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Cat No. | Product Name | Synonyms | Targets |
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T30102 | Apoptosis inducer 5d | ||
Apoptosis inducer 5D is a new type of inducer that induces cell death by activating the apoptosis of cancer cells. | |||
T30480 | BiP inducer X | BIX | Apoptosis |
BiP inducer X (BIX) is a selective inducer of immunoglobulin heavy chain binding protein (BiP)/GRP78 and an ER chaperone inducer. BiP inducer X prevents cell death in neurons and retinal cell lines. | |||
T78686 | Apoptosis inducer 11 | Apoptosis | |
Apoptosis Inducer 11 (compound 3u) promotes apoptosis via the mitochondrial pathway and elicits a G2/M block alongside a marked reduction in the S phase within non-Hodgkin lymphoma cell lines [1]. | |||
T79252 | Apoptosis inducer 13 | Reactive Oxygen Species | |
Apoptosis Inducer 13 (Compound Ru4) promotes apoptosis in cancer cells while also suppressing their migration and invasion. Additionally, it facilitates the conversion of coenzyme NADH to NAD+, and elevates intracellular... | |||
T63232 | Apoptosis inducer 6 | ||
Apoptosis inducer 6 is an anticancer agent with broad-spectrum anticancer activity that induces apoptosis, which triggers cell death. | |||
T74787 | Apoptosis inducer 12 | ||
Apoptosis Inducer 12 (Compound 3z) is a compound that promotes cell death via the mitochondrial pathway and is utilized in cancer research [1]. | |||
T62399 | Apoptosis inducer 10 | ||
Apoptosis inducer 10 is a potent apoptosis inducer with anti-proliferative activity. apoptosis inducer 10 induces apoptosis in HeLa cancer cells using a mitochondria-dependent endogenous pathway. | |||
T63485 | Apoptosis inducer 8 | ||
Apoptosis inducer 8 is a galectin-1 (gal-1)-mediated apoptosis inducer and a PET imaging agent that significantly reduces gal-1 protein levels and can be used in major lung cancer studies worldwide. | |||
T74493 | Apoptosis inducer 4 | ||
Apoptosis Inducer 4 (Compound 12b) is a compound that induces apoptosis and exhibits anticancer properties [1]. | |||
T74490 | Apoptosis inducer 3 | ||
Apoptosis Inducer 3 (Compound 3), a selective apoptosis triggering agent, induces both apoptosis and late-apoptosis phases, demonstrating cytotoxic effects against cancer cells [1]. | |||
T31821 | Fluorizoline | ||
Fluorizoline is an inducer of p53 independent apoptosis in a variety of tumor cell lines. | |||
T33296 | Merodantoin | Apoptosis | |
Merodantoin is an apoptosis inducer and triggers cell apoptosis associated with ROS-dependent autophagy. Merodantoin targets cancer cells expressing KRAS mutations involved in Akt-dependent ROS production. | |||
T8762 | SW106065 | SW-106065 | Apoptosis |
SW106065 is a novel pharmacologic inducer of apoptosis in MPNST (malignant peripheral nerve sheath tumors).SW106065 is an apoptosis inducer in malignant peripheral nerve sheath tumors (MPNST). It inhibits ATP consumption... | |||
T16901 | SMIP004 | Apoptosis , Others , E1/E2/E3 Enzyme | |
SMIP004 is an SKP2 E3 ligase inhibitor. SMIP004 is a cancer cell-selective apoptosis inducer of human prostate cancer cells. | |||
T8331 | NUN82647 | CU-242 | Others |
NUN82647 (CU-242) is an Inhibitor of cell cycle at G2 phase, and apoptosis inducer. | |||
T6149 | YH239-EE | Apoptosis , E1/E2/E3 Enzyme | |
YH239-EE, the ethyl ester of YH239, is a potent p53-MDM2 antagonist and an apoptosis inducer. | |||
T16754 | RIPGBM | Apoptosis | |
RIPGBM is a selective inducer of apoptosis in glioblastoma multiforme cancer stem cells (EC50: ≤500 nM). | |||
T6191 | Tasisulam | LY573636 | Apoptosis , Caspase |
Tasisulam (LY573636) is an apoptosis inducer and an antitumor agent via the intrinsic pathway. | |||
T6834 | FCCP | Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone,Trifluoromethoxy carbonylcyanide phenylhydrazone | ATPase , Mitochondrial Metabolism |
FCCP (Trifluoromethoxy carbonylcyanide phenylhydrazone) is an oxidative phosphorylation (OXPHOS) inhibitor and mitochondrial proton carrier uncoupler. FCCP is often used as an apoptosis inducer. | |||
T22661 | CHM-1 | Apoptosis , Others , Microtubule Associated | |
