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Cat No. | Product Name | Synonyms | Targets |
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T0229 | Rivastigmine | SDZ-ENA 713,S-Rivastigmine,Exelon | AChE |
Rivastigmine (Exelon) is a Cholinesterase Inhibitor, used for therapy of Alzheimer disease. | |||
T1628 | Rivastigmine tartrate | SDZ-ENA 713,ENA 713 | AChR , AChE |
Rivastigmine tartrate (SDZ-ENA 713) is a carbamate-derived reversible CHOLINESTERASE INHIBITOR that is selective for the CENTRAL NERVOUS SYSTEM and is used for the treatment of DEMENTIA in ALZHEIMER DISEASE and PARKINSON... | |||
T23131 | PE 154 | AChE | |
PE 154 is a potent fluorescent inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50s of 280 pM and 16 nM respectively. PE 154 is commonly used to label β-amyloid plaques in histochemical an... | |||
T10630 | BuChE-IN-TM-10 | TM-10 | AChR |
BuChE-IN-TM-10 (TM-10) is a potent butyrylcholinesterase (BuChE) inhibitor, with an IC50 of 8.9 nM. BuChE inhibitor 1 inhibits and disaggregates self-induced Aβ aggregation, exhibiting potent antioxidant activity and goo... | |||
T21393 | Ethopropazine Hydrochloride | Lysivane,Parphezein,Dibutil,Parfezin,Profenamine HCl,Pardisol | |
Ethoproprazine hydrochloride is an butyrylcholinesterase inhibitor. It reduces extrapyramidal motor effects and used as an antidyskinetic, characteristic of Parkinson′s disease. It also alleviates thermal hyperalgesia in... | |||
T16814 | RX 67668 | Others | |
RX 67668 is a muscle relaxant used to relieve skeletal muscle fatigue. RX 67668 is an effective cholinesterase inhibitor (IC50: 5 μM for both acetylcholinesterase and butyrylcholinesterase). RX 67668 can reverse the neur... | |||
T26827 | Bisnorcymserine | N1 N8 Bisnorcymserine,N1N8Bisnorcymserine,N1-N8-Bisnorcymserine | |
Bisnorcymserine is a reversible inhibitor of butyrylcholinesterase. The leaving group, bisnoreseroline, interacts in a non-covalent way with Ser(200) and His(440), disrupting the existing interactions within the catalyti... | |||
T38740 | Rivastigmine carbamate impurity | 3-Nitrophenyl ethyl(methyl)carbamate | |
Rivastigmine carbamate impurity (3-Nitrophenyl ethyl(methyl)carbamate) is a byproduct found in Rivastigmine, which is recognized as a powerful and orally active inhibitor of cholinesterase (ChE). Specifically, Rivastigmi... | |||
T61669 | BChE-IN-4 | ||
BChE-IN-4 is a highly potent inhibitor of the enzyme butyrylcholinesterase, capable of crossing the blood-brain barrier. It effectively reduces learning and memory impairments resulting from a deficiency in cholinergic a... | |||
T75145 | TRV-7019 | ||
TRV-7019 is a BBB-penetrable radioligand for brain imaging that target butyrylcholinesterase . TRV-7019 can be used for the diagnosis of an amyloid disease, multiple sclerosis, a brain tumor, or butyrylcholinesterase act... | |||
T61399 | Z164597606 | ||
Z164597606 is a compound that acts as a selective inhibitor of the enzyme Butyrylcholinesterase (BChE), with IC50 values of 1.3 μM and 1.7 μM for equine BChE and human BChE, respectively. Through a π-π stacking interacti... | |||
T69495 | Affinisine | ||
Affinisine is a monoterpenoid indole alkaloid which can be isolated from plants of the genus Tabernaemontana. It may be an effective inhibitor of both acetylcholinesterase and butyrylcholinesterase based on previous rese... | |||
T70607 | Cymserine | ||
Cymserine is a drug related to physostigmine, which acts as a reversible cholinesterase inhibitor, with moderate selectivity for the plasma cholinesterase enzyme butyrylcholinesterase, and relatively weaker inhibition of... | |||
T79422 | BuChE-IN-8 | ||
BuChE-IN-8 (compound 19c), a butyrylcholinesterase (BuChE) inhibitor, exhibits an IC50 value of 559 nM and concurrently inhibits human β-secretase (BACE1) and Aβ40 aggregation. It also demonstrates notable antiamnesic pr... | |||
T40904 | ACG548B | ||
