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Search Results for " cathepsin b "

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T80052	Cathepsin B
	Cathepsin B, a cysteine protease, plays a role in various forms of programmed cell death, such as apoptosis, pyroptosis, ferroptosis, necroptosis, and autophagic cell death [1].
T3420	CA-074 methyl ester	Cathepsin B Inhibitor IV,CA-074Me	Cysteine Protease
	CA-074 methyl ester (Cathepsin B Inhibitor IV) is a specific inhibitor of Cathepsin B with neuroprotective, anti-cancer, and anti-inflammatory effects.		Cysteine Protease
T27989	MDK0734	Cathepsin B Inhinitor-42
	MDK0734 is a selective inhibitor of cathepsin B endopeptidase and exopeptidase activities.
T28003	MDK7677	Cathepsin B Inhinitor-17,MDK 7677
	MDK7677 is a selective inhibitor of cathepsin B endopeptidase and exopeptidase activities.
T10924	Cysteine protease inhibitor-2		Cysteine Protease
	Cysteine protease inhibitor 2 is a cysteine protease inhibitor. Cysteine protease inhibitor 2 inhibited DCT116 and PC3 cells with GI50 values of 6.5 μM and 4.4 μM, respectively.		Cysteine Protease
T6015	Cathepsin Inhibitor 1		Cysteine Protease
	Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively.		Cysteine Protease
T21509	CA 074		Cysteine Protease
	CA 074 is a potent inhibitor of cathepsin B with a Ki value of 2 to 5 nM.CA 074 inhibits ischemic hippocampal neuronal death in primates and attenuates retinopathy and optic neuritis in experimental autoimmune encephalom...		Cysteine Protease
T13288	VBY-825		Cysteine Protease
	VBY-825 is a reversible inhibitor of cathepsin with high potency against cathepsins B, L, S and V.		Cysteine Protease
T37504L	Cathepsin D and E FRET Substrate acetate(839730-93-7 Free base)	Cathepsin D and E FRET Substrate acetate(839730-93-7 Free base)
	Cathepsin D and E FRET Substrate acetate is a fluorogenic substrate for cathepsins D and E but not for B, H, or L. Cathepsin D and E FRET Substrate acetate can be used in mechanistic studies on cathepsins D and E studies...
T16089	MK-0674		Cysteine Protease
	MK-0674 is an orally available, selective and potent cathepsin K inhibitor (IC50: 0.4 nM) that inhibits Cat B, Cat F, Cat L, and Cat S. It can be used in metabolism-related diseases.		Cysteine Protease
T1850	Balicatib	AAE581	Cysteine Protease
	Balicatib (AAE581) is a potent and selective inhibitor of cathepsin K, used in trials studying the treatment of osteoporosis.		Cysteine Protease
T15641	K777	APC-3316	P450 , Cysteine Protease , CCR
	K777 is a potent, orally active and irreversible inhibitor of cysteine protease. K777 is a potent CYP3A4 inhibitor (IC50= 60 nM). K777 is also a selective CCR4 antagonist featuring the potent chemotaxis inhibition. K777 ...		P450 , Cysteine Protease , CCR
T16092	L-873724		Others
	L-873724 inhibits bone resorption. L-873724 is an effective, selective, and reversible non-basic cathepsin K inhibitor (IC50s: 0.2, 178, 264, and 5239 nM for cathepsin K, cathepsin S, cathepsin L, cathepsin B, respective...		Others
T37053	Z-(L-Arg)-AMC (hydrochloride)
	Z-(L-Arg)-AMC is a fluorogenic substrate for trypsin, cathepsin B, and cathepsin H.1,2Upon enzymatic cleavage by trypsin, cathepsin B, or cathepsin H, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can b...
T80739	Z-FG-NHO-BzOME
	Z-FG-NHO-BzOME is a chemical compound functioning as a cysteine protease inhibitor, selectively targeting and inhibiting cathepsin B, cathepsin L, cathepsin S, and papain [1].
T78186	Ac-VLPE-FMK	Ac-Val-Leu-Pro-Glu(OMe)-CH2F
	Ac-VLPE-FMK, a tetrapeptidyl mono-fluoromethyl ketone (m-FMK), functions as an inhibitor of both Cathepsin B (Cat-B) and Cathepsin L (Cat-L), and is utilized in research pertaining to the aggressiveness of cancer [1] [2]...
T75367	Z-Arg-Arg-4MβNA triacetate
	Z-Arg-Arg-4MβNA triacetate serves as a specific substrate for cathepsin B, resulting in the generation of the fluorescent end product 4MβNA, which exhibits an excitation wavelength (λ ex) of 355 nm and an emission wavele...
T76599	Ac-Leu-Val-Lys-Aldehyde
	Ac-Leu-Val-Lys-Aldehyde is a potent inhibitor of cathepsin B, exhibiting inhibitory concentration (IC50) values of 4 nM. It notably diminishes cell death in the striatum induced by quinolinic acid and leads to the accumu...
T73220	RO5461111
	RO5461111, a highly specific and orally active Cathepsin S antagonist, exhibits potent inhibitory effects with IC50 values of 0.4 nM (human Cathepsin S) and 0.5 nM (murine Cathepsin S), respectively. It effectively suppr...
T38254	Cathepsin D and E FRET Substrate acetate
	Cathepsin D and E FRET Substrate acetate is a fluorogenic substrate selectively cleaved by cathepsins D and E at the Phe-Phe amide bond, without activity towards cathepsins B, H, or L. This specificity makes it an essent...
T15064	DBCO-NHCO-PEG4-NHS ester		Others
	DBCO-NHCO-PEG4-NHS ester ester is a MMP-2- and cathepsin B- (CatB) cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].		Others
T73554	SPR38
	SPR38, a potent inhibitor of the SARS-CoV-2 main protease, exhibits a Ki value of 0.260 μM. Additionally, it effectively inhibits human cathepsin L (hCatL) and human cathepsin B (hCatB), displaying Ki values of 1.92 μM a...
T36942	SSAA09E1	SSAA09E1
	SSAA09E1 is an inhibitor of severe acute respiratory syndrome coronavirus (SARS-CoV) viral entry.1It reduces infection of HEK293T cells transiently transfected with angiotensin-converting enzyme 2 (ACE2) by an HIV-based ...
TP2161	Z-WEHD-FMK		Caspase
	Z-WEHD-FMK is a cell-permeable and irreversible inhibitor of caspase-1/5. It also shows a robust inhibitory effect on cathepsin B activity (IC50: 6 μM).		Caspase
T73553	SPR39
	SPR39, a potent inhibitor of the SARS-CoV-2 main protease (Mpro), demonstrates inhibitory Ki values of 0.252 µM for SARS-CoV-2 Mpro, and 3.38 and 7.88 µM for human Cathepsin L (hCatL) and human Cathepsin B (hCatB) respec...
T62494	Cathepsin C-IN-5
	Cathepsin C-IN-5 (compound SF38) is a potent, selective, and orally active inhibitor of Cathepsin C, demonstrating IC50 values of 59.9 nM for Cat C, and showing significantly lower potency against Cat L (4.26 µM), Cat S,...
T6564L	Leupeptin	Leupeptin Ac-LL,NK-381
	Leupeptin is a competitive protease inhibitor produced by actinomycetes. Leupeptin can inhibit cysteine, serine and threonine peptidases. Leupeptin inhibits serine proteinases (trypsin (Ki=3.5 nM), plasmin (Ki= 3.4 nM), ...
T21949	Calpain Inhibitor XII
	(Rac)-Calpain Inhibitor XII is a reversible and selective inhibitor targeting calpain I (μ-calpain) with a Ki value of 19 nM. It exhibits lower affinities for calpain II (m-calpain, Ki=120 nM) and cathepsin B (Ki=750 nM)...
T11864	Iptacopan	LNP023	Others
	Iptacopan (LNP023) is an inhibitor with high affinity for factor B.		Others
T69297	Leupeptin HCl
	Leupeptin is a naturally occurring protease inhibitor that can inhibit cysteine, serine and threonine peptidases. Leupeptin is an organic compound produced by actinomycetes. Leupeptin inhibits serine proteinases (trypsin...

