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Cat No. | Product Name | Synonyms | Targets |
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T1743 | Aprepitant | MK-869,MK-0869,L-754030,Aprepitant` | HIV Protease , Antibacterial , Antibiotic , Neurokinin receptor |
Aprepitant (Aprepitant`) is a Substance P/Neurokinin-1 Receptor Antagonist. The mechanism of action of aprepitant is as a Neurokinin 1 Antagonist, and Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 2C9 Inducer, and C... | |||
T2393 | Efavirenz | EFV,DMP 266,Sustiva,Stocrin,L-743726 | HIV Protease , Reverse Transcriptase , Autophagy |
Efavirenz (DMP 266) is a Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor. The mechanism of action of efavirenz is as a Non-Nucleoside Reverse Transcriptase Inhibitor, and Cytochrome P... | |||
T1434 | Clarithromycin | A-56268 | P450 , ribosome , MRP , Antibacterial , Antibiotic , Autophagy |
Clarithromycin (A-56268) is a Macrolide Antimicrobial. The mechanism of action of clarithromycin is as a Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 3A Inhibitor, and P-Glycoprotein Inhibitor. The chemical classif... | |||
T63954 | CYP3A4-IN-1 | ||
CYP3A4-IN-1 is a potent inhibitor of cytochrome P450 3A4 (CYP3A4) (IC50: 0.085 μM). | |||
T35714 | N-Desethyl Vardenafil | ||
N-Desethyl vardenafil is a metabolite of vardenafil , a phosphodiesterase 5 inhibitor, that is formed by the action of cytochrome P450 (CYP)3A4 and CYP3A5. | |||
T64032 | CYP3A4-IN-3 | ||
CYP3A4-IN-3 is a specific, highly affinity cytochrome P450 3A4 (CYP3A4) (cytochrome P450 3A4 (CYP3A4)) inhibitor (IC50: 0.075 μM). CYP3A4-IN-3 is an analogue of ritonavir with a simpler structure and twice as much inhibi... | |||
T64037 | CYP3A4-IN-2 | ||
CYP3A4-IN-2 is a specific inhibitor of cytochrome P450 3A4 (CYP3A4) (IC50: 0.055 μM). CYP3A4-IN-2 is a ritonavir analogue with a more hydrophobic R2 side group and stronger inhibition than ritonavir. CYP3A4-IN-2 is capab... | |||
T37788 | Resorufin benzyl ether | ||
Resorufin benzyl ether is a fluorometric probe that acts as a substrate for cytochrome P450 (CYP)3A4. It is typically used near its apparent Km value of 30 μM to screen the inhibition/activation potential of test compoun... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T82556 | Dihydrocubebin | (-)-Dihydrocubebin | |
Dihydrocubebin, isolated from Piper cubeba, serves as a potent and selective inhibitor of cytochrome P450 3A4 (CYP3A4) [1]. |
Cat No. | Product Name | Species | Expression System |
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TMPY-05321 | CYP3A4 Protein, Human, Recombinant (His) | Human | E. coli |
CYP3A4 is an important member of the cytochrome P450 enzyme superfamily, with 33 allelic variants. Human cytochrome P450 3A4 (CYP3A4) is an important drug metabolizing enzyme involved in a number of drug-drug and food-dr... |