CHM-1 is an inducer of apoptosis, and displays potent antitumor ability in human hepatocellular carcinoma by activation of Cdc2 kinase activity. CHM-1 inhibits tubulin polymerization in vitro and in vivo. | |||
T14125 | Adarotene | ST1926 | Apoptosis |
Adarotene (ST1926) is an effective apoptosis inducer. It surprisingly produces DNA damage and exhibits a potent antiproliferative activity on a large panel of human tumor cells. | |||
T11052L | Disitertide acetate | P144 acetate,Disitertide acetate(272105-42-7 Free base) | TGF-beta/Smad |
Disitertide acetate (P144 acetate) is a peptidic transforming growth factor-beta 1 (TGF-β1) inhibitor specifically designed to block the interaction with its receptor. Disitertide acetate is also a PI3K inhibitor and an ... | |||
T6170 | Elesclomol | STA-4783 | Apoptosis , HSP , Reactive Oxygen Species |
Elesclomol (STA-4783) is an oxidative stress inducer and a highly lipophilic copper ion carrier. Elesclomol induces apoptosis in tumor cells and is used in copper death related studies. Elesclomol also inhibits FDX1-medi... | |||
T9083 | TC11 | CLT-003,1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11 | BCL , Caspase , CDK |
TC11 (1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11) is a potent inhibitor of tumor cell proliferation and an inducer of apoptosis via activation of caspase-3, 8 and 9. | |||
T60202 | MMRi62 | 7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol | Ferroptosis |
MMRi62 (7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol), a ferroptosis inducer targeting MDM2-MDM4 (negative regulators of tumor suppressor p53). MMRi62 shows a P53-independent pro-apoptotic activity aga... | |||
T33454 | ML407 | ML-407,ML 407 | |
ML407 is a cryptococcus yeast cell apoptosis inducer. | |||
T29104 | Verticillin A | ||
Verticillin A, an apoptosis inducer, inhibits Leiomyosarcoma and Malignant peripheral nerve sheath tumor growth. | |||
T29449 | 5-AcTMF | 5-ATMF,5-ATAN,5 ATMF | |
5-AcTMF is an inducer of G2/M arrest, apoptosis and autophagy in cancer cells. | |||
T31988 | Govaniadine | ||
Govaniadine is a natural potent inducer of apoptosis in MCF-7 cell lines. | |||
T24660 | YLT205 | YLT-205,YLT 205 | |
YLT205 is an inducer of apoptosis in human colorectal cells that acts by inhibiting tumor growth. | |||
T34829 | Tetrazanbigen | TNBG | |
Tetrazanbigen is an inducer of S phase arrest and apoptosis in hepatocellular carcinoma QGY-7701. | |||
T67284 | BDE No 47 solution | ||
BDE-47 is an apoptosis inducer involving ROS mediated mitochondrial pathway and Nrf2 pathway activation. | |||
T24513 | MYRA-A | NSC-339585,NSC 339585,NSC339585 | |
MYRA-A is an inducer of apoptosis in a Myc-dependent manner that acts by inhibiting Myc-driven transformation and disrupting MYC-Max interaction. | |||
T34791 | TCCP | ||
TCCP is a natural inducer of apoptosis in MDA-MB-231 breast cancer cells via ROS mediated mitochondrial damage and restoration of p53 activity. | |||
T70805 | Diethylnorspermine HBr | ||
Diethylnorspermine, also known as DENSPM, BE-333, DE-333 and N(1),N(11)-Diethylnorspermine, is a highly potent known inducer of the polyamine catabolic enzyme, spermidine/spermine N1-acetyltransferase (SSAT). A designed... | |||
T79138 | Antitumor agent-100 hydrochloride | Molecular Glues | |
Antitumor agent-100 hydrochloride (compound A6), serving as both an apoptosis inducer and molecular glue, exhibits superior anti-tumor activity [1]. | |||
T78742 | Anticancer agent 132 | Apoptosis | |
Compound Rh1 (Anticancer agent 132) acts as an inducer of apoptosis and autophagy, exhibiting both antitumor and antimetastatic activities. It also arrests the cell cycle and inhibits cell proliferation [1]. | |||
T78940 | EGFR-IN-78 | Apoptosis | |
EGFR-IN-78 (compound A5), a 2-aminopyrimidine derivative, serves as a reversible EGFR C797S-TK inhibitor and an apoptosis inducer. It exhibits anti-proliferative properties, impedes EGFR phosphorylation, and induces G2/M... | |||
T75831 | NTR 368 TFA | ||