ACG548B (compound 24) is a highly effective inhibitor of acetyl- and butyrylcholinesterase (AChE and BChE) with IC50 values of 1.78 and 0.496 μM, respectively. It exhibits a greater affinity for AChE and demonstrates sel... | |||
T62336 | BChE-IN-3 | ||
BChE-IN-3 is a selective, selective, time-dependent, pseudo-irreversible inhibitor of BChE butyrylcholinesterase (IC50: 56.9 nM).BChE-IN-3 exhibits borderline reversible (time-independent) inhibition of AChE acetylcholin... | |||
T61638 | Dihydro Donepezil | ||
Dihydro Donepezil, also known as Dihydro E2020, is a metabolite derived from Donepezil. Donepezil is a highly specific and potent inhibitor of acetylcholinesterase (AChE) with IC50 values of 8.12 nM and 11.6 nM for butyr... | |||
T61418 | BuChE-IN-6 | ||
BuChE-IN-6 (compound 1b) is a highly effective and specific inhibitor of BuChE (butyrylcholinesterase), demonstrating an IC50 value of 0.46 μM for eqBuChE and 0.51 μM for hBuChE. Furthermore, BuChE-IN-6 has the additiona... | |||
T39678 | Multitarget AD inhibitor-1 | ||
Multitarget AD inhibitor-1 is a reversible and selective inhibitor of butyrylcholinesterase (BuChE) with IC50 values of 7.22 μM and 1.55 μM for human BuChE (hBuChE) and equine serum BuChE (eqBuChE), respectively. Additio... | |||
T62538 | AChE-IN-15 | ||
AChE-IN-15 (Compound 3d) is a reversible inhibitor of human acetylcholinesterase (huAChE) and human butyrylcholinesterase (huBChE) with IC50 values of 6.8 μM and 16.1 μM for huAChE and huBChE, respectively, with signific... | |||
T61342 | BChE-IN-13 | ||
BChE-IN-13 (Compound 17c) is an orally active, potent, and selective inhibitor of Butyrylcholinesterase (BChE). It exhibits IC50 values of 0.22 μM and 0.016 μM for eqBChE and hBChE, respectively. BChE-IN-13 demonstrates ... | |||
T72876 | SEH/AChE-IN-4 | ||
sEH/AChE-IN-4 -15) is a potent and BBB-penetrated dual inhibitor of sEH (soluble epoxide hydrolase) and AChE (acetylcholinesterase), with IC 50 values of 3.1 nM (hsEH), 1660 nM (hAChE), 179 nM (hBChE, human butyrylcholin... | |||
T78905 | AChE-IN-29 | ||
AChE-IN-29, a 3-OH pyrrolidine derivative, acts as a cholinesterase (ChE) inhibitor with potent activity against human acetylcholinesterase (hAChE), electric eel acetylcholinesterase (eeAChE), and equine butyrylcholinest... | |||
T82915 | BChE-IN-21 | ||
BChE-IN-21, a potent inhibitor of butyrylcholinesterase (BChE), exhibits an inhibition constant (IC50) of 0.14 ± 0.02 μM, indicating promise for research in Alzheimer's disease [1]. | |||
T64156 | AChE/BChE-IN-1 | ||
AChE/BChE-IN-1 is a potent dual inhibitor of acetylcholinesterase and butyrylcholinesterase with blood-brain barrier permeability, exhibiting an IC50 value of 1.06 and 7.3 nM for hAChE and hBChE, respectively, and showin... | |||
T81998 | K1833 | ||
K1833 is an inhibitor and reactivator of human acetylcholinesterase (hrAChE), exhibiting an inhibition concentration (IC50) of 58$. Additionally, K1833 demonstrates potent inhibition (IC50 = 0.57$) and minimal reactivati... | |||
T72804 | Isograndifoliol | ||
Isograndifoliol is a selective inhibitor of butyrylcholinesterase ( BChE ) with an IC 50 value of 0.9 μM. And Isograndifoliol moderately inhibits acetylcholinesterase ( AChE ) with an IC 50 value of 342.9 μM. Isograndifo... | |||
T78695 | BChE-IN-16 | ||
BChE-IN-16 (compound 87) is a potent inhibitor of human butyrylcholinesterase (hBChE) exhibiting an inhibition concentration half-maximum (IC50) of 3.8 nM. It demonstrates low cytotoxicity and potential for central nervo... | |||
T61603 | H3R antagonist 2 | ||
H3R antagonist 2 (Compound 23) is a multitarget histamine H3 receptor antagonist. It exhibits inhibitory effects on acetylcholinesterase, butyrylcholinesterase, and human monoamine oxidase B (hMAO B) with IC50 values of ... | |||
T79502 | PD24 | ||
