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Membrane transporter/Ion channel Chloride channel

Chloride channel

Chloride channels are a superfamily of poorly understood ion channels specific for chloride. These channels may conduct many different ions, but are named for chloride because its concentration in vivo is much higher than other anions. Several families of voltage-gated channels and ligand-gated channels have been characterized in humans.
Cat No. product name
T8960 MONNA MONNA is a potent TMEM16A (Anoctamin-1) blocker (IC50 : 80 nM). It induces vasorelaxation of rodent resistance arteries in presence or absence of chloride ions.
T4503 Talniflumate Talniflumate is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cell culture. It poss...
T6307 Lubiprostone Lubiprostone, an activator of ClC-2 chloride channels, is used in the therapy of idiopathic chronic constipation.
T0954 Anestan Halothane is a nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adeq...
T2498 Adjudin Adjudin is a small molecule compound known to possess antispermatogenic function, attenuates microglia activation by suppression of the NF-κB pathway.
T0051 Urethane Urethane was an antineoplastic agent .Now is used for other medicinal purposes.
T0019 Betaine hydrochloride Betaine hydrochloride is an acidic form of betaine, a vitamin-like substance observed in grains and other foods; gains the amplification of DNA by decreasing the...
T0052L Strychnine Sulfate In smaller doses, strychnine functions as a stimulant and an athletic performance-enhancer. The most common source is from the seeds of the Strychnos nux-vomica ...
T4330 CaCCinh-A01 CaCCinh-A01 is an inhibitor of the calcium-activated chloride channel (CaCC, 10 μM) and TMEM16A (IC50: 2.1 μM).
T1125 (+)-Shikonin Shikonin is an TMEM16A chloride channel inhibitor (IC50: 6.5 μM). Shikonin is also a selective PKM2 inhibitor and can also suppress activation of the NF-κB pat...
T4811 D-Alanine Alanine is a nonessential amino acid made in the body from the conversion of the carbohydrate pyruvate or the breakdown of DNA and the dipeptides carnosine and a...
T16346 NS1652 NS1652 is an anion conductance inhibitor. NS1652 blocks chloride channel has an IC50 of 1.6 μM in human and mouse red blood cells.
T5225 Hypotaurine Hypotaurine, an intermediate in taurine biosynthesis from cysteine in astrocytes, is an endogenous inhibitory amino acid of the glycine receptor.
T7638 NPPB NPPB is a chloride channel blocker with IC50 of 80 nM .
T8039 Brucine sulfate heptahydrate Brucine is an alkaloid that acts as an antagonist at glycine receptors and paralyzes inhibitory neurons.
TN1035 Irisolidone Irisolidone is a potent volume-regulated anion channel (VRAC) current inhibitor, it exhibits high efficacy for VRAC blockade with IC50s of 5-13 μM.
T10979 DCPIB DCPIB, a known specific and potent inhibitor of volume-regulated anion channels (VRAC),DCPIB displayed superior selectivity toward TRESK with an IC50 of 0.14 μM...
T13536 Afoxolaner Afoxolaner is an isoxazoline insecticide/acaricide against Ixodes scapularis in dogs. Afoxolaner acts on the insect GABA and glutamate receptors, inhibiting GABA...
T15192 Eact Eact is a selective and potent TMEM16A activator. It directly activates the TRPV1 channels in sensory nociceptors. Which also produces itch, acute nociception an...
T15233 Endovion Endovion is a pharmacological anion channel and an Anoctamin-1 (ANO 1) channel inhibitor. Endovion is also the specific VRAC/VSOAC blocker.
T13059 T16Ainh-A01 T16Ainh-A01 is a potent inhibitor of TMEM16A Chloride channel, inhibiting TMEM16A-mediated chloride currents (IC50 of 1 µM),and functions as a calcium-activated...
T0275 Meticrane Meticrane is a sulphonamide-derivative with thiazide-like diuretic activity.
MONNA
T8960CAS 1572936-83-4
MONNA is a potent TMEM16A (Anoctamin-1) blocker (IC50 : 80 nM). It induces vasorelaxation of rodent resistance arteries in presence or absence of chloride ions.
