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Membrane transporter/Ion channel Calcium Channel

Calcium Channel

A calcium channel is an ion channel which shows selective permeability to calcium ions. It is sometimes synonymous with voltage-gated calcium channel, although there are also ligand-gated calcium channels.
Cat No. product name
T0077 Dantrolene sodium salt Dantrolene is a skeletal muscle relaxant and can interfere with excitation-contraction coupling in the muscle fiber. It is used for the treatment of spasticity ...
T0112 Diltiazem hydrochloride Diltiazem Hydrochloride is a benzothiazepine calcium channel blocking agent with vasodilating action due to its antagonism of the actions of CALCIUM ion on memb...
T0119 Nitrendipine Nitrendipine is a calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel block...
T0121 Azelnidipine Azelnidipine is a dihydropyridine used as calcium channel blocker.
T0145 Felodipine Felodipine is a longlasting 1,4-dihydropyridine calcium channel repressor.
T0163 Nisoldipine Nisoldipine is a dihydropyridine calcium channel antagonist that acts as a potent arterial vasodilator and antihypertensive agent.
T0192 Levetiracetam Levetiracetam is a relatively unique anticonvulsant that is typically used in combination with other antiepileptic medications for partial onset seizures. Levet...
T0193 Manidipine dihydrochloride Manidipine dihydrochloride is a potent calcium channel blocker for Ca2+ current(IC50=2.6 nM).
T0207 Ranolazine dihydrochloride Ranolazine(RS-43285), an antianginal agent, can treat arrhythmia via a novel mechanism of action (inhibition of the late phase of the inward sodium current), an...
T0231 Amlodipine Besylate Amlodipine Besylate is a long-lasting calcium channel blocker.
T0267 Zonisamide Zonisamide, a sulfonamide anticonvulsant, is approved for use as an adjunctive treatment in adults with partial-onset seizures. It may inhibit a carbonic anhydr...
T0283 Trimethadione Trimethadione is a dione-type anticonvulsant with antiepileptic activity.
T0327 Fendiline hydrochloride Fendiline is a non-selective blocker of calcium channel.
T0343 Nimodipine Nimodipine, a 1, 4-dihydropyridine calcium channel blocker, acts primarily on vascular smooth muscle cells.
T0388 Cilnidipine Cilnidipine(FRC8653) is a dual L- and N-type calcium channel blocker and displays antihypertensive, sympatholytic and neuroprotective activity.
T0702 Gabapentin Gabapentin is a GABA analogue, used to treat seizures and neuropathic pain.
T0728 Ethosuximide Ethosuximide is an anticonvulsant, blocks the low voltage-activated T-type calcium channel used in the treatment of absence seizures unaccompanied by other type...
T0806 Flunarizine dihydrochloride Flunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. Flunarizine hydrochloride is effective i...
T0903 Stugeron Cinnarizine is a piperazine derivative having histamine H1-receptor and calcium-channel blocking activity with vasodilating and antiemetic properties but it ind...
T0957 Isradipine Isradipine is a dihydropyridine calcium channel blockers with antihypertensive and vasodilator activities. Isradipine blocks the calcium entry through the calci...
T0999 Clevidipine butyrate Clevidipine is a dihydropyridine L-type calcium channel blocker that is selective for vascular smooth muscle and is indicated for blood pressure reduction when ...
T1010 Verapamil hydrochloride Verapamil hydrochloride is a calcium channel blocker that is a class IV anti-arrhythmia agent.
T10713 CCR4 antagonist 2 CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of CC chemokine receptor 4 (CCR4) that inhibits Treg trafficki...
T1073 Dronedarone hydrochloride Dronedarone hydrochloride is an amiodarone analog which has an effective and promising treatment for Atrial fibrillation.
T10991 Dehydronitrosonisoldipine Dehydronitrosonisoldipine is a calcium channel antagonist.
T11080 Dopropidil Dopropidil is a new anti-angina pectoris calcium regulator, which has intracellular calcium antagonist activity and anti-ischemic effects in various predicted a...
T11102 DS16570511 DS16570511 is a cellular osmotic inhibitor of mitochondrial calcium monoab, which blocks MCU or MICU1-dependent Ca2+ influx.
T11353 Gallopamil  Gallopamil inhibits acid secretion in a concentration-dependent manner with an IC50 of 10.9 μM. Gallopamil is a potent antiarrhythmic and vasodilator agent....
T11353L Gallopamil hydrochloride Gallopamil hydrochloride is a methoxy derivative of Verapamil and is a phenylalkylamine calcium antagonist. It is a potent antiarrhythmic and vasodilator agent....
T1146 Nifedipine Nifedipine is a dihydropyridine calcium channel blocking agent. Nifedipine inhibits the transmembrane influx of extracellular calcium ions into myocardial and v...
T11553 Heptamidine dimethanesulfote Heptamidine dimethanesulfonate is a potent Pentamidine-related inhibitor of the calcium-binding protein S100B (Kd=6.9 μM), selectively kills melanoma cells wit...
T11666 IPR-803 IPR-803 binds directly to uPAR with sub-micromolar affinity. IPR-803 displays anti-tumor activity.IPR-803 is a potent inhibitor of the uPAR•uPA protein-protei...
T1197 Trimebutine maleate Trimebutine maleate is a weak mu-opioid agonist and has antimuscarinic effects. Trimebutine is an agonist of peripheral mu, delta, and kappa opiate receptors se...
T11979 McN5691 McN5691 is a voltage sensitive calcium channel blocker.
T12032 Mibefradil dihydrochloride Mibefradil dihydrochloride is an blocker of calcium channel with moderate selectivity for T-type Ca2+ channels (T-type and L-type currents with IC50s of 2.7 μM...
T12108 MRS1845 MRS1845 is a selective inhibitor of store-operated calcium (SOC) channel (IC50 of 1.7 μM).
T1215 Nicardipine hydrochloride Nicardipine Hydrochloride is the hydrochloride salt form of nicardipine, a synthetic derivative of nitrophenyl-pyridine and potent calcium channel blocker, Nica...
T12153 N-type calcium channel blocker-1 N-type calcium channel blocker-1 is an orally active analgesic agent,shows high affinity to functionally block N-type calcium channels.
T12204 NecroX-5 NecroX-5 is a derivative of the NecroX and with anti-inflammatory and anti-cancer activity.
T12205 Ned 19 Ned 19 is a selective membrane-permeant non competitive antagonist of NAADP and strongly inhibits tumor growth and vascularization as well as lung metastases in...
T12205L trans-Ned 19 trans-Ned 19 is a NAADP antagonist and TPC blocker and inhibits the calcium signal in human umbilical vein endothelial cells and the rat aorta relaxation in res...
T12244 Norverapamil Norverapamil is a blocker of L-type calcium channel and an inhibitor of P-glycoprotein (P-gp) function .
T12322 ORM-10962 ORM-10962 is a potent, highly selective inhibitor of sodium-calcium exchanger (NCX) (for the reverse and forward mode inhibition with IC50 values of 67 and 55 n...
T1234 5,5-Dimethyloxazolidine-2,4-dione An anticonvulsant that is the active metabolite of TRIMETHADIONE.
T12358 Palonidipine Palonidipine is an antagonist of calcium, is potential for the therapy of angina-pectoris and hypertension.
