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Neuroscience Beta Amyloid

Beta Amyloid

Amyloid beta (Aβ or Abeta) denotes peptides of 36–43 amino acids that are crucially involved in Alzheimer's disease as the main component of the amyloid plaques found in the brains of people with Alzheimer's disease. The peptides derive from the amyloid precursor protein (APP), which is cleaved by beta secretase and gamma secretase to yield Aβ. Aβ molecules can aggregate to form flexible soluble oligomers which may exist in several forms. It is now believed that certain misfolded oligomers (known as "seeds") can induce other Aβ molecules to also take the misfolded oligomeric form, leading to a chain reaction akin to a prion infection.
Cat No. product name
T6202 DAPTHOT DAPT is a novel γ-secretase inhibitor which reduces the Aβ production (IC50: 20 nM in HEK 293 cells) and Aβ42 levels (IC50: 200 nM).
T6274 RO4929097HOT RO4929097, a γ secretase inhibitor (IC50: 4 nM), inhibits cellular processing of Aβ40 and Notch (EC50: 14/5 nM).
T21825 TAE-1 TAE-1 is an inhibitor of amyloid-β fibril formation and aggregation. It inhibits cholinesterases AChE and BuChE with IC50 of 0.3 μM and 3.9 μM, respectively.
T5810 TABERSONINE HYDROCHLORIDE TABERSONINE HYDROCHLORIDE is a natural product extracted from the bean of Voacanga africana, is a potent inhibitor against Aβ(1−42) aggregation and toxicity.
TP1856 Colivelin Colivelin is a neuroprotective peptide and activator of STAT3. Colivelin is a hybrid peptide synthesized to enhance the neuroprotective effects of humanin (HN).
TP1007 Amyloid β-Peptide (1-42) human Amyloid β-Peptide (1-42) human is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease.
T7680 GSNKGAIIGLM(131602-53-4(free base)) GSNKGAIIGLM is the fragment Aβ(25-35) of the Alzheimer's amyloid β-peptide.
T7905 PBD-150 PBD-150 is an inhibitor of human glutaminyl cyclase (hQC) Y115E-Y117E variant( ki : 490 nM)
T8012 Scyllo-Inositol Scyllo-Inositol is one of the inositol stereoisomers, rare in the nature, and expected as a promising disease-modifying therapeutic agent for Alzheimer's diseas...
T7562 β-Amyloid 31-35(TFA) β-Amyloid 31-35(TFA) is the shortest sequence of native Amyloid-β peptide.
TQ0026 MDR-1339 MDR-1339 (DWK-1339) is an orally active and blood-brain-barrier-permeable inhibitor of amyloid-β (Aβ) aggregation.
T7527 Frentizole Frentizole, an immunosuppressive agent, is an inhibitor of the Aβ-ABAD interaction
T7490 ARN2966 ARN2966 is an inhibitor of amyloid precursor protein (APP)and amyloid-β (Aβ) secretion.
T4077 PE859 PE859 is a potent inhibitor of both tau and Aβ aggregation.
T4422 Edonerpic maleate Edonerpic maleate is a novel neurotrophic agent which can inhibit amyloid-β peptides (Aβ).
TN1341 8-Deoxygartanin 8-Deoxygartanin is a butyrylcholinesterase (BChE) selective inhibitor, it exhibits significant inhibition of self-induced α²-amyloid (Aα²) aggregation, it h...
T6495 EUK 134 EUK 134, a synthetic superoxide dismutase (SOD)/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related a...
T2262 CHF5074 CHF5074, a γ-secretase modulator, reduces Aβ42/40 secretion (IC50: 3.6/18.4 μM).
T2872 Ginsenoside Re Ginsenoside Re may have properties that inhibit or prevent the growth of tumors.
T2625 MK0752 MK-0752, a γ-secretase inhibitor, reduces Aβ40 production(IC50=5 nM).
T0883 Homotaurine Because of its similarity in structure to the neurotransmitter gamma-aminobutyric acid (GABA), it has GABAergic effects and may be useful as an anticonvulsant. ...
T2212 Geniposide Geniposide is an iridoid glycoside with a variety of biological activities including neuroprotective, anti-diabetic, antiproliferative, and antioxidative activi...
T2777 Ginsenoside Rg1 Ginsenosides are a class of steroid glycosides, and triterpene saponins found exclusively in the plant genus Panax (ginseng). It improves spatial learning and i...
T3394 Timosaponin BII Timosaponin BII has anti-dementia activity and may be useful for the treatment of type 2 diabetes. Timosaponin BII has antioxidant activity, can inhibit the up-...
TN1116 Schisandrone Schisandrone has strong activities of anti-oxidation, effectively scavenges hydroxyl radical and superoxide anion, and has protective effects on cells under act...
