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Search Results for " aorta "

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T34862	Thromboxane A2	Rabbit aorta contracting substance,TXA-2,TXA2,TXA 2
	Thromboxane A2, as an unstable intermediate between the prostaglandin endoperoxides and thromboxane B2, is a potent inducer of platelet aggregation and causes vasoconstriction.
T6716	Valsartan	Diovan,Tareg,CGP 48933	RAAS
	Valsartan (CGP 48933) is a tetrazole derivative and angiotensin II type 1 receptor blocker that is used to treat hypertension.		RAAS
TP1917L1	Sar-[D-Phe8]-des-Arg9-Bradykinin acetate	Sar-[D-Phe8]-des-Arg9-Bradykinin acetate(126959-88-4 free base)	Bradykinin Receptor
	Sar-[D-Phe8]-des-Arg9-Bradykinin acetate is a potent and selective bradykinin B1 receptor agonist (EC50 = 9.02 nM in rabbit aorta) that is resistant to aminopeptidase, kininase I and II (ACE) and neutral endopeptidase cl...		Bradykinin Receptor
T23557	Talibegron hydrochloride	ZD2079 hydrochloride,ZD 2079	Adrenergic Receptor
	Talibegron hydrochloride (ZD2079 hydrochloride) is an β3 adrenergic receptor agonist with a pD2 of 3.72 on phenylephrine-preconstricted rat mesenteric artery. Relaxes rat mesenteric artery and isolated aorta in vitro. In...		Adrenergic Receptor
T68030	Acitemate	Chinoin 123	Others
	Acitemate(Chinoin 123) has an inhibitory effect on atherosclerosis and reduces the permeability of the aorta in rabbits fed a hyperlipidemic diet, which can be used to study atherosclerosis.		Others
TP2106L	Urantide acetate(669089-53-6 free base)		Neurotensin Receptor
	Urantide acetate is a selective and competitive urotensin-II (UT) receptor antagonist (pKB = 8.3). Blocks hU-II induced contractions in thoracic aorta ex vivo. Exhibits no effect on noradrenaline or endothelin 1-induced ...		Neurotensin Receptor
T13340	Win-62005		Others
	Win-62005 is an inhibitor of cyclic AMP phosphodiesterase III (PDE III)(Kis: 25 and 26 nM for rat heart and canine aorta).		Others
TP2119	Sarafotoxin S6a
	Endothelin receptor agonist (EC50 values are 7.5 and > 150 nM for contraction of pig coronary artery and guinea pig aorta respectively). Nociceptive in vivo.
T27164	DHP-218	PAK-9,PAK9,PAK 9,DHP218
	DHP-218 is a calcium channel antagonist. DHP-218 inhibits Calcium-induced contraction of the rat aorta in high K+ solution with the pA2 value of 9.11. The IC50 value for the inhibitory effects of DHP-218 in high K+-induc...
T26665	AS604872	AS-604872,AS 604872
	AS604872 is a selective antagonist of the FP receptor.. AS604872 significantly accelerated degeneration of the media in both cerebral artery and aorta as evidenced by thinning of the media and disruption of the elastic l...
T27574	ZM 169369	ICI169369,ICI-169369
	ICI 169369, a 5-HT2/5-HT1C antagonist, can evoke endothelium-dependent relaxation in rabbit aorta.
TP1928	[Orn5]-URP
	Urotensin-II (UT) receptor pure antagonist (pEC50 = 7.24). Displays no agonist activity unlike other U-II/URP analogs. Inhibits the action of U-II in the rat aorta ring assay.
T36565	Adrenomedullin (13-52) (human) (trifluoroacetate salt)
	Adrenomedullin (13-52) is a truncated form of adrenomedullin (1-52) . It induces nitric oxide-dependent relaxation of and inhibits release of angiotensin II and endothelin-1 from isolated rat aorta. In vivo, adrenomedull...
T118302	N062-0012
	Aorta, EC50: 4.88 nM
T12205L	Trans-Ned 19		Calcium Channel
	trans-Ned 19 is a NAADP antagonist and TPC blocker and inhibits the calcium signal in human umbilical vein endothelial cells and the rat aorta relaxation in response to low histamine concentrations.		Calcium Channel
T28391	PF-9404C	PF9404C