T12385 PD0176078 PD0176078 is a newly blocker of N-type Calcium channel.
T12625 (R)-Lercanidipine D3 hydrochloride (R)-lercanidipine D3 hydrochloride is a deuterium labeled (R)-Lercanidipine hydrochloride. (R)-Lercanidipine D3 (hydrochloride) is a calcium channel blocker.
T12626 (R)-Lercanidipine hydrochloride (R)-Lercanidipine hydrochloride is the R-enantiomer of Lercanidipine. (R)-lercanidipine hydrochloride is a blocker of calcium channel.
T12845 SB-423557 SB-423557 is an orally active antagonist of calcium-sensing receptor (CaR) with IC50 of 520 nM
T12880 Semotiadil recemate fumarate Semotiadil recemate fumarate is the recemate of Semotiadil fumarate. Semotiadil fumarate is a novel antagonist of vasoselective Ca2+ channel.
T12993 SQ-31765 SQ-31765 is a blocker of benzazepine calcium channel.
T13117 Teludipine hydrochloride Teludipine hydrochloride is a blocker of lipophilic calcium channel.
T13154 Tiapamil hydrochloride Tiapamil hydrochloride is a blocker of calcium channel.
T13219 TTA-Q6 TTA-Q6 is a selective antagonist of T-type Ca2+ channel, used in the neurological disease.
T13250 UK51656 UK51656 is an antagonist of calcium(IC50 of 4 nM).
T13328 AE0047 Hydrochloride AE0047 Hydrochloride is a blocker of calcium,and used in the research of hypertensive disease.
T1385 Amlodipine Amlodipine is a synthetic dihydropyridine and a calcium channel blocker with antihypertensive and antianginal properties.
T13879 (S)-Verapamil hydrochloride (S)-Verapamil hydrochloride is an inhibitor of leukotriene C4 (LTC4) and calcein transport by MRP1,and leads to the death of potentially resistant tumor cells.
T1422 Nilvadipine Nilvadipine, a calcium channel blocker (CCB), is utilized for treatment of hypertension.
T1435 Praziquantel Praziquantel increases the permeability of the tegument of susceptible worms, resulting in an influx and increase in intra-tegumental calcium leading to rapid c...
T1439 Lacidipine Lacidipine is a lipophilic dihydropyridine calcium antagonist with an intrinsically slow onset of activity. Due to its long duration of action, lacidipine does ...
T1474 Otilonium bromide Otilonium Bromide, an antimuscarinic, is utilized as a spasmolytic agent.
T14872 Carboxyamidotriazole Carboxyamidotriazole is a cytostatic inhibitor of non-voltage-operated calcium channels and calcium channel-mediated signaling pathways. It shows anti-inflammat...
T15257 Etripamil Etripamil is an antagonist of short-acting L-type calcium-channel for the treatment of Paroxysmal Supraventricular Tachycardia.
T15301 Fluspirilene Fluspirilene is a non-competitive L-type calcium channel antagonist (IC50: 0.03 μM). It is a long-acting injectable depot antipsychotic drug used for schizop...
T15423 GSK-7975A GSK-7975A is a potent and orally available inhibitor of CRAC channel.
T1545 (S)-Amlodipine Levamlodipine belongs to the dihydropyridine group of calcium channel blockers. Levamlodipine, also known as S-amlodipine, is a pharmacologically active enantio...
T15553 Iganidipine Iganidipine is an antagonist of Ca2+ .
T15740 Levamlodipine besylate Levamlodipine besylate is a powerful dihydropyridine calcium channel blocker. It has possessing vasodilation properties and used in the treatment of hypertensio...
T15755 Lidoflazine Lidoflazine is a high-affinity blocker of the HERG K+ channel and is an antianginal calcium channel blocker. This carries an obvious risk of QT interval prolong...
T16339 Norverapamil hydrochloride Norverapamil hydrochloride ((±)-Norverapamil hydrochloride) is an N-demethylated metabolite of Verapamil and it is an L-type calcium channel blocker and a P-gl...
T16357 NSC 663284 NSC 663284 is a cell-permeable and irreversible Cdc25 dual specificity phosphatase inhibitor (IC50 for Cdc25B2: 0.21 μM). NSC 663284 inhibits NSD2 (IC50 of 170...
T1641 Strontium ranelate Strontium ranelate, a strontium (II) salt of the ranelic acid, is a medication for osteoporosis. Studies indicate it can also slow the course of osteoarthritis ...
T16447 β-Amino Acid Imagabalin Hydrochloride β-Amino Acid Imagabalin Hydrochloride is the voltage-dependent calcium channel ligand for the α2δ subunit.
T16571 Pranidipine Pranidipine is an effective, long-acting 1,4-dihydropyridine calcium channel blocker. It also has antihypertensive activity.
T16887 Sipatrigine Sipatrigine is a glutamate release inhibitor and voltage-dependent sodium channel.
T1730 NPS 2143 NPS-2143 is a novel potent and selective antagonist of Ca(2+) receptor.
T19253 Cyclic ADP-​ribose Cyclic ADP-ribose (cADPR) is an effective calcium mobilization second messenger, which is synthesized from NAD + by ADP-ribosyl cyclase. Cyclic ADP-ribose mainl...
T2323 Efonidipine Efonidipine(NZ-105) is a dihydropyridine calcium channel blocker, blocking both T-type and L-type calcium channels.
T2519 Lercanidipine Lercanidipine is a calcium channel blocker of the dihydropyridine class.
T2604 1-Ethyl-2-benzimidazolinone 1-Ethyl-2-benzimidazolinone is a calium channel agonist.
T2996 Tetrandrine Tetrandrine is a natural, bis-benzylisoquinoline alkaloid isolated from the root of the plant. Tetrandrine non-selectively inhibits calcium channel activity and...
T2S0118 Daurinoline Daurinoline is a non-competitive antagonist, it exerts marked relaxation effect on basilar artery of rabbits through non-competitive antagonism, it would have a...
T3229 Cytochalasin D Cytochalasin D is an actin inhibitor, the removal of actin stress fibers is crucial for the chondrogenic differentiation. It may be an inhibitor of some fertili...
T3377 phenylalanine Phenylalanine is an essential amino acid and the precursor of the amino acid tyrosine, acts as an antagonist at α2δ calcium channels.
T3484 (±)-trans-ACPD (±)-trans-ACPD is an equimolecular mixture of (1S,3R)- and (1R,3S)-ACPD. (±)-trans-ACPD is a selective agonist of the mGluR (metabotropic glutamate receptor);...
T3508 SEA-0400 SEA0400 is a selective inhibitor of the Na+/Ca2+ exchanger.
T3543 NS 638 NS-638 is a Ca2+-channel blocker. It can block K+-stimulated intracellular Ca2+-elevation (IC50: 3.4 μM).
T3703 ABT-639 ABT-639 is a potent and selective T-type calcium channel blocker.
T3904 Gomisin J Gomisin J is a natural product and have vasodilatory activity. Gomisin J suppresses lipid accumulation by regulating the expression of lipogenic and lipolytic ...
T3S0289 Araloside X Aralosides possess protective effect against experimental myocardial ischemia and infarction, the mechanism of myocardial protection may be attributed to the am...
T4001 Euxanthone Euxanthone has vasorelaxation effect, may be through multiple pathways involved PKC-mediated signal pathway and calcium-independent pathway, it induces its vaso...
