Search Result

Search Results for " androgen-receptor "

Targets

160

Compounds

Natural Products

Recombinant Proteins

Libraries

Cat No.	Product Name	Synonyms	Targets
T10320	Androgen receptor antagonist 1		Others
	Androgen receptor antagonist 1 is an orally available full androgen receptor antagonist (IC50: 59 nM). It can be used in the synthesis of PROTAC AR degraders, which results in 24% and 47 % AR protein degradation in LNCaP...		Others
T0380	Bicalutamide	ICI-176334	Androgen Receptor , Autophagy
	Bicalutamide (ICI-176334), a synthetic, nonsteroidal antiandrogen, competitively binds to cytosolic androgen receptors in target tissues, thereby inhibiting the receptor binding of androgens.		Androgen Receptor , Autophagy
T9035	Testosterone undecanoate		Others , Androgen Receptor
	Testosterone undecanoate is a metabolite of Testosterone, which is a promising androgen for male hormonal contraception.		Others , Androgen Receptor
T22263	Bavdegalutamide	ARV-110	Androgen Receptor
	Bavdegalutamide (ARV-110) is a PROTAC degrader of androgen receptor (AR). Bavdegalutamide can be used in studies about prostate cancer. Bavdegalutamide shows oral activity and selectivity and facilitates the ubiquitinati...		Androgen Receptor
T60988	Androgen receptor antagonist 4
	Androgen receptor antagonist 4 (Compound AT2) has anticancer activities. Androgen receptor antagonist 4 potently antagonizes the activity of AR transcriptional, inhibits downstream target gene of AR, and blocks the DHT-i...
T80633	Androgen receptor degrader-1		Androgen Receptor
	Androgen Receptor Degrader-1 (Compound 18) is a potent agent for androgen receptor degradation, applicable in cancer research [1].		Androgen Receptor
T60987	Androgen receptor antagonist 3
	Androgen receptor antagonist 3 (Compound C18) has anticancer activities that is an antagonist of androgen receptor (AR) (IC 50 = 2.4 μM) [1].
T12928	SK33		Androgen Receptor
	SK33 is a potent and tissue selective anti-androgen agent. SK33 reduces androgen receptor (AR) transcriptional activity.		Androgen Receptor
T79024	Androgen receptor-IN-5		Androgen Receptor
	Androgen receptor-IN-5 is a potent inhibitor of the androgen receptor with anticancer properties. It additionally suppresses the synthesis of IL-17A, IL-17F, and INF-γ.		Androgen Receptor
T83119	Androgen receptor antagonist 9		Androgen Receptor
	Androgen Receptor Antagonist 9 (compound 28) serves as an antagonist to the androgen receptor [1].		Androgen Receptor
T63324	Androgen receptor antagonist 5
	Androgen receptor antagonist 5 is a potent antagonist of the androgen receptor (AR) (IC50: 6.17 μM). Androgen receptor antagonist 5 inhibited the proliferation of prostate cancer cells LNCaP and showed antitumor effect i...
T80647	Androgen receptor degrader-2		Androgen Receptor
	Androgen Receptor Degrader-2 (Compound 9) is a potent degrader of androgen receptors, with potential application in cancer research [1].		Androgen Receptor
T79891	Androgen receptor degrader-3		Androgen Receptor
	Androgen Receptor Degrader-3 (ARD-3) is a compound that inhibits androgen receptor signaling and promotes the degradation of the receptor, with potential applications in prostate cancer research [1].		Androgen Receptor
T6829	EPI-001	EPI001,EPI 001	Apoptosis , Androgen Receptor , PPAR
	EPI-001 is an androgen receptor N-terminal domain antagonist with IC50 of ～6 μM and a selective PPAR-gamma modulator.		Apoptosis , Androgen Receptor , PPAR
T14116	ACP-105		Androgen Receptor
	ACP-105 is a novel and potent nonsteroidal selective androgen receptor modulator (SARM) with partial agonist activity relative to the natural androgen testosterone.		Androgen Receptor
T13272	UT-155		Androgen Receptor
	UT-155 is a selective and potent antagonist of the androgen receptor (AR) (Ki: 267 nM for UT-155 binding to AR-LBD).		Androgen Receptor
T12323	ORM-15341		Androgen Receptor
	ORM-15341 is a potent and full antagonist for human AR (hAR)( with IC50 values of 38 nM as shown by transactivation assays in AR-HEK293 cells)		Androgen Receptor
