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Search Result

Search Results for " cannabinoid cb1 receptor "

Targets

Cannabinoid Receptor

75

Compounds

5

Natural Products

2

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T14881 CB1 antagonist 2 AM4113 Cannabinoid Receptor
CB1 antagonist 2 (AM4113) is caimabinoid 1 (CB1) antagonist which inhibits CB1 in vivo with an IC50 of 25.5 nM.
T8511 TM38837 Cannabinoid Receptor
TM38837 is an antagonist of cannabinoid receptor type 1 (CB1), with potential for the treatment of obesity and type 2 diabetes.
T9466 RTICBM-189 Others
RTICBM-189 is a potent, brain-penetrant allosteric modulator of the cannabinoid type-1 (CB1) receptor with a pIC50 of 7.54 in Ca2+ mobilization assay. RTICBM-189 has pIC50s of 5.29 and 6.25 for hCB1 and mCB1, respectivel...
T12306 OMDM-5 Cannabinoid Receptor , Endogenous Metabolite , TRP/TRPV Channel
OMDM-5 is a selective anandamide cellular uptake (ACU)inhibitor(Ki of 4.8 μM).
T2264 AM281 Cannabinoid Receptor
AM 281, a cannabinoid antagonist, reduces neurologic dysfunction and mortality rate after cecal ligation and puncture in rats.
T5996 CB1-IN-1 DBPR211 Cannabinoid Receptor
CB1-IN-1 (DBPR211) is a peripherally restricted CB1R antagonist, for CB1R and CB2R with Ki of 0.3 nM and 21 nM,respectively.
T12302 OMDM-1 (Z)-N-[(2S)-1-hydroxy-3-(4-hydroxyphenyl)propan-2-yl]octadec-9-enamide Endogenous Metabolite
OMDM-1 ((Z)-N-[(2S)-1-hydroxy-3-(4-hydroxyphenyl)propan-2-yl]octadec-9-enamide) is a selective and metabolically stable anandamide cellular uptake (ACU)inhibitor with a Ki of 2.4 μM.
T29930 AM-1235 AM 1235,AM1235 Cannabinoid Receptor
AM-1235 is a potent and selective cannabinoid receptor CB1 agonist.
T22114 NESS 0327 Cannabinoid Receptor
NESS 0327 is a high selectivity antagonist of the cannabinoid CB1 receptor. NESS 0327 is more than 60,000-fold selective for the CB1 receptor.
T2635 Org 27569 Cannabinoid Receptor
Org 27569, an allosteric modulator of cannabinoid CB1 receptor, can induce a CB1 receptor state that is characterized by decreased inverse agonist affinity and enhanced agonist affinity.
T6527 GW842166X Cannabinoid Receptor
GW842166X is a potent and highly selective agonist of cannabinoid receptor CB2 receptor with EC50 of 63 nM, shows no significant activity at CB1 receptor. Phase 2.
T6755 AM1241 Cannabinoid Receptor
AM-1241 is a selective cannabinoid CB2 receptor agonist with Ki of 3.4 nM, exhibits 82-fold selectivity over CB1 receptor.
T1519 Rimonabant hydrochloride SR 151716A,SR 141716A Cannabinoid Receptor , Antibacterial
Rimonabant hydrochloride (SR 141716A) is a cannabinoid receptor antagonist, binding selectively to central cannabinoid receptors (CB1) with high affinity.
T79909 AEF0117 Cannabinoid Receptor
AEF0117, a signaling-specific inhibitor of cannabinoid receptor 1 (CB1-SSi), inhibits cannabinoid self-administration and behavioral disorders associated with THC, and can be used to study cannabis withdrawal.
T7375 A-836339 Cannabinoid Receptor
A-836339 acts as a potent cannabinoid receptor full agonist which has a higher affinity for the peripheral CB2 receptor (Ki = 0.64 nM) over the central CB1 receptor (Ki = 270 nM). It displays analgesic, anti-inflammatory...
T41350 6-Bromopravadoline WIN 54461 Cannabinoid Receptor
6-Bromopravadoline (WIN 54461) (WIN 54461) is an antagonist of CB1. 6-Bromopravadoline acts as an inhibitor of the binding of [3H]Win 55212-2 (IC 50 =515 nM) reflective of cannabinoid receptor binding [1] [2].