T4243 Reticuline Reticuline is a key compound in the biosynthetic pathway for isoquinoline alkaloids in plants, which include morphine, codeine and berberine. Reticuline possess...
T4284 (S)-Amlodipine Besylate (103129-82-4(free base)) Levamlodipine, also known as S-amlodipine, is a pharmacologically active enantiomer of amlodipine, an antihypertensive and anti-anginal medication. Levamlodipin...
T4669 Fantofarone Fantofarone is a highly potent Calcium Channel antagonist.
T5120 alpha-L-Rhamnose Addition of the Rhamnose-rich polysaccharide, RROP-1, to normal human dermal fibroblasts (NHDFs) and human endothelial cells produced a dose-dependent stimulati...
T5376 Aranidipine Aranidipine (MPC1304) is a calcium channel antagonist with potent and long-lasting antihypertensive effects.
T5391 Bepridil hydrochloride Bepridil is a calcium channel blocker and also inhibits Na+/Ca2+ exchange (NCX), sodium channels and cardiac sarcolemmal KATP channels.
T5632 MK-8998 MK-8998 as potent inhibitors of T-type calcium channels.
T5856 Barnidipine Barnidipine is a dihydropyridine calcium channel blocker that has an IC50 value of 0.35 nM in potassium-induced tonic contraction of pig coronary artery
T6507 Gabapentin HCl Gabapentin HCl is a GABA analogue, used to treat seizures and neuropathic pain.
T6571 Lomerizine hydrochloride Lomerizine dihydrochloride is an antagonist of L- and T-type voltage-gated calcium channels used to treat migraine.
T6577 Manidipine Manidipine, a calcium channel blocker, which is dihydropyridine type. It is utilized
T6633 Ranolazine Ranolazine 2HCl,a calcium uptake inhibitor,is used to treat chronic angina via the sodium/calcium channa.
T6777 Bay K 8644 Bay K 8644 is a potent, selective activator of L-type Ca2+ channel with IC50 of 17.3 nM.
T6874 Lercanidipine hydrochloride Lercanidipine is a calcium channel blocker of the dihydropyridine class.
T6S1500 Ginsenoside-Rf Ginsenoside Rf is a trace component of ginseng root. Ginsenoside Rf inhibits N-type Ca2+ channel.
T7009 Soyacerebroside II Soyacerebroside II exhibits ionophoretic activity for Ca2+ ion. Soyacerebrosides I and II have modulating the cellular immune response effects, they show obviou...
T7056 Dronedarone Dronedarone is an amiodarone analogue which has an effective and promising treatment for Atrial fibrillation.
T7216 Mirogabalin Mirogabalin is a calcium channel blocker with analgesic effects.
T7334 NP118809 NP118809 is a potent N-type calcium channel blocker(IC50 : 0.11 μM).
T7338 DHBP dibromide DHBP dibromide is calcium release and a muscle relaxant inhibitor.
T7373 CDN1163 CDN1163 is a small molecule activator of sarco/endoplasmic reticulum Ca2+-ATPase (SERCA). 
T7550 Barnidipine Barnidipine is a calcium channel blocker.
T7603 Pinaverium bromide Pinaverium bromide is an calcium channel blocker with Antispasmodic and effectively relieves pain, diarrhea and intestinal discomfort.
T8401 Efonidipine hydrochloride monoethanolate Efonidipine hydrochloride monoethanolate is a Ca(2+)-channel Blocker, Enhances the Production of Dehydroepiandrosterone Sulfate in NCI-H295R Human Adrenocortica...
T8674 SR33805 SR33805 is a potent antagonist of Ca2+ channel(EC50s of 4.1 nM and 33 nM in depolarized and polarized conditions, respectively)
TCS0102 Pulegone 1. Pulegone has cytotoxicity followed by regenerative cell proliferation is the MOA for Pulegone-induced urothelial tumors in female rats. 2. Pulegone induces a...
TL0014 Pinusolide Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, ...
TMA0763 Methyl 3,4,5-trimethoxycinnamate Methyl 3,4,5-trimethoxycinnamate may protect the heart from arrhythmias via its inhibitory effect on calcium channel.
TMA0805 Lupanine Lupanine has a weak sedative effect on the central nervous system, interaction with specific drugs used for treatment of the CNS and for analgesic activity. Lup...
TN1032 Geissoschizine methyl ether Geissoschizine methyl ether is a potent serotonin A receptor agonist and candidate for amelioration of aggressiveness and sociality by yokukansan
TN1121 Evocarpine Evocarpine shows antimycobacterial, and vasorelaxant effects, it can inhibit Ca2+ influx through voltage-dependent calcium channels.
TN1136 Procyanidin A1 Procyanidin A1 has antiallergic effects, it inhibits degranulation downstream of protein kinase C activation or Ca2+; influx from an internal store in RBL-2H3 c...
TN1154 6-Methoxyluteolin 6-Methoxyluteolin has antioxidant activity, it is a potent inhibitor of histamine release and calcium influx via down-regulation of the FcεRI α chain.
TN1338 7Beta-Hydroxycholesterol 7beta-Hydroxycholesterol, a major cytotoxin in oxidized LDL, induces Ca(2+) oscillations, MAP kinase activation and apoptosis in human aortic smooth muscle cell...
TN1367 Alismol Alismol has antihypertensive action, it decreases cardiac output, heart rate and left ventricular pressure, but it increases coronary flow, it has been used for...
TN1519 Coclaurine (+)-R-Coclaurine and (+)-S-reticuline show negative inotropic effects, coclaurine derivatives and of paeoniflorin derivatives have neuromuscular blocking action...
TN1544 D-Menthol Menthol is a common compound in pharmaceutical and commercial products and a popular additive to cigarettes, it attenuates α±7 mediated Ca 2+ transients in th...
TN1588 Dihydroisotanshinone I Dihydroisotanshinone I has protective action against menadione-induced hepatotoxicity, attributed to its antioxidant properties including the free radical scave...
TN1624 Ethyl cinnamate Ethyl cinnamate has antifungal, and vasorelaxant effects, it can inhibit the tonic contractions induced by high K+ and phenylephrine (PE) in a concentration-dep...
TN1721 Gypenoside L Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release. It also ...
TN1757 Hypophyllanthin Hypophyllanthin and phyllanthin have antitumour effects against Ehrlich Ascites Carcinoma in mice.
TN1913 Marmin Marmin have anti-ulcer effects, which are ascribed primarily to the maintenance of the mucosal barrier integrity and inhibition of gastric motor activity and se...
TN2054 Periplocymarin Periplocymarin, a cardiac glycoside, has potential anti-cancer activity.
TN2078 Pinocembrin chalcone Pinocembrin chalcone has tyrosinase inhibitory activity.It also shows antimutagenic effect, which is mainly due to the inhibition of the first step of enzymatic...
TN2116 Pteropodine Pteropodine acts as a positive modulator of muscarinic M(1) and 5-HT(2) receptors. Pteropodine shows antigenotoxic, antioxidant and lymphocyte induction effects...
TN2169 Saikogenin D Saikogenin D possesses a dual effect: an inhibition of A23187-induced PGE2 production without a direct inhibition of cyclooxygenase activity; and an elevation o...
