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Search Result

Search Results for " chloride-channel "

Targets

Sodium Channel

39

Compounds

8

Natural Products

13

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T12608 QX-314 chloride Sodium Channel
QX-314 chloride is a membrane-impermeable permanently charged blocker of sodium channel.
T7638 NPPB Chloride channel
NPPB is a chloride channel blocker with IC50 of 80 nM .
T15192 Eact Chloride channel
Eact is a selective and potent TMEM16A activator. It directly activates the TRPV1 channels in sensory nociceptors. Which also produces itch, acute nociception and thermal hypersensitivity.
T8960 MONNA Chloride channel
MONNA is a potent TMEM16A (Anoctamin-1) blocker (IC50 : 80 nM). It induces vasorelaxation of rodent resistance arteries in presence or absence of chloride ions.
T7538 Tetraethylammonium chloride Potassium Channel
Tetraethylammonium chloride is a quaternary ammonium compound. It is a non-selective potassium channel blocker. It is a good substrate for organic cation transporter proteins and has antitumor properties.
T10979 DCPIB Potassium Channel , Chloride channel
DCPIB, a known specific and potent inhibitor of volume-regulated anion channels (VRAC),DCPIB displayed superior selectivity toward TRESK with an IC50 of 0.14 μM, demonstrating at least 100-fold higher affinity over TREK1...
T0979 Dequalinium chloride Dequafungan,Danical,Decabis Potassium Channel , PKC
Dequalinium chloride (Decabis) , a topical bacteriostat, is a selective blocker of apamin-sensitive K+ channels. It is used in wound dressings and mouth infections and may also have antifungal action, but may cause skin ...
T8391 Cesium chloride CsCl Potassium Channel
Cesium chloride (CsCl) is considered to be the most toxic of the alkali chlorides, inhibiting fungal growth.
T13059 T16Ainh-A01 Chloride channel
T16Ainh-A01 is a potent inhibitor of TMEM16A Chloride channel, inhibiting TMEM16A-mediated chloride currents (IC50 of 1 µM),and functions as a calcium-activated chloride channel (CaCC).
T16346 NS1652 Chloride channel
NS1652 is an anion conductance inhibitor. NS1652 blocks chloride channel has an IC50 of 1.6 μM in human and mouse red blood cells.
T23213 QX-222 chloride QX 222,Lidocaine N-Methyl Hydrochloride Sodium Channel
QX-222 chloride (Lidocaine N-Methyl Hydrochloride) is a sodium channel blocker.
T7191 Diphenyleneiodonium chloride DPI NOS , Reactive Oxygen Species , NADPH , TRP/TRPV Channel
Diphenyleneiodonium chloride (DPI)(DPI) is an irreversible inhibitor of iNOS and eNOS (IC50 values of 50 nM and 0.3 μM, respectively),and displays broad-spectrum bactericidal activity.
T15233 Endovion NS3728 Chloride channel
Endovion (NS3728) is a pharmacological anion channel and an Anoctamin-1 (ANO 1) channel inhibitor. Endovion is also the specific VRAC/VSOAC blocker.
T0275 Meticrane Fontiliz,Arresten Chloride channel , Sodium Channel
Meticrane (Arresten) is a sulphonamide-derivative with thiazide-like diuretic activity.
T0858 Flufenamic acid Arlef,Nichisedan,Achless Potassium Channel , Calcium Channel , Chloride channel , COX , AMPK , Parasite
Flufenamic acid (Arlef) is an anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties. It is used in musculoskeletal and joint disorders and administered by mouth and topically.
T2498 Adjudin AF-2364 Chloride channel , Mitochondrial Metabolism
Adjudin (AF-2364) is a small molecule compound known to possess antispermatogenic function, attenuates microglia activation by suppression of the NF-κB pathway.
T0693 Niflumic acid Nifluril,Forenol,Landruma Others , Phospholipase , Chloride channel , COX , Monocarboxylate transporter , UGT
Niflumic acid (Nifluril) is a Ca2+-activated Cl- channel blocker and an analgesic and anti-inflammatory agent used in the therapy of rheumatoid arthritis.
T4330 CaCCinh-A01 Chloride channel
CaCCinh-A01 is an inhibitor of the calcium-activated chloride channel (CaCC, 10 μM) and TMEM16A (IC50: 2.1 μM).
T1049 Oxybutynin chloride Oxybutynin hydrochloride,Oxybutynin HCl Potassium Channel , AChR
Oxybutynin chloride (Oxybutynin HCl) is an anticholinergic medication used to relieve urinary and bladder difficulties. It competitively antagonizes the M1, M2, and M3 subtypes of the muscarinic acetylcholine receptor.
T13536 Afoxolaner Chloride channel , GABA Receptor , Parasite
Afoxolaner is an isoxazoline insecticide/acaricide against Ixodes scapularis in dogs. Afoxolaner acts on the insect GABA and glutamate receptors, inhibiting GABA & glutamate-regulated uptake of chloride ions, resulting i...