NTR 368 TFA, a peptide derived from the p75 neurotrophin receptor (p75NTR) and corresponding to residues 368-381 of the human receptor, exhibits a helix-forming propensity in the presence of micellar lipid. It is a poten... | |||
T36934 | PK7242 (maleate) | PK7242 (maleate) | |
The protein p53, often called the 'guardian of the genome,' is a transcription factor that is activated in response to cellular stress (low oxygen levels, heat shock, DNA damage, etc.) and acts to prevent further prolife... | |||
T68875 | Xylocydine | ||
Xylocydine is a novel Cdk inhibitor, which is an effective inducer of apoptosis in hepatocellular carcinoma cells in vitro and in vivo. Xylocydine also strongly inhibits the activity of Cdk7 and Cdk9, in vitro as well as... | |||
T36882 | CAY10773 | ||
CAY10773 is a derivative of the ferroptosis inducer sorafenib .1It selectively inhibits proliferation of BEL-7402, MGC803, and T24 bladder cancer cells (IC50s = 5.77, 5.21 and 3.97 μM, respectively) over non-cancerous HC... | |||
T79403 | VEGFR-2-IN-36 | VEGFR | |
VEGFR-2-IN-36 (compound 15) serves as a potent VEGFR-2 inhibitor, exhibiting an IC50 value of 0.067 μM, and acts as an apoptosis inducer with demonstrated anticancer efficacy. It modulates apoptotic pathways by upregulat... | |||
T63556 | EGFR-IN-59 | ||
EGFR-IN-59 is an EGFR inhibitor with an IC50 value of 190 nM and an all-time apoptosis inducer. EGFR-IN-59 exhibited cytotoxicity against a non-small lung cancer cell line (A549) and normal lung fibroblasts (WI38) with I... | |||
T37851 | Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III) | ||
Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III) is an inducer of ferroptosis.1 It induces ferroptosis, but not apoptosis or necroptosis, in NB1 cancer cells when used at a concentration of 3 μM.1 Chlorido[N,N... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T72509 | Apoptosis inducer 5 | ||
Apoptosis Inducer 5, a lignan enantiomer extracted from Crataegus pinnatifida, demonstrates cytotoxic properties through inducing apoptosis and autophagy in Hep3B cells. | |||
TN6705 | Graveoline | 2-(Benzo[d][1,3]dioxol-5-yl)-1-methylquinolin-4(1H)-one,Foliosine | Autophagy |
Graveoline (2-(Benzo[d][1,3]dioxol-5-yl)-1-methylquinolin-4(1H)-one) is an apoptosis and autophagy inducer in skin melanoma cancer cells | |||
T5132 | 9-dihydro-13-acetylbaccatin III | 13-Acetyl-9-dihydrobaccatin III,9-DHAB III | Apoptosis |
9-dihydro-13-acetylbaccatin III (9-DHAB III)is an apoptosis inducer. It shows cytotoxicity against the MCF7 cell line and drug-resistant cell line MCF7-ADR. | |||
T2799 | (20S)-Protopanaxadiol | 20-Epiprotopanaxadiol,20(S)-APPD | Apoptosis , Reactive Oxygen Species , P-gp |
(20S)-Protopanaxadiol (20-Epiprotopanaxadiol) (20-Epiprotopanaxadiol), an apoptosis inducer, is an aglycon metabolic derivative of the protopanaxadiol-type ginseng saponin. | |||
TN2082 | Pinostrobin | Beta Amyloid , IL Receptor , Serine/threonin kinase , TNF | |
Pinostrobin, a potent flavonoid inducer, exerts a neuroprotective effect against Aα²(25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiting oxidative damage and calcium overload, as well as suppress... | |||
TN5888 | Toddaculin | Others | |
Toddaculine may be beneficial for the prevention and treatment of osteoporosis, it can not only inhibit the differentiation of osteoclasts via activation of the NF-κB, ERK 1/2, and p38 MAPK signaling pathways, but can in... | |||
T21005 | Lupulon | ||
Lupulon has a role as an apoptosis inducer, antimicrobial agent, angiogenesis inhibitor, and antineoplastic agent. | |||
T13624 | Conophylline | Others | |
Conophylline is a natural alkaloid extracted from a tropical plant Ervatamia microphylla. Conophylline is a differentiation inducer of for pancreatic cells and suppresses HSC and induces apoptosis. | |||
TN5486 | Pinobanksin 3-(2-methyl)butyrate | Apoptosis | |
Pinobanksin 3-(2-methyl)butyrate is a Pinobanksin derivative. pinobanksin is a apoptosis inducer that can induce apoptosis of F6 cells. | |||
TN3616 | Cedrelone | Apoptosis , MMP , Antifection | |
