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GPCR/G Protein 5-HT Receptor

5-HT Receptor

5-hydroxytryptamine receptors or 5-HT receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems. They mediate both excitatory and inhibitory neurotransmission. The serotonin receptors are activated by the neurotransmitter serotonin, which acts as their natural ligand.
Cat No. product name
T28167 NGB2904 HCl NGB2904 is a potent and selective antagonist of dopamine D3 receptor (Ki values are 1.4, 217, 223, 642, > 5000, > 10000 and > 10000 nM for D3, D2, 5-HT2, α1, D4...
T0074L Chlorprothixene hydrochloride Chlorprothixene brings strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors. Chlorprothixene is a t...
T1774 SB 742457 SB742457 is a highly selective 5-HT6 receptor antagonist, used in trials studying the treatment of Alzheimer's Disease.
T0445 Promethazine Tafluprost(AFP-168) is an analogue of anti-glaucoma prostaglandin (PG) .
T0113 Mebhydrolin napadisylate Mebhydrolin (napadisylate) is an antihistamine used to relieve allergic symptoms caused by histamine release, including nasal allergies and allergic dermatosis.
T0647 Tryptamine Tryptamine is a monoamine alkaloid found in animals, plants, and fungi. It contains an indole ring structure and is structurally analogous to the tryptophan. It ...
T1077 Fluvoxamine maleate Fluvoxamine maleate is a selective serotonin reuptake inhibitor that is used in the treatment of depression and a variety of anxiety disorders.
T1509 Cyclobenzaprine hydrochloride Cyclobenzaprine Hydrochloride, a centrally acting muscle relaxant with antidepressant activity, leads to a reduction in muscle spasms.
T1644 Dopamine hydrochloride Dopamine is a naturally occurring catecholamine formed by decarboxylation of dihydroxyphenylalanine and a precursor of norepinephrine and epinephrine. Dopamine b...
T3453 WAY-100635 maleate salt WAY-100635 is a specific and effective 5-HT receptor antagonist (IC50=0.95 nM).
T0088 Urapidil hydrochloride Urapidil hydrochloride is 5-HT1A receptor agonist and an α1-adrenoceptor antagonist.
T1090 Perphenazine Perphenazine is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties.
T3526 Dasotraline hydrochloride Dasotraline hydrochloride (SEP-225289 hydrochloride) is a triple reuptake inhibitor  that inhibits dopamine, norepinephrine, and serotonin transporters with IC5...
T1384 Chlorpromazine hydrochloride Chlorpromazine hydrochloride is the prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are ...
T2076 Pimavanserin Pimavanserin(ACP-103) is an effective and specific 5-HT2A receptor inverse agonist (mean pIC50: 8.7, in the cell-based functional assay). Pimavanserin is an atyp...
T6946 Pimavanserin tartrate Pimavanserin is an effective and specific serotonin 5-HT2A inverse agonist (pIC50: 8.73), used in the therapy of psychosis associated with Parkinson's disease.
T0811 Amisulpride Amisulpride (trade name Solian) is an antipsychotic drug sold by Sanofi-Aventis. It is not approved for use in the United States, but is approved for use in Eu...
T1069 Metoclopramide hydrochloride Metoclopramide hydrochloride is a selective dopamine D2 receptor antagonist, used as an antiemetic.
T0333 Aniracetam Aniracetam(Ro 13-5057), a nootropic and neuroprotective drug, selectively modulates the AMPA receptor and nAChR.
T1066 Ketanserin Ketanserin is a quinazoline derivative and serotonin (5-hydroxytryptamine, 5HT) receptor subtype 2 (5-HTR2) antagonist with potential antihypertensive and antipl...
T1483 Citalopram HBr Citalopram, a selective serotonin reuptake inhibitor (SSRI), selectively inhibits the CNS neuronal reuptake of serotonin, thereby potentiating serotonergic activ...
T0991 Desipramine hydrochloride Desipramine Hydrochloride a secondary amine tricyclic antidepressant (TCA), is the hydrochloride salt form of desipramine. In the central nervous system (CNS), d...
T2190 Methiothepin mesylate Methiothepin mesylate is a potent and non-selective 5-HT2 receptor antagonist, used as an antipsychotic.
T1045 Trimipramine maleate Trimipramine maleate appears to inhibit serotonin transport and norepinephrine uptake by nerve terminals. This increases available norepinephrine or serotonin an...
T3341 Elemicin Elemicin is a constituent of several plant species' essential oils with anticholinergic effects in human.
