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Endocrinology/Hormones Androgen Receptor

Androgen Receptor

The androgen receptor (AR), also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of nuclear receptor that is activated by binding any of the androgenic hormones, including testosterone and dihydrotestosterone in the cytoplasm and then translocating into the nucleus.
Cat No. product name
T6002 EnzalutamideHOT Enzalutamide (MDV 3100) is a non-steroidal androgen receptor (AR) antagonist (IC50: 36 nM in LNCaP prostate cells).
T8933 JNJ-63576253 JNJ-63576253 is a potent and orally active full antagonist of androgen receptor (AR), with IC50s of 37 and 54 nM for F877L mutant AR and wild-type AR in LNCaP ce...
T2195 Epiandrosterone Epiandrosterone is a dehydroepiandrosterone metabolite and a precursor of testosterone and estradiol with hypolipidemic and anabolic property.
T0135 Estradiol valerate β-estradiol 17-valerate (EV) is a synthetic estrogen. In hormone replacement therapy drugs, it is widely used in combination with other steroid hormones.
T2339 Apalutamide Apalutamide is a small molecule and androgen receptor (AR) antagonist with potential antineoplastic activity.
T0380 Bicalutamide Bicalutamide, a synthetic, nonsteroidal antiandrogen, competitively binds to cytosolic androgen receptors in target tissues, thereby inhibiting the receptor bind...
T0856 Dehydroepiandrosterone acetate Dehydroepiandrosterone acetate is a primary C19 steroid generated by the adrenal cortex.
T6509 Galeterone Galeterone is an orally bioavailable small-molecule androgen receptor modulator and CYP17 lyase inhibitor with potential antiandrogen activity. Galeterone exhibi...
T2408 Ostarine Ostarine is a non-steroidal agent with anabolic activity. Selective androgen receptor modulator (SARM) GTx-024 is designed to work like testosterone, thus promot...
T3393 Triptophenolide Triptophenolide is a compound isolated from Tripterygium wilfordii Hook with anti-inflammatory activity.
T1541 Drospirenone Drospirenone is a synthetic spironolactone analogue and progestin with progestational and anti-mineralocorticoid activity.
T0272 Nilutamide Nilutamide, an antineoplastic hormonal agent, is mainly used in the treatment of prostate Y. Nilutamide is a pure, nonsteroidal anti-androgen with affinity for a...
T0856L Dehydroepiandrosterone Dehydroepiandrosterone (DHEA) is an endogenous steroid hormone that is secreted primarily by the adrenal gland and is the most abundant sex steroid. Although th...
T0476 Abbolactone Spironolactone is an Aldosterone Antagonist. The mechanism of action of spironolactone is as an Aldosterone Antagonist.
T1167 Cyproterone acetate Cyproterone binds the androgen receptor (AR), thereby preventing androgen-induced receptor activation in target tissues and inhibiting the growth of testosterone...
T4357 LGD3303 LGD-3303 is an androgen receptor modulator, with good oral bioavailability.
T2108 Andarine Andarine (S-4) is an active partial agonist and an investigational selective androgen receptor modulator (SARM).
T2207 Adrenosterone Adrenosterone is a steroid hormone isolated from the adrenal cortex.
T1596 Chlormadinone acetate Chlormadinone acetate is an orally active synthetic progestational hormone used often in combinations as an oral contraceptive.
T6829 EPI001 EPI-001 is an androgen receptor N-terminal domain antagonist with IC50 of ~6 μM and a selective PPAR-gamma modulator.
T2991 3,3'-Diindolylmethane DIM (3, 3'-diindolylmethane), a small molecule compound, is a proposed Y preventive agent.
T3357 17 alpha-propionate 17 alpha-propionate is a new topical and peripherally selective androgen antagonist.
T1480 Danazol Danazol is a synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary ou...
T6889 MI136 MI-136 inhibits expression of androgen receptor (AR) target genes that DHT induced.
T2236 RU58841 RU 58841 is a specific androgen receptor antagonist or anti-androgen; RU 58841 has a significant effect on hair regrowth.
T3618 GSK2881078 GSK2881078 is a selective androgen receptor modulator (SARM) that is being evaluated for effects on muscle growth and strength in subjects with muscle wasting to...