	PF-9404C is the S-S diesteroisomer of a beta adrenergic receptors blocker with vasodilatory properties. PF9404C increased the formation of cyclic GMP from 3 pmol mg−1 protein in basal conditions, to 53 pmol mg−1 protein ...
TP1917	Sar-[D-Phe8]-des-Arg9-Bradykinin
	Potent and selective bradykinin B1 receptor agonist (EC50 = 9.02 nM in rabbit aorta) that is resistant to aminopeptidase, kininase I and II (ACE) and neutral endopeptidase cleavage. Exhibits hypotensive and angiogenic ac...
TP2106	Urantide
	Selective and competitive urotensin-II (UT) receptor antagonist (pKB = 8.3). Blocks hU-II induced contractions in thoracic aorta ex vivo. Exhibits no effect on noradrenaline or endothelin 1-induced contraction or on acet...
TP2104	UFP-803	UFP 803
	Urotensin-II (UT) receptor ligand; behaves as a silent antagonist in most in vitro assays and in vivo, but does retain small residual agonist activity under certain conditions in some assays. Competitively antagonizes U-...
T69133	Etozolin HCl
	Etozolin HCl is a safe and effective diuretic agent in the treatment of acute cardiac failure. In isolated rings of guinea-pig aorta not responding to acetylcholine, the diuretic dexetozoline did not influence basal vasc...
T36209	15-keto Prostaglandin A1	15-keto Prostaglandin A1
	Prostaglandin A1 (PGA1) was first isolated as a dehydration product of the PGE1 compounds found in human semen. 15-keto PGA1 is a metabolite of PGA1, produced by 15-hydroxy PG dehydrogenase. It can be produced from PGA1 ...
T23154	Piclamilast	RPR 73401,RP 73401	PDE
	Piclamilast (RP 73401) is a PDE4 inhibitor.		PDE
T76712	Satralizumab
	Satralizumab, a humanized monoclonal antibody and potent Interleukin-6 (IL-6) inhibitor, prevents the formation and progression of descending thoracic aorta aneurysm (dTAA) in Rattus norvegicus. It is also used in resear...
T83164	Adrenomedullin (porcine)
	Adrenomedullin (porcine) is a vasodilatory peptide that elicits endothelium-dependent relaxation in rat aorta at an IC50 of 2.4 nM and also induces endothelium-independent relaxation in porcine coronary arteries, with an...
T37862	9(R)-HODE
	9(R)-HODE is one of several monohydroxylated products of linoleic acid. All known mammalian lipoxygenases appear to catalyze the oxygenation of arachidonic and linoleic acid to give products having strictly the (S) confi...
T35506	(±)12-HEPE
	(±)12-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 12(S)-HEPE and 12(R)-HEPE. The biological activity of (±)12-HEPE is likely mediated by one of the individual isomers, most commonly t...
T83803	UDP-β-S sodium	Uridine-5' O-(2-thiodiphosphate)
	UDP-β-S, serving as a specific agonist for the purinergic P2Y6 receptor, effectively promotes inositol phosphate accumulation in 1321N1 cells containing P2Y6 receptors, with an EC50 value of 28 nM. This selectivity is ev...
T74778	ASM-IN-1		Phospholipase
	ASM-IN-1 is a potent, orally active inhibitor of acid sphingomyelinase (ASM) with an IC50 of 1.5 µM, demonstrating antiatherosclerotic and anti-inflammatory activity. It effectively reduces lipid plaques in the aortic ar...		Phospholipase
T35985	CAY10487
	The early stage of atherosclerosis is characterized by the aggregation of foam cells, so called a fatty streak, in the inner arterial wall. CAY10487 inhibits formation of fatty streak lesions of the thoracic aorta in hig...
T36166	8-iso-15-keto Prostaglandin F2α	8-iso-15-keto Prostaglandin F2α
	8-iso-15-keto Prostaglandin F2α (8-iso-15-keto PGF2α) is a metabolite of the isoprostane 8-iso PGF2α in rabbits, monkeys, and humans. 8-isoprostane (8-iso PGF2α) is a prostaglandin-like product of non-specific lipid pero...
T13262	FCE 28654
	FCE 28654 is a water-soluble acyl-CoA inhibitor.