Cedrelone is a citrulline analog and a phenazine biosynthesis-like domain protein (PBLD) activator.Cedrelone induces apoptosis in cancer cells.Cedrelone is a very potent inducer of apoptosis, causing cell cycle arrest.Ce... | |||
T35605 | Apoptolidin | ||
Apoptolidin is an apoptosis inducer originally isolated from Nocardiopsis bacteria. It inhibits the mitochondrial F1FO ATPase (Ki = 4-5 μM). Apoptolidin selectively kills transformed glial cells without significantly aff... | |||
TQ0112 | Tubulysin A | TubA | Microtubule Associated |
Tubulysin A is a natural product from myxobacterial. It has many function in vitro assays, including anti-microtubule, anti-mitotic, an apoptosis inducer, anticancer, and anti-angiogenic. | |||
T72965 | Inuviscolide | ||
Inuviscolide, an apoptosis inducer, demonstrates the capacity to induce G2/M arrest in human melanoma cell lines. Exhibiting both antineoplastic and anti-inflammatory activities, this compound shows potential in cancer t... | |||
T75508 | Bleomycin A5 | ||
Bleomycin A5 (Pingyangmycin), a glycopeptide antibiotic that is orally active, functions as an antineoplastic agent, an apoptosis inducer, and a bacterial metabolite [1] [2]. | |||
TN6501 | Isololiolide | ||
Isololiolide has phytotoxicity, it inhibited seedling growth of cress and barnyard grass. It also showed in vitro activity against both trypomastigote and intracellular amastigotes of Trypanosoma cruzi, with IC50 values ... | |||
T14121 | Actinonin | (-)-Actinonin | Aminopeptidase |
Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces and a potent reversible peptide deformylase (PDF) inhibitor with a Ki of 0.28 nM, it also is an apoptosis inducer. Actinonin ... | |||
T79971 | Asparanin A | Apoptosis | |
Asparanin A, an apoptosis inducer with anticancer properties, arrests the cell cycle in the G0/G1 phase via the mitochondria and PI3K/AKT signaling pathways. It effectively inhibits cancer cell proliferation and has show... | |||
TN3152 | 6-Acetonyldihydrochelerythrine | ERK , BCL , Akt , HIV Protease , PPAR , p53 | |
6-Acetonyldihydrochelerythrine exhibits significant antioxidant activities, it exhibits significant anti-HIV activity in H9 lymphocytes with EC50 and TI (Therapeutic Index) values of 1.77 microg/mL and 14.6, respectively... |
Cat No. | Product Name | Species | Expression System |
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TMPY-01288 | Osteopontin Protein, Human, Recombinant (His) | Human | HEK293 |
Osteopontin, also known as Secreted phosphoprotein 1, Bone sialoprotein 1, BSP-1, OPN, and SPP1, is a member of the osteopontin family and a SIBLING glycoprotein. Osteopontin has been classified as T-helper 1 cytokine an... | |||
TMPY-06988 | Osteopontin Protein, Human, Recombinant (aa 17-166, His) | Human | HEK293 |
Osteopontin, also known as Secreted phosphoprotein 1, Bone sialoprotein 1, BSP-1, OPN, and SPP1, is a member of the osteopontin family and a SIBLING glycoprotein. Osteopontin has been classified as T-helper 1 cytokine an... | |||
TMPH-00266 | Galectin-1/LGALS1 Protein, Bovine, Recombinant (His & SUMO) | Bovine | E. coli |
Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore th... | |||
TMPK-00727 | TNFSF12/TWEAK Protein, Human, Recombinant (hFc) | Human | HEK293 |
Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a well known multifunctional cytokine extensively distributed in cell types and tissues. Accumulating evidence has shown that TWEAK binding to the receptor ... | |||
TMPY-03302 | TWEAK/TNFSF12 Protein, Rat, Recombinant (hFc) | Rat | HEK293 |
TNFSF12 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. It is a ligand for the FN14/TWEAKR receptor. TNFSF12 has overlapping signaling functions with TNF, but displays a much wider tissue dis... | |||
TMPY-05041 | TWEAK/TNFSF12 Protein, Mouse, Recombinant (rFc) | Mouse | HEK293 |
TNFSF12 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. It is a ligand for the FN14/TWEAKR receptor. TNFSF12 has overlapping signaling functions with TNF, but displays a much wider tissue dis... | |||
TMPY-00584 | TWEAK/TNFSF12 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
