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Search Results for " a498 "

3

Compounds

3

Natural Products

Cat No. Product Name Synonyms Targets
T36314 Wortmannin-Rapamycin Conjugate
Phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) act synergistically in promoting cancer. Wortmannin is a potent inhibitor of PI3K enzymes, while rapamycin blocks mTOR Complex 1 TORC1. Wortmannin...
T1661 Crizotinib PF-02341066 c-Met/HGFR , ROS , ALK , Autophagy , ROS Kinase
Crizotinib (PF-02341066) is an ATP-competitive small-molecule tyrosine kinases inhibitor of c-MET (IC50: 8 nM) and ALK (IC50: 20 nM) receptor.
T64164 Topoisomerase II inhibitor 11
Topoisomerase II inhibitor 11 (compound 3d) is a potent inhibitor of Topoisomerase II (IC50: 2.89 μM). Topoisomerase II inhibitor 11 inhibits cell proliferation and has apoptotic activity by blocking the cell cycle in th...
Cat No. Product Name Synonyms Targets
T83435 19-Hydroxy-10-deacetylbaccatin III
19-Hydroxy-10-deacetylbaccatin III (compound 13), a taxane potentially active against tumors, exhibits low cytotoxicity towards A498 and NCI-H226 cell lines. At a concentration of 30 μg/mL, it inhibits A498 and NCI-H226 ...
T83471 10-Deacetyl-13-oxobaccatin III
10-Deacetyl-13-oxobaccatin III, a taxane isolated from Taxus sumatrana, exhibits cytotoxicity at a concentration of 30 μg/mL, inhibiting A498, NCI-H226, A549, and PC-3 cancer cell lines with respective rates of 29.7%, 49...
T36439 Gramicidin A Antibacterial , HIF , Parasite
Gramicidin A is a peptide antibiotic isolated from B. brevis.Gramicidin A is a highly hydrophobic channel-forming ion carrier that forms monovalent cation-permeable channels in artificial membranes.Gramicidin A induces t...
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