PD24 serves as an inhibitor of both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), with inhibitory concentrations (IC50) of 1.72 μM for human AChE (hAChE), 1.76 μM for electric eel AChE (eeAChE), and 2.64... | |||
T78828 | AChE/BChE-IN-15 | ||
AChE/BChE-IN-15 (Compound 6d) serves as an inhibitor for both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), presenting inhibition constants (IC50) of 20 nM for AChE and 220 nM for BChE. It interacts with ... | |||
T60983 | BChE-IN-14 | ||
BChE-IN-14 (compound 19c) can restore cognitive impairment in vivo that can be used in the Alzheimer’s disease research. BChE-IN-14 has primary cell safety and good blood brain barrier permeability. BChE-IN-14 is a selec... | |||
T79548 | AChE/BChE-IN-13 | ||
AChE/BChE-IN-13 (compound 5j) serves as a potent dual inhibitor of both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), exhibiting half-maximal inhibitory concentrations (IC50) of 20.89 μM for AChE and 17.3... | |||
T79501 | PD10 | ||
PD10 is a dual inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), exhibiting inhibitory potency at human AChE (hAChE IC50: 0.56 μM), electric eel AChE (eeAChE IC50: 0.59 μM), and equine serum BuC... | |||
T79966 | AChE/BChE-IN-14 | ||
AChE/BChE-IN-14 (compound 13), a benzylisoquinoline alkaloid extracted from Fissistigma polyanthum roots, demonstrates inhibitory effects on both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), coupled with... | |||
T82242 | HAChE-IN-6 | ||
hAChE-IN-6 (compound 51) is a brain-penetrant acetylcholinesterase (AChE) inhibitor exhibiting an IC50 of 0.16 μM. It also demonstrates inhibitory effects on human butyrylcholinesterase (hBuChE) and glycogen synthase kin... | |||
T79423 | BuChE-IN-9 | ||
BuChE-IN-9 (compound 22a), an eqBuChE (equine serum-derived butyrylcholinesterase) inhibitor, exhibits potent activity with an IC50 of 173 nM. In addition to eqBuChE, it also inhibits human BACE1, Aβ aggregation, and mou... | |||
T62578 | BuChE-IN-1 | ||
BuChE-IN-1 (Compound 23) is a potent, highly blood-brain barrier-permeable, low cytotoxicity inhibitor of butyrylcholinesterase (BuChE). BuChE-IN-1 is a BuChE inhibitor that has the potential to be used in the study of A... | |||
T72875 | SEH/AChE-IN-3 | ||
sEH/AChE-IN-3 -15) is a potent and BBB-penetrated dual inhibitor of sEH (soluble epoxide hydrolase) and AChE (acetylcholinesterase), with IC 50 values of 0.4 nM (hsEH), 1.94 nM (hAChE), 615 (hBChE, human butyrylcholinest... | |||
T61206 | AChE/BChE/BACE-1-IN-1 | ||
AChE/BChE/BACE-1-IN-1 (Compound 4k) is an orally active inhibitor that targets acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and β-site amyloid precursor protein cleaving enzyme 1 (BACE-1). It displays IC50 ... | |||
T79342 | BChE-IN-17 | ||
BChE-IN-17 (compound 6n) is a potent, selective inhibitor of butyrylcholinesterase (BChE), demonstrating inhibitory half-maximal inhibitory concentrations (IC50s) of 10.5 nM for equine BChE (eqBChE) and 32.5 nM for human... | |||
T62504 | BChE-IN-8 | ||
BChE-IN-8 (compound 20) is an orally active BChE (butyrylcholinesterase) inhibitor that crosses the blood-brain barrier and acts on eqBChE (IC50: 0.15 nM), hBChE (IC50: 45.2 nM). BChE-IN-8 can be used in the study of Alz... | |||
T64238 | Aβ1–42 aggregation inhibitor 1 | ||
Aβ1-42 aggregation inhibitor 1 inhibits AChE (acetylcholinesterase) and BuChE (butyrylcholinesterase) with the IC 50 value of 2.64 μM and 1.29 μM, respectively. Aβ1-42 aggregation inhibitor 1 inhibits self-mediated Aβ1-4... | |||
T62441 | AChE-IN-14 | ||
AChE-IN-14 is a potent cholinesterase inhibitor, acting on electric eel acetylcholinesterase (eeAChE) (IC50: 0.46 μM), human recombinant acetylcholinesterase (hAChE) (IC50: 0.48 μM) and equine serum butyrylcholinesterase... | |||
T36639 | Donecopride (fumarate hydrate) | ||
Donecopride is a partial agonist of the serotonin (5-HT) receptor subtype 5-HT4E(Ki= 8.5 nM) and an inhibitor of acetylcholinesterase (AChE; IC50= 16 nM).1It is selective for AChE over butyrylcholinesterase (BChE; IC50= ... | |||