Talniflumate
T4503CAS 66898-62-2
Talniflumate is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cell culture. It poss...
Lubiprostone
T6307CAS 136790-76-6
Lubiprostone, an activator of ClC-2 chloride channels, is used in the therapy of idiopathic chronic constipation.
Anestan
T0954CAS 151-67-7
Halothane is a nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adeq...
Adjudin
T2498CAS 252025-52-8
Adjudin is a small molecule compound known to possess antispermatogenic function, attenuates microglia activation by suppression of the NF-κB pathway.
Urethane
T0051CAS 51-79-6
Urethane was an antineoplastic agent .Now is used for other medicinal purposes.
Betaine hydrochloride
T0019CAS 590-46-5
Betaine hydrochloride is an acidic form of betaine, a vitamin-like substance observed in grains and other foods; gains the amplification of DNA by decreasing the...
Strychnine Sulfate
T0052LCAS 60-41-3
In smaller doses, strychnine functions as a stimulant and an athletic performance-enhancer. The most common source is from the seeds of the Strychnos nux-vomica ...
CaCCinh-A01
T4330CAS 407587-33-1
CaCCinh-A01 is an inhibitor of the calcium-activated chloride channel (CaCC, 10 μM) and TMEM16A (IC50: 2.1 μM).
(+)-Shikonin
T1125CAS 517-89-5
Shikonin is an TMEM16A chloride channel inhibitor (IC50: 6.5 μM). Shikonin is also a selective PKM2 inhibitor and can also suppress activation of the NF-κB pat...
D-Alanine
T4811CAS 338-69-2
Alanine is a nonessential amino acid made in the body from the conversion of the carbohydrate pyruvate or the breakdown of DNA and the dipeptides carnosine and a...
NS1652
T16346CAS 1566-81-0
NS1652 is an anion conductance inhibitor. NS1652 blocks chloride channel has an IC50 of 1.6 μM in human and mouse red blood cells.
Hypotaurine
T5225CAS 300-84-5
Hypotaurine, an intermediate in taurine biosynthesis from cysteine in astrocytes, is an endogenous inhibitory amino acid of the glycine receptor.
NPPB
T7638CAS 107254-86-4
NPPB is a chloride channel blocker with IC50 of 80 nM .
Brucine sulfate heptahydrate
T8039CAS 60583-39-3
Brucine is an alkaloid that acts as an antagonist at glycine receptors and paralyzes inhibitory neurons.
Irisolidone
TN1035CAS 2345-17-7
Irisolidone is a potent volume-regulated anion channel (VRAC) current inhibitor, it exhibits high efficacy for VRAC blockade with IC50s of 5-13 μM.
DCPIB
T10979CAS 82749-70-0
DCPIB, a known specific and potent inhibitor of volume-regulated anion channels (VRAC),DCPIB displayed superior selectivity toward TRESK with an IC50 of 0.14 μM...
Afoxolaner
T13536CAS 1093861-60-9
Afoxolaner is an isoxazoline insecticide/acaricide against Ixodes scapularis in dogs. Afoxolaner acts on the insect GABA and glutamate receptors, inhibiting GABA...
Eact
T15192CAS 461000-66-8
Eact is a selective and potent TMEM16A activator. It directly activates the TRPV1 channels in sensory nociceptors. Which also produces itch, acute nociception an...
Endovion
T15233CAS 265646-85-3
Endovion is a pharmacological anion channel and an Anoctamin-1 (ANO 1) channel inhibitor. Endovion is also the specific VRAC/VSOAC blocker.
T16Ainh-A01
T13059CAS 552309-42-9
T16Ainh-A01 is a potent inhibitor of TMEM16A Chloride channel, inhibiting TMEM16A-mediated chloride currents (IC50 of 1 µM),and functions as a calcium-activated...
Meticrane
T0275CAS 1084-65-7
Meticrane is a sulphonamide-derivative with thiazide-like diuretic activity.