T0489 Flutamide Flutamide is an antiandrogen with about the same potency as cyproterone in rodent and canine species.
T3137 Parenabol Boldenone undecylenate is a synthetic steroid.
T6915 Darolutamide ODM-201 is an androgen receptor (AR) antagonist that blocks AR nuclear translocation (Ki: 11 nM).
T4358 Testolone RAD140 is an investigational selective androgen receptor modulator (SARM) for the treatment of conditions such as muscle wasting and breast cancer.
T7358 YK11 YK11 is an androgen receptor partial agonist that activates androgen receptor transcriptional activity in HEK293 cells overexpressing androgen receptors when use...
T8709 Nandrolone phenpropionate Nandrolone phenpropionate is an androgen receptor agonist. It mainly used to treat women with breast cancer and osteoporosis
T14008 2,2,5,7,8-Pentamethyl-6-Chromanol 2,2,5,7,8-Pentamethyl-6-Chromanol is the anti-oxidant moiety of vitamin E (α-tocopherol), which has potent androgen receptor (AR) signaling modulation and anti-...
TN4774 Physalin A Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate canc...
TMA1012 Ganoderiol F Ganoderiol F has anti-inflammatory, cytotoxic and anti-HIV activity, it inhibits activity of topoisomerases in vitro, and it inhibits human immunodeficiency viru...
TCS1372 Atraric acid Atraric acid derivatives as a new chemical lead structure for novel therapeutic compounds as AR antagonists, that can be used for prophylaxis or treatment of pro...
T8592 CTK8A3536 CTK8A3536 is an inhibitor of Androgen receptor.
T22263 ARV-110 ARV-110 is an oral degrader of androgen receptor PROTAC for prostate cancer treatment.
T15816 LY341495 LY341495 is an antagonist of metabotropic glutamate receptor (IC50s: 2.9 nM, 10 nM, 170 nM for mGluR-2, mGluR-3, mGluR-8, respectively).
T15750 Ligandrol Ligandrol is a novel nonsteroidal, oral SARM that binds to the androgen receptor with high affinity (Ki: 1 nM) and selectivity.
T15749 LGD-2226 LGD-2226 is a selective and orally active androgen receptor modulator (EC50: 0.2 nM, Ki: 1.5 nM for the human androgen receptor). LGD-2226 can be used for muscle...
T13273 UT-34 UT-34 is a selective and orally active antagonist of second-generation pan-androgen receptor (AR) and degrader(IC50s of 211.7 nM, 262.4 nM and 215.7 nM for wild-...
T13272 UT-155 UT-155 is a selective and potent antagonist of the androgen receptor (AR) (Ki: 267 nM for UT-155 binding to AR-LBD).
T14843 Bifluranol Bifluranol is an anti-androgen.
T14675 BMS-564929 BMS-564929 is an agonist of androgen receptor (AR, Ki of 2.11±0.16 nM).
T10946 D4-abiraterone D4-Abiraterone is an inhibitor of CYP17A1, 3b-hydroxysteroid dehydrogenase (3βHSD) and steroid 5a-reductase (SRD5A), the main metabolite of abiraterone. D4-Abir...
T7440 4,4'-DDE 4,4'-DDE is a metabolite and degradation product of the organochlorine pesticide DDT
T12323 ORM-15341 ORM-15341 is a potent and full antagonist for human AR (hAR)( with IC50 values of 38 nM as shown by transactivation assays in AR-HEK293 cells)
T19450 N-desmethyl Enzalutamide N-desmethyl Enzalutamide is the active Enzalutamide metabolite.It is the active metabolite of Enzalutamide. N-desmethyl Enzalutamide demonstrates primary and s...
T19449 N-desmethyl Enzalutamide D6 N-desmethyl Enzalutamide D6 is a deuterium labeled N-desmethyl Enzalutamide.
TN2245 Sunset yellow Sunset yellow FCF and Brilliant Blue FCF are used as colorant food additives in many food products, they can have cytotoxic and genotoxic potential, it care must...
TN1663 Ganoderic acid DM Ganoderic acid DM is an antiandrogenic osteoclastogenesis inhibitor, it especially suppresses the expression of c-Fos and nuclear factor of activated T cells c1 ...
TN1370 Allura Red AC Allura Red AC and amaranth are very important food azo dyes used in food, drug, paper, cosmetic and textile industries.