T20625	Prochloraz	Sporgon,Prelude	Estrogen Receptor/ERR , AhR , Androgen Receptor , Antifungal
	Prochloraz (Prelude) is a broad-spectrum contact imidazole fungicide. Prochloraz inhibits human placental microsomal aromatase in vitro (IC50 = 40 nM). Prochloraz also acts as an estrogen receptor (IC50s = 25 μM) and and...
T7690	2-hydroxy Flutamide		Androgen Receptor
	2-hydroxy Flutamide is competitive inhibition of androgen receptor (AR) for the treatment of prostate cancer		Androgen Receptor
T26539	AC-262536	AC262536	Androgen Receptor
	AC-262536 is a selective androgen receptor (SAR) modulator. It has partial agonist activity with respect to testosterone and suppresses luteinizing hormone.		Androgen Receptor
T9246	JNJ-63576253		Androgen Receptor
	JNJ-63576253 is a Clinical Stage Androgen Receptor Antagonist for F877L Mutant and Wild-Type Castration-Resistant Prostate Cancer (mCRPC).		Androgen Receptor
T3618	GSK-2881078	GSK2881078,GSK 2881078	Androgen Receptor
	GSK-2881078 is a selective androgen receptor modulator (SARM) that is being evaluated for effects on muscle growth and strength in subjects with muscle wasting to improve their physical function.		Androgen Receptor
T2339	Apalutamide	ARN-509	Androgen Receptor , GABA Receptor
	Apalutamide (ARN-509) is a small molecule and androgen receptor (AR) antagonist with potential antineoplastic activity.		Androgen Receptor , GABA Receptor
T5100	DJ-V-159	DJ-V159	GPR , Androgen Receptor
	DJ-V-159 is a GPRC6A agonist, targeting the G protein-coupled receptor family C group 6 member A (GPRC6A).		GPR , Androgen Receptor
T8217	Enzalutamide carboxylic acid		Androgen Receptor , Drug Metabolite
	Enzalutamide carboxylic acid is an antagonist of androgen receptor (AR) .		Androgen Receptor , Drug Metabolite
T21740	RD162		Androgen Receptor
	RD162 is a non-steroidal antiandrogen (NSAA) specifically binding to the androgen receptor (AR).		Androgen Receptor
T0489	Flutamide	SCH 13521	Androgen Receptor
	Flutamide (SCH 13521) is an antiandrogen with about the same potency as cyproterone in rodent and canine species.		Androgen Receptor
T39695	ARD-2128		Androgen Receptor
	ARD-2128 is a highly potent, orally bioavailable PROTAC (proteolysis-targeting chimera) degrader of the androgen receptor (AR), effectively diminishing AR protein levels, suppressing AR-regulated gene expression in tumor...		Androgen Receptor
T6889	MI-136		Apoptosis , Epigenetic Reader Domain , Androgen Receptor
	MI-136 inhibits expression of androgen receptor (AR) target genes that DHT induced.
T0476	Spironolactone	SC9420,Abbolactone	Glucocorticoid Receptor , Androgen Receptor , Autophagy
	Spironolactone (SC9420) is an Aldosterone Antagonist. The mechanism of action of spironolactone is as an Aldosterone Antagonist.
T6002	Enzalutamide	MDV3100	Androgen Receptor , Autophagy
	Enzalutamide (MDV3100) is an androgen receptor (AR) antagonist (IC50=36 nM in LNCaP). Enzalutamide activates autophagy, has antitumor activity, and is commonly used in the treatment of desmoplasia-resistant prostate canc...		Androgen Receptor , Autophagy
T13273	UT-34		Androgen Receptor
	UT-34 is a selective and orally active antagonist of second-generation pan-androgen receptor (AR) and degrader(IC50s of 211.7 nM, 262.4 nM and 215.7 nM for wild-type, F876L and W741L AR, respectively), and has anti-prost...		Androgen Receptor
T8933	JNJ-63576253 free base	TRC253,JNJ-63576253	Androgen Receptor
	JNJ-63576253 free base (TRC253) is a potent and orally active full antagonist of androgen receptor (AR), with IC50s of 37 and 54 nM for F877L mutant AR and wild-type AR in LNCaP cells. JNJ-63576253 can be used for the re...		Androgen Receptor
T6400	AZD3514		Androgen Receptor
	AZD3514 is a potent and oral androgen receptor downregulator with Ki of 2.2 μM and has ability of reducing AR protein expression.Phase 1.		Androgen Receptor
T72985	Masofaniten	Androgen receptor-IN-2
	Masofaniten (Androgen receptor-IN-2), a potent, orally active inhibitor of the androgen receptor, demonstrates significant antitumor activity against prostate cancer.
T6915	Darolutamide	ODM-201,BAY-1841788	Androgen Receptor
