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Search Results for " adenylyl cyclase "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T16333	NKY80	Adenylyl cyclase type V Inhibitor	Adenylyl cyclase
	NKY80 regulates the adenylyl cyclase catalytic activity in heart and lung tissues. NKY80 is a non-competitive inhibitor of adenylyl cyclase type V isoform (IC50s: 8.3 µM, 132 µM, and 1.7 mM for type V, III and II, respe...		Adenylyl cyclase
T10066	2',5'-Dideoxyadenosine		Adenylyl cyclase , Adrenergic Receptor , AChR
	2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor via binding the P-site (IC50: 3 μM).		Adenylyl cyclase , Adrenergic Receptor , AChR
T15658	KH7		cAMP , AChR
	KH7 is a soluble inhibitor of adenylyl cyclase (sAC)-specific. It has IC50s of 3-10 μM toward both recombinant purified human sACt protein and heterologously expressed sACt in cellular assays. KH7 is also a cAMP inhibito...		cAMP , AChR
T16938	ST034307		Adenylyl cyclase
	ST034307 is an effective and selective inhibitor of adenylyl cyclase 1 (IC50: 2.3 μM).		Adenylyl cyclase
T60003	AC1-IN-1		Adenylyl cyclase
	AC1-IN-1 is a selective inhibitor of adenylyl cyclase type 1 (AC1, IC50 = 0.54 µM).		Adenylyl cyclase
T0322	Fipexide		Dopamine Receptor , AChR
	Fipexide (Attentil, Vigilor), a psychoactive drug of the piperazine chemical class, was developed in Italy in 1983. It was served as a nootropic drug in France and Italy, mainly for the therapy of senile dementia, but is...		Dopamine Receptor , AChR
T16275	NB001	HTS 09836	Adenylyl cyclase
	NB001 (HTS 09836) is an inhibitor of adenyl cyclase 1 exhibiting effects on neural and non-neural pain.		Adenylyl cyclase
T83169	Adenylyl cyclase-IN-1
	Adenylyl cyclase-IN-1 is a potential adenylyl cyclase inhibitor for ocular hypotonia research [1].
T26869	BMS-986122	BMS 986122	Opioid Receptor
	BMS-986122 (BMS 986122) is a positive allosteric modulator of μ-opioid receptors that increases β-arrestin recruitment stimulated by endomorphin 1 in U2OS-OPRM1 human osteosarcoma cells expressing μ-opioid receptors (EC5...		Opioid Receptor
T8702	SKF-83566		Dopamine Receptor , 5-HT Receptor , AChR
	SKF-83566 is a blood-brain permeable and orally active antagonist of D1-like dopamine receptor and a weaker competitive 5-HT2 receptor antagonist with Ki of 11 nM		Dopamine Receptor , 5-HT Receptor , AChR
T63893	Adenylyl cyclase type 2 agonist-1
	Adenylyl cyclase type 2 agonist-1 is a potent agonist of adenylyl cyclase type 2 (AC2) (EC50: 90 nM). It is a potential lead compound in the fight against respiratory diseases.
T2172	SQ22536	9-(tetrahydrofuran-2-yl)-9h-purin-6-amine,SQ 22536	AChR
	SQ22536 (9-(tetrahydrofuran-2-yl)-9h-purin-6-amine) , the adenosine analogue 9-(Tetrahydro-2-furyl)adenine, inhibited adenylate cyclase activity of crude membrane preparations from catfish (Ictalurus melas) and rat isola...		AChR
T11918	Lysipressin	Lysine vasopressin,[Lys8]-Vasopressin	Others
	Lysipressin ([Lys8]-Vasopressin), Induces contraction of the rabbit urinary bladder smooth muscle, activate adenylate-cyclase. Lysipressin is Antidiuretic hormone that have been found in pigs and some marsupial families.		Others
T15787	LRE1		Adenylyl cyclase
	LRE1 is a specific and allosteric soluble adenylyl cyclase inhibitor.		Adenylyl cyclase
T8959	OS-3-106		Dopamine Receptor
	OS-3-106 is a novel arylamide phenylpiperazines, as partial agonists at the D3R in the adenylyl cyclase inhibition assay.		Dopamine Receptor
T7813	α-MSH	MSH, amide,CZEN-002,α-Melanocyte-Stimulating Hormone (MSH), amide	Melanocortin Receptor , Adenylyl cyclase
	α-MSH (MSH, amide) is amide stimulates melanocortin 1 receptor that results in the activation of adenylyl cyclase.		Melanocortin Receptor , Adenylyl cyclase
