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Search Results for " atp-citrate-lyase "

Targets

8

Compounds

9

Natural Products

2

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T7424 NDI-091143 ATP Citrate Lyase
NDI-091143 is a potent and high-affinity human ATP-citrate lyase (ACLY) inhibitor with an IC50 of 2.1 nM (ADP-Glo assay),indirectly disrupting citrate binding via an unexpected mechanism of inhibition.
T16861 SB 204990 ATP Citrate Lyase
SB 204990 is an effective and specific ATP citrate lyase enzyme inhibitor.
T2337 BMS-303141 BMS 303141 ATP Citrate Lyase
BMS-303141 is a potent ATP-citrate lyase (ACL) inhibitor (IC50: 0.13 uM, human recombinant ACL).
T22967 MEDICA16 MEDICA 16 GPR , Others , ATP Citrate Lyase
MEDICA16 is a selective agonist for GPR40 as well as a partial agonist for GPR120. MEDICA16, an ATP-citrate lyase inhibitor, significantly reduces intracellular TG content in gastrocnemius muscle with an increase in insu...
T3625 Bempedoic acid ETC1002,ESP-55016,ETC 1002,ETC-1002 ATP Citrate Lyase , AMPK
Bempedoic acid (ETC1002) is an orally available, once-daily LDL-C lowering small molecule designed to lower elevated levels of LDL-C and to avoid side effects associated with existing LDL-C lowering therapies. Bempedoic ...
T70466 SB-201076
SB-201076 is a potent ATP citrate-lyase inhibitor. SB-204990 is the prodrug of SB-201076.
T16322 Nicodicosapent Others
Nicodicosapent is a fatty acid niacin conjugate. It is also an inhibitor of the sterol regulatory element-binding protein (SREBP). The sterol regulatory element-binding protein (SREBP) is a key regulator of cholesterol m...
T37498 Antimycin A4
Antimycin A4 is an active component of the antimycin A antibiotic complex that is more polar than antimycin A1 , antimycin A2 , and antimycin A3 . Antimycin A4 inhibits ATP-citrate lyase with a Ki value of 64.8 μM. The a...
Cat No. Product Name Synonyms Targets
T11590 (-)-Hydroxycitric acid Garcinia acid ATP Citrate Lyase
(-)-Hydroxycitric acid (Garcinia acid) (Garcinia acid) is the principal acid of fruit rinds of Garcinia cambogia. It is a potent and competitive inhibitor of ATP citrate lyase. (-)-Hydroxycitric acid suppresses fatty aci...
T11589 Hydroxycitric acid tripotassium hydrate Potassium citrate monohydrate ATP Citrate Lyase , HIF/HIF Prolyl-Hydroxylase , HIF
Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) effectively inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation, and anti-tumor effects. Hydroxycitric acid tr...
T0256 Citric acid trilithium salt tetrahydrate Lithium citrate tribasic tetrahydrate,Trilithium citrate tetrahydrate Dehydrogenase , GSK-3 , HIF/HIF Prolyl-Hydroxylase , Antibacterial , GluR
Citric acid trilithium salt tetrahydrate (Lithium citrate tribasic tetrahydrate) , the active component of Lithium, is a medicine used in the therapy of psychiatric disease. It has shown the effects of signaling pathways...
T12045 (-)-Hydroxycitric acid lactone Garcinia lactone ATP Citrate Lyase
(-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent.(-)-Hydroxycitric acid lactone was a potent inhibitor of ATP citrate lyase, which catalyzes the extramitochondrial cleavage of citrate to oxaloac...
T5544 2-Furoic acid Furan-2-carboxylic acid Anti-infection , ATP Citrate Lyase , Endogenous Metabolite , Acyltransferase
2-Furoic acid (Furan-2-carboxylic acid), an orally active selective human cathepsin K inhibitor, may have the therapeutic potential for the treatment of diseases characterized by excessive bone loss including osteoporosi...
T79936 Forrestiacids K ATP Citrate Lyase
Forrestiacid K, a terpenoid derived from Pseudotsuga forrestii, functions as an inhibitor of ATP-citrate lyase (ACL) [1].
T79935 Forrestiacids J ATP Citrate Lyase
Forrestiacid J is an inhibitor of ATP-citrate lyase (ACL), exhibiting an IC50 value of 2.6 μM [1].
T82274 Gnetuhainin I
Gnetuhainin I (Compound 5), a lignin sourced from Pouzolzia zeylanica, exhibits potent inhibition of ATP citrate lyase (ACLY) with an IC50 value of 2.63 μM [1].
TN1751 Hydroxycitric acid ERK , p38 MAPK , Fatty Acid Synthase
(-)-Hydroxycitric acid (HCA) can inhibit fat synthesis and reduces food intake, the primary mechanism of action of HCA appears to be related to its ability to act as a competitive inhibitor of the enzyme ATP-citrate lyas...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-02483 ATP citrate lyase/ACLY Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
ATP citrate lyase, also known as Acly or Acl, is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is composed of two polymer chains which are polypeptides in human. ATP...
TMPY-02002 PHPT1 Protein, Human, Recombinant (His) Human E. coli
PHPT1, also known as 14 kDa phosphohistidine phosphatase, phosphohistidine phosphatase 1, protein janus-A homolog, PHP14, is a cytoplasm protein which belongs to the janus family. PHPT1 / PHP14 is expressed abundantly in...
TargetMol