	Darolutamide (BAY-1841788) is an androgen receptor (AR) antagonist that blocks AR nuclear translocation (Ki: 11 nM).		Androgen Receptor
T0272	Nilutamide	RU23908	Androgen Receptor
	Nilutamide (RU23908), an antineoplastic hormonal agent, is mainly used in the treatment of prostate Y. Nilutamide is a pure, nonsteroidal anti-androgen with affinity for androgen receptors, but not for estrogen, progesto...		Androgen Receptor
T2556	Nandrolone decanoate	19-Nortestosterone decanoate	Others , HIV Protease
	Nandrolone decanoate (19-Nortestosterone decanoate) is the decanoate salt form of nandrolone, an anabolic steroid analog of testosterone with androgenic, anabolic, and erythropoietin stimulating effects. Nandrolone enter...		Others , HIV Protease
T12146	N-Desmethyl-Apalutamide	N-Desmethyl Apalutamide	P450 , Androgen Receptor
	N-Desmethyl-Apalutamide is a less potent antagonist of the androgen receptor, is an active Apalutamide metabolite.		P450 , Androgen Receptor
T7358	YK11		Androgen Receptor
	YK11 is an androgen receptor partial agonist that activates androgen receptor transcriptional activity in HEK293 cells overexpressing androgen receptors when used at a concentration of 0.1 μM, with osteogenic activity.		Androgen Receptor
T9179	CLP-3094	2-([2-(4-CHLOROPHENOXY)ETHYL]THIO)-1H-BE	Androgen Receptor
	CLP-3094 (2-([2-(4-CHLOROPHENOXY)ETHYL]THIO)-1H-BE) is a potent androgen receptor BF3 (binding function 3) inhibitor. BF3-IN-1 inhibits AR transcriptional activity with IC50 of 4 μM. CLP-3094 is a selective and potent GP...		Androgen Receptor
T1167	Cyproterone acetate	Androcur,Cyproterone 17-O-acetate	Androgen Receptor
	Cyproterone acetate (Cyproterone 17-O-acetate) binds the androgen receptor (AR), thereby preventing androgen-induced receptor activation in target tissues and inhibiting the growth of testosterone-sensitive tumor cells. ...		Androgen Receptor
T7440	P,p'-DDE	p,p'-dichlorodiphenyldichloroethylene,4,4'-DDE,Dichlorodiphenyldichloroethylene	Androgen Receptor , Drug Metabolite
	p,p'-DDE (p,p'-dichlorodiphenyldichloroethylene) is a metabolite and degradation product of the organochlorine pesticide DDT		Androgen Receptor , Drug Metabolite
T20789	S-23	(S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide,S23	Androgen Receptor
	S-23 ((S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide) is an oral selective androgen receptor modulator (SARM) with a Ki of 1.7 nM. S-23 increases prostate, seminal ve...		Androgen Receptor
T2236	RU 58841	RU58841,PSK-3841,HMR-3841	Androgen Receptor
	RU 58841 (PSK-3841) is a specific androgen receptor antagonist or anti-androgen; RU 58841(PSK-3841) has a significant effect on hair regrowth.		Androgen Receptor
T19450	N-desmethyl Enzalutamide	N-desmethyl MDV 3100	Androgen Receptor
	N-desmethyl Enzalutamide (N-desmethyl MDV 3100) is the active Enzalutamide metabolite.It is the active metabolite of Enzalutamide. N-desmethyl Enzalutamide demonstrates primary and secondary pharmacodynamics of similar p...		Androgen Receptor
T3357	Clascoterone	Cortexolone 17 alpha-propionate,17 alpha-propionate,CB-03-01,Cortexolone 17α-propionate	Androgen Receptor
	Clascoterone (CB-03-01) is a new topical and peripherally selective androgen antagonist.		Androgen Receptor
T6509	Galeterone	VN-124-1,TOK-001,VN/124-1,VN 124	P450 , Androgen Receptor
	Galeterone (VN 124) is an orally bioavailable small-molecule androgen receptor modulator and CYP17 lyase inhibitor with potential antiandrogen activity. Galeterone exhibits three distinct mechanisms of action: 1) as an a...		P450 , Androgen Receptor
T16090	MK-0773	PF-05314882	Androgen Receptor
	MK-0773 (PF-05314882) is a selective androgen receptor modulator that binds to AR (IC50: 6.6 nM) for the study of diseases caused by endocrine abnormalities.		Androgen Receptor
T10359	AR antagonist 1		Androgen Receptor , Ligand for E3 Ligase , Ligands for Target Protein for PROTAC
	AR antagonist 1 is a potent antagonist of the androgen receptor. It binds to E3 ligase ligands with weak binding affinities to VHL protein in the synthesis of PROTAC ARD-266.