T1266 Terfenadine Terfenadine is a prodrug that is metabolized by intestinal CYP3A4 to the active form fexofenadine, a selective histamine H1-receptor antagonist with antihistamin...
T2395 Vortioxetine Vortioxetine is a serotonergic antidepressant used for major depression disorders. Vortioxetine has been associated with a low rate of minor serum aminotransfera...
T0802 Procaine hydrochloride Procaine Hydrochloride is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine ...
T0663 2-Bromo-6-methoxynaphthalene 2-Bromo-6-methoxynaphthalene was used in the synthesis of nabumetone [4-(6-methoxy-2-naphthalenyl)-2-butanone] by Heck reaction.
T0965 Histamine Histamine is an amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscl...
T0225 Pizotifen Malate Pizotifen malate, a highly selective 5-HT receptor blocking agent, is a drug based on benzocycloheptane.
T2565 Hesperetin Hesperetin belongs to the flavanone class of flavonoids. Hesperetin, in the form of its glycoside hesperidin, is the predominant flavonoid in lemons and oranges....
T2874 Tetrahydroberberine THB Tetrahydroberberine is an isoquinoline alkaloid isolated from corydalis tuber, has a micromolar affinity for dopamine D(2) receptors.
T2459 BRL54443 BRL 54443 is a potent 5-HT1E/1F receptor agonist (pKi values are 8.7 and 8.9 respectively).
T0025 Haloperidol Haloperidol is a highly potent neuroleptic by relieving nervous through the depression of nerve function. In addition, haloperidol has shown about 50-fold effica...
T0766 Promazine hydrochloride Promazine hydrochloride is a phenothiazine with actions similar to CHLORPROMAZINE but with less antipsychotic activity. It is primarily used in short-term treatm...
T0450 Fluoxetine Fluoxetine is the first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than tra...
T0678 Amitriptyline hydrochloride Amitriptyline Hydrochloride is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptive activities.
T3183 WAY181187 WAY-181187 has high-affinity binding at the human 5-HT6 receptor.
T0428 Alverine citrate Alverine Citrate is utilized in functional gastrointestinal disorders.
T0450L Fluoxetine hydrochloride Fluoxetine is the first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than tra...
T6600 Naftopidil DiHCl Naftopidil DiHCl is a selective 5-HT1A and α1-adrenergic receptor antagonist with IC50 of 0.1 μM and 0.2 μM, respectively.
T3269 Metadoxine Metadoxine is a neurotransmitter stimulant.
T2599 Pirenperone Pirenperone is a putative 5-HT2 receptor antagonist with the central antiserotonergic and antidopaminergic action.
T3369 Nuciferine Nuciferine is an alkaloid found within the plants Nymphaea caerulea and Nelumbo nucifera. It has a profile of action associated with dopamine receptor blockade.
T4560 Alprenolol Alprenolol is a non-selective β-adrenergic receptor (β-AR) antagonist that is also an antagonist of the serotonin (5-HT) receptor subtypes 5-HT1A and 5-HT1B.
T4008 Metergoline Metergoline is a dopamine agonist and serotonin antagonist. It has been used similarly to BROMOCRIPTINE as a dopamine agonist and also for migraine disorder ther...
T4266 LY 334370 LY334370 is a selective 5-HT1F receptor agonist with a Ki of 1.6 nM
T4375 Methiothepin maleate Methiothepin is a 5-HT1, 5-HT6, 5-HT7 serotonin receptor antagonist, which blocks serotonin autoreceptors.
T4118 SB 271046 hydrochloride SB 271046 hydrochloride is selective, orally active 5-HT6 antagonist (pKi values are 9.02-8.92, 6.35, 6.55, 6.27 at 5-HT6, 5-HT1A, 5-HT1D and D3, and 6.05, 5.95,...
T2226 Pergolide mesylate salt PERGOLIDE MESYLATE is a long-acting dopamine agonist which has been used to treat PARKINSON DISEASE and HYPERPROLACTINEMIA but withdrawn from some markets due to...
T4305 8-OH-Dpat 8-OH-Dpat is a serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin.
T4568 Dolasetron Dolasetron(MDL-73147) is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy.
T4562 Ramosetron Ramosetron is a serotonin 5-HT3 receptor antagonist for the treatment of nausea and vomiting. It is believed to have higher potency and longer antiemetic action ...
T4576 Perospirone Perospirone is an antagonist of serotonin 5HT2A receptors and dopamine D2 receptors. It also displays affinity towards 5HT1A receptors as a partial agonist.
