologic malignancies and solid tumors. | |||
T1798 | RITA | NSC 652287,RITA (NSC 652287) | Mdm2 , DNA Alkylator/Crosslinker , p53 , Autophagy |
RITA (NSC-652287)(NSC-652287) induced cross-links of both DNA-DNA and DNA-protein with no detectable DNA single-strand breaks. RITA, like nutlin-3, can disrupt the p53/Mdm2 interaction. | |||
T0707 | Cyclophosphamide hydrate | Cyclophosphamide monohydrate | DNA Alkylator/Crosslinker , DNA , MRP |
Cyclophosphamide hydrate is a DNA alkylating agent, an inhibitor of DNA synthesis. Cyclophosphamide hydrate has antitumor and immunosuppressive activities. | |||
T3091 | Carmustine | bis-chloroethylnitrosourea,Nitrumon,Gliadel,BCNU,BiCNU,Carmubris | DNA Alkylator/Crosslinker , DNA Alkylation |
Carmustine (bis-chloroethylnitrosourea) is a cell-cycle phase nonspecific alkylating antineoplastic agent. | |||
T1250 | Thio-TEPA | Tiofosyl,Triethylenethiophosphoramide,Tiofosfamid | DNA Alkylator/Crosslinker , DNA Alkylation , Antibacterial , Antibiotic |
Thio-TEPA (Tiofosyl) is a polyfunctional, organophosphorus alkylating agent with antineoplastic activity. | |||
T17212 | VAL-083 | Dianhydrogalactitol,Dianhydrodulcitol | DNA Alkylator/Crosslinker , DNA Alkylation |
VAL-083 (Dianhydrogalactitol) is an alkylating compound that creates N7 methylation on DNA. It also has antitumor activity. | |||
T14858 | Calicheamicin | Calicheamicin γ1 | Others |
Calicheamicin (Calicheamicin γ1) is an antitumor antibiotic and is a DNA synthesis inhibitor. It also is a cytotoxic agent that causes double-strand DNA breaks. | |||
T1488 | Procarbazine hydrochloride | NSC-77213 HCl,Procarbazine HCl | DNA Alkylator/Crosslinker , DNA/RNA Synthesis |
Procarbazine hydrochloride (NSC-77213 HCl) is the hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cytotoxicity has not been elucidated, procarba... | |||
T4570 | Pipobroman | Vercyte,A-8103,Amedel | Others , DNA Alkylator/Crosslinker |
Pipobroman (Vercyte) is an anti-cancer drug that probably acts as an alkylating agent. Pipobroman has well documented clinical activity in polycythemia vera (PV) and essential thrombocythemia (ET). Pipobroman allows, wit... | |||
T4350 | Palifosfamide | ZIO-201,Isophosphamide mustard,Isophosphoramide mustard | DNA Alkylator/Crosslinker , DNA Alkylation , Drug Metabolite |
Palifosfamide (Isophosphamide mustard) lysine (ZIO-201) is a stable form of palifosfamide. Palifosfamide lysine has broad activity in sarcoma lines in vitro. The IC50 ranges from 2.25 to 6.75 μM for most cell lines excep... | |||
T6798 | Tretazicar | 5-Aziridino-2,4-dinitrobenzamide,CB1954,NSC 115829 | DNA Alkylator/Crosslinker , DNA Alkylation |
CB1954(Tretazicar (NSC-115829)), an anticancer prodrug, is activated by NAD(P)H quinone oxidoreductase 2. It is converted in the presence of the enzyme NQO2 and co-substrate caricotamide ( EP-0152R) (EP) into a potent cy... | |||
T7221 | Satraplatin | BMS182751,JM216,BMY45594 | DNA Alkylator/Crosslinker , DNA Alkylation |
Satraplatin (BMS182751) is an orally available antineoplastic platinum(IV) complex.Satraplatin has a favorable toxicity profile and appears to have clinical activity against a variety of malignancies. | |||
T1178 | Temozolomide | NSC 362856,TZM,CCRG 81045,TMZ | Apoptosis , DNA Alkylator/Crosslinker , DNA/RNA Synthesis , Autophagy |
Temozolomide (TMZ) is a DNA alkylating agent with blood-brain barrier permeability and oral activity. Temozolomide has antitumor activity and antiangiogenic activity, and also induces apoptosis and autophagy. | |||
T0095 | Bendamustine hydrochloride | SDX-105,SDX-105 (Cytostasane) HCl,Bendamustine HCl,EP-3101 | Apoptosis , DNA Alkylator/Crosslinker , DNA/RNA Synthesis |
Bendamustine hydrochloride (EP-3101) (IC50 of 50 μM) is an alkylating agent associated with DNA damage. | |||
T4459 | PK11000 | DNA Alkylator/Crosslinker | |
PK11000 is a p53 targeting compound, has anti-tumor activities through activation of unstable p53. | |||
T1241 | Altretamine | Hexamethylmelamine,NSC13875,RB-1515,ENT-50852,WR-95704 | DNA Alkylator/Crosslinker , DNA Alkylation |
Altretamine (ENT-50852) is an alkylating agent with antineoplastic activity. | |||
T4169 | N-Nitroso-N-methylurea | 1-Methyl-1-nitrosourea,N-Methyl-N-nitrosourea,Methylnitrosourea | Others , DNA Alkylator/Crosslinker |
N-Nitroso-N-methylurea (Methylnitrosourea) is a nitrosourea compound with alkylating, carcinogenic, and mutagenic properties. |
Cat No. | Product Name | Synonyms | Targets |
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T4558 | Trioxsalen | Trimethylpsoralen,Trioxysalen,Trisoralen | DNA Alkylator/Crosslinker , DHFR |
Trioxsalen (Trioxysalen) is a furanocoumarin and a psoralen derivative, in conjunction with UV-A for phototherapy treatment of vitiligo and hand eczema. After photoactivation it creates interstrand cross-links in DNA, wh... | |||
T1507 | Streptozocin | STZ,Streptozotocin,NSC-85998,U 9889 | DNA Alkylator/Crosslinker , DNA Alkylation , DNA/RNA Synthesis , Antibacterial , Antibiotic , Autophagy |
Streptozocin (NSC-85998) is an antibiotic that induces DNA methylation. Streptozocin is toxic to insulin-producing pancreatic islet B-cells and is commonly used in the construction of animal models of type 1 diabetes. Th... |