TN2211 Silybin B Silybin B and silybin A are potent inhibitors of both raloxifene 4'- and 6-glucuronidation in all enzyme systems; they show strong effects on cell growth inhibi...
TN2215 Sodium taurochenodeoxycholate Sodium taurochenodeoxycholate can increase glucose-induced insulin secretion and stimulate the electrical activity of α²-cells and enhance cytosolic Ca(2+) co...
TN2287 Turkesterone Turkesterone is a phytoecdysteroid possessing an 11alpha-hydroxyl group, also is an analogue of the insect steroid hormone 20-hydroxyecdysone. It has immunomodu...
TN2322 Yangambin Yangambin is a selective antagonist of the cardiovascular effects of platelet activating factor (PAF); it has hypotensive effect, which is probably due to a per...
TN2534 1-Hydroxy-2,3,5-trimethoxyxanthone 1-Hydroxy-2,3,5-trimethoxyxanthone (HM-1) has vasodilator action ,which involves both an endothelium-dependent mechanism involving NO and an endothelium-indepen...
TN2641 15-Methoxypinusolidic acid 15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Metho...
TN2703 2',3'-Dihydroxy-4'-methoxyacetophenone 2,3-Dihydroxy-4-methoxyacetophenone improves cognitive function and may be helpful for the treatment of Alzheimer's disease.
TN2918 3-Acetoxy-8(17),13E-labdadien-15-oic acid ent-3-Acetoxy-labda-8(17),13-dien-15-oic acid have vasorelaxant and hypotensive actions, the mechanisms underlying the cardiovascular actions of the labdane inv...
TN3042 4-Hydroxycinnamamide 4-Hydroxycinnamamide has antioxidant activity. 4-Hydroxycinnamamide derivatives are specific inhibitors of tyrosine-specific protein kinases.
TN3260 8(14),15-Isopimaradien-3-ol ent-8(14),15-pimaradien-3beta-ol (8(14),15-Isopimaradien-3-ol) can induce vascular relaxation. It displays high antibacterial activities (MIC values lower than ...
TN3319 9-Hydroxycanthin-6-one 9-Hydroxycanthin-6-one might be the active component that contributed to the aphrodisiac effect of E. longifolia by antagonizing the smooth muscle tone of CC as...
TN3466 Atherosperminine Atherosperminine shows cholinesterase inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Atherosperminine shows strong an...
TN3568 Calceolarioside A Calceolarioside A shows potent activity against visceral leishmaniasis. It can induce a dose-related aggregant effect on rabbit platelets, which may be partly r...
TN3660 Cinnamyl caffeate Cinnamyl caffeate has cardiovascular protective effects, it can increase H9c2 cellular antioxidant potential, decrease intracellular calcium ion ([Ca2+]i) level...
TN3831 Denudatin B Denudatin B has nonspecific antiplatelet action at high concentration by inhibiting phosphoinositides breakdown induced by collagen and thrombin, it inhibits th...
TN3844 Didrovaltrate Didrovaltrate shows cytotoxic against human cancer cell lines. Didrovaltrate blocks I(Ca-L) in a concentration-dependent manner and probably inhibits I(Ca-L) in...
TN4051 Fargesone B Fargesone B inhibits the vascular smooth muscle contraction by suppressing the voltage- and receptor-activated calcium influxes in a nonselective manner.
TN4303 Isokaempferide Isokaempferide shows hepatoprotective, antiproliferative, and anti-inflammatory effects, the anti-inflammatory effects can be explained, at least in part, by re...
TN4819 (-)-Praeruptorin A (-)-Praeruptorin A has anti-inflammatory, anti-contractile and anti-hyperplasia activities, it exerts distinct relaxant effects on isolated rat aorta rings depe...
TN5073 Strophanthidine Strophanthidin can induce calcium overload in vivo.
TN5109 Taxezopidine L Taxezopidines K and taxezopidine L can markedly inhibit Ca2+-induced depolymerization of microtubules.
TN5234 Vindorosine Vindorosine has blood vessel relaxation effect, possible underlying mechanisms involving the inhibition of Ca(2+) entry via L-type Ca(2+) channels in vascular s...
TN5279 Zeorin Zeorin shows strong inhibition activity against bacteria and fungi. It markedly exhibits inhibitory activity on histamine release from mast cell induced by DNP2...
TP2170 CALP3 TFA CALP3 TFA is a potent Ca2+ channel blocker that activates EF-hand motifs of Ca2+-binding proteins. It can functionally mimic increased [Ca2+]i by modulating the...
TQ0144 (S)-(-)-Bay K 8644 (S)-(-)-Bay-K-8644 is an agonist of L-type Ca2+ channel. It activates Ba2+ currents (IBa) (EC50: 32 nM).
TQ0145 (R)-(+)-Bay K 8644 (R)-(+)-Bay K 8644 is a calcium channel inhibitor. It inhibits Ba2+ currents (IBa) (IC50: 975 nM).
TQ0153 Mibefradil Mibefradil is a calcium channel blocker with moderate selectivity for T-type Ca2+ channels (IC50s: 2.7 μM and 18.6 μM for T-type and L-type currents).
TQ0302 Thapsigargin Thapsigargin is a microsomal Ca2+-ATPase inhibitor and Endoplasmic Reticulum stress-inducing agent.
Dantrolene sodium salt
T0077CAS 14663-23-1
Dantrolene is a skeletal muscle relaxant and can interfere with excitation-contraction coupling in the muscle fiber. It is used for the treatment of spasticity ...
Diltiazem hydrochloride
T0112CAS 33286-22-5
Diltiazem Hydrochloride is a benzothiazepine calcium channel blocking agent with vasodilating action due to its antagonism of the actions of CALCIUM ion on memb...
Nitrendipine
T0119CAS 39562-70-4
Nitrendipine is a calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel block...
Azelnidipine
T0121CAS 123524-52-7
Azelnidipine is a dihydropyridine used as calcium channel blocker.
Felodipine
T0145CAS 72509-76-3
Felodipine is a longlasting 1,4-dihydropyridine calcium channel repressor.
Nisoldipine
T0163CAS 63675-72-9
Nisoldipine is a dihydropyridine calcium channel antagonist that acts as a potent arterial vasodilator and antihypertensive agent.
Levetiracetam
T0192CAS 102767-28-2
Levetiracetam is a relatively unique anticonvulsant that is typically used in combination with other antiepileptic medications for partial onset seizures. Levet...
Manidipine dihydrochloride
T0193CAS 89226-75-5
Manidipine dihydrochloride is a potent calcium channel blocker for Ca2+ current(IC50=2.6 nM).
Ranolazine dihydrochloride
T0207CAS 95635-56-6
Ranolazine(RS-43285), an antianginal agent, can treat arrhythmia via a novel mechanism of action (inhibition of the late phase of the inward sodium current), an...
Amlodipine Besylate
T0231CAS 111470-99-6
Amlodipine Besylate is a long-lasting calcium channel blocker.
Zonisamide
T0267CAS 68291-97-4
Zonisamide, a sulfonamide anticonvulsant, is approved for use as an adjunctive treatment in adults with partial-onset seizures. It may inhibit a carbonic anhydr...
Trimethadione
T0283CAS 127-48-0
Trimethadione is a dione-type anticonvulsant with antiepileptic activity.