T6615 Ondansetron Ondansetron is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic.
T4S1659 Xanthotoxol Xanthotoxol is a biologically active linear furocoumarin, shows strong pharmacological activities as anti-inflammatory, antioxidant, 5-HT antagonistic, and neuro...
T2S0007 Sodium ferulic Sodium ferulate (SF), the sodium salt of ferulic acid, is a drug used in traditional Chinese medicine for treatment of cardiovascular and cerebrovascular disease...
T4494 CLOZAPINE N-OXIDE Clozapine N-oxide is a major metabolite of clozapine that can be detected in the earliest excretion time interval after clozapine administration [1]. It is produ...
TJS0341 7-Amino-4-(trifluoromethyl)coumarin 7-Amino-4-(trifluoromethyl)coumarin is a 5-Hydroxytryptamine Receptor Subtype 1E (HTR1E) antagonist. 7-Amino-4-(trifluoromethyl)coumarin is a Galanin Receptor 2 ...
T3S0478 Scopolamine 1. Scopolamine, a nonselective muscarinic receptor antagonist, induces distinct behaviors of attenuated motility and C-like hyperactivity. 2. Scopolamine can inc...
T6S0654 Isocorynoxeine 1. Isocorynoxeine shows the effects of lowering blood pressure, vasodilatation, and protection against ischemia-induced neuronal damage. 2. Isocorynoxeine exhibi...
T4577 Cariprazine Cariprazine is a novel antipsychotic drug candidate that exhibits high affinity for the D3 (Ki=0.085 nM) and D2 (Ki=0.49 nM) receptors, and moderate affinity for...
T4978 Sarpogrelate hydrochloride Sarpogrelate(MCI-9042) hydrochloride, a selective 5-HT2 antagonist, has been widely used as an anti-platelet agent for the treatment of PAD. Target: 5-HT2 Recept...
T4297 Flibanserin Flibanserin is a serotonergic antidepressant used to treat hypoactive sexual desire disorder. Flibanserin has been associated with a low rate of minor serum amin...
T6616 Ondansetron HCl Ondansetron is a serotonin 5-HT3 receptor antagonist, used to prevent nausea and vomiting caused by cancer chemotherapy, and radiation therapy.
T1636 Paroxetine hydrochloride Paroxetine hydrochloride is a serotonin uptake inhibitor that is effective in the treatment of depression.
T6959 PRX-08066 Maleic acid PRX-08066 Maleic acid is a selective 5-HT2B receptor antagonist with IC50 of 3.4 nM, prevents the severity of pulmonary arterial hypertension in the MCT rat mode...
T0482 Sertraline hydrochloride Sertraline hydrochloride is a selective serotonin uptake inhibitor that is used in the treatment of depression.
T1291 Cisapride Cisapride is a serotonin type 4 (5-HT4) receptor agonists are potent prokinetic agents that act on serotonin receptors in the intestine and promote intestinal pe...
T0869 Atomoxetine hydrochloride Atomoxetine Hydrochloride is the hydrochloride salt of atomoxetine, a phenoxy-3-propylamine derivative and selective non-stimulant,  norepinephrine reuptake ...
T3275 Nefazodone hydrochloride Nefazodone is a serotoninergic modulating antidepressant that is used in therapy of depression, aggressive behavior and panic disorder.
T0680 Lamotrigine Lamotrigine is an Anti-epileptic Agent and Mood Stabilizer. The physiologic effect of lamotrigine is by means of Decreased Central Nervous System Disorganized El...
T6572 Lorcaserin HCl Lorcaserin is a selective serotonin agonist that has been recently approved as a weight loss agent.
T0137 Mirtazapine Mirtazapine is a tetracyclic antidepressant with a somewhat unique mechanism of action. Mirtazapine therapy can be associated with transient asymptomatic elevati...
T1951 Asenapine Maleate Asenapine is a second generation (atypical) antipsychotic agent that is taken sublingually and used in the treatment of schizophrenia and manic or mixed episodes...
T2589 Dalasetron Mesylate Hydrate Dolasetron mesylate, a selective serotonin receptor antagonist, competitively blocks the action of serotonin at 5HT3 receptors, resulting in suppression of chemo...
T0472 Venlafaxine hydrochloride Venlafaxine hydrochloride is a cyclohexanol and phenylethylamine derivative that functions as a SEROTONIN AND NORADRENALINE REUPTAKE INHIBITOR (SNRI) and is used...
T1327 Nortriptyline hydrochloride Nortriptyline hydrochloride is a metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, ...