Compounds

Androgen receptor antagonist 1

Target: Androgen Receptor, Autophagy

Testosterone undecanoate

T9035

Synonym:

Target: Others, Androgen Receptor

Bavdegalutamide

T22263

Synonym: ARV-110

Target: Androgen Receptor

Androgen receptor antagonist 4

T60988

Synonym:

Target:

Androgen receptor degrader-1

T80633

Synonym:

Target: Androgen Receptor

Androgen receptor antagonist 3

Target: Androgen Receptor

Androgen receptor-IN-5

T79024

Synonym:

Target: Androgen Receptor

Androgen receptor antagonist 9

T83119

Synonym:

Target: Androgen Receptor

Androgen receptor antagonist 5

T63324

Synonym:

Target:

Androgen receptor degrader-2

T80647

Synonym:

Target: Androgen Receptor

Androgen receptor degrader-3

T79891

Synonym:

Target: Androgen Receptor

EPI-001

T6829

Synonym: EPI001,EPI 001

Target: Apoptosis, Androgen Receptor, PPAR

ACP-105

T14116

Synonym:

Target: Androgen Receptor

UT-155

T13272

Synonym:

Target: Androgen Receptor

ORM-15341

T12323

Synonym:

Target: Androgen Receptor

Prochloraz

T20625

Synonym: Sporgon,Prelude

Target: Estrogen Receptor/ERR, AhR, Androgen Receptor, Antifungal

2-hydroxy Flutamide

T7690

Synonym:

Target: Androgen Receptor

AC-262536

T26539

Synonym: AC262536

Target: Androgen Receptor

JNJ-63576253

T9246

Synonym:

Target: Androgen Receptor

GSK-2881078

T3618

Synonym: GSK2881078,GSK 2881078

Target: Androgen Receptor

Apalutamide

T2339

Synonym: ARN-509

Target: Androgen Receptor, GABA Receptor

DJ-V-159

T5100

Synonym: DJ-V159

Target: GPR, Androgen Receptor

Enzalutamide carboxylic acid

T8217

Synonym:

Target: Androgen Receptor, Drug Metabolite

RD162

T21740

Synonym:

Target: Androgen Receptor

Flutamide

T0489

Synonym: SCH 13521

Target: Androgen Receptor

ARD-2128

T39695

Synonym:

Target: Androgen Receptor

MI-136

T6889

Synonym:

Target: Apoptosis, Epigenetic Reader Domain, Androgen Receptor

Spironolactone

T0476

Synonym: SC9420,Abbolactone

Target: Glucocorticoid Receptor, Androgen Receptor, Autophagy

Enzalutamide

T6002

Synonym: MDV3100

Target: Androgen Receptor, Autophagy

UT-34

T13273

Synonym:

Target: Androgen Receptor

JNJ-63576253 free base

T8933

Synonym: TRC253,JNJ-63576253

Target: Androgen Receptor

AZD3514

T6400

Synonym:

Target: Androgen Receptor

Masofaniten

T72985

Synonym: Androgen receptor-IN-2

Target:

Darolutamide

T6915

Synonym: ODM-201,BAY-1841788

Target: Androgen Receptor

Nilutamide

T0272

Synonym: RU23908

Target: Androgen Receptor

Nandrolone decanoate

T2556

Synonym: 19-Nortestosterone decanoate

Target: Others, HIV Protease

N-Desmethyl-Apalutamide

T12146

Synonym: N-Desmethyl Apalutamide

Target: P450, Androgen Receptor

YK11

T7358

Synonym:

Target: Androgen Receptor

CLP-3094

T9179

Synonym: 2-([2-(4-CHLOROPHENOXY)ETHYL]THIO)-1H-BE

Target: Androgen Receptor

Cyproterone acetate

T1167

Synonym: Androcur,Cyproterone 17-O-acetate

Target: Androgen Receptor

p,p'-DDE

T7440

Synonym: p,p'-dichlorodiphenyldichloroethylene,4,4'-DDE,Dichlorodiphenyldichloroethylene

Target: Androgen Receptor, Drug Metabolite

S-23

T20789

Synonym: (S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide,S23

Target: Androgen Receptor

RU 58841

T2236

Synonym: RU58841,PSK-3841,HMR-3841

Target: Androgen Receptor

N-desmethyl Enzalutamide

T19450

Synonym: N-desmethyl MDV 3100

Target: Androgen Receptor

Clascoterone

T3357

Synonym: Cortexolone 17 alpha-propionate,17 alpha-propionate,CB-03-01,Cortexolone 17α-propionate

Target: Androgen Receptor

Galeterone

T6509

Synonym: VN-124-1,TOK-001,VN/124-1,VN 124

Target: P450, Androgen Receptor

MK-0773

T16090

Synonym: PF-05314882

Target: Androgen Receptor

AR antagonist 1

T10359

Synonym:

Target: Androgen Receptor, Ligand for E3 Ligase, Ligands for Target Protein for PROTAC