T4503 Talniflumate Somalgen Chloride channel , COX , N-Acetylglucosaminyltransferase , Anion Exchanger
Talniflumate (Somalgen) is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cell culture. It possesses anti-inflammatory actions via inhibition o...
T22330 Fenamic acid 2-Anilinobenzoic acid,Diphenylamine-2-carboxylic acid,2-(Phenylamino)benzoic acid,N-Phenylanthranilic acid Chloride channel
Fenamic acid (N-Phenylanthranilic acid) is a chloride channel blocker that causes renal papillary necrosis in rats. Fenamic acid serves as a parent structure for several nonsteroidal anti-inflammatory drugs (NSAIDs), inc...
T4059 Selamectin UK-124114 Chloride channel , P-gp , Parasite
Selamectin (UK-124114) is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes. In an H. contortus larval development assay, sel...
T6307 Lubiprostone SPI-0211,RU-0211 Chloride channel
Lubiprostone (RU-0211), an activator of ClC-2 chloride channels, is used in the therapy of idiopathic chronic constipation.
T15212 Emamectin Benzoate MK-244 Apoptosis , Reactive Oxygen Species , GABA Receptor , Parasite
Emamectin Benzoate (MK-244), by binding gamma-aminobutyric acid (GABA) receptor and glutamate-gated chloride channels disrupting nerve signals within arthropods, acts as a chloride channel activator.
T5454 N-(p-amylcinnamoyl) Anthranilic Acid ACA Phospholipase , TRP/TRPV Channel
N-(p-amylcinnamoyl) Anthranilic Acid (ACA) is a broad spectrum Phospholipase A2 (PLA2) inhibitor and TRP channel blocker.
T0124 UK-124114 UNII-A2669OWX9N,Selamectin Others
UK-124114 (Selamectin) is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes. In an H. contortus larval development assay, sel...
T1240 Flumazenil Ro 15-1788 GABA Receptor
Flumazenil (Ro 15-1788) antagonizes the benzodiazepine binding site of the gamma-aminobutyric acid (GABA)/benzodiazepine receptor complex in the central nervous system (CNS), thereby preventing the chloride channel openi...
T69610 Taplucainium chloride
Taplucainium chloride is a sodium channel blocker with applications as a pain reliever.
T69550 NS-3736
NS-3736 is a chloride channel inhibitor that has been shown to prevent osteoclastic acidification and resorption.
T35734 Doramectin monosaccharide
Doramectin monosaccharide is an acid degradation product of doramectin , a disaccharide-containing anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes. Doramectin undergoes acid-...
T61818 DFBTA
DFBTA is a highly effective and orally active inhibitor of ANO1, specifically the calcium-activated chloride channel anoctamin-1. It exhibits potent inhibitory activity, with an IC 50 of 24 nM. Notably, DFBTA demonstrate...
T37748 Ivermectin B1b
Ivermectin B1b is the minor component . It produces antiparasitic activity by binding to glutamate-gated chloride channels expressed on nematode neurons and pharyngeal muscle cells, inducing irreversible channel opening ...
TP1285 Chlorotoxin(linear)
Chlorotoxin(linear) is a linear 36 amino-acid peptide which can be used in Chlorotoxin related research. Chlorotoxin is a chloride channel blocker which has been found in the venom of the Egyptian scorpion Leiurus quinqu...
T40750 12,14-Dichlorodehydroabietic acid
12,14-Dichlorodehydroabietic acid, a chlorinated resin acid, exhibits potent calcium-activated potassium (BK) channel opening activity. It effectively inhibits GABA-dependent chloride influx in the mammalian brain, funct...
T35733 Doramectin aglycone
Doramectin aglycone is an acid degradation product of doramectin , a disaccharide-containing anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes, and its acid-catalyzed hydrolysi...
T37756 Phloxine B
Phloxine B is a red dye, the USP grade of which is used as a color additive for food, drugs, and cosmetics. It has also been used as an alternative to Gram staining, to differentiate between Gram-negative and Gram-positi...
T79578 CFTR corrector 12 CFTR
CFTR Corrector 12 (Compound 17C), a bithiazole derivative, functions as a CFTR corrector by remedying certain folding-defective mutants of the channel that regulates chloride transport across the plasma membrane. Additio...
T35746 Milbemycin A3
Milbemycin A3 is a member of a complex family of macrocyclic lactones that contain a characteristic spiroketal group produced from the fermentation of soil bacterium S. hygroscopicus subsp. aureolacrimosus. As a compound...