TN1150 Procyanidin B3 Procyanidin B3(B3) is a procyanidin dimer that is widely studied due to its high abundance in the human diet and antioxidant activity.
TN1067 6'-O-Galloyl paeoniflorin 6'-O-Galloylpaeoniflorin (GPF) may be developed as a cytoprotector against ROS-mediated oxidative stress
TN1061 Ganoderol B Ganoderol B is a potent β ±-glucosidase and angiotensin-converting enzyme inhibitor, with an IC(50) of β ±-glucosidase is 119.8 uM. It may be useful in prost...
T8217 Enzalutamide carboxylic acid Enzalutamide carboxylic acid is an antagonist of androgen receptor (AR) .
TQ0214 Dimethylcurcumin Dimethylcurcumin (ASC-J9) is an androgen receptor degradation enhancer. It effectively suppresses castration-resistant prostate cancer cell proliferation and inv...
TQ0209 Ailanthone Ailanthone is an effective inhibitor of both full-length androgen receptor (AR) (IC50: 69 nM) and constitutively active truncated AR splice variants (IC50: 309...
T7690 2-hydroxy Flutamide 2-hydroxy Flutamide is competitive inhibition of androgen receptor (AR) for the treatment of prostate cancer
T6400 AZD3514 AZD3514 is a potent and oral androgen receptor downregulator with Ki of 2.2 μM and has ability of reducing AR protein expression.Phase 1.
Enzalutamide HOT
T6002CAS 915087-33-1
Enzalutamide (MDV 3100) is a non-steroidal androgen receptor (AR) antagonist (IC50: 36 nM in LNCaP prostate cells).
JNJ-63576253
T8933CAS 2110426-27-0
JNJ-63576253 is a potent and orally active full antagonist of androgen receptor (AR), with IC50s of 37 and 54 nM for F877L mutant AR and wild-type AR in LNCaP ce...
Epiandrosterone
T2195CAS 481-29-8
Epiandrosterone is a dehydroepiandrosterone metabolite and a precursor of testosterone and estradiol with hypolipidemic and anabolic property.
Estradiol valerate
T0135CAS 979-32-8
β-estradiol 17-valerate (EV) is a synthetic estrogen. In hormone replacement therapy drugs, it is widely used in combination with other steroid hormones.
Apalutamide
T2339CAS 956104-40-8
Apalutamide is a small molecule and androgen receptor (AR) antagonist with potential antineoplastic activity.
Bicalutamide
T0380CAS 90357-06-5
Bicalutamide, a synthetic, nonsteroidal antiandrogen, competitively binds to cytosolic androgen receptors in target tissues, thereby inhibiting the receptor bind...
Dehydroepiandrosterone acetate
T0856CAS 853-23-6
Dehydroepiandrosterone acetate is a primary C19 steroid generated by the adrenal cortex.
Galeterone
T6509CAS 851983-85-2
Galeterone is an orally bioavailable small-molecule androgen receptor modulator and CYP17 lyase inhibitor with potential antiandrogen activity. Galeterone exhibi...
Ostarine
T2408CAS 841205-47-8
Ostarine is a non-steroidal agent with anabolic activity. Selective androgen receptor modulator (SARM) GTx-024 is designed to work like testosterone, thus promot...
Triptophenolide
T3393CAS 74285-86-2
Triptophenolide is a compound isolated from Tripterygium wilfordii Hook with anti-inflammatory activity.
Drospirenone
T1541CAS 67392-87-4
Drospirenone is a synthetic spironolactone analogue and progestin with progestational and anti-mineralocorticoid activity.
Nilutamide
T0272CAS 63612-50-0
Nilutamide, an antineoplastic hormonal agent, is mainly used in the treatment of prostate Y. Nilutamide is a pure, nonsteroidal anti-androgen with affinity for a...
Dehydroepiandrosterone
T0856LCAS 53-43-0
Dehydroepiandrosterone (DHEA) is an endogenous steroid hormone that is secreted primarily by the adrenal gland and is the most abundant sex steroid. Although th...
Abbolactone
T0476CAS 52-01-7
Spironolactone is an Aldosterone Antagonist. The mechanism of action of spironolactone is as an Aldosterone Antagonist.