Cat No.	Product Name	Synonyms	Targets
T14008	2,2,5,7,8-Pentamethyl-6-Chromanol	PMC	Androgen Receptor
	2,2,5,7,8-Pentamethyl-6-Chromanol (PMC) is the anti-oxidant moiety of vitamin E (α-tocopherol), which has potent androgen receptor (AR) signaling modulation and anti-cancer activity against prostate cancer cell lines.		Androgen Receptor
T19470	Nandrolone propionate		Others , Androgen Receptor
	Nandrolone propionate is an anabolic steroid action primarily consisting of androgenic and nitrogen-retentive properties.		Others , Androgen Receptor
TQ0209	Ailanthone	Δ13-Dehydrochaparrinone	Androgen Receptor
	Ailanthone (Δ13-Dehydrochaparrinone) is an effective inhibitor of both full-length androgen receptor (AR) (IC50: 69 nM) and constitutively active truncated AR splice variants (IC50: 309 nM).		Androgen Receptor
T8117	Metenolone acetate	Methenolone acetate	Others , Androgen Receptor
	Metenolone acetate (Methenolone acetate) is an androgen and anabolic steroid (AAS) medication which is used mainly in the treatment of anemia due to bone marrow failure.		Others , Androgen Receptor
T3393	Triptophenolide	Hypolide,(+)-Triptophenolide	Androgen Receptor
	Triptophenolide (Hypolide) is a compound isolated from Tripterygium wilfordii Hook with anti-inflammatory activity.		Androgen Receptor
T8709	Nandrolone phenylpropionate	Nandrolone phenpropionate	Androgen Receptor
	Nandrolone phenylpropionate (Nandrolone phenpropionate) is an androgen receptor agonist. It mainly used to treat women with breast cancer and osteoporosis		Androgen Receptor
TQ0214	Dimethylcurcumin	ASC-J9,GO-Y025	Androgen Receptor
	Dimethylcurcumin (ASC-J9) (ASC-J9) is an androgen receptor degradation enhancer. It effectively suppresses castration-resistant prostate cancer cell proliferation and invasion.		Androgen Receptor
TC0025	Testosterone acetate	NSC523836,NSC-523836,NSC 523836	Others
	Testosterone acetate (NSC-523836) is a hormone with in vitro antitumor activity.		Others
T2991	3,3'-Diindolylmethane	HB 236,DIM,Arundine	Androgen Receptor , Autophagy
	3,3'-Diindolylmethane (DIM), a small molecule compound, is a proposed Y preventive agent.		Androgen Receptor , Autophagy
T1261	Medroxyprogesterone Acetate	Medroxyprogesterone 17-acetate,Provera,Metigestrona,NSC-26386,Farlutin,Medroxyprogesterone (acetate)	Glucocorticoid Receptor , Estrogen/progestogen Receptor , Progesterone Receptor , Androgen Receptor , Endogenous Metabolite
	Medroxyprogesterone Acetate (Farlutin) is a synthetic progestin that is derived from 17-hydroxyprogesterone. It is a long-acting contraceptive that is effective both orally or by intramuscular injection and has also been...
T2895	Lupeol	Fagarasterol,Monogynol B,Clerodol,(3β,13ξ)-Lup-20(29)-en-3-ol,Farganasterol	Apoptosis , Androgen Receptor , Akt
	Lupeol (Monogynol B) is a novel androgen receptor inhibitor with anti-inflammatory and antioxidant activity.		Apoptosis , Androgen Receptor , Akt
T2207	Adrenosterone	11-ketoandrostenedione,11-oxoandrostenedione,Reichstein's substance G	Androgen Receptor , Endogenous Metabolite
	Adrenosterone (11-ketoandrostenedione) is a steroid hormone isolated from the adrenal cortex.		Androgen Receptor , Endogenous Metabolite
T0856	Dehydroisoandrosterone 3-acetate	Dehydroepiandrosterone 3-acetate,Dehydroepiandrosterone acetate,Prasterone acetate,DHEA acetate,androstenolone acetate	Androgen Receptor
	Dehydroisoandrosterone 3-acetate (Prasterone acetate) is a primary C19 steroid generated by the adrenal cortex.		Androgen Receptor
TN1805	Isosilybin B		Apoptosis , Androgen Receptor
	Isosilybin B is a flavonolignan extracted from silymarin that exhibits anti-prostate cancer (PCA) activity, inhibits cancer cell proliferation, and contributes to G1-phase blockade and apoptosis.Isosilybin B induces degr...		Apoptosis , Androgen Receptor
TN1677	Gartanin		BCL , Caspase , JNK
	Gartanin is an androgen receptor degradation enhancer, it is also a potential neuroprotective agent against glutamate-induced oxidative injury partially through increasing Nrf-2-independed HO-1 and AMPK/SIRT1/PGC-1α±sign...		BCL , Caspase , JNK
TN1308	6-Hydroxyflavanone		Others , Lipoxygenase , COX , GABA Receptor
	6-Hydroxyflavanone, extracted from the leaves of Acorus calamus, exhibits anti-inflammatory and anti-neuropathic pain activity by targeting cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX), as well as opioid and GABA-A r...		Others , Lipoxygenase , COX , GABA Receptor
T4000	(±)-Equol	Equol,(R,S)-Equol	Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Drug Metabolite
	(±)-Equol ((R,S)-Equol) is a non-steroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzen by human intestinal microflora. The estrogen receptor (ER) agonist activity of the naturally occu...
T6491	(-)-(S)-Equol	(−)-Equol,Equol,4',7-Dihydroxyisoflavan,4',7-Isoflavandiol	Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Endogenous Metabolite
	(-)-(S)-Equol (4',7-Dihydroxyisoflavan) is an orally bioavailable, non-steroidal estrogen naturally produced by the metabolism of the isoflavonoid daidzein by human intestinal microflora, with potential chemoprotective a...
T11834	Leelamine hydrochloride		Others
	Leelamine hydrochloride, a tricyclic diterpene extracted from pine tree bark, inhibits the transcriptional activity of the androgen receptor, known to regulate fatty acid synthesis [2,3]. This compound acts as a cannabin...		Others
T75702	Galloylalbiflorin
	Galloylalbiflorin (6′-O-Galloylalbiflorin), an androgen receptor (AR) antagonist with an IC50 value of 53.3 μM, is a compound isolated from the roots of Paeonia lactiflora. It exhibits anti-androgen activity [1].
TN6337	Lupichromone	5,7-Dihydroxy-6,8-diprenylchromone
	Eriosemation significant androgen receptor (AR) inhibition activity, suggests that it could be a promising candidate for further evaluation for prostate cancer prevention or management.
TN4774	Physalin A		ERK , BCL , p38 MAPK , NF-κB , Androgen Receptor , ROS , JAK , JNK , STAT , p53 , Autophagy
	Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate cancer cell growth through activation of cell apoptosis and dow...
TN1061	Ganoderol B		Androgen Receptor
	Ganoderol B is a potent β ±-glucosidase and angiotensin-converting enzyme inhibitor, with an IC(50) of β ±-glucosidase is 119.8 uM. It may be useful in prostate cancer and benign prostatic hyperplasia (BPH) therapy throu...		Androgen Receptor