T64355	TDI-10229		cAMP
	TDI-10229 is a potent and orally available inhibitor of soluble adenylyl cyclase (sAC, ADCY10). TDI-10229 displays nanomolar inhibition of sAC in both biochemical and cellular assays (IC50= 195 nM). TDI-10229 exhibits mo...		cAMP
T22615	BPIPP		Others
	guanylyl cyclase (GC) and adenylyl cyclase (AC) inhibitor		Others
T26960	CB7833407
	CB7833407 is a selective Adenylyl Cyclase isoform-2 (AC2) inhibitor.
T23863	CB-6673567	CB 6673567
	CB-6673567 is a selective inhibitor of adenylyl cyclase.
T28622	RU-0207148
	RU-0207148 is a novel allosteric soluble adenylyl cyclase (sAC) inhibitor.
T22467	1,9-Dideoxyforskolin		Others
	The compound is an inactive analog of forskolin(an adenylyl cyclase activator).		Others
T69543	CFM-1571(free base)
	CFM 1571 is the free base of CFM 1571 Hydrochloride (C291720), which acts as a soluble guanylyl cyclase (sGC) activator while ignoring adenylyl cyclase.
T38782	Mant-GTPγS
	Mant-GTPγS, an effective GTP analog, displays strong competitive inhibition of adenylyl cyclase (AC). Additionally, it acts as a potent inhibitor of YdeH.
T83843	2'(3')-O-Anthraniloylguanosine-5'-O-triphosphate sodium	2'(3')-ANT-GTP
	2'(3')-O-Anthraniloylguanosine-5'-O-triphosphate (2'-ANT-GTP) and 3'-ANT-GTP are fluorescent derivatives of GTP that exhibit spontaneous isomerization. 2'(3')-ANT-GTP features an emission peak at 428 nm when excited at 3...
T76657L	Human PTH-(1-31) amide
	Human PTH-(1-31) amide, an analog of PTH, effectively stimulates phosphatidylcholine hydrolysis and promotes the release of adenylyl cyclase [1].
T73297	TDI-11861
	TDI-11861, a second-generation soluble Adenylyl Cyclase (sAC, ADCY10) inhibitor, demonstrates slow dissociation rates and effectively inhibits sAC activity in cells, evidenced by an IC50 value of 5.5 nM.
TP2033	[Des-His1,Glu9]-Glucagon amide	des-His1-[Glu9]-Glucagon (1-29) amide
	Glucagon receptor antagonist (pA2 = 7.2 for inhibition of glucagon-induced adenylyl cyclase activation in rat liver membranes); displays no agonist activity. Enhances glucose-stimulated pancreatic insulin release in vitr...
T71122	Carsatrin (free base)
	Carsatrin is purinylpiperazine derivative. as cardiotonic and antiarrhythmic. Carsatrin acts as positive inotropic agent that increases twitch tension and prolongs the action potential (AP) duration of ventricular muscle...
T37131	MS 15203
	Potent and selective GPR171 partial agonist (EC50 = 90 nM; 28% inhibition of forskolin activated adenylyl cyclase activity in rat hypothalamic memebranes). Exhibits minimal binding to a panel of ~70 GPCRs and 10 other re...
T70975	Carsatrin succinate
	Carsatrin succinate is the salt form of Carsatin, a purinylpiperazine derivative used as a cardiotonic and antiarrhythmic. Carsatrin acts as positive inotropic agent that increases twitch tension and prolongs the action ...
T36720	Deacetylforskolin
	Deacetylforskolin is a diterpene and a derivative of forskolin that has been found inC. forskohliiand has diverse biological activities.1,2,3,4It activates rat adipocyte adenylyl cyclase (IC50= 20 μM) and inhibits glucos...
T83820	TNP-GTP sodium	TNP-Guanosine 5'-triphosphate
	TNP-GTP, a fluorescent derivative of guanosine 5'-triphosphate (GTP), essential for protein synthesis and gluconeogenesis, exhibits an emission peak at 552 nm when excited at 410 nm in water. Its fluorescence intensity i...
T83811	2'(3')-O-Anthraniloyladenosine-5'-O-triphosphate sodium	2'(3')-ANT-ATP
	2'(3')-O-Anthraniloyladenosine-5'-O-triphosphate (2'-ANT-ATP) and its isomer 3'-ANT-ATP are fluorescent derivatives of ATP that spontaneously isomerize. Emitting a maximum light of 428 nm when excited at 330 nm in water,...