Compounds

QX-314 chloride
T12608
Synonym:
Target: Sodium Channel
NPPB
T7638
Synonym:
Target: Chloride channel
Eact
T15192
Synonym:
Target: Chloride channel
MONNA
T8960
Synonym:
Target: Chloride channel
Tetraethylammonium chloride
T7538
Synonym:
Target: Potassium Channel
DCPIB
T10979
Synonym:
Target: Potassium Channel, Chloride channel
Dequalinium chloride
T0979
Synonym: Dequafungan,Danical,Decabis
Target: Potassium Channel, PKC
Cesium chloride
T8391
Synonym: CsCl
Target: Potassium Channel
T16Ainh-A01
T13059
Synonym:
Target: Chloride channel
NS1652
T16346
Synonym:
Target: Chloride channel
QX-222 chloride
T23213
Synonym: QX 222,Lidocaine N-Methyl Hydrochloride
Target: Sodium Channel
Diphenyleneiodonium chloride
T7191
Synonym: DPI
Target: NOS, Reactive Oxygen Species, NADPH, TRP/TRPV Channel
Endovion
T15233
Synonym: NS3728
Target: Chloride channel
Meticrane
T0275
Synonym: Fontiliz,Arresten
Target: Chloride channel, Sodium Channel
Flufenamic acid
T0858
Synonym: Arlef,Nichisedan,Achless
Target: Potassium Channel, Calcium Channel, Chloride channel, COX, AMPK, Parasite
Adjudin
T2498
Synonym: AF-2364
Target: Chloride channel, Mitochondrial Metabolism
Niflumic acid
T0693
Synonym: Nifluril,Forenol,Landruma
Target: Others, Phospholipase, Chloride channel, COX, Monocarboxylate transporter, UGT
CaCCinh-A01
T4330
Synonym:
Target: Chloride channel
Oxybutynin chloride
T1049
Synonym: Oxybutynin hydrochloride,Oxybutynin HCl
Target: Potassium Channel, AChR
Afoxolaner
T13536
Synonym:
Target: Chloride channel, GABA Receptor, Parasite
Talniflumate
T4503
Synonym: Somalgen
Target: Chloride channel, COX, N-Acetylglucosaminyltransferase, Anion Exchanger
Fenamic acid
T22330
Synonym: 2-Anilinobenzoic acid,Diphenylamine-2-carboxylic acid,2-(Phenylamino)benzoic acid,N-Phenylanthranilic acid
Target: Chloride channel
Selamectin
T4059
Synonym: UK-124114
Target: Chloride channel, P-gp, Parasite
Lubiprostone
T6307
Synonym: SPI-0211,RU-0211
Target: Chloride channel
Emamectin Benzoate
T15212
Synonym: MK-244
Target: Apoptosis, Reactive Oxygen Species, GABA Receptor, Parasite
N-(p-amylcinnamoyl) Anthranilic Acid
T5454
Synonym: ACA
Target: Phospholipase, TRP/TRPV Channel
UK-124114
T0124
Synonym: UNII-A2669OWX9N,Selamectin
Target: Others
Flumazenil
T1240
Synonym: Ro 15-1788
Target: GABA Receptor
Taplucainium chloride
T69610
Synonym:
Target:
NS-3736
T69550
Synonym:
Target:
Doramectin monosaccharide
T35734
Synonym:
Target:
DFBTA
T61818
Synonym:
Target:
Ivermectin B1b
T37748
Synonym:
Target:
Chlorotoxin(linear)
TP1285
Synonym:
Target:
12,14-Dichlorodehydroabietic acid
T40750
Synonym:
Target:
Doramectin aglycone
T35733
Synonym:
Target:
Phloxine B
T37756
Synonym:
Target:
CFTR corrector 12
T79578
Synonym:
Target: CFTR
Milbemycin A3
T35746
Synonym:
Target:
Cat No. Product Name Synonyms Targets
T1221 Acetylcholine chloride ACh chloride,Pilofrin Calcium Channel , Endogenous Metabolite , AChR
Acetylcholine Chloride is the chloride salt form of acetylcholine, a synthetic, quaternary amino alcohol with cholinergic properties. Acetylcholine chloride (Pilofrin) mimics the parasympathomimetic effect of the endogen...
TN1035 Irisolidone IL Receptor , NF-κB , Chloride channel
Irisolidone is a potent volume-regulated anion channel (VRAC) current inhibitor, it exhibits high efficacy for VRAC blockade with IC50s of 5-13 μM.
T1125 Shikonin NSC 252844,Isoarnebin 4,(+)-Shikonin,Alkanna Red,C.I. 75535,Anchusa acid TNF , NF-κB , Chloride channel , HIV Protease , PKM
Shikonin (Anchusa acid) is a natural product, a TMEM16A chloride channel inhibitor (IC50=6.5 μM) and selective PKM2 inhibitor. Shikonin exhibits antitumor, anti-inflammatory and wound healing activities.
T16535 Picrotoxinin Chloride channel , GABA Receptor
Picrotoxinin is a blocker of chloride channel and a noncompetitive antagonist of GABAA with an IC50 of 1.15 μM for α1β2γ2L GABAA. Picrotoxinin shows convulsant properties.
T1131 Ivermectin MK-933 Mitophagy , GluCls , P2X Receptor , SARS-CoV , HIV Protease , Antibiotic , Parasite , Autophagy , HSV
Ivermectin (MK-933) is a glutamate-gated chloride channel (GluCls) activator, with antiparasitic activity.
T75722 Chlorotoxin TFA
Chlorotoxin TFA, a peptide derived from the Leiurus quinquestriatus scorpion venom, functions as a chloride channel blocker [1] and exhibits anti-cancer activity [2].
TN1834 Kobusin Others , NOS , NF-κB
Kobusin, a Calmodulin inhibitor, shows mild antiplasmodial,anti-inflammatory, and cytotoxic activities; it may be beneficial for the treatment of neuro-inflammatory diseases through the inhibition of iNOS expression and ...
TN3351 Aflatrem GABA Receptor
Aflatrem is a tremorgenic mycotoxin with acute neurotoxic effects, a single low dose of aflatrem is able to induce degeneration of neuronal processes in hippocampal neurotransmitter systems. Aflatrem potentiates the gamm...

Natural Products

Acetylcholine chloride
T1221
Synonym: ACh chloride,Pilofrin
Target: Calcium Channel, Endogenous Metabolite, AChR
Irisolidone
TN1035
Synonym:
Target: IL Receptor, NF-κB, Chloride channel
Shikonin
T1125
Synonym: NSC 252844,Isoarnebin 4,(+)-Shikonin,Alkanna Red,C.I. 75535,Anchusa acid
Target: TNF, NF-κB, Chloride channel, HIV Protease, PKM
Picrotoxinin
T16535
Synonym:
Target: Chloride channel, GABA Receptor
Ivermectin
T1131
Synonym: MK-933
Target: Mitophagy, GluCls, P2X Receptor, SARS-CoV, HIV Protease, Antibiotic, Parasite, Autophagy, HSV
Chlorotoxin TFA
T75722
Synonym:
Target:
Kobusin
TN1834
Synonym:
Target: Others, NOS, NF-κB
Aflatrem
TN3351
Synonym:
Target: GABA Receptor

Recombinant Proteins

Species：
Human (12)
Rabbit (1)
Expression System：
E. coli (12)
HEK293 (1)
Tag：
His (3)
N-terminal 6xHis-tagged (3)
N-6His (2)
N-terminal 10xHis-tagged and C-terminal Myc-tagged (2)
C-6His (1)
N-6His,C-Fc (1)
N-GST (1)
Cat No. Product Name Species Expression System
TMPJ-01363 CLIC5 Protein, Human, Recombinant (His) Human E. coli
Chloride Intracellular Channel Protein 5 (CLIC5) is a single-pass membrane protein which belongs to the chloride channel CLIC family. It contains one GST C-terminal domain. Chloride intracellular channels are involved in...
TMPJ-00719 CLIC3 Protein, Human, Recombinant (His) Human E. coli
Chloride intracellular channel protein 3 (CLIC3) is encoded by the CLIC3 gene. CLIC3 is a single-pass membrane protein which belongs to the chloride channel CLIC family. It contains one GST C-terminal domain and one GST ...
TMPY-04075 CLIC1 Protein, Human, Recombinant (His) Human E. coli
Members of the CLIC family are largely soluble proteins that possess the intriguing property of spontaneous insertion into phospholipid bilayers to form integral membrane ion channels. Chloride intracellular channel 1 (C...
TMPJ-00666 CLIC2 Protein, Human, Recombinant (His) Human E. coli
Chloride Intracellular Channel Protein 2 (CLIC2) is a critical component of all living cells; it regulatescellular traffic of Chloride ion and it can be inserted into membranes anf form chloride ion channels. Membrane in...
TMPY-01890 CLIC4 Protein, Human, Recombinant (His) Human E. coli
Chloride intracellular channel protein 4, also known as Intracellular chloride ion channel protein p64H1 and CLIC4, is a member of the chloride channel CLIC family. It contains oneGST C-terminal domain. CLIC4 is a mem...
TMPH-03209 CLNS1A Protein, Rabbit, Recombinant (His & Myc) Rabbit E. coli
Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins. Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blo...
TMPH-02331 GLRA1 Protein, Human, Recombinant (His & Myc) Human E. coli
Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel opening is also triggered by taurine and beta-alanine. Channel characteristics depend on the subunit co...
TMPH-01368 GABRP Protein, Human, Recombinant (His) Human E. coli
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. In the uterus, the function of th...
TMPH-01367 GABRB2 Protein, Human, Recombinant (His) Human E. coli
Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain. Plays an important role in the formation of functional inhibitory GABAergi...
TMPH-01366 GABRA1 Protein, Human, Recombinant (His) Human E. coli
Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain. Plays an important role in the formation of functional inhibitory GABAergi...
TMPY-03629 Syntaxin 8 Protein, Human, Recombinant (His) Human HEK293
STX8, also known as syntaxin 8, directly interacts with HECTd3. STX8 forms the SNARE complex with syntaxin 7, vti1b and endobrevin. STX8 belongs to the syntaxin family. Members of this family are key molecules implicated...
TMPJ-00015 GABARAP Protein, Human, Recombinant (His & hFc) Human E. coli
Gamma-Aminobutyric Acid Receptor-Associated Protein (GABARAP) is a ligand-gated chloride channel protein that mediates inhibitory neurotransmission and belongs to the MAP1 LC3 family. GABARAP is highly positively charged...
TMPJ-00016 GABARAP Protein, Human, Recombinant (GST) Human E. coli
Gamma-Aminobutyric Acid Receptor-Associated Protein (GABARAP) is a ligand-gated chloride channel protein that mediates inhibitory neurotransmission and belongs to the MAP1 LC3 family. GABARAP is highly positively charged...
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