Fendiline hydrochloride
T0327CAS 13636-18-5
Fendiline is a non-selective blocker of calcium channel.
Nimodipine
T0343CAS 66085-59-4
Nimodipine, a 1, 4-dihydropyridine calcium channel blocker, acts primarily on vascular smooth muscle cells.
Cilnidipine
T0388CAS 132203-70-4
Cilnidipine(FRC8653) is a dual L- and N-type calcium channel blocker and displays antihypertensive, sympatholytic and neuroprotective activity.
Gabapentin
T0702CAS 60142-96-3
Gabapentin is a GABA analogue, used to treat seizures and neuropathic pain.
Ethosuximide
T0728CAS 77-67-8
Ethosuximide is an anticonvulsant, blocks the low voltage-activated T-type calcium channel used in the treatment of absence seizures unaccompanied by other type...
Flunarizine dihydrochloride
T0806CAS 30484-77-6
Flunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. Flunarizine hydrochloride is effective i...
Stugeron
T0903CAS 298-57-7
Cinnarizine is a piperazine derivative having histamine H1-receptor and calcium-channel blocking activity with vasodilating and antiemetic properties but it ind...
Isradipine
T0957CAS 75695-93-1
Isradipine is a dihydropyridine calcium channel blockers with antihypertensive and vasodilator activities. Isradipine blocks the calcium entry through the calci...
Clevidipine butyrate
T0999CAS 167221-71-8
Clevidipine is a dihydropyridine L-type calcium channel blocker that is selective for vascular smooth muscle and is indicated for blood pressure reduction when ...
Verapamil hydrochloride
T1010CAS 152-11-4
Verapamil hydrochloride is a calcium channel blocker that is a class IV anti-arrhythmia agent.
CCR4 antagonist 2
T10713CAS 2206788-99-8
CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of CC chemokine receptor 4 (CCR4) that inhibits Treg trafficki...
Dronedarone hydrochloride
T1073CAS 141625-93-6
Dronedarone hydrochloride is an amiodarone analog which has an effective and promising treatment for Atrial fibrillation.
Dehydronitrosonisoldipine
T10991CAS 87375-91-5
Dehydronitrosonisoldipine is a calcium channel antagonist.
Dopropidil
T11080CAS 79700-61-1
Dopropidil is a new anti-angina pectoris calcium regulator, which has intracellular calcium antagonist activity and anti-ischemic effects in various predicted a...
DS16570511
T11102CAS
DS16570511 is a cellular osmotic inhibitor of mitochondrial calcium monoab, which blocks MCU or MICU1-dependent Ca2+ influx.
Gallopamil
T11353CAS 16662-47-8
 Gallopamil inhibits acid secretion in a concentration-dependent manner with an IC50 of 10.9 μM. Gallopamil is a potent antiarrhythmic and vasodilator agent....
Gallopamil hydrochloride
T11353LCAS 16662-46-7
Gallopamil hydrochloride is a methoxy derivative of Verapamil and is a phenylalkylamine calcium antagonist. It is a potent antiarrhythmic and vasodilator agent....
Nifedipine
T1146CAS 21829-25-4
Nifedipine is a dihydropyridine calcium channel blocking agent. Nifedipine inhibits the transmembrane influx of extracellular calcium ions into myocardial and v...
Heptamidine dimethanesulfote
T11553CAS 161374-55-6
Heptamidine dimethanesulfonate is a potent Pentamidine-related inhibitor of the calcium-binding protein S100B (Kd=6.9 μM), selectively kills melanoma cells wit...
IPR-803
T11666CAS 892243-35-5
IPR-803 binds directly to uPAR with sub-micromolar affinity. IPR-803 displays anti-tumor activity.IPR-803 is a potent inhibitor of the uPAR•uPA protein-protei...
Trimebutine maleate
T1197CAS 34140-59-5
Trimebutine maleate is a weak mu-opioid agonist and has antimuscarinic effects. Trimebutine is an agonist of peripheral mu, delta, and kappa opiate receptors se...
McN5691
T11979CAS 99254-95-2
McN5691 is a voltage sensitive calcium channel blocker.
Mibefradil dihydrochloride
T12032CAS 116666-63-8
Mibefradil dihydrochloride is an blocker of calcium channel with moderate selectivity for T-type Ca2+ channels (T-type and L-type currents with IC50s of 2.7 μM...
MRS1845
T12108CAS 544478-19-5
MRS1845 is a selective inhibitor of store-operated calcium (SOC) channel (IC50 of 1.7 μM).
Nicardipine hydrochloride
T1215CAS 54527-84-3
Nicardipine Hydrochloride is the hydrochloride salt form of nicardipine, a synthetic derivative of nitrophenyl-pyridine and potent calcium channel blocker, Nica...
N-type calcium channel blocker-1
T12153CAS 241499-17-2
N-type calcium channel blocker-1 is an orally active analgesic agent,shows high affinity to functionally block N-type calcium channels.
NecroX-5
T12204CAS 1383718-29-3
NecroX-5 is a derivative of the NecroX and with anti-inflammatory and anti-cancer activity.
Ned 19
T12205CAS 874374-25-1
Ned 19 is a selective membrane-permeant non competitive antagonist of NAADP and strongly inhibits tumor growth and vascularization as well as lung metastases in...
trans-Ned 19
T12205LCAS 1354235-96-3
trans-Ned 19 is a NAADP antagonist and TPC blocker and inhibits the calcium signal in human umbilical vein endothelial cells and the rat aorta relaxation in res...
Norverapamil
T12244CAS 67018-85-3
Norverapamil is a blocker of L-type calcium channel and an inhibitor of P-glycoprotein (P-gp) function .
ORM-10962
T12322CAS 763926-98-3
ORM-10962 is a potent, highly selective inhibitor of sodium-calcium exchanger (NCX) (for the reverse and forward mode inhibition with IC50 values of 67 and 55 n...
5,5-Dimethyloxazolidine-2,4-dione
T1234CAS 695-53-4
An anticonvulsant that is the active metabolite of TRIMETHADIONE.
Palonidipine
T12358CAS 96515-73-0
Palonidipine is an antagonist of calcium, is potential for the therapy of angina-pectoris and hypertension.
PD0176078
T12385CAS 248922-46-5
PD0176078 is a newly blocker of N-type Calcium channel.
(R)-Lercanidipine D3 hydrochloride
T12625CAS 1217724-52-1
(R)-lercanidipine D3 hydrochloride is a deuterium labeled (R)-Lercanidipine hydrochloride. (R)-Lercanidipine D3 (hydrochloride) is a calcium channel blocker.
(R)-Lercanidipine hydrochloride
T12626CAS 187731-34-6
(R)-Lercanidipine hydrochloride is the R-enantiomer of Lercanidipine. (R)-lercanidipine hydrochloride is a blocker of calcium channel.
SB-423557
T12845CAS 351490-26-1
SB-423557 is an orally active antagonist of calcium-sensing receptor (CaR) with IC50 of 520 nM
Semotiadil recemate fumarate
T12880CAS 123388-25-0
Semotiadil recemate fumarate is the recemate of Semotiadil fumarate. Semotiadil fumarate is a novel antagonist of vasoselective Ca2+ channel.
SQ-31765
T12993CAS 138383-07-0
SQ-31765 is a blocker of benzazepine calcium channel.