Compounds

NKY80

T16333

Synonym: Adenylyl cyclase type V Inhibitor

Target: Adenylyl cyclase

2',5'-Dideoxyadenosine

T10066

Synonym:

Target: Adenylyl cyclase, Adrenergic Receptor, AChR

Target: Adenylyl cyclase

AC1-IN-1

T60003

Synonym:

Target: Adenylyl cyclase

Fipexide

T0322

Synonym:

Target: Dopamine Receptor, AChR

NB001

T16275

Synonym: HTS 09836

Target: Adenylyl cyclase

Adenylyl cyclase-IN-1

Target: Opioid Receptor

SKF-83566

T8702

Synonym:

Target: Dopamine Receptor, 5-HT Receptor, AChR

Adenylyl cyclase type 2 agonist-1

Synonym: 9-(tetrahydrofuran-2-yl)-9h-purin-6-amine,SQ 22536

Target: AChR

Lysipressin

T11918

Synonym: Lysine vasopressin,[Lys8]-Vasopressin

Target: Adenylyl cyclase

OS-3-106

T8959

Synonym:

Target: Dopamine Receptor

α-MSH

T7813

Synonym: MSH, amide,CZEN-002,α-Melanocyte-Stimulating Hormone (MSH), amide

Target: Melanocortin Receptor, Adenylyl cyclase

2'(3')-O-Anthraniloylguanosine-5'-O-triphosphate sodium

T83843

Synonym: 2'(3')-ANT-GTP

Target:

Human PTH-(1-31) amide

[Des-His1,Glu9]-Glucagon amide

TP2033

Synonym: des-His1-[Glu9]-Glucagon (1-29) amide

Target:

Carsatrin (free base)

Synonym: TNP-Guanosine 5'-triphosphate

Target:

2'(3')-O-Anthraniloyladenosine-5'-O-triphosphate sodium

T83811

Synonym: 2'(3')-ANT-ATP

Target:

Cat No.	Product Name	Synonyms	Targets
T2939	Forskolin	Coleonol,Colforsin	FXR , Adenylyl cyclase , AChR , Autophagy
	Forskolin (Coleonol) is a natural product, an adenylate cyclase activator (EC50=0.5 μM). Forskolin increases cAMP levels, activates PXR and FXR, and induces autophagy. Forskolin produces positive inotropic effects in the...		FXR , Adenylyl cyclase , AChR , Autophagy

Natural Products

Forskolin

T2939

Synonym: Coleonol,Colforsin

Target: FXR, Adenylyl cyclase, AChR, Autophagy

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPH-00574	Adenylate cyclase Protein, E. coli, Recombinant (His)	E. coli	in vitro E. coli expression system
	Catalyzes the formation of the second messenger cAMP from ATP. Its transcript is probably degraded by endoribonuclease LS (rnlA), decreasing cAMP levels and the negative regulator Crp-cAMP, which then induces its own tra...
TMPH-00892	A1AR Protein, Human, Recombinant (His)	Human	in vitro E. coli expression system
	Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.
TMPH-02672	GIPR Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
TMPH-01386	GLP2R Protein, Human, Recombinant (His)	Human	HEK293
	This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
TMPH-01378	GIPR Protein, Human, Recombinant (His & Myc)	Human	HEK293
	This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
TMPH-01377	GIPR Protein, Human, Recombinant (His)	Human	E. coli
	This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
TMPH-01201	DRD2 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5.
TMPH-01385	GLP1R Protein, Human, Recombinant (His)	Human	HEK293
	G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a ...
TMPH-01384	GLP1R Protein, Human, Recombinant (E. coli, His)	Human	E. coli
	G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a ...
TMPH-03301	GLP1R Protein, Rat, Recombinant (E. coli, His)	Rat	E. coli
	G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a ...
TMPH-02676	GLP1R Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a ...
TMPY-03506	VILIP1 Protein, Human, Recombinant	Human	E. coli
	VILIP-1, also known as VSNL1, is strongly expressed in granule cells of the cerebellum where it associates with membranes in a calcium-dependent manner and modulates intracellular signaling pathways of the central nervou...
TMPY-02648	PACAP receptor/ADCYAP1R1 Protein, Human, Recombinant (hFc)	Human	HEK293
	Pituitary adenylate cyclase activating polypeptide (PACAP, Adcyap1) activation of PAC1 receptors ( Adcyap1r1) significantly increases excitability of guinea pig cardiac neurons. This modulation of excitability is mediate...
TMPJ-01048	VSNL1 Protein, Human, Recombinant (His)	Human	E. coli
	Visinin-Like Protein 1 (VILIP) is a a member of the Visinin/Recoverin subfamily of neuronal calcium sensor proteins. VILIP is strongly expressed in the Granule Cells of the Cerebellum where it associates with membranes i...
TMPY-02236	PTH1R Protein, Human, Recombinant (His)	Human	HEK293
	Parathyroid hormone / parathyroid hormone-related peptide receptor, also known as PTH / PTHrP type I receptor, PTH/PTHr receptor, Parathyroid hormone 1 receptor, PTH1 receptor, PTH1R and PTHR, is a multi-pass membrane pr...