Compounds

Synonym: Cathepsin B Inhibitor IV,CA-074Me

Target: Cysteine Protease

MDK0734

T27989

Synonym: Cathepsin B Inhinitor-42

Target:

MDK7677

T28003

Synonym: Cathepsin B Inhinitor-17,MDK 7677

Target:

Cysteine protease inhibitor-2

T10924

Synonym:

Target: Cysteine Protease

Cathepsin Inhibitor 1

T6015

Synonym:

Target: Cysteine Protease

CA 074

T21509

Synonym:

Target: Cysteine Protease

VBY-825

T13288

Synonym:

Target: Cysteine Protease

Cathepsin D and E FRET Substrate acetate(839730-93-7 Free base)

T37504L

Synonym: Cathepsin D and E FRET Substrate acetate(839730-93-7 Free base)

Target: Cysteine Protease

Balicatib

T1850

Synonym: AAE581

Target: Cysteine Protease

K777

T15641

Synonym: APC-3316

Target: P450, Cysteine Protease, CCR

Z-(L-Arg)-AMC (hydrochloride)

Synonym: Ac-Val-Leu-Pro-Glu(OMe)-CH2F

Target:

Z-Arg-Arg-4MβNA triacetate

T75367

Synonym:

Target:

Ac-Leu-Val-Lys-Aldehyde

Cathepsin D and E FRET Substrate acetate

T38254

Synonym:

Target:

DBCO-NHCO-PEG4-NHS ester

Synonym: Leupeptin Ac-LL,NK-381

Target:

Calpain Inhibitor XII

Cat No.	Product Name	Synonyms	Targets
T6564	Leupeptin Hemisulfate		Serine Protease , Cysteine Protease
	Leupeptin hemisulfate is a protease inhibitor with cell membrane-permeable, reversible, competitive, and oral activities. Leupeptin hemisulfate inhibits the activity of Cathepsin B, Cathepsin H, and Cathepsin L, and bloc...		Serine Protease , Cysteine Protease
TN1249	3-Epiursolic acid		Cysteine Protease , Immunology/Inflammation related
	3-Epiursolic acid may have antiinflammatory activity, it shows inhibition on Cathepsins L (catL), the IC50 value of 6.5 μM, cathepsins L (catL) and B play an important role in tumor progression and have been considered p...		Cysteine Protease , Immunology/Inflammation related
TJS2216	Aurantiamide acetate	Asperglaucide	Cysteine Protease
	Aurantiamide acetate (Asperglaucide) was isolated from the fermentation broth of Aspergillus penicilloides for the first time. Aurantiamide acetate is a selective and orally active cathepsin inhibitor. Aurantiamide aceta...		Cysteine Protease
T3417	Amentoflavone	Didemethyl-ginkgetin,Amenthoflavone,3',8''-Biapigenin	Apoptosis , P450 , Phospholipase , Reactive Oxygen Species , Opioid Receptor , COX , Antibacterial , RSV , Antifungal
	Amentoflavone (3',8''-Biapigenin), as a potent inhibitor of CYP3A4 and CYP2C9, can interact with many other medications. CYP3A4 and CYP2C9 are proteins used for drug metabolism in the body. Amentoflavone also is an inhib...

Natural Products

Leupeptin Hemisulfate

T6564

Synonym:

Target: Serine Protease, Cysteine Protease

3-Epiursolic acid

TN1249

Synonym:

Target: Cysteine Protease, Immunology/Inflammation related

Aurantiamide acetate

TJS2216

Synonym: Asperglaucide

Target: Cysteine Protease

Amentoflavone

T3417

Synonym: Didemethyl-ginkgetin,Amenthoflavone,3',8''-Biapigenin

Target: Apoptosis, P450, Phospholipase, Reactive Oxygen Species, Opioid Receptor, COX, Antibacterial, RSV, Antifungal