Natural Products

2,2,5,7,8-Pentamethyl-6-Chromanol

T14008

Synonym: PMC

Target: Androgen Receptor

Nandrolone propionate

T19470

Synonym:

Target: Others, Androgen Receptor

Ailanthone

TQ0209

Synonym: Δ13-Dehydrochaparrinone

Target: Androgen Receptor

Metenolone acetate

T8117

Synonym: Methenolone acetate

Target: Others, Androgen Receptor

Triptophenolide

T3393

Synonym: Hypolide,(+)-Triptophenolide

Target: Androgen Receptor

Nandrolone phenylpropionate

T8709

Synonym: Nandrolone phenpropionate

Target: Androgen Receptor

Dimethylcurcumin

TQ0214

Synonym: ASC-J9,GO-Y025

Target: Androgen Receptor

Testosterone acetate

TC0025

Synonym: NSC523836,NSC-523836,NSC 523836

Target: Others

3,3'-Diindolylmethane

T2991

Synonym: HB 236,DIM,Arundine

Target: Androgen Receptor, Autophagy

Medroxyprogesterone Acetate

T1261

Synonym: Medroxyprogesterone 17-acetate,Provera,Metigestrona,NSC-26386,Farlutin,Medroxyprogesterone (acetate)

Target: Glucocorticoid Receptor, Estrogen/progestogen Receptor, Progesterone Receptor, Androgen Receptor, Endogenous Metabolite

Lupeol

T2895

Synonym: Fagarasterol,Monogynol B,Clerodol,(3β,13ξ)-Lup-20(29)-en-3-ol,Farganasterol

Target: Apoptosis, Androgen Receptor, Akt

Adrenosterone

T2207

Synonym: 11-ketoandrostenedione,11-oxoandrostenedione,Reichstein's substance G

Target: Androgen Receptor, Endogenous Metabolite

Dehydroisoandrosterone 3-acetate

T0856

Synonym: Dehydroepiandrosterone 3-acetate,Dehydroepiandrosterone acetate,Prasterone acetate,DHEA acetate,androstenolone acetate

Target: Androgen Receptor

Isosilybin B

TN1805

Synonym:

Target: Apoptosis, Androgen Receptor

Gartanin

TN1677

Synonym:

Target: BCL, Caspase, JNK

6-Hydroxyflavanone

TN1308

Synonym:

Target: Others, Lipoxygenase, COX, GABA Receptor

(±)-Equol

T4000

Synonym: Equol,(R,S)-Equol

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Drug Metabolite

(-)-(S)-Equol

T6491

Synonym: (−)-Equol,Equol,4',7-Dihydroxyisoflavan,4',7-Isoflavandiol

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Endogenous Metabolite

Leelamine hydrochloride

Synonym: 5,7-Dihydroxy-6,8-diprenylchromone

Target: ERK, BCL, p38 MAPK, NF-κB, Androgen Receptor, ROS, JAK, JNK, STAT, p53, Autophagy

Ganoderol B

TN1061

Synonym:

Target: Androgen Receptor

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPH-00932	Androgen receptor Protein, Human, Recombinant (His & Myc & SUMO)	Human	E. coli
	Androgen receptor Protein, Human, Recombinant (His & Myc & SUMO) is expressed in E. coli.
TMPH-02284	USP26 Protein, Human, Recombinant (His)	Human	E. coli
	Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome. Deubiquitinates the androgen receptor and regulates the androgen receptor signaling pathway.
TMPY-00611	UBE2B Protein, Mouse, Recombinant	Mouse	E. coli
	The ubiquitin-conjugating enzyme E2B (Ube2b) is a critical target gene of androgen receptor (AR), mediating the function of AR in spermatogenesis by promoting H2A ubiquitylation. Moreover, UBE2B plays an important role i...
TMPY-03259	Calreticulin Protein, Human, Recombinant (His)	Human	HEK293
	Calreticulin is a multifunctional protein. It acts as a main Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. Calreticulin binds Ca2+ ions (a second messenger in signal transduction), rendering...
TMPY-03258	Calreticulin Protein, Human, Recombinant (hFc)	Human	HEK293
	Calreticulin is a multifunctional protein. It acts as a main Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. Calreticulin binds Ca2+ ions (a second messenger in signal transduction), rendering...
TMPY-06327	Calreticulin Protein, Human, Recombinant	Human	HEK293
	Calreticulin is a multifunctional protein. It acts as a main Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. Calreticulin binds Ca2+ ions (a second messenger in signal transduction), rendering...
TMPK-01387	EPhA3 Protein, Canine, Recombinant (His)	Canine	HEK293
	Erythropoietin‑producing hepatocellular carcinoma cell surface type‑A receptor 3 (EPHA3) has been found to promote the proliferation and survival of prostate cancer (PCa) cell lines and prostate tumor development in nude...
TMPK-00850	MFGE8 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	MFGE8 (Milk Fat Globule EGF And Factor V/VIII Domain Containing) is a Protein Coding gene. Diseases associated with MFGE8 include Anal Paget's Disease and Topographical Agnosia. Among its related pathways are Activated P...
TMPY-03056	LSD1 Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	LSD1 belongs to the flavin monoamine oxidase family. It contains 1 SWIRM domain and is a component of an RCOR/GFI/LSD1/HDAC complex. LSD1 interacts directly with GFI1 and GFI1B. LSD1 specifically removes histone H3K4me2 ...
TMPY-02844	EBP1 Protein, Human, Recombinant (His)	Human	E. coli
	EBP1, also known as PA2G4, is an RNA-binding protein that belongs to the peptidase M24 family. It can be detected n several cell lines tested, including primary and transformed cell lines. EBP1 also present in pre-riboso...
TMPH-00851	HSD3B1 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	A bifunctional enzyme responsible for the oxidation and isomerization of 3beta-hydroxy-Delta(5)-steroid precursors to 3-oxo-Delta(4)-steroids, an essential step in steroid hormone biosynthesis. Specifically catalyzes the...
TMPY-04408	CAMKII beta/CAMK2B Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	Calcium/calmodulin-dependent protein kinase II beta (CAMK2B) is a member of the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. CaMKII is an important player in pro...
TMPY-04484	ACK1 Protein, Human, Recombinant (GST)	Human	Baculovirus-Insect Cells
	ACK1 (also known as ACK, TNK2, or activated Cdc42 kinase) is a structurally unique non-receptor tyrosine kinase that is expressed in diverse cell types. This downstream effector of CDC42 mediates CDC42-dependent cell mig...
TMPH-02235	TMPRSS2 Protein, Human, Recombinant (Cell-Free, His)	Human	in vitro E. coli expression system
	Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate. Androgen-induced TMPRSS2 activates several substrates that include pro-...
TMPH-02238	TMPRSS2 Protein, Human, Recombinant (Avi & His & MBP), Biotinylated	Human	E. coli
	Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate. Androgen-induced TMPRSS2 activates several substrates that include pro-...
TMPH-02236	TMPRSS2 Protein, Human, Recombinant (E. coli, His)	Human	E. coli
	Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate. Androgen-induced TMPRSS2 activates several substrates that include pro-...
TMPH-02237	TMPRSS2 Protein, Human, Recombinant (His & Myc)	Human	HEK293
	Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate. Androgen-induced TMPRSS2 activates several substrates that include pro-...
TMPH-01900	DDX5 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop r...
TMPY-02216	S100P Protein, Human, Recombinant	Human	E. coli
	Protein S100-P, also known as Protein S100-E, S100 calcium-binding protein P, S100P and S100E, is a nucleus and cytoplasm protein that belongs to the S-100 family. S100P / S100E contains twoEF-hand domains. S100P protein...
TMPY-02043	PARK7/DJ-1 Protein, Human, Recombinant (His)	Human	E. coli
	Parkinson's disease locus DJ-1 (PARK7) is a differentially expressed transcript. DJ-1 plays a physiologic role in protection of erythroid cells from oxidant damage, a function unmasked in the context of oxidative stress....
TMPY-04944	S100P Protein, Human, Recombinant, Biotinylated	Human	E. coli
	Protein S100-P, also known as Protein S100-E, S100 calcium-binding protein P, S100P and S100E, is a nucleus and cytoplasm protein that belongs to the S-100 family. S100P / S100E contains twoEF-hand domains. S100P protein...
TMPH-01616	LRP2 Protein, Human, Recombinant (mFc)	Human	HEK293
	Multiligand endocytic receptor. Acts together with CUBN to mediate endocytosis of high-density lipoproteins. Mediates receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B. In the...