Cyproterone acetate
T1167CAS 427-51-0
Cyproterone binds the androgen receptor (AR), thereby preventing androgen-induced receptor activation in target tissues and inhibiting the growth of testosterone...
LGD3303
T4357CAS 917891-35-1
LGD-3303 is an androgen receptor modulator, with good oral bioavailability.
Andarine
T2108CAS 401900-40-1
Andarine (S-4) is an active partial agonist and an investigational selective androgen receptor modulator (SARM).
Adrenosterone
T2207CAS 382-45-6
Adrenosterone is a steroid hormone isolated from the adrenal cortex.
Chlormadinone acetate
T1596CAS 302-22-7
Chlormadinone acetate is an orally active synthetic progestational hormone used often in combinations as an oral contraceptive.
EPI001
T6829CAS 227947-06-0
EPI-001 is an androgen receptor N-terminal domain antagonist with IC50 of ~6 μM and a selective PPAR-gamma modulator.
3,3'-Diindolylmethane
T2991CAS 1968-05-4
DIM (3, 3'-diindolylmethane), a small molecule compound, is a proposed Y preventive agent.
17 alpha-propionate
T3357CAS 19608-29-8
17 alpha-propionate is a new topical and peripherally selective androgen antagonist.
Danazol
T1480CAS 17230-88-5
Danazol is a synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary ou...
MI136
T6889CAS 1628316-74-4
MI-136 inhibits expression of androgen receptor (AR) target genes that DHT induced.
RU58841
T2236CAS 154992-24-2
RU 58841 is a specific androgen receptor antagonist or anti-androgen; RU 58841 has a significant effect on hair regrowth.
GSK2881078
T3618CAS 1539314-06-1
GSK2881078 is a selective androgen receptor modulator (SARM) that is being evaluated for effects on muscle growth and strength in subjects with muscle wasting to...
Flutamide
T0489CAS 13311-84-7
Flutamide is an antiandrogen with about the same potency as cyproterone in rodent and canine species.
Parenabol
T3137CAS 13103-34-9
Boldenone undecylenate is a synthetic steroid.
Darolutamide
T6915CAS 1297538-32-9
ODM-201 is an androgen receptor (AR) antagonist that blocks AR nuclear translocation (Ki: 11 nM).
Testolone
T4358CAS 1182367-47-0
RAD140 is an investigational selective androgen receptor modulator (SARM) for the treatment of conditions such as muscle wasting and breast cancer.
YK11
T7358CAS 1370003-76-1
YK11 is an androgen receptor partial agonist that activates androgen receptor transcriptional activity in HEK293 cells overexpressing androgen receptors when use...
Nandrolone phenpropionate
T8709CAS 62-90-8
Nandrolone phenpropionate is an androgen receptor agonist. It mainly used to treat women with breast cancer and osteoporosis
2,2,5,7,8-Pentamethyl-6-Chromanol
T14008CAS 950-99-2
2,2,5,7,8-Pentamethyl-6-Chromanol is the anti-oxidant moiety of vitamin E (α-tocopherol), which has potent androgen receptor (AR) signaling modulation and anti-...
Physalin A
TN4774CAS 23027-91-0
Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate canc...
Ganoderiol F
TMA1012CAS 114567-47-4
Ganoderiol F has anti-inflammatory, cytotoxic and anti-HIV activity, it inhibits activity of topoisomerases in vitro, and it inhibits human immunodeficiency viru...
Atraric acid
TCS1372CAS 4707-47-5
Atraric acid derivatives as a new chemical lead structure for novel therapeutic compounds as AR antagonists, that can be used for prophylaxis or treatment of pro...
CTK8A3536
T8592CAS 926228-58-2
CTK8A3536 is an inhibitor of Androgen receptor.
ARV-110
T22263CAS 2222112-77-6
ARV-110 is an oral degrader of androgen receptor PROTAC for prostate cancer treatment.
LY341495
T15816CAS 201943-63-7
LY341495 is an antagonist of metabotropic glutamate receptor (IC50s: 2.9 nM, 10 nM, 170 nM for mGluR-2, mGluR-3, mGluR-8, respectively).
Ligandrol
T15750CAS 1165910-22-4
Ligandrol is a novel nonsteroidal, oral SARM that binds to the androgen receptor with high affinity (Ki: 1 nM) and selectivity.