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-00731	Cathepsin B Protein, Human, Recombinant (His)	Human	HEK293
	Cathepsin B is a papain-family cysteine protease that is normally located in lysosomes, where it is involved in the turnover of proteins and plays various roles in maintaining the normal metabolism of cells. This proteas...
TMPY-04503	Cathepsin B Protein, Rat, Recombinant (His)	Rat	HEK293
	Cathepsin B is a papain-family cysteine protease that is normally located in lysosomes, where it is involved in the turnover of proteins and plays various roles in maintaining the normal metabolism of cells. This proteas...
TMPY-02144	Cathepsin B Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Cathepsin B is a papain-family cysteine protease that is normally located in lysosomes, where it is involved in the turnover of proteins and plays various roles in maintaining the normal metabolism of cells. This proteas...
TMPH-01059	Cathepsin B Protein, Human, Recombinant (GST)	Human	E. coli
	Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Cleaves matrix extracellular phosphoglycoprotein MEPE. Involved in the solubilization of cross-linked TG/thyroglobuli...
TMPJ-00497	CTSB Protein, Human, Recombinant (His)	Human	Human Cells
	Cathepsin B is an enzymatic protein belonging to the peptidase (or protease) families. The protein encoded by this gene is a lysosomal cysteine protease composed of a dimer of disulfide-linked heavy and light chains, bot...
TMPY-00735	Cathepsin S Protein, Human, Recombinant (His)	Human	HEK293
	Cathepsin S (CTSS), one of the lysosomal proteinases, has many important physiological functions in the nervous system, especially in process of extracellular matrix degradation and endocellular antigen presentation. CTS...
TMPY-02751	Cathepsin S Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Cathepsin S (CTSS), one of the lysosomal proteinases, has many important physiological functions in the nervous system, especially in process of extracellular matrix degradation and endocellular antigen presentation. CTS...
TMPY-02699	Cathepsin Z Protein, Human, Recombinant (His)	Human	HEK293
	Cathepsin Z (CTSZ), also known as Cathepsin X or CATX, belongs to the C1 family of lysosomal cysteine proteases. Its gene structure and activity properties show several unique features that distinguish it clearly from ot...
TMPY-00736	Cathepsin Z Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Cathepsin Z (CTSZ), also known as Cathepsin X or CATX, belongs to the C1 family of lysosomal cysteine proteases. Its gene structure and activity properties show several unique features that distinguish it clearly from ot...
TMPY-00362	Cathepsin S Protein, Rat, Recombinant (His)	Rat	HEK293
	Cathepsin S (CTSS), one of the lysosomal proteinases, has many important physiological functions in the nervous system, especially in process of extracellular matrix degradation and endocellular antigen presentation. CTS...
TMPJ-00845	CTSE Protein, Human, Recombinant (His)	Human	Human Cells
	Cathepsin E (CTSE) is a gastric aspartyl protease that functions as a disulfide-linked homodimer. It is a member of the Peptidase C1 family, and has a specificity similar to that of Pepsin A and Cathepsin D. CTSE is loca...
TMPY-01644	Cystatin S Protein, Human, Recombinant (His)	Human	HEK293
	Cystatin-S, also known as Cystatin-4, Salivary acidic protein 1, Cystatin-SA-III and CST4, is a secreted protein which belongs to thecystatin family. Cystatin-4 / CST4 is expressed in submandibular and sublingual sali...
TMPJ-00869	GLB1 Protein, Human, Recombinant (His)	Human	Human Cells
	β Galactosidase is a lysosomal β Galactosidase that hydrolyzes the terminal β Galactose from Ganglioside and Keratan sulfate. In lysosome, the mature β Galactosidase protein associates with Cathepsin A and Neuraminidase ...
TMPY-00768	CST6 Protein, Human, Recombinant (His)	Human	HEK293
	Cystatin E/M, also referred to as CST6, is a member of type 2 cysteine proteinase inhibitors of the cystatin superfamily, and inhibits papain and cathepsin B. Cystatin E is a low molecular mass secreted protein existing ...
TMPY-02665	CST6 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Cystatin E/M, also referred to as CST6, is a member of type 2 cysteine proteinase inhibitors of the cystatin superfamily, and inhibits papain and cathepsin B. Cystatin E is a low molecular mass secreted protein existing ...
TMPK-01413	H-2K (b) &B2M&OVA (SIINFEKL) Monomer Protein, Mouse, MHC (His & Avi)	Mouse	HEK293
	Ovalbumin (OVA) has been historically a popular source of such antigens, since OVA can induce both humoral and cellular immune responses based on well-characterised peptide epitopes. The OVA257-264 octapeptide was one of...
TMPK-01416	HLA-B*15:01&B2M&SARS-CoV-2 epitope (NQKLIANQF) Monomer Protein, Human, MHC (His & Avi), Biotinylated	Human	HEK293
	HLA-B15:01 is strongly associated with asymptomatic infection with SARS-CoV-2 and is likely to be involved in the mechanism underlying early viral clearance. T cells from pre-pandemic individuals carrying HLA-B15:01 we...
TMPK-01412	HLA-B*15:01&B2M&SARS-CoV-2 epitope (NQKLIANQF) Monomer Protein, Human, MHC (His & Avi)	Human	HEK293
	HLA-B15:01 is strongly associated with asymptomatic infection with SARS-CoV-2 and is likely to be involved in the mechanism underlying early viral clearance. T cells from pre-pandemic individuals carrying HLA-B15:01 we...