Androgen receptor Protein, Human, Recombinant (His & Myc & SUMO)

TMPH-00932

Species: Human

Expression System: E. coli

USP26 Protein, Human, Recombinant (His)

TMPH-02284

Species: Human

Expression System: E. coli

UBE2B Protein, Mouse, Recombinant

TMPY-00611

Species: Mouse

Expression System: E. coli

Calreticulin Protein, Human, Recombinant (His)

TMPY-03259

Species: Human

Expression System: HEK293

Calreticulin Protein, Human, Recombinant (hFc)

TMPY-03258

Species: Human

Expression System: HEK293

Calreticulin Protein, Human, Recombinant

TMPY-06327

Species: Human

Expression System: HEK293

EPhA3 Protein, Canine, Recombinant (His)

TMPK-01387

Species: Canine

Expression System: HEK293

MFGE8 Protein, Mouse, Recombinant (His)

TMPK-00850

Species: Mouse

Expression System: HEK293

LSD1 Protein, Human, Recombinant (His & GST)

TMPY-03056

Species: Human

Expression System: Baculovirus-Insect Cells

EBP1 Protein, Human, Recombinant (His)

TMPY-02844

Species: Human

Expression System: E. coli

HSD3B1 Protein, Human, Recombinant (His & Myc)

TMPH-00851

Species: Human

Expression System: E. coli

CAMKII beta/CAMK2B Protein, Human, Recombinant (His & GST)

TMPY-04408

Species: Human

Expression System: Baculovirus-Insect Cells

ACK1 Protein, Human, Recombinant (GST)

TMPY-04484

Species: Human

Expression System: Baculovirus-Insect Cells

TMPRSS2 Protein, Human, Recombinant (Cell-Free, His)

TMPH-02235

Species: Human

Expression System: in vitro E. coli expression system

TMPRSS2 Protein, Human, Recombinant (Avi & His & MBP), Biotinylated

TMPH-02238

Species: Human

Expression System: E. coli

TMPRSS2 Protein, Human, Recombinant (E. coli, His)

TMPH-02236

Species: Human

Expression System: E. coli

TMPRSS2 Protein, Human, Recombinant (His & Myc)

TMPH-02237

Species: Human

Expression System: HEK293

DDX5 Protein, Human, Recombinant (His & Myc)

TMPH-01900

Species: Human

Expression System: E. coli

S100P Protein, Human, Recombinant

TMPY-02216

Species: Human

Expression System: E. coli

PARK7/DJ-1 Protein, Human, Recombinant (His)

TMPY-02043

Species: Human

Expression System: E. coli

S100P Protein, Human, Recombinant, Biotinylated

TMPY-04944

Species: Human

Expression System: E. coli

LRP2 Protein, Human, Recombinant (mFc)

TMPH-01616

Species: Human

Expression System: HEK293

Cat No.	Product Name
L2195	Anti-Prostate Cancer Compound Library		2096 compounds
	2096 compounds associated with prostate cancer that can be used for high-throughput and high-content screening.

Libraries

Anti-Prostate Cancer Compound Library

L2195

Compounds: 2096