T2306 Brexpiprazole Brexpiprazole is a partial agonist of human 5-hydroxytryptamine (5-HT) 5-HT1A and dopamine D2 receptors.
T1580 Desvenlafaxine Desvenlafaxine is a cyclohexanol and phenol derivative and metabolite of venlafaxine that functions as a serotonin and noradrenaline reuptake inhibitor (SNRI) an...
T2395L Vortioxetine HBr Vortioxetine (Lu AA21004) is a serotonin (5-HT) modulator and stimulator (SMS), inhibits 5-HT1A/1B/3A/7 receptor and SERT (IC50: 15/33/3.7/19/1.6 nM).
T6814 Cyproheptadine HCl Cyproheptadine HCl is a hydrochloride salt form of cyproheptadine which is a histamine receptor antagonist.
T6562 Latrepirdine Latrepirdine is an orally active, and neuroactive antagonist of multiple drug targets, including histamine receptors, GluR, and 5-HT receptors, used as an antihi...
T0205 Brompheniramine hydrogen maleate Brompheniramine maleate is an antagonist against histamine H1 receptors.
T0217 Levodropropizine Levodropropizine is a histamine receptor inhibitor. It is used as an effective and very well tolerated peripheral antitussive drug.
T1317 Cinchonidine Cinchonidine is an alkaloid extracted from Cinchona officinalis. It is a pseudo-enantiomer and stereoisomer of cinchonine.
T3704 Lasmiditan Lasmiditan, also known as COL-144 and LY573144, is a novel, centrally acting, highly selective 5-HT(1F) receptor agonist (K1=2.21 μM) without vasoconstrictor ac...
T5158 N-Desmethylclozapine N-Desmethylclozapine is an antagonist of serotonin (5-HT) receptor subtype 5-HT2C (IC50: 7.1 nM). It also is an antagonist at dopamine D4 receptors, an agonist a...
T3648 YL0919 YL0919 is a novel antidepressant candidate with dual activity as a 5-HT1A receptor agonist and a selective serotonin reuptake inhibitor.
T0185 Escitalopram Escitalopram is a furancarbonitrile that is one of the SEROTONIN UPTAKE INHIBITORS used as an antidepressant. The drug is also effective in reducing ethanol upta...
T3497 Ocaperidona Ocaperidona (Ocaperidone), a very high affinity dopamine D2 antagonist.
T1566 Aripiprazole Aripiprazole is an antipsychotic agent that is structurally related to piperazines and quinolones. It is a partial agonist of SEROTONIN RECEPTOR, 5-HT1A and DOPA...
T6426 Buclizine HCl Buclizine HCl is the hydrochloride salt form of buclizine, a piperazine histamine H1 receptor antagonist with primarily antiemetic and antivertigo activities. Bu...
T0365 Thioridazine hydrochloride Thioridazine, an antipsychotic drug, is used in the therapy of psychosis and schizophrenia and shows serotonin antagonism or D4 selectivity.
T0370 Pheniramine maleate Pheniramine Maleate, an alkylamine derivative with antihistaminic and vasodilatory properties, binds to histamine H1 receptors, thereby inhibiting phospholipase ...
T1567 Olanzapine Olanzapine is an atypical antipsychotic that is used currently in the treatment of schizophrenia and bipolar illness.
T1180 Blonanserin Blonanserin is an atypical antipsychotic approved in Japan in January, 2008. Relative to many other antipsychotics, blonanserin has an improved tolerability prof...
T0735 Pindolol Pindolol is a moderately lipophilic beta blocker (ADRENERGIC BETA-ANTAGONISTS). It is non-cardioselective and has intrinsic sympathomimetic actions, but little m...
T1540 Doxepin hydrochloride Doxepin Hydrochloride is a dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mech...
T1156 Palonosetron hydrochloride Palonosetron is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting.
T1471 Duloxetine hydrochloride Duloxetine hydrochloride is a thiophene derivative and selective neurotransmitter uptake inhibitor for SEROTONIN and NORADRENALINE (SNRI). It is an ANTIDEPRESSIV...
T1445 Agomelatine Agomelatine is structurally closely related to melatonin. Agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2C (5-HT2C) recep...
T0031 Ziprasidone hydrochloride monohydrate Ziprasidone(CP88059) is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of the antipsychotic activity.
T1092 Zolmitriptan Zolmitriptan selectively binds to and activates serotonin (5-HT) 1B receptors expressed in intracranial arteries and 5-HT 1D receptors located on peripheral trig...