Teludipine hydrochloride
T13117CAS 108700-03-4
Teludipine hydrochloride is a blocker of lipophilic calcium channel.
Tiapamil hydrochloride
T13154CAS 57010-32-9
Tiapamil hydrochloride is a blocker of calcium channel.
TTA-Q6
T13219CAS 910484-28-5
TTA-Q6 is a selective antagonist of T-type Ca2+ channel, used in the neurological disease.
UK51656
T13250CAS 88150-59-8
UK51656 is an antagonist of calcium(IC50 of 4 nM).
AE0047 Hydrochloride
T13328CAS 116308-56-6
AE0047 Hydrochloride is a blocker of calcium,and used in the research of hypertensive disease.
Amlodipine
T1385CAS 88150-42-9
Amlodipine is a synthetic dihydropyridine and a calcium channel blocker with antihypertensive and antianginal properties.
(S)-Verapamil hydrochloride
T13879CAS 36622-28-3
(S)-Verapamil hydrochloride is an inhibitor of leukotriene C4 (LTC4) and calcein transport by MRP1,and leads to the death of potentially resistant tumor cells.
Nilvadipine
T1422CAS 75530-68-6
Nilvadipine, a calcium channel blocker (CCB), is utilized for treatment of hypertension.
Praziquantel
T1435CAS 55268-74-1
Praziquantel increases the permeability of the tegument of susceptible worms, resulting in an influx and increase in intra-tegumental calcium leading to rapid c...
Lacidipine
T1439CAS 103890-78-4
Lacidipine is a lipophilic dihydropyridine calcium antagonist with an intrinsically slow onset of activity. Due to its long duration of action, lacidipine does ...
Otilonium bromide
T1474CAS 26095-59-0
Otilonium Bromide, an antimuscarinic, is utilized as a spasmolytic agent.
Carboxyamidotriazole
T14872CAS 99519-84-3
Carboxyamidotriazole is a cytostatic inhibitor of non-voltage-operated calcium channels and calcium channel-mediated signaling pathways. It shows anti-inflammat...
Etripamil
T15257CAS 1593673-23-4
Etripamil is an antagonist of short-acting L-type calcium-channel for the treatment of Paroxysmal Supraventricular Tachycardia.
Fluspirilene
T15301CAS 1841-19-6
Fluspirilene is a non-competitive L-type calcium channel antagonist (IC50: 0.03 μM). It is a long-acting injectable depot antipsychotic drug used for schizop...
GSK-7975A
T15423CAS 1253186-56-9
GSK-7975A is a potent and orally available inhibitor of CRAC channel.
(S)-Amlodipine
T1545CAS 103129-82-4
Levamlodipine belongs to the dihydropyridine group of calcium channel blockers. Levamlodipine, also known as S-amlodipine, is a pharmacologically active enantio...
Iganidipine
T15553CAS 119687-33-1
Iganidipine is an antagonist of Ca2+ .
Levamlodipine besylate
T15740CAS 150566-71-5
Levamlodipine besylate is a powerful dihydropyridine calcium channel blocker. It has possessing vasodilation properties and used in the treatment of hypertensio...
Lidoflazine
T15755CAS 3416-26-0
Lidoflazine is a high-affinity blocker of the HERG K+ channel and is an antianginal calcium channel blocker. This carries an obvious risk of QT interval prolong...
Norverapamil hydrochloride
T16339CAS 67812-42-4
Norverapamil hydrochloride ((±)-Norverapamil hydrochloride) is an N-demethylated metabolite of Verapamil and it is an L-type calcium channel blocker and a P-gl...
NSC 663284
T16357CAS 383907-43-5
NSC 663284 is a cell-permeable and irreversible Cdc25 dual specificity phosphatase inhibitor (IC50 for Cdc25B2: 0.21 μM). NSC 663284 inhibits NSD2 (IC50 of 170...
Strontium ranelate
T1641CAS 135459-87-9
Strontium ranelate, a strontium (II) salt of the ranelic acid, is a medication for osteoporosis. Studies indicate it can also slow the course of osteoarthritis ...
β-Amino Acid Imagabalin Hydrochloride
T16447CAS 610300-00-0
β-Amino Acid Imagabalin Hydrochloride is the voltage-dependent calcium channel ligand for the α2δ subunit.
Pranidipine
T16571CAS 99522-79-9
Pranidipine is an effective, long-acting 1,4-dihydropyridine calcium channel blocker. It also has antihypertensive activity.
Sipatrigine
T16887CAS 130800-90-7
Sipatrigine is a glutamate release inhibitor and voltage-dependent sodium channel.
NPS 2143
T1730CAS 284035-33-2
NPS-2143 is a novel potent and selective antagonist of Ca(2+) receptor.
Cyclic ADP-​ribose
T19253CAS 119340-53-3
Cyclic ADP-ribose (cADPR) is an effective calcium mobilization second messenger, which is synthesized from NAD + by ADP-ribosyl cyclase. Cyclic ADP-ribose mainl...
Efonidipine
T2323CAS 111011-63-3
Efonidipine(NZ-105) is a dihydropyridine calcium channel blocker, blocking both T-type and L-type calcium channels.
Lercanidipine
T2519CAS 100427-26-7
Lercanidipine is a calcium channel blocker of the dihydropyridine class.
1-Ethyl-2-benzimidazolinone
T2604CAS 10045-45-1
1-Ethyl-2-benzimidazolinone is a calium channel agonist.
Tetrandrine
T2996CAS 518-34-3
Tetrandrine is a natural, bis-benzylisoquinoline alkaloid isolated from the root of the plant. Tetrandrine non-selectively inhibits calcium channel activity and...
Daurinoline
T2S0118CAS 2831-75-6
Daurinoline is a non-competitive antagonist, it exerts marked relaxation effect on basilar artery of rabbits through non-competitive antagonism, it would have a...
Cytochalasin D
T3229CAS 22144-77-0
Cytochalasin D is an actin inhibitor, the removal of actin stress fibers is crucial for the chondrogenic differentiation. It may be an inhibitor of some fertili...
phenylalanine
T3377CAS 63-91-2
Phenylalanine is an essential amino acid and the precursor of the amino acid tyrosine, acts as an antagonist at α2δ calcium channels.
(±)-trans-ACPD
T3484CAS 67684-64-4
(±)-trans-ACPD is an equimolecular mixture of (1S,3R)- and (1R,3S)-ACPD. (±)-trans-ACPD is a selective agonist of the mGluR (metabotropic glutamate receptor);...
SEA-0400
T3508CAS 223104-29-8
SEA0400 is a selective inhibitor of the Na+/Ca2+ exchanger.
NS 638
T3543CAS 150493-34-8
NS-638 is a Ca2+-channel blocker. It can block K+-stimulated intracellular Ca2+-elevation (IC50: 3.4 μM).
ABT-639
T3703CAS 1235560-28-7
ABT-639 is a potent and selective T-type calcium channel blocker.
Gomisin J
T3904CAS 66280-25-9
Gomisin J is a natural product and have vasodilatory activity. Gomisin J suppresses lipid accumulation by regulating the expression of lipogenic and lipolytic ...
Araloside X
T3S0289CAS 344911-90-6
Aralosides possess protective effect against experimental myocardial ischemia and infarction, the mechanism of myocardial protection may be attributed to the am...