T7316 LY2828360 Cannabinoid Receptor
LY2828360 is a cannabinoid (CB) receptor 2 agonist (Ki = 40.3 nM). It selectively activates CB2 over CB1 in a GTPγS binding assay (EC50s = 20.1 and >100,000 nM, respectively).
T1519L Rimonabant SR141716 Cannabinoid Receptor , Antibacterial , Acyltransferase
Rimonabant (SR141716) is an inverse agonist for the cannabinoid receptor CB1. It is an anorectic anti-obesity drug produced and marketed by Sanofi-Aventis. Its main avenue of effect is a reduction in appetite. Rimonabant...
T36520 COR659 Cannabinoid Receptor , GABA Receptor
COR659 is a GABAB positive allosteric modulator (PAM) . COR659 suppresses alcohol and chocolate self-administration in rats[1]. COR659 apparently exerts its effects via a composite mechanism, including positive allosteri...
T3530 Otenabant CP-945598 Cannabinoid Receptor
Otenabant (CP-945598) has been investigated for the treatment of Obesity.
T41231 GP 1a Cannabinoid Receptor , PERK , Arrestin
GP 1a is a potent agonist of cannabinoid receptor 2 (CB2) (EC50=7.1), as shown in cAMP, GTPγS and β-arrestin recruitment assays. GP 1a is approximately 30-fold more selective for CB2 receptors than CB1 receptors and incr...
T27803 LBP-1 LBP1
LBP-1 is a cannabinoid receptor type 1 (CB1) agonist.
T28657 SAD-448
SAD-448 is a cannabinoid receptor type 1 (CB1) agonist. SAD-448 controls spasticity via action on the peripheral nerve CB1 receptor.
T29929 AM-1220 AM 1220,AM1220
AM-1220 is a potent and moderately selective agonist of the cannabinoid receptor CB1.
T13081 Taranabant racemate MK-0364 racemate Cannabinoid Receptor
Taranabant racemate is an antagonist and/or inverse agonist of the Cannabinoid-1 (CB1) receptor.
T28006 MDMB-CHMINACA (S)-MDMB-CHMINACA
MDMB-CHMINACA, an indazole-based synthetic cannabinoid, acts as a potent agonist of the CB1 receptor.
T32336 JWH-149
JWH 149, a synthetic cannabinoid (CB), can potently bind both the central CB1 receptor (Ki = 5.0 nM) and the peripheral CB2 receptor (Ki = 0.73 nM).
T24231 JWH-198 JWH 198
JWH 198 is a synthetic cannabinoid. It binds the central CB1 receptor with high affinity (Ki: 10 nM).
T68515 AZD-1175
AZD-1175 is a cannabinoid receptor CB1 antagonist and highly lipophilic compound for the treatment of type 2 diabetes and obesity.
T32341 JWH-251
JWH 251, a cannabimimetic indole, has a high affinity tothe central cannabinoid (CB1) receptor (Ki = 29 nM) and a comparatively modest affinity for the peripheral cannabinoid (CB2) receptor (Ki = 146 nM). JWH 251 can st...
T24230 JWH-193 JWH 193
JWH 193 is a synthetic cannabinoid (CB) that binds the central CB1 receptor with high affinity (Ki: 6 nM).
T25874 NMP-7 NMP7,NMP 7
NMP-7 is a non-selective CB1 and CB2 cannabinoid receptor agonist that works by blocking T-type calcium channels.
T14504 BAY 38-7271 Cannabinoid Receptor
BAY 38-7271 has strong neuroprotective properties.[1] BAY 38-7271 is selective and highly potent and cannabinoid CB1/CB2 receptor agonist. With Kis of 1.85 nM and 5.96 nM for recombinant human CB1 receptor and CB2 recept...
T61105 GAT228
GAT228, an allosteric ligand for the cannabinoid receptor 1 (CB1), functions as the enantiomer of GAT211 [1].
T17027 Tedalinab GRC-10693 Cannabinoid Receptor
Tedalinab is an effective and selective cannabinoid receptor 2 agonist. Tedalinab has the potential for neuropathic pain and osteoarthritis treatment. Tedalinab has >4700-fold functional selectivity for CB2 over CB1.