T1170 Olopatadine hydrochloride Olopatadine hydrochloride is an antihistamine with mast-cell stabilizing properties used as eye drops in the treatment of ALLERGIC CONJUNCTIVITIS.
T2428 TG6-10-1 TG6-10-1 is an EP2 antagonist.
T6602 Naratriptan hydrochloride Naratriptan Hydrochloride is the hydrochloride salt form of naratriptan, a sulfonamide with selective serotonin (5-HT) 1 receptor agonistic activity and anti-mig...
T1528 Azasetron hydrochloride Azasetron Hydrochloride is a 5-HT3 receptor antagonist which is used as an anti-emetic.
T0031L Ziprasidone hydrochloride Ziprasidone (hydrochloride) is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of antipsychotic activity.
T1512 Rizatriptan benzoate Rizatriptan benzoate selectively binds to and activates serotonin (5-HT) 1B receptors and 5-HT 1D receptors providing relief of migraine headaches.
T2631 WAY-100635 Maleate WAY-100635 is a specific and effective 5-HT receptor antagonist (IC50=0.95 nM).
T0172 Maprotiline hydrochloride Maprotiline hydrochloride is a bridged-ring tetracyclic antidepressant that is both mechanistically and functionally similar to the tricyclic antidepressants, in...
T0203 Sumatriptan succinate Sumatriptan succinate, a serotonin1 (5-HT1) receptor agonist, is used in the acute treatment of a migraine headache.
T1478 Ondansetron hydrochloride Ondansetron hydrochloride is a competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chem...
T1173 Tropisetron hydrochloride Tropisetron Hydrochloride is the hydrochloride salt form of tropisetron, a selective, competitive serotonin 5-hydroxytryptamine type 3 (5-HT3) receptor antagonis...
T0351 Risperidal Risperidone is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that act as an atypical antipsychotic agent.
T1042 Granisetron hydrochloride Granisetron hydrochloride is a serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic for cancer chemotherapy patients.
T2289 RU 24969 hemisuccinate RU 24969 is a selective agonist at the 5-HT1A and 5-HT1B receptors.
T6488 Epinastine HCl Epinastine is an antihistamine and mast cell stabilizer that is used in eye drops to treat allergic conjunctivitis.
T0302 Triflupromazine hydrochloride Triflupromazine hydrochloride, an antipsychotic medication, is Dopamine D1/D2 receptor antagonists.
T2525 Alosetron hydrochloride Alosetron Hydrochloride is the hydrochloride salt form of alosetron, a potent and selective 5-HT3 receptor antagonist. Alosetron blocks the actions of serotonin ...
T0162 Quetiapin Quetiapine is used for the therapy of schizophrenia, and for the treatment of acute manic episodes associated with bipolar I disorder. The mechanism of quetiapin...
T6241 Quetiapine Fumarate Quetiapine Fumarate, an atypical antipsychotic, is used in the treatment of bipolar I mania, schizophrenia, bipolar II depression, bipolar I depression.
T6597 Mosapride Citrate Mosapride Citrate, a gastroprokinetic agent, utilizes as a selective 5HT4 agonist.
T0074 Chlorprothixene Chlorprothixene is a typical antipsychotic drug of the thioxanthene class, which was the first of the series to be synthesized.
T0318 Ataractan Azacyclonol is a drug used to diminish hallucinations in psychotic individuals.
T0081 Lafutidine Lafutidine is a newly developed histamine H(2)-receptor antagonist, which can inhibit gastric acid secretion.
T0039 Dapoxetine Dapoxetine is a selective serotonin reuptake inhibitor, for the treatment of premature ejaculation.
T0204 Protriptyline hydrochloride Protriptyline Hydrochloride is the hydrochloride salt form of protriptyline, a tricyclic secondary amine with an antidepressant property. Protriptyline hydrochlo...
T0076 Paliperidone Paliperidone(Invega) is used as an atypical antipsychotic. It applies to the acute and maintenance treatment of schizophrenia. Chemically, paliperidone is the pr...
T0031L2 Ziprasidone Ziprasidone is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of antipsychotic activity.
T0174 Cyproheptadine hydrochloride Cyproheptadine hydrochloride sesquihydrate, an antihistamine, is an antagonist of serotonin and histamine2.
T1081 Nafronyl oxalate Nafronyl oxalate is a drug used in the management of peripheral and cerebral vascular disorders. It is claimed to enhance cellular oxidative capacity and to be a...
T0785 Dexchlorpheniramine Maleate Dexchlorpheniramine (trade name Polaramine) is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria....