Euxanthone
T4001CAS 529-61-3
Euxanthone has vasorelaxation effect, may be through multiple pathways involved PKC-mediated signal pathway and calcium-independent pathway, it induces its vaso...
Reticuline
T4243CAS 485-19-8
Reticuline is a key compound in the biosynthetic pathway for isoquinoline alkaloids in plants, which include morphine, codeine and berberine. Reticuline possess...
(S)-Amlodipine Besylate (103129-82-4(free base))
T4284CAS T4284
Levamlodipine, also known as S-amlodipine, is a pharmacologically active enantiomer of amlodipine, an antihypertensive and anti-anginal medication. Levamlodipin...
Fantofarone
T4669CAS 114432-13-2
Fantofarone is a highly potent Calcium Channel antagonist.
alpha-L-Rhamnose
T5120CAS 3615-41-6
Addition of the Rhamnose-rich polysaccharide, RROP-1, to normal human dermal fibroblasts (NHDFs) and human endothelial cells produced a dose-dependent stimulati...
Aranidipine
T5376CAS 86780-90-7
Aranidipine (MPC1304) is a calcium channel antagonist with potent and long-lasting antihypertensive effects.
Bepridil hydrochloride
T5391CAS 68099-86-5
Bepridil is a calcium channel blocker and also inhibits Na+/Ca2+ exchange (NCX), sodium channels and cardiac sarcolemmal KATP channels.
MK-8998
T5632CAS 953778-58-0
MK-8998 as potent inhibitors of T-type calcium channels.
Barnidipine
T5856CAS 104757-53-1
Barnidipine is a dihydropyridine calcium channel blocker that has an IC50 value of 0.35 nM in potassium-induced tonic contraction of pig coronary artery
Gabapentin HCl
T6507CAS 60142-95-2
Gabapentin HCl is a GABA analogue, used to treat seizures and neuropathic pain.
Lomerizine hydrochloride
T6571CAS 101477-54-7
Lomerizine dihydrochloride is an antagonist of L- and T-type voltage-gated calcium channels used to treat migraine.
Manidipine
T6577CAS 89226-50-6
Manidipine, a calcium channel blocker, which is dihydropyridine type. It is utilized
Ranolazine
T6633CAS 95635-55-5
Ranolazine 2HCl,a calcium uptake inhibitor,is used to treat chronic angina via the sodium/calcium channa.
Bay K 8644
T6777CAS 71145-03-4
Bay K 8644 is a potent, selective activator of L-type Ca2+ channel with IC50 of 17.3 nM.
Lercanidipine hydrochloride
T6874CAS 132866-11-6
Lercanidipine is a calcium channel blocker of the dihydropyridine class.
Ginsenoside-Rf
T6S1500CAS 52286-58-5
Ginsenoside Rf is a trace component of ginseng root. Ginsenoside Rf inhibits N-type Ca2+ channel.
Soyacerebroside II
T7009CAS 115074-93-6
Soyacerebroside II exhibits ionophoretic activity for Ca2+ ion. Soyacerebrosides I and II have modulating the cellular immune response effects, they show obviou...
Dronedarone
T7056CAS 141626-36-0
Dronedarone is an amiodarone analogue which has an effective and promising treatment for Atrial fibrillation.
Mirogabalin
T7216CAS 1138245-13-2
Mirogabalin is a calcium channel blocker with analgesic effects.
NP118809
T7334CAS 41332-24-5
NP118809 is a potent N-type calcium channel blocker(IC50 : 0.11 μM).
DHBP dibromide
T7338CAS 6159-05-3
DHBP dibromide is calcium release and a muscle relaxant inhibitor.
CDN1163
T7373CAS 892711-75-0
CDN1163 is a small molecule activator of sarco/endoplasmic reticulum Ca2+-ATPase (SERCA). 
Barnidipine
T7550CAS 104713-75-9
Barnidipine is a calcium channel blocker.
Pinaverium bromide
T7603CAS 53251-94-8
Pinaverium bromide is an calcium channel blocker with Antispasmodic and effectively relieves pain, diarrhea and intestinal discomfort.
Efonidipine hydrochloride monoethanolate
T8401CAS 111011-76-8
Efonidipine hydrochloride monoethanolate is a Ca(2+)-channel Blocker, Enhances the Production of Dehydroepiandrosterone Sulfate in NCI-H295R Human Adrenocortica...
SR33805
T8674CAS 121345-64-0
SR33805 is a potent antagonist of Ca2+ channel(EC50s of 4.1 nM and 33 nM in depolarized and polarized conditions, respectively)
Pulegone
TCS0102CAS 89-82-7
1. Pulegone has cytotoxicity followed by regenerative cell proliferation is the MOA for Pulegone-induced urothelial tumors in female rats. 2. Pulegone induces a...
Pinusolide
TL0014CAS 31685-80-0
Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, ...
Methyl 3,4,5-trimethoxycinnamate
TMA0763CAS 7560-49-8
Methyl 3,4,5-trimethoxycinnamate may protect the heart from arrhythmias via its inhibitory effect on calcium channel.
Lupanine
TMA0805CAS 550-90-3
Lupanine has a weak sedative effect on the central nervous system, interaction with specific drugs used for treatment of the CNS and for analgesic activity. Lup...
Geissoschizine methyl ether
TN1032CAS 60314-89-8
Geissoschizine methyl ether is a potent serotonin A receptor agonist and candidate for amelioration of aggressiveness and sociality by yokukansan
Evocarpine
TN1121CAS 15266-38-3
Evocarpine shows antimycobacterial, and vasorelaxant effects, it can inhibit Ca2+ influx through voltage-dependent calcium channels.
Procyanidin A1
TN1136CAS 103883-03-0
Procyanidin A1 has antiallergic effects, it inhibits degranulation downstream of protein kinase C activation or Ca2+; influx from an internal store in RBL-2H3 c...
6-Methoxyluteolin
TN1154CAS 520-11-6
6-Methoxyluteolin has antioxidant activity, it is a potent inhibitor of histamine release and calcium influx via down-regulation of the FcεRI α chain.
7Beta-Hydroxycholesterol
TN1338CAS 566-27-8
7beta-Hydroxycholesterol, a major cytotoxin in oxidized LDL, induces Ca(2+) oscillations, MAP kinase activation and apoptosis in human aortic smooth muscle cell...
Alismol
TN1367CAS 87827-55-2
Alismol has antihypertensive action, it decreases cardiac output, heart rate and left ventricular pressure, but it increases coronary flow, it has been used for...
Coclaurine
TN1519CAS 486-39-5
(+)-R-Coclaurine and (+)-S-reticuline show negative inotropic effects, coclaurine derivatives and of paeoniflorin derivatives have neuromuscular blocking action...
D-Menthol
TN1544CAS 15356-60-2
Menthol is a common compound in pharmaceutical and commercial products and a popular additive to cigarettes, it attenuates α±7 mediated Ca 2+ transients in th...
Dihydroisotanshinone I
TN1588CAS 20958-18-3
Dihydroisotanshinone I has protective action against menadione-induced hepatotoxicity, attributed to its antioxidant properties including the free radical scave...
Ethyl cinnamate
TN1624CAS 103-36-6
Ethyl cinnamate has antifungal, and vasorelaxant effects, it can inhibit the tonic contractions induced by high K+ and phenylephrine (PE) in a concentration-dep...
Gypenoside L
TN1721CAS 94987-09-4
Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release. It also ...
Hypophyllanthin
TN1757CAS 33676-00-5
Hypophyllanthin and phyllanthin have antitumour effects against Ehrlich Ascites Carcinoma in mice.
Marmin
TN1913CAS 14957-38-1
Marmin have anti-ulcer effects, which are ascribed primarily to the maintenance of the mucosal barrier integrity and inhibition of gastric motor activity and se...
Periplocymarin
TN2054CAS 32476-67-8
Periplocymarin, a cardiac glycoside, has potential anti-cancer activity.
Pinocembrin chalcone
TN2078CAS 4197-97-1
Pinocembrin chalcone has tyrosinase inhibitory activity.It also shows antimutagenic effect, which is mainly due to the inhibition of the first step of enzymatic...
Pteropodine
TN2116CAS 5629-60-7
Pteropodine acts as a positive modulator of muscarinic M(1) and 5-HT(2) receptors. Pteropodine shows antigenotoxic, antioxidant and lymphocyte induction effects...
Saikogenin D
TN2169CAS 5573-16-0
Saikogenin D possesses a dual effect: an inhibition of A23187-induced PGE2 production without a direct inhibition of cyclooxygenase activity; and an elevation o...
Silybin B
TN2211CAS 142797-34-0
Silybin B and silybin A are potent inhibitors of both raloxifene 4'- and 6-glucuronidation in all enzyme systems; they show strong effects on cell growth inhibi...
Sodium taurochenodeoxycholate
TN2215CAS 6009-98-9
Sodium taurochenodeoxycholate can increase glucose-induced insulin secretion and stimulate the electrical activity of α²-cells and enhance cytosolic Ca(2+) co...
Turkesterone
TN2287CAS 41451-87-0
Turkesterone is a phytoecdysteroid possessing an 11alpha-hydroxyl group, also is an analogue of the insect steroid hormone 20-hydroxyecdysone. It has immunomodu...
Yangambin
TN2322CAS 13060-14-5
Yangambin is a selective antagonist of the cardiovascular effects of platelet activating factor (PAF); it has hypotensive effect, which is probably due to a per...
1-Hydroxy-2,3,5-trimethoxyxanthone
TN2534CAS 22804-49-5
1-Hydroxy-2,3,5-trimethoxyxanthone (HM-1) has vasodilator action ,which involves both an endothelium-dependent mechanism involving NO and an endothelium-indepen...
15-Methoxypinusolidic acid
TN2641CAS 769928-72-5
15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Metho...
2',3'-Dihydroxy-4'-methoxyacetophenone
TN2703CAS 708-53-2
2,3-Dihydroxy-4-methoxyacetophenone improves cognitive function and may be helpful for the treatment of Alzheimer's disease.
3-Acetoxy-8(17),13E-labdadien-15-oic acid
TN2918CAS 63399-37-1
ent-3-Acetoxy-labda-8(17),13-dien-15-oic acid have vasorelaxant and hypotensive actions, the mechanisms underlying the cardiovascular actions of the labdane inv...
4-Hydroxycinnamamide
TN3042CAS 194940-15-3
4-Hydroxycinnamamide has antioxidant activity. 4-Hydroxycinnamamide derivatives are specific inhibitors of tyrosine-specific protein kinases.
8(14),15-Isopimaradien-3-ol
TN3260CAS 4728-30-7
ent-8(14),15-pimaradien-3beta-ol (8(14),15-Isopimaradien-3-ol) can induce vascular relaxation. It displays high antibacterial activities (MIC values lower than ...
9-Hydroxycanthin-6-one
TN3319CAS 138544-91-9
9-Hydroxycanthin-6-one might be the active component that contributed to the aphrodisiac effect of E. longifolia by antagonizing the smooth muscle tone of CC as...
Atherosperminine
TN3466CAS 5531-98-6
Atherosperminine shows cholinesterase inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Atherosperminine shows strong an...
Calceolarioside A
TN3568CAS 84744-28-5
Calceolarioside A shows potent activity against visceral leishmaniasis. It can induce a dose-related aggregant effect on rabbit platelets, which may be partly r...
Cinnamyl caffeate
TN3660CAS 115610-32-7
Cinnamyl caffeate has cardiovascular protective effects, it can increase H9c2 cellular antioxidant potential, decrease intracellular calcium ion ([Ca2+]i) level...
Denudatin B
TN3831CAS 87402-88-8
Denudatin B has nonspecific antiplatelet action at high concentration by inhibiting phosphoinositides breakdown induced by collagen and thrombin, it inhibits th...
Didrovaltrate
TN3844CAS 18296-45-2
Didrovaltrate shows cytotoxic against human cancer cell lines. Didrovaltrate blocks I(Ca-L) in a concentration-dependent manner and probably inhibits I(Ca-L) in...
Fargesone B
TN4051CAS 116424-70-5
Fargesone B inhibits the vascular smooth muscle contraction by suppressing the voltage- and receptor-activated calcium influxes in a nonselective manner.
Isokaempferide
TN4303CAS 1592-70-7
Isokaempferide shows hepatoprotective, antiproliferative, and anti-inflammatory effects, the anti-inflammatory effects can be explained, at least in part, by re...
(-)-Praeruptorin A
TN4819CAS 14017-71-1
(-)-Praeruptorin A has anti-inflammatory, anti-contractile and anti-hyperplasia activities, it exerts distinct relaxant effects on isolated rat aorta rings depe...
Strophanthidine
TN5073CAS 66-28-4
Strophanthidin can induce calcium overload in vivo.
Taxezopidine L
TN5109CAS 219749-76-5
Taxezopidines K and taxezopidine L can markedly inhibit Ca2+-induced depolymerization of microtubules.
Vindorosine
TN5234CAS 5231-60-7
Vindorosine has blood vessel relaxation effect, possible underlying mechanisms involving the inhibition of Ca(2+) entry via L-type Ca(2+) channels in vascular s...
Zeorin
TN5279CAS 22570-53-2
Zeorin shows strong inhibition activity against bacteria and fungi. It markedly exhibits inhibitory activity on histamine release from mast cell induced by DNP2...
CALP3 TFA
TP2170CAS
CALP3 TFA is a potent Ca2+ channel blocker that activates EF-hand motifs of Ca2+-binding proteins. It can functionally mimic increased [Ca2+]i by modulating the...
(S)-(-)-Bay K 8644
TQ0144CAS 98625-26-4
(S)-(-)-Bay-K-8644 is an agonist of L-type Ca2+ channel. It activates Ba2+ currents (IBa) (EC50: 32 nM).
(R)-(+)-Bay K 8644
TQ0145CAS 98791-67-4
(R)-(+)-Bay K 8644 is a calcium channel inhibitor. It inhibits Ba2+ currents (IBa) (IC50: 975 nM).
Mibefradil
TQ0153CAS 116644-53-2
Mibefradil is a calcium channel blocker with moderate selectivity for T-type Ca2+ channels (IC50s: 2.7 μM and 18.6 μM for T-type and L-type currents).
Thapsigargin
TQ0302CAS 67526-95-8
Thapsigargin is a microsomal Ca2+-ATPase inhibitor and Endoplasmic Reticulum stress-inducing agent.