LGD-2226
T15749CAS 328947-93-9
LGD-2226 is a selective and orally active androgen receptor modulator (EC50: 0.2 nM, Ki: 1.5 nM for the human androgen receptor). LGD-2226 can be used for muscle...
UT-34
T13273CAS 2168525-92-4
UT-34 is a selective and orally active antagonist of second-generation pan-androgen receptor (AR) and degrader(IC50s of 211.7 nM, 262.4 nM and 215.7 nM for wild-...
UT-155
T13272CAS 2031161-35-8
UT-155 is a selective and potent antagonist of the androgen receptor (AR) (Ki: 267 nM for UT-155 binding to AR-LBD).
Bifluranol
T14843CAS 34633-34-6
Bifluranol is an anti-androgen.
BMS-564929
T14675CAS 627530-84-1
BMS-564929 is an agonist of androgen receptor (AR, Ki of 2.11±0.16 nM).
D4-abiraterone
T10946CAS 154229-21-7
D4-Abiraterone is an inhibitor of CYP17A1, 3b-hydroxysteroid dehydrogenase (3βHSD) and steroid 5a-reductase (SRD5A), the main metabolite of abiraterone. D4-Abir...
4,4'-DDE
T7440CAS 72-55-9
4,4'-DDE is a metabolite and degradation product of the organochlorine pesticide DDT
ORM-15341
T12323CAS 1297537-33-7
ORM-15341 is a potent and full antagonist for human AR (hAR)( with IC50 values of 38 nM as shown by transactivation assays in AR-HEK293 cells)
N-desmethyl Enzalutamide
T19450CAS 1242137-16-1
N-desmethyl Enzalutamide is the active Enzalutamide metabolite.It is the active metabolite of Enzalutamide. N-desmethyl Enzalutamide demonstrates primary and s...
N-desmethyl Enzalutamide D6
T19449CAS T19449
N-desmethyl Enzalutamide D6 is a deuterium labeled N-desmethyl Enzalutamide.
Sunset yellow
TN2245CAS 2783-94-0
Sunset yellow FCF and Brilliant Blue FCF are used as colorant food additives in many food products, they can have cytotoxic and genotoxic potential, it care must...
Ganoderic acid DM
TN1663CAS 173075-45-1
Ganoderic acid DM is an antiandrogenic osteoclastogenesis inhibitor, it especially suppresses the expression of c-Fos and nuclear factor of activated T cells c1 ...
Allura Red AC
TN1370CAS 25956-17-6
Allura Red AC and amaranth are very important food azo dyes used in food, drug, paper, cosmetic and textile industries.
Procyanidin B3
TN1150CAS 23567-23-9
Procyanidin B3(B3) is a procyanidin dimer that is widely studied due to its high abundance in the human diet and antioxidant activity.
6'-O-Galloyl paeoniflorin
TN1067CAS 122965-41-7
6'-O-Galloylpaeoniflorin (GPF) may be developed as a cytoprotector against ROS-mediated oxidative stress
Ganoderol B
TN1061CAS 104700-96-1
Ganoderol B is a potent β ±-glucosidase and angiotensin-converting enzyme inhibitor, with an IC(50) of β ±-glucosidase is 119.8 uM. It may be useful in prost...
Enzalutamide carboxylic acid
T8217CAS 1242137-15-0
Enzalutamide carboxylic acid is an antagonist of androgen receptor (AR) .
Dimethylcurcumin
TQ0214CAS 52328-98-0
Dimethylcurcumin (ASC-J9) is an androgen receptor degradation enhancer. It effectively suppresses castration-resistant prostate cancer cell proliferation and inv...
Ailanthone
TQ0209CAS 981-15-7
Ailanthone is an effective inhibitor of both full-length androgen receptor (AR) (IC50: 69 nM) and constitutively active truncated AR splice variants (IC50: 309...
2-hydroxy Flutamide
T7690CAS 52806-53-8
2-hydroxy Flutamide is competitive inhibition of androgen receptor (AR) for the treatment of prostate cancer
AZD3514
T6400CAS 1240299-33-5
AZD3514 is a potent and oral androgen receptor downregulator with Ki of 2.2 μM and has ability of reducing AR protein expression.Phase 1.