TN1653 Fustin Fustin shows protective effects on 6-hydroxydopamine-induced neuronal cell death.
TP1866L β-amyloid 1-11 acetate(190436-05-6 free base) β-amyloid 1-11 acetate is a fragment of Amyloid-β peptide, maybe used in the research of neurological disease.
TMS1461 Otophylloside B Qingyangshengenin B is a C-21 steroidal glycoside isolated from Qingyangshen. Qingyangshengenin B protects against Aβ toxicity, which decreases Aβ deposition...
TP1786L Amyloid β-Protein 10-20 acetate(152286-31-2 free base) Amyloid β-Protein (10-20) acetate is a fragment of Amyloid-β peptide, maybe used in the research of neurological disease.Amyloid β protein fragment containin...
T19011L Hoechst 34580 xHCl(23555-00-2(free base) Hoechst 34580 xHCl is a cell-permeable fluorescent dye, is used for staining DNA and nuclei.
TP1214L β-Amyloid 15-21 acetate β-amyloid (15-21) acetate is a fragment of Amyloid-β peptide, maybe used in the research of neurological disease. This fragment is involved in beta sheet form...
T19892 BSBM7 BSBM7 is an inhibitor of Aβ aggregation and neuronal toxicity.
TN4865 Putraflavone Putraflavone possesses a good antioxidant activity via its DPPH free radical scavenging.
TN4635 Neoechinulin A Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, it may block t...
TN4571 Mirabijalone D Mirabijalone D is a non-competitive inhibitor based on the Dixon plot.It inhibits Aβ1-42 production by 43.7% in APPSW-N2a cells.
TN3618 Cedrin Cedrin has protective effects on PC12 cells against the neurotoxicity induced by amyloid β1-42, the protective effect is related to the inhibition of oxidative...
TN3410 Anatabine Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheim...
TN3218 7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one 7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one as a beneficial compound to ameliorate the deleterious effects of Aβ on dendrite integrity and cell survival, and m...
T19013 Hoechst 34580 tetrahydrochloride (23555-00-2 free base) Hoechst 34580 tetrahydrochloride, a cell-permeable fluorescent dye, is used for staining DNA and nuclei.
TN1725 Hederacolchiside E Hederacolchiside E has antioxidant activity, it shows inhibition on lipid peroxidation of linoleic acid emulsion; it may exert its anti-inflammatory effects by ...
T19011 Hoechst 34580 Hoechst 34580, a cell-permeable fluorescent dye, is used for staining DNA and nuclei.
T10453 BACE1-IN-5 BACE1-IN-5 is a BACE1 inhibitor (IC50: 9.1 nM) and also inhibits cellular amyloid-β (Aβ; IC50: 0.82 nM). BACE1-IN-5 has medicinal chemistry that improves hERG...
T14673 BMS 299897 BMS 299897 is a sulfonamide γ-secretase inhibitor. It has an IC50 of 7 nM for Aβ production inhibition in HEK293 cells stably overexpressing amyloid precursor...
T14525 Begacestat Begacestat is a selective thiophene sulfonamide amyloid precursor protein gamma-secretase inhibitor (Aβ40,IC50=15 nM),and for the treatment of Alzheimer's dise...
T14284 Amyloid beta-peptide(25-35) Amyloid beta-peptide(25-35) is the fragment Aβ(25-35) of the Alzheimer's amyloid β-peptide. Which has shown neurotoxic activities in cultured cells.
T14199 ALZ-801 ALZ-801 is an advanced and markedly improved candidate for the treatment of alzheimer’s disease. ALZ-801 is a potent and orally available small-molecule β-am...
T19142 4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine 4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine is a potent amyloid imaging agent that binds to Amyloid-β (1-40) (KD: 1.7 nM).
TN2082 Pinostrobin Pinostrobin, a potent flavonoid inducer, exerts a neuroprotective effect against Aα²(25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibit...
TN1919 Medioresinol Medioresinol possesses antioxidative, a lesishmanicidal activity and cardiovascular disease risk reduction, it has antiamyloidogenic activity via reduction in t...
TN1798 Isorosmanol Isorosmanol possesses antioxidant, neuroprotective and neurotrophic effects, it might be useful in ageing disorders such as the declining of cognitive functions...
T2639 LY2811376 LY2811376, an orally available non-peptidic β-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Aβ secretion (EC50: 300 nM). It has 10-fold selectiv...
DAPT HOT
T6202CAS 208255-80-5
DAPT is a novel γ-secretase inhibitor which reduces the Aβ production (IC50: 20 nM in HEK 293 cells) and Aβ42 levels (IC50: 200 nM).
RO4929097 HOT
T6274CAS 847925-91-1
RO4929097, a γ secretase inhibitor (IC50: 4 nM), inhibits cellular processing of Aβ40 and Notch (EC50: 14/5 nM).
TAE-1
T21825CAS 1414469-59-2
TAE-1 is an inhibitor of amyloid-β fibril formation and aggregation. It inhibits cholinesterases AChE and BuChE with IC50 of 0.3 μM and 3.9 μM, respectively.
TABERSONINE HYDROCHLORIDE
T5810CAS 29479-00-3
TABERSONINE HYDROCHLORIDE is a natural product extracted from the bean of Voacanga africana, is a potent inhibitor against Aβ(1−42) aggregation and toxicity.
Colivelin
TP1856CAS 867021-83-8
Colivelin is a neuroprotective peptide and activator of STAT3. Colivelin is a hybrid peptide synthesized to enhance the neuroprotective effects of humanin (HN).
Amyloid β-Peptide (1-42) human
TP1007CAS 107761-42-2
Amyloid β-Peptide (1-42) human is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease.
GSNKGAIIGLM(131602-53-4(free base))
T7680CAS T7680
GSNKGAIIGLM is the fragment Aβ(25-35) of the Alzheimer's amyloid β-peptide.
PBD-150
T7905CAS 790663-33-1
PBD-150 is an inhibitor of human glutaminyl cyclase (hQC) Y115E-Y117E variant( ki : 490 nM)
Scyllo-Inositol
T8012CAS 488-59-5
Scyllo-Inositol is one of the inositol stereoisomers, rare in the nature, and expected as a promising disease-modifying therapeutic agent for Alzheimer's diseas...
β-Amyloid 31-35(TFA)
T7562CAS 149385-65-9
β-Amyloid 31-35(TFA) is the shortest sequence of native Amyloid-β peptide.
MDR-1339
TQ0026CAS 1018946-38-7
MDR-1339 (DWK-1339) is an orally active and blood-brain-barrier-permeable inhibitor of amyloid-β (Aβ) aggregation.
Frentizole
T7527CAS 26130-02-9
Frentizole, an immunosuppressive agent, is an inhibitor of the Aβ-ABAD interaction
ARN2966
T7490CAS 102212-26-0
ARN2966 is an inhibitor of amyloid precursor protein (APP)and amyloid-β (Aβ) secretion.
PE859
T4077CAS 1402727-29-0
PE859 is a potent inhibitor of both tau and Aβ aggregation.
Edonerpic maleate
T4422CAS 519187-97-4
Edonerpic maleate is a novel neurotrophic agent which can inhibit amyloid-β peptides (Aβ).
8-Deoxygartanin
TN1341CAS 33390-41-9
8-Deoxygartanin is a butyrylcholinesterase (BChE) selective inhibitor, it exhibits significant inhibition of self-induced α²-amyloid (Aα²) aggregation, it h...
EUK 134
T6495CAS 81065-76-1
EUK 134, a synthetic superoxide dismutase (SOD)/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related a...
CHF5074
T2262CAS 749269-83-8
CHF5074, a γ-secretase modulator, reduces Aβ42/40 secretion (IC50: 3.6/18.4 μM).
Ginsenoside Re
T2872CAS 52286-59-6
Ginsenoside Re may have properties that inhibit or prevent the growth of tumors.
MK0752
T2625CAS 471905-41-6
MK-0752, a γ-secretase inhibitor, reduces Aβ40 production(IC50=5 nM).
Homotaurine
T0883CAS 3687-18-1
Because of its similarity in structure to the neurotransmitter gamma-aminobutyric acid (GABA), it has GABAergic effects and may be useful as an anticonvulsant. ...
Geniposide
T2212CAS 24512-63-8
Geniposide is an iridoid glycoside with a variety of biological activities including neuroprotective, anti-diabetic, antiproliferative, and antioxidative activi...
Ginsenoside Rg1
T2777CAS 22427-39-0
Ginsenosides are a class of steroid glycosides, and triterpene saponins found exclusively in the plant genus Panax (ginseng). It improves spatial learning and i...
Timosaponin BII
T3394CAS 136656-07-0
Timosaponin BII has anti-dementia activity and may be useful for the treatment of type 2 diabetes. Timosaponin BII has antioxidant activity, can inhibit the up-...
Schisandrone
TN1116CAS 98619-25-1
Schisandrone has strong activities of anti-oxidation, effectively scavenges hydroxyl radical and superoxide anion, and has protective effects on cells under act...
Fustin
TN1653CAS 20725-03-5
Fustin shows protective effects on 6-hydroxydopamine-induced neuronal cell death.
β-amyloid 1-11 acetate(190436-05-6 free base)
TP1866LCAS TP1866L
β-amyloid 1-11 acetate is a fragment of Amyloid-β peptide, maybe used in the research of neurological disease.
Otophylloside B
TMS1461CAS 106758-54-7
Qingyangshengenin B is a C-21 steroidal glycoside isolated from Qingyangshen. Qingyangshengenin B protects against Aβ toxicity, which decreases Aβ deposition...
Amyloid β-Protein 10-20 acetate(152286-31-2 free base)
TP1786LCAS TP1786L
Amyloid β-Protein (10-20) acetate is a fragment of Amyloid-β peptide, maybe used in the research of neurological disease.Amyloid β protein fragment containin...
Hoechst 34580 xHCl(23555-00-2(free base)
T19011LCAS T19011L
Hoechst 34580 xHCl is a cell-permeable fluorescent dye, is used for staining DNA and nuclei.
β-Amyloid 15-21 acetate
TP1214LCAS TP1214L
β-amyloid (15-21) acetate is a fragment of Amyloid-β peptide, maybe used in the research of neurological disease. This fragment is involved in beta sheet form...
BSBM7
T19892CAS 6968-11-2
BSBM7 is an inhibitor of Aβ aggregation and neuronal toxicity.
Putraflavone
TN4865CAS 23624-21-7
Putraflavone possesses a good antioxidant activity via its DPPH free radical scavenging.
Neoechinulin A
TN4635CAS 51551-29-2
Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, it may block t...
Mirabijalone D
TN4571CAS 485811-84-5
Mirabijalone D is a non-competitive inhibitor based on the Dixon plot.It inhibits Aβ1-42 production by 43.7% in APPSW-N2a cells.
Cedrin
TN3618CAS 75513-81-4
Cedrin has protective effects on PC12 cells against the neurotoxicity induced by amyloid β1-42, the protective effect is related to the inhibition of oxidative...
Anatabine
TN3410CAS 581-49-7
Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheim...
7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one
TN3218CAS 100667-52-5
7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one as a beneficial compound to ameliorate the deleterious effects of Aβ on dendrite integrity and cell survival, and m...
Hoechst 34580 tetrahydrochloride (23555-00-2 free base)
T19013CAS T19013
Hoechst 34580 tetrahydrochloride, a cell-permeable fluorescent dye, is used for staining DNA and nuclei.
Hederacolchiside E
TN1725CAS 33783-82-3
Hederacolchiside E has antioxidant activity, it shows inhibition on lipid peroxidation of linoleic acid emulsion; it may exert its anti-inflammatory effects by ...
Hoechst 34580
T19011CAS 23555-00-2
Hoechst 34580, a cell-permeable fluorescent dye, is used for staining DNA and nuclei.
BACE1-IN-5
T10453CAS T10453
BACE1-IN-5 is a BACE1 inhibitor (IC50: 9.1 nM) and also inhibits cellular amyloid-β (Aβ; IC50: 0.82 nM). BACE1-IN-5 has medicinal chemistry that improves hERG...
BMS 299897
T14673CAS 290315-45-6
BMS 299897 is a sulfonamide γ-secretase inhibitor. It has an IC50 of 7 nM for Aβ production inhibition in HEK293 cells stably overexpressing amyloid precursor...
Begacestat
T14525CAS 769169-27-9
Begacestat is a selective thiophene sulfonamide amyloid precursor protein gamma-secretase inhibitor (Aβ40,IC50=15 nM),and for the treatment of Alzheimer's dise...
Amyloid beta-peptide(25-35)
T14284CAS 131602-53-4
Amyloid beta-peptide(25-35) is the fragment Aβ(25-35) of the Alzheimer's amyloid β-peptide. Which has shown neurotoxic activities in cultured cells.
ALZ-801
T14199CAS 1034190-08-3
ALZ-801 is an advanced and markedly improved candidate for the treatment of alzheimer’s disease. ALZ-801 is a potent and orally available small-molecule β-am...
4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine
T19142CAS 566169-98-0
4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine is a potent amyloid imaging agent that binds to Amyloid-β (1-40) (KD: 1.7 nM).
Pinostrobin
TN2082CAS 480-37-5
Pinostrobin, a potent flavonoid inducer, exerts a neuroprotective effect against Aα²(25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibit...
Medioresinol
TN1919CAS 40957-99-1
Medioresinol possesses antioxidative, a lesishmanicidal activity and cardiovascular disease risk reduction, it has antiamyloidogenic activity via reduction in t...
Isorosmanol
TN1798CAS 93780-80-4
Isorosmanol possesses antioxidant, neuroprotective and neurotrophic effects, it might be useful in ageing disorders such as the declining of cognitive functions...
LY2811376
T2639CAS 1194044-20-6
LY2811376, an orally available non-peptidic β-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Aβ secretion (EC50: 300 nM). It has 10-fold selectiv...