T68500 AZD-2207
AZD-2207 is a cannabinoid receptor CB1 antagonist and highly lipophilic compound for the treatment of type 2 diabetes mellitus and obesity.
T30103 APP-CHMINACA PX-3,PX3
APP-CHMINACA is a synthetic cannabinoid (CB) featuring a 1-(cyclohexylmethyl)-1H-indazole-3-carboxamide (CHMINACA) base. It displays a 10-fold greater affinity for the central CB1 receptor than that of JWH 018.
T79137 Monlunabant (S)-MRI-1891 Cannabinoid Receptor
Monlunabant ((S)-MRI-1891), a solid dispersion compound, functions as an inhibitor of the cannabinoid CB1 receptor [1].
T24939 Virodhamine trifluoroacetate Virodhamine-trifluoroacetate,Virodhamine trifluoroacetate salt
Virodhamine trifluoroacetate is an antagonist of endogenous cannabinoid receptor mixed that acts by being a full agonist at GPR55 and CB2 and partial antagonist at CB1.
T24218 JTE 7-31
JTE 7-31 is a selective agonist of the cannabinoid receptor. It is a reasonably highly selective CB2 agonist (Ki: 0.088 nM at CB2 vs 11 nM at CB1).
T32334 JWH-098
JWH 098, a potent synthetic cannabinoid (CB), can activate the CB1 receptor with a Ki value of 4.5 nM and the CB2 receptor with a Ki value of 1.88 nM. Its effects in cells and animals are still on study.
T32582 LASSBio-881 LASSBio881,LASSBio 881
LASSBio-881 is a non-selective partial agonist of the CB1 and CB2 cannabinoid receptors, as well as an antagonist of the TRPV1 receptor.
T32338 JWH-182 JWH182
JWH 182, a potent synthetic cannabinoid (CB) can activate the central CB1 receptor and the peripheral CB2 receptor with a Ki value of 0.65 nM and 1.1 nM, respectively. Its effects in cells and animals have not evaluated.
T39410 Zevaquenabant (S)-MRI-1867
Zevaquenabant ((S)-MRI-1867), a dual cannabinoid CB1 receptor and inducible NOS (iNOS) antagonist, is orally bioavailable and peripherally restricted. It effectively mitigates obesity-induced chronic kidney disease (CKD)...
T32331 JWH 072 JWH072,JWH-072
JWH 072 , known as synthetic cannabinoid (CB), displays a higher affinity to the peripheral CB2 receptor (Ki = 170 nM) than the central CB1 receptor (Ki = 1,050 nM). Its physiological and toxicological properties are sti...
T13080L Taranabant MK-0364 Cannabinoid Receptor
Taranabant (MK-0364) is a selective and potent cannabinoid 1 (CB1) receptor inverse agonist used in the study of obesity and nicotine dependence.
T38049 Glycerophospho-N-Palmitoyl Ethanolamine
N-Acylated ethanolamines (NAE) are naturally-occurring lipids that have diverse bioactivities. For example, arachidonoyl ethanolamide (AEA) is an endogenous neurotransmitter that evokes cellular responses by activating t...
T38199 (±)-WIN 55,212 (mesylate)
(±)-WIN 55,212-2 is a potent aminoalkylindole cannabinoid (CB) receptor agonist with a Ki value of 62.3 and 3.3 nM for human recombinant central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors, respectively....
T30903 CHM-081 CHM 081
JWH 081, a cannabimimetic aminoalkylindole, has a high-affinity to the central cannabinoid (CB1) receptor (Ki =1.2 nM) and ten-fold reduced affinity to the peripheral cannabinoid (CB2) receptor (Ki = 12.4 nM). JWH 081-N-...
T78674 Isopropyl dodec-11-enylfluorophosphonate IDEFP FAAH
Isopropyl dodec-11-enylfluorophosphonate (IDEFP) is an organophosphorus ester functioning as a central cannabinoid receptor (CB1) antagonist and exhibits equipotent inhibition of fatty acid amide hydrolase (FAAH), with b...