Compounds

Thromboxane A2

T34862

Synonym: Rabbit aorta contracting substance,TXA-2,TXA2,TXA 2

Target:

Valsartan

T6716

Synonym: Diovan,Tareg,CGP 48933

Target: RAAS

Sar-[D-Phe8]-des-Arg9-Bradykinin acetate

TP1917L1

Synonym: Sar-[D-Phe8]-des-Arg9-Bradykinin acetate(126959-88-4 free base)

Target: Bradykinin Receptor

Talibegron hydrochloride

T23557

Synonym: ZD2079 hydrochloride,ZD 2079

Target: Adrenergic Receptor

Urantide acetate(669089-53-6 free base)

TP2106L

Synonym:

Target: Neurotensin Receptor

Synonym: PAK-9,PAK9,PAK 9,DHP218

Target:

AS604872

T26665

Synonym: AS-604872,AS 604872

Target:

ZM 169369

T27574

Synonym: ICI169369,ICI-169369

Adrenomedullin (13-52) (human) (trifluoroacetate salt)

Target: Calcium Channel

Sar-[D-Phe8]-des-Arg9-Bradykinin

15-keto Prostaglandin A1

T36209

Synonym: 15-keto Prostaglandin A1

Target:

Piclamilast

T23154

Synonym: RPR 73401,RP 73401

Adrenomedullin (porcine)

Synonym: Uridine-5' O-(2-thiodiphosphate)

Target: Phospholipase

8-iso-15-keto Prostaglandin F2α

T36166

Synonym: 8-iso-15-keto Prostaglandin F2α

Cat No.	Product Name	Synonyms	Targets
TN6575	Pilosidine
	Pilosidine has vasoconstrictor activity, it showed facilitating effect on adrenaline evoked contractions in rabbit aorta isolated preparations.
T27436	GS 389	GS-389,GS389
	GS 389 is a novel tetrahydroisoquinoline analog with vasorelaxant properties. GS-389 significantly inhibited cGMP phosphodiesterase from the rabbit brain and increased cGMP levels in the rat aorta.
TN4819	(-)-Praeruptorin A		ATPase , IL Receptor , Calcium Channel , P-gp
	(-)-Praeruptorin A has anti-inflammatory, anti-contractile and anti-hyperplasia activities, it exerts distinct relaxant effects on isolated rat aorta rings dependent on endothelium and nitric oxide synthesis;it also can ...		ATPase , IL Receptor , Calcium Channel , P-gp
T83596	(+)-Osbeckic acid
	(+)-Osbeckic acid, extracted from Tartary Buckwheat, acts as a vasorelaxant and demonstrates a significant vasorelaxant effect in Sprague-Dawley rat thoracic aorta rings, with an EC50 value of 887 μM [1].
T5S2073	Senkyunolide A		Others
	Senkyunolide A is a useful standard compound for the quality evaluation and chemical differentiation between Rhizoma chuanxiong and Angelica sinensis, and suitable for the analysis of a large number of samples. Senkyunol...		Others

Natural Products

Synonym: GS-389,GS389

Target: ATPase, IL Receptor, Calcium Channel, P-gp

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPJ-01204	TPSAB1 Protein, Human, Recombinant (His)	Human	Human Cells
	Tryptases are serine proteases with trypsin-like specificity. Together with chymases and Cathepsin G, tryptases are important players in mast cell mediation of inflammatory and allergic responses. Tryptase alpha/beta-1(T...
TMPY-01475	Jagged 1 Protein, Human, Recombinant (His)	Human	HEK293
	Protein Jagged 1, also known as JAG1, JAGL1, and CD339, is a single-pass type I membrane protein that contains 1 DSL domain and 15 EGF-like domains. JAG1/Jagged 1 is widely expressed in adult and fetal tissues. The expre...
TMPH-02636	Elastin Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulat...
TMPJ-01319	TINAGL1 Protein, Human, Recombinant (His)	Human	Human Cells
	TINAGL1 is a secreted protein and contains one SMB (somatomedin-B) domain. TINAGL1 is expressed in aorta, lymph nodes, heart, bone marrow, placenta, lung, kidney, skeletal muscle, pancreas, thyroid, adrenal gland and so ...
TMPY-01470	Jagged 1 Protein, Human, Recombinant (hFc)	Human	HEK293
	Protein Jagged 1, also known as JAG1, JAGL1, and CD339, is a single-pass type I membrane protein that contains 1 DSL domain and 15 EGF-like domains. JAG1/Jagged 1 is widely expressed in adult and fetal tissues. The expre...
TMPJ-01005	Lumican Protein, Mouse, Recombinant (His)	Mouse	Human Cells
	Keratan sulfate proteoglycan lumican, mostly known as lumican, belongs to the SLRP class II subfamily and the small leucine-rich proteoglycan (SLRP) family. Lumican binds to laminin. It has positive regulation of transcr...
TMPY-04471	APEG1 Protein, Human, Recombinant (His)	Human	E. coli
	Striated muscle preferentially expressed protein kinase, also known as aortic preferentially expressed protein 1, APEG-1, SPEG and KIAA1297, is a protein that belongs to the protein kinase superfamily and CAMK Ser/Thr pr...