T82243 | HAChE-IN-5 | GSK-3 | |
hAChE-IN-5 (compound 49) is a dual inhibitor of human acetylcholinesterase (hAChE) and human butyrylcholinesterase (hBuChE), exhibiting inhibitory potency with IC50 values of 0.17 μM for both enzymes. Additionally, it de... | |||
T72763 | AChE/BuChE-IN-1 | ||
AChE/BuChE-IN-1 , a chrysin derivative, is a selective butyrylcholinesterase (BuChE) inhibitor with an IC 50 of 0.48 μM. AChE/BuChE-IN-1 inhibits acetylcholinesterase (AChE) with an IC 50 of 7.16 μM. AChE/BuChE-IN-1 show... |
Cat No. | Product Name | Synonyms | Targets |
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TN1305 | Ethoxysanguinarine | 6-Ethoxydihydrosanguinarine | Apoptosis , AChR |
Ethoxysanguinarine (6-Ethoxydihydrosanguinarine) shows human blood acetylcholinesterase (HuAChE) and human plasma butyrylcholinesterase (HuBuChE) inhibitory activity, with IC50 values of 0.83 +/- 0.04 microM and 4.20 +/-... | |||
TN1341 | 8-Deoxygartanin | Beta Amyloid , NF-κB , Parasite | |
8-Deoxygartanin is a butyrylcholinesterase (BChE) selective inhibitor, it exhibits significant inhibition of self-induced α2-amyloid (Aα2) aggregation, it has multifunctional activities against Alzheimer's disease (AD) a... | |||
T11366 | Garcinol | Apoptosis , Endogenous Metabolite , Histone Acetyltransferase , AChR , AChE | |
Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and anti-cancer activity. Garcinol, a polyisoprenylated benzophenone... | |||
T3819 | Ursolic acid acetate | Acetylursolic acid,3-Acetylursolic Acid | AChE |
Ursolic acid acetate (Acetylursolic acid) has cytotoxic activity, antimalarial activity, antitumor and anticancer activities. Acetylursolic acid has NO production inhibitory activities. Acetylursolic acid has inhibition ... | |||
T7052 | Gnetol | Tyrosinase , COX , HDAC , AChR | |
Gnetol competitivity inhibits butyrylcholinesterase (IC50: 1.3 uM). Gnetol has a strong inhibitory effect on murine tyrosinase activity. Gnetol significantly suppresses melanin biosynthesis in murine B16 melanoma cells. ... | |||
TN3466 | Atherosperminine | cAMP , Calcium Channel , AChR , Parasite | |
Atherosperminine shows cholinesterase inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Atherosperminine shows strong anti-plasmodial activity against Plasmodium falciparum, with t... | |||
T3S1612 | Kuwanon G | Moracenin B,Kuwanone G | Phosphatase , Antibacterial , Bombesin Receptor , AChR , AChE , Glucosidase |
1. Kuwanon G (Moracenin B) as dual inhibitors of PTP1B and α-glucosidase enzymes, as well as insulin sensitizers, it may potentially be utilized as an effective treatment for Type II diabetes mellitus. 2. Kuwanon G has a... | |||
TN3696 | Conodurine | AChR | |
Conodurine shows leishmanicidal and antibacterial activities, it shows inhibition activity for acetyl (AChE) and butyrylcholinesterase (BuChE). | |||
TN4570 | Minumicrolin | Others | |
Minumicrolin is a plant growth inhibitor against the 2nd leaf sheath elongation of rice seedlings. Murrangatin exhibits cytotoxicity against cholangiocarcinoma cell line, KKU-100, it might be valuable anti-tumor-promotin... | |||
TN6050 | Macusine B | ||
Macusine B is a dual inhibitor, has almost equal inhibitory activity on both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). | |||
TN2504 | 1,5-Dihydroxyxanthone | EGFR , AChR | |
1,5-Dihydroxyxanthone exhibits the epidermal growth factor receptor (EGFR) -tyrosine kinase inhibitory activity, with the IC50 value of 90.34 nM. It may have anticholinesterase activity on acetylcholinesterase (AChE) and... | |||
TN4613 | (-)-N-methylcoclaurine | N-Methylcoclaurine | Others |
N-Methylcoclaurine shows binding affinities for the ĸ opioid receptor with the equilibrium dissociation constant (Ki) value of 0.9 ± 0.1 uM. N-methylcoclaurine also shows promising butyrylcholinesterase inhibition a... | |||
TN1848 | Kuwanon E | AChR | |
Kuwanon E inhibited cholinesterase enzyme in a dose-dependent manner with K i values ranging between 3.1 and 37.5 μM and between 1.7 and 19.1 μM against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzyme... | |||
TN3287 | 8-Lavandulylkaempferol | Reductase , AChR | |
8-Lavandulylkaempferol exhibits significant inhibitory effects with IC(50) values of 7.10 and 8.11 microM for butyrylcholinesterase and acetylcholinesterase, respectively. It shows inhibitory activities against aldose re... | |||
T75514 | Blestrin D | ||
Blestrin D is a potent butyrylcholinesterase (BChE) mixed-type inhibitor with an IC 50 value of 8.1 μM. Blestrin D can be isolated from Bletilla striata . Blestrin D can be used for the research of Alzheimer's disease (A... | |||
TN4456 | Lucidadiol | AChR , HSV | |
Lucidadiol exhibits butyrylcholinesterase-inhibitory activity at concentrations up to 200 uM, it also possesses inhibitory activity against acetylcholinesterase (AChE) with the percentage inhibition at 100 uM. Lucidadiol... | |||
T75511 | BChE-IN-10 | ||
BChE-IN-10 (compound 6) is a potent butyrylcholinesterase (BChE) mixed-type inhibitor with an IC 50 value of 6.4 μM. BChE-IN-10 can be isolated from Bletilla striata . BChE-IN-10 can be used for the research of Alzheimer... | |||
T73202 | BChE-IN-11 | ||
BChE-IN-11 is a potent, selective and non-competitive BChE (butyrylcholinesterase) inhibitor, with an IC 50 of 2.1 μM. BChE-IN-11 can be used for Alzheimer's disease (AD) research . | |||
T4700 | 1,3,5-Trihydroxy-4-prenylxanthone | ||
1,3,5-Trihydroxy-4-prenylxanthone is a relatively potent inhibitor of phosphodiesterase type 5 (PDE5), with an IC50 value of 3.0 μM; it shows in vitro inhibitory activity against acetylcholinesterase (AChE) and butyrylch... | |||
TN3744 | Cyclomorusin | NOS , AChR | |
Cyclomorusin exhibits competitive inhibition toward monophenolase activity of mushroom tyrosinase, the IC50 value of 0.092 microM. It evokes the stimulation of superoxide anion generation in fMLP-stimulated rat neutrophi... | |||
T79973 | Dehydrodiscretamine chloride | ||
Dehydrodiscretamine chloride, a dual inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), exhibits IC50 values of 17.8 μM and 118.8 μM, respectively. It also possesses antioxidant activity and is ut... | |||
T75513 | BChE-IN-12 | ||
BChE-IN-12 (compound 12) is a potent butyrylcholinesterase (BChE) non-competitive inhibitor with an IC 50 value of 2.3 μM. BChE-IN-12 can be isolated from Bletilla striata . BChE-IN-12 can be used for the research of Alz... | |||
TC0022 | Desoxypeganine | Deoxypeganine | AChE |
Desoxypeganine (Deoxypeganine) is an inhibitor of cholinesterase. It acting preferentially on butyrylcholinesterase, and as a selective inhibitor of monoamine oxidase A but not monoamine oxidase B.Desoxypeganine is being... | |||
T79963 | Feralolide | ||
Feralolide, a dihydroisocoumarin from the methanolic extract of aloe vera resin, functions as a dual inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), with IC50 values of 55 μg/mL and 52 μg/mL, ... |
Cat No. | Product Name | Species | Expression System |
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TMPY-01596 | Butyrylcholinesterase Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Butyrylcholinesterase (BCHE), also known as cholinesterase or BuChE, is an enzyme defined as "pseudo" or "non-neuronal" cholinesterase. Butyrylcholinesterase (BCHE) is widely distributed in the nervous system as well as ... | |||
TMPY-01693 | Butyrylcholinesterase Protein, Human, Recombinant (His) | Human | HEK293 |
Butyrylcholinesterase (BCHE), also known as cholinesterase or BuChE, is an enzyme defined as "pseudo" or "non-neuronal" cholinesterase. Butyrylcholinesterase (BCHE) is widely distributed in the nervous system as well as ... |