TNFSF12 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. It is a ligand for the FN14/TWEAKR receptor. TNFSF12 has overlapping signaling functions with TNF, but displays a much wider tissue dis... | |||
TMPY-03374 | TWEAK/TNFSF12 Protein, Human, Cynomolgus, Recombinant (mFc) | Human,Cynomolgus | HEK293 |
TNFSF12 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. It is a ligand for the FN14/TWEAKR receptor. TNFSF12 has overlapping signaling functions with TNF, but displays a much wider tissue dis... | |||
TMPY-01216 | XIAP Protein, Human, Recombinant (Avi) | Human | E. coli |
E3 ubiquitin-protein ligase XIAP / BIRC4, also known as an inhibitor of apoptosis protein 3, X-linked inhibitor of apoptosis protein, and IAP-like protein, is a protein that belongs to a family of apoptotic suppressor pr... | |||
TMPY-02922 | XIAP Protein, Human, Recombinant (His) | Human | E. coli |
E3 ubiquitin-protein ligase XIAP / BIRC4, also known as an inhibitor of apoptosis protein 3, X-linked inhibitor of apoptosis protein, and IAP-like protein, is a protein that belongs to a family of apoptotic suppressor pr... | |||
TMPY-01426 | Fas/CD95 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
CD95 (APO-1/Fas) is an important inducer of the extrinsic apoptosis signaling pathway and therapy induced apoptosis of many tumor cells has been linked to the activity of CD95. is a prototype death receptor characterized... | |||
TMPY-03834 | Fas/CD95 Protein, Cynomolgus, Recombinant (hFc) | Cynomolgus | HEK293 |
CD95 (APO-1/Fas) is an important inducer of the extrinsic apoptosis signaling pathway and therapy induced apoptosis of many tumor cells has been linked to the activity of CD95. is a prototype death receptor characterized... | |||
TMPY-04282 | Fas/CD95 Protein, Rat, Recombinant (hFc) | Rat | HEK293 |
CD95 (APO-1/Fas) is an important inducer of the extrinsic apoptosis signaling pathway and therapy induced apoptosis of many tumor cells has been linked to the activity of CD95. is a prototype death receptor characterized... | |||
TMPY-00799 | Fas/CD95 Protein, Human, Recombinant (hFc) | Human | HEK293 |
CD95 (APO-1/Fas) is an important inducer of the extrinsic apoptosis signaling pathway and therapy induced apoptosis of many tumor cells has been linked to the activity of CD95. is a prototype death receptor characterized... | |||
TMPY-02057 | Fas/CD95 Protein, Rat, Recombinant (His) | Rat | HEK293 |
CD95 (APO-1/Fas) is an important inducer of the extrinsic apoptosis signaling pathway and therapy induced apoptosis of many tumor cells has been linked to the activity of CD95. is a prototype death receptor characterized... | |||
TMPY-01704 | Fas/CD95 Protein, Human, Recombinant (His) | Human | HEK293 |
CD95 (APO-1/Fas) is an important inducer of the extrinsic apoptosis signaling pathway and therapy induced apoptosis of many tumor cells has been linked to the activity of CD95. is a prototype death receptor characterized... | |||
TMPY-00632 | Fas/CD95 Protein, Cynomolgus, Recombinant | Cynomolgus | HEK293 |
CD95 (APO-1/Fas) is an important inducer of the extrinsic apoptosis signaling pathway and therapy induced apoptosis of many tumor cells has been linked to the activity of CD95. is a prototype death receptor characterized... | |||
TMPH-01055 | Caspase-1 Protein, Human, Recombinant (HA) | Human | E. coli |
Thiol protease involved in a variety of inflammatory processes by proteolytically cleaving other proteins, such as the precursors of the inflammatory cytokines interleukin-1 beta (IL1B) and interleukin 18 (IL18) as well ... | |||
TMPY-02757 | TWEAKR/TNFRSF12A Protein, Human, Recombinant (hFc) | Human | HEK293 |
Fn14 (tumor necrosis factor receptor superfamily, member 12A), also known as TNFRSF12A, is the receptor for TNFSF12/TWEAK. Fn14 shares 82% amino acid identity with the mouse sequence. It contains a signal peptide, an ext... | |||
TMPJ-01312 | TWEAKR/TNFRSF12A Protein, Mouse, Recombinant (hFc) | Mouse | Human Cells |
Tumor necrosis factor receptor superfamily member 12A(Tnfrsf12a) is a single-pass type I membrane protein and contains 1 TNFR-Cys repeat. It is weak inducer of apoptosis in some cell types.It promotes angiogenesis and it... |