Compounds

CB1 antagonist 2
T14881
Synonym: AM4113
Target: Cannabinoid Receptor
TM38837
T8511
Synonym:
Target: Cannabinoid Receptor
RTICBM-189
T9466
Synonym:
Target: Others
OMDM-5
T12306
Synonym:
Target: Cannabinoid Receptor, Endogenous Metabolite, TRP/TRPV Channel
AM281
T2264
Synonym:
Target: Cannabinoid Receptor
CB1-IN-1
T5996
Synonym: DBPR211
Target: Cannabinoid Receptor
OMDM-1
T12302
Synonym: (Z)-N-[(2S)-1-hydroxy-3-(4-hydroxyphenyl)propan-2-yl]octadec-9-enamide
Target: Endogenous Metabolite
AM-1235
T29930
Synonym: AM 1235,AM1235
Target: Cannabinoid Receptor
NESS 0327
T22114
Synonym:
Target: Cannabinoid Receptor
Org 27569
T2635
Synonym:
Target: Cannabinoid Receptor
GW842166X
T6527
Synonym:
Target: Cannabinoid Receptor
AM1241
T6755
Synonym:
Target: Cannabinoid Receptor
Rimonabant hydrochloride
T1519
Synonym: SR 151716A,SR 141716A
Target: Cannabinoid Receptor, Antibacterial
AEF0117
T79909
Synonym:
Target: Cannabinoid Receptor
A-836339
T7375
Synonym:
Target: Cannabinoid Receptor
6-Bromopravadoline
T41350
Synonym: WIN 54461
Target: Cannabinoid Receptor
LY2828360
T7316
Synonym:
Target: Cannabinoid Receptor
Rimonabant
T1519L
Synonym: SR141716
Target: Cannabinoid Receptor, Antibacterial, Acyltransferase
COR659
T36520
Synonym:
Target: Cannabinoid Receptor, GABA Receptor
Otenabant
T3530
Synonym: CP-945598
Target: Cannabinoid Receptor
GP 1a
T41231
Synonym:
Target: Cannabinoid Receptor, PERK, Arrestin
LBP-1
T27803
Synonym: LBP1
Target:
SAD-448
T28657
Synonym:
Target:
AM-1220
T29929
Synonym: AM 1220,AM1220
Target:
Taranabant racemate
T13081
Synonym: MK-0364 racemate
Target: Cannabinoid Receptor
MDMB-CHMINACA
T28006
Synonym: (S)-MDMB-CHMINACA
Target:
JWH-149
T32336
Synonym:
Target:
JWH-198
T24231
Synonym: JWH 198
Target:
AZD-1175
T68515
Synonym:
Target:
JWH-251
T32341
Synonym:
Target:
JWH-193
T24230
Synonym: JWH 193
Target:
NMP-7
T25874
Synonym: NMP7,NMP 7
Target:
BAY 38-7271
T14504
Synonym:
Target: Cannabinoid Receptor
GAT228
T61105
Synonym:
Target:
Tedalinab
T17027
Synonym: GRC-10693
Target: Cannabinoid Receptor
AZD-2207
T68500
Synonym:
Target:
APP-CHMINACA
T30103
Synonym: PX-3,PX3
Target:
Monlunabant
T79137
Synonym: (S)-MRI-1891
Target: Cannabinoid Receptor
Virodhamine trifluoroacetate
T24939
Synonym: Virodhamine-trifluoroacetate,Virodhamine trifluoroacetate salt
Target:
JTE 7-31
T24218
Synonym:
Target:
JWH-098
T32334
Synonym:
Target:
LASSBio-881
T32582
Synonym: LASSBio881,LASSBio 881
Target:
JWH-182
T32338
Synonym: JWH182
Target:
Zevaquenabant
T39410
Synonym: (S)-MRI-1867
Target:
JWH 072
T32331
Synonym: JWH072,JWH-072
Target:
Taranabant
T13080L
Synonym: MK-0364
Target: Cannabinoid Receptor
Glycerophospho-N-Palmitoyl Ethanolamine
T38049
Synonym:
Target:
(±)-WIN 55,212 (mesylate)
T38199
Synonym:
Target:
CHM-081
T30903
Synonym: CHM 081
Target:
Isopropyl dodec-11-enylfluorophosphonate
T78674
Synonym: IDEFP
Target: FAAH
1 2
Cat No. Product Name Synonyms Targets
T2S0271 Voacamine Voacanginine Cannabinoid Receptor , P-gp
Voacamine (Voacanginine) is an indole alkaloid. Voacamine exhibits potent cannabinoid CB1 receptor antagonistic activity. Voacamine also inhibits P-glycoprotein (P-gp) action in multidrug-resistant tumor cells.Voacangini...
TC0019 Pregnenolone acetate 3β-Hydroxy-5-pregnen-20-one acetate Cannabinoid Receptor , Endogenous Metabolite
Pregnenolone acetate is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. It acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of te...
TN5131 Tetrahydrocannabivarin THCV,delta9-Tetrahydrocannabivarin,CRM,Tetrahydrocannavarin Cannabinoid Receptor
Tetrahydrocannabivarin (CRM) is a neutral cannabis receptor subtype (CB1) receptor antagonist, it can increases neural responding to rewarding and aversive stimuli, this effect profile suggests therapeutic activity in ob...
T11834 Leelamine hydrochloride Others
Leelamine hydrochloride, a tricyclic diterpene extracted from pine tree bark, inhibits the transcriptional activity of the androgen receptor, known to regulate fatty acid synthesis [2,3]. This compound acts as a cannabin...
T16574 Pregnenolone monosulfate sodium salt 3β-Hydroxy-5-pregnen-20-one monosulfate sodium salt Others
Pregnenolone monosulfate sodium salt is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium salt can protect the brain from cannabis intoxica...

Natural Products

Voacamine
T2S0271
Synonym: Voacanginine
Target: Cannabinoid Receptor, P-gp
Pregnenolone acetate
TC0019
Synonym: 3β-Hydroxy-5-pregnen-20-one acetate
Target: Cannabinoid Receptor, Endogenous Metabolite
Tetrahydrocannabivarin
TN5131
Synonym: THCV,delta9-Tetrahydrocannabivarin,CRM,Tetrahydrocannavarin
Target: Cannabinoid Receptor
Leelamine hydrochloride
T11834
Synonym:
Target: Others
Pregnenolone monosulfate sodium salt
T16574
Synonym: 3β-Hydroxy-5-pregnen-20-one monosulfate sodium salt
Target: Others

Recombinant Proteins

Species：
Human (1)
Rat (1)
Expression System：
HEK293 (1)
in vitro E. coli expression system (1)
Tag：
C-terminal 10xHis-tagged (This tag can be tested only under denaturing conditions) (1)
N-terminal 10xHis-tagged (1)
Cat No. Product Name Species Expression System
TMPH-03256 CNR1 Protein, Rat, Recombinant (His) Rat in vitro E. coli expression system
G-protein coupled receptor for cannabinoids, including endocannabinoids (eCBs), such as N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effe...
TMPH-01035 CNR1 Protein-VLP, Human, Recombinant (His) Human HEK293
G-protein coupled receptor for endogenous cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG), as well as phytocannabinoids, such as delta(9)-tetrah...
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