T1619 Trazodone hydrochloride Trazodone hydrochloride is a serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depress...
T0338 Minaprine Minaprine is a reversible inhibitor of MAO-A, used in the treatment of various depressive states.
T6655 SB269970 HCl SB269970 HCl, a hydrochloride salt form of SB-269970, is a 5-HT7 receptor antagonist (pKi of 8.3) and exhibits >50-fold selectivity against other receptors.
T3431 Pardoprunox hydrochloride Pardoprunox hydrochloride is a novel partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist, D2 (pKi = 8.1) and D3 receptor (pKi = 8.6...
T1769 Pardoprunox Pardoprunox is a partial dopamine D2 agonist and noradrenergic agonist with serotonin 5-HT1A agonist properties. Pardoprunox has been used in trials studying the...
T1412 Loxapine succinate salt Loxapine succinate, a D2DR and D4DR inhibitor, is utilized in schizophrenia.
T2402 Tianeptine sodium Tianeptine sodium is a selective serotonin reuptake enhancer (SSRE), used to treat major depressive episodes.
T3086 Mesoridazine Besylate Mesoridazine (Serentil) is a piperidine neuroleptic drug belonging to the class of drugs called phenothiazines, used in the treatment of schizophrenia. It is a m...
T6493 Escitalopram Oxalate Escitalopram Oxalate is a selective serotonin (5-HT) reuptake inhibitor (SSRI) with Ki of 0.89 nM.
T2132 Buspirone hydrochloride Buspirone is a 5HT(1A) receptor agonist, used to treat generalized anxiety disorder (GAD).
T0165 Urapidil Urapidil, a sympatholytic antihypertensive drug, acts as a 5-HT1A receptor agonist and as an α1-adrenoceptor antagonist.
T1735 Lurasidone hydrochloride Lurasidone hydrochloride is a thiazole derivative and atypical antipsychotic agent that functions as a dopamine D2 receptor antagonist; serotonin 5-HT2 receptor ...
T2815 Puerarin Puerarin, also known as Kakonein, is a member of the class of compounds known as isoflavonoid C-glycosides. It is a 5-HT2C receptor antagonist.
T3085 Piperacetazine Piperacetazine, an antipsychotic prodrug, is used forschizophrenia.
T6188 Desvenlafaxine succinate hydrate Desvenlafaxine succinate hydrate is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI).
T0236 Azatadine Maleate Azatadine dimaleate is an inhibitor for histamine(IC50=6.5 nM) and cholinergic(IC50=10 nM).
T2092 Amitifadine hydrochloride Amitifadine hydrochloride is a triple reuptake inhibitor (TRI) or serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI).
T0525 Flopropione Flopropione, a spasmolytic or antispasmodic agent, is used as a 5-HT1A receptor antagonist.
T0783 Mianserin hydrochloride Mianserin hydrochloride is a tetracyclic compound with antidepressant effects. it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin r...
T0723 Cloperastine hydrochloride Cloperastine hydrochloride is a type of flavonoid.
T0216 Eletriptan HBr Eletriptan hydrobromide is an orally active agonist with specific affinity for the 5-hydroxytriptamine1B/1D receptor.
T2278 Piboserod Piboserod (SB 207266) is a selective 5-HT(4) receptor antagonist.
T2209 Serotonin hydrochloride Serotonin hydrochloride is an endogenous 5-HT receptor agonist, a monoamine neurotransmitter in the CNS, and a catechol O-methyltransferase (COMT) inhibitor(Ki=4...
T6728 VUF 10166 VUF10166 is a novel, potent and competitive antagonist for 5-HT3A receptor with Ki of 0.04 nM, its affinity at 5-HT3AB receptor is significantly lower.
T1442 Pizotifen Pizotifen is a strong serotonin and tryptamine antagonist, with weak anticholinergic, anti-histaminic and anti-kinin effects. It also possesses sedative and appe...
T0716 Molindone hydrochloride Molindone hydrochloride is an indole derivative effective in schizophrenia and other psychoses by blocking the effects of dopamine in the brain.
T6232 Vilazodone HCl Vilazodone HCl, a partial agonist of 5-HT1A receptors and specific serotonin reuptake inhibitor (SSRI), is utilized in treating of the major depressive disorder....
T1279 Vilazodone Vilazodone is a selective serotonin (5-HT) reuptake inhibitor (SSRI) and a 5-HT-1A receptor partial agonist, with antidepressant and anti-anxiety activities. Vil...
T0255 Clomipramine hydrochloride Clomipramine hydrochloride is a tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily abso...
T2542 Prucalopride Prucalopride is a selective, high-affinity 5-HT4A/4B receptor agonist (Ki: 2.5/8 nM). It has >290-fold selectivity for 5-HT4A/4B receptor than other 5-HT recepto...
T3046 BMY 7378 dihydrochloride BMY-7378, α1D-adrenergic receptor antagonist, is a weak partial agonist/antagonist of 5-HT1A receptor.
T6958 Prucalopride Succinate Prucalopride is a selective, high affinity 5-HT4 receptor agonist, inhibiting human 5-HT(4a) and 5-HT(4b) receptor with Ki value of 2.5 nM and 8 nM, respectively...
T3179 Eptapirone F 11440 is a highly effective and selective 5-HT1A receptor agonist with marked antidepressant and anxiolytic potential.
T2317 Almotriptan Malate Almotriptan Malate, a selective 5-HT1B/1D receptor agonist, is used in the therapy of Migraine attacks in adults.
T2344 LY344864 LY344864, a specifc receptor agonist, is an affinity of 6 nM (Ki) at the recently cloned 5-HT1F receptor.
T1551 Tegaserod maleate Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. Its use was the only drug approve...
T2688 LY310762 LY310762 is a 5-HT1D receptor antagonist with Ki of 249 nM.
T6423 BRL-15572 dihydrochloride BRL-15572 is a 5-HT1D receptor antagonist with pKi of 7.9, also shows a considerable affinity at 5-HT1A and 5-HT2B receptors, exhibiting 60-fold selectivity over...
T6973 RS127445 RS-127445 is a selective 5-HT2B receptor antagonist with pKi of 9.5 and pIC50 of 10.4, exhibits >1000-fold selectivity against other 5-HT receptors.
T6656 SB271046 SB271046 is a potent, selective and orally active 5-HT6 receptor antagonist with pKi of 8.9, exhibits 200-fold greater selectivity over other 5-HT receptor subty...
T5179 AVN492 AVN-492 is a potent and selective 5-HT6R Antagonist (Ki: 91 pM).
T5336 Zacopride hydrochloride Zacopride is a highly potent 5-HT3 receptor antagonist (Kd = 0.38 nM) and 5-HT4 receptor agonist (Ki = 373 nM). It also is a selective IK1 channel agonist.
TP1127L1 Nemifitide acetate(173240-15-8 free base) Nemifitide acetate is a synthetic pentapeptide antidepressant with a potential for rapid onset of action. It is a peptide analog of melanocyte-inhibiting factor ...
T16481 PF-04995274 PF-04995274 is an effective, high-affinity, and partial serotonin 4 receptor (5-HT4R) agonist. PF-04995274 is brain penetrant and can be used for cognitive disor...
T8475 3-AQC 3-AQC is a competitive antagonist of 5-HT3.
T19381 Isobutyryl-L-carnitine Isobutyryl-L-carnitine is a member of the class of compounds known as acylcarnitines. Isobutyryl-L-carnitine is a product of the acyl-CoA dehydrogenases.
T16283 Neocarzinostatin Neocarzinostatin is an effective DNA-damaging, anti-tumor antibiotic. It recognizes double-stranded DNA bulge and induces DNA double strand breaks (DSBs). Neocar...
T22236 Alprenolol hydrochloride Alprenolol hydrochloride is a non-selective blocker of beta, and also is a antagonist of5-HT1A receptor.
T16378 Ogerin Ogerin is a selective GPR68 positive allosteric modulator (pEC50: 6.83). Ogerin blocks recall in fear conditioning in mice. Ogerin displays inverse agonist and a...
T16399 Opiranserin Opiranserin is a development as an injectable agent for the treatment of postoperative pain. Opiranserin is a non-opioid and non-NSAID analgesic candidate and is...
T16401 Org-12962 Org-12962 is an effective and selective 5-HT2C receptor agonist pEC50: 7.01). Org-12962 shows antiaversive effects in a rat model of panic-like anxiety. Org-129...
T16433 Pancopride Pancopride is a new effective and selective antagonist of the 5-HT3 receptor.
T16556 PNU-142633 PNU-142633 has anti-migraine efficacy. PNU-142633 is a high affinity and selective 5-HT1D receptor agonist (Kis of 6 nM and > 18 000 nM for human 5-HT1D receptor...
T15760 Lintopride Lintopride is an antagonist of 5HT4. It has moderate 5HT3 antagonist properties.
T16669 PRX-08066 PRX-08066 is a selective 5-hydroxytryptamine receptor 2B (5-HT2BR, IC50= 3.4 nM) antagonist that induces selective vasodilation of pulmonary arteries.
T16683 Pumosetrag Hydrochloride Pumosetrag Hydrochloride is an orally available 5-HT3 partial agonist. It is developed for the treatment of irritable bowel syndrome and gastroesophageal reflux ...
T16711 Flesinoxan Flesinoxan is a hypotensive agent and is an effective, high affinity, and selective 5-hydroxytryptamine1A receptor agonist (EC50: 24 nM).
T11839 Lesopitron dihydrochloride Lesopitron dihydrochloride with IC50 of 125 nM in rat hippocampal membranes, is a full and selective 5-HT1A receptor agonist.
T16759 Ritanserin Ritanserin is a highly effective, relatively selective, long-acting antagonist of 5-HT2 receptor (IC50: 0.9 nM), less active on Histamine H1, Dopamine D2, Adren...
T16779 Rodatristat ethyl Rodatristat ethyl decreases the level of 5-HT and significantly reduces pulmonary arterial hypertension. Rodatristat ethyl is a first-in-class oral tryptophan hy...
T12632L (S)-Mirtazapine (S)-Mirtazapine is an S(+)-enantiomer of Mirtazapine. (S)-Mirtazapine is a stereoselective 5-HT2 receptor antagonist.
T11948 Masupirdine free base Masupirdine free base (SUVN-502 free base) shows high selectivity over 5-HT2A receptor and other 100 target sites, and has potential for treatment of Alzheimer's...
T16421 P-MPPI hydrochloride p-MPPI hydrochloride is a selective antagonist of 5-HT1A receptor, and has antidepressant and anxiolytic-like effects.
T15552 Iferanserin Iferanserin (S-MPEC) is a selective antagonist of the 5-HT receptor (serotonin receptor) with an affinity for 5-HT2A receptors. Iferanserin has the potential fo...
T16856 SB228357 SB228357 is a selective and potent 5-HT2C/2B receptor antagonist (pKi: 6.9, 8.0, and 9.0 for 5-HT2A, 5-HT2B and 5-HT2C, respectively).
T11216 Eplivanserin mixture Eplivanserin mixture is a selective serotonin reuptake inhibitor and a 5-HT2A receptor antagonist,
T12843 SB-399885 hydrochloride SB-399885 hydrochloride is an antagonist of 5-HT6 receptor.
T12855 SB 258719 SB 258719 is a selective antagonist of 5-HT7 receptor(pKi of 7.5).
T12899L SEP-363856 hydrochloride SEP-363856 hydrochloride is an agent of orally active and CNS active psychotropic with a unique, non-D2/5-HT2A mechanism of action, exerts its antipsychotic-lik...
T12988 5-HT3 antagonist 2 5-HT3 antagonist 2 is an antagonist of 5-HT3 receptor.
T13007 ST1936 oxalate ST1936 oxalate is a selective, nanomolar affinity agonist of 5-HT6 receptor(Ki values of 13 nM, 168 nM and 245 nM for human 5-HT6, 5-HT7 and 5-HT2B receptors, re...
T13021 Sulamserod Sulamserod is an antagonist of 5-HT4 receptor, has antiarrhythmic activities.
T13110 Tedatioxetine hydrobromide Tedatioxetine hydrobromide is an inhibitor of triple reuptake and antagonist of 5-HT2A, 5-HT2C, 5-HT3 and α1A-adrenergic receptor.
T11183 EMDT oxalate EMDT oxalate is a selective 5-HT6 agonist, and has antidepressant effects.
T11217 Eplivanserin Eplivanserin was a potent selective oral 5-HT2 receptor antagonist, with a cortical membrane IC50 of 5.8 nM and a Kd of 1.14 nM in rats.
T10824 Cis-Urocanic acid cis-Urocanic acid is a 5-HT2A receptor agonist (Kd: 4.6 nM). It is an immune modulator that induces immunosuppression by binding to the 5-HT2A receptor.
T11293 FK1052 hydrochloride FK1052 hydrochloride is a potent 5-HT3 and 5-HT4 receptor dual antagonist.
T11302 Flumexadol Flumexadol is a selective and affinity 5-HT2C receptor agonist with a Ki of 25 nM for the (+)-enantiomer of Flumexadol, and is 40-fold selective over the 5-HT2A ...
T11326 Frovatriptan succinate hydrate Frovatriptan succinate hydrate is effective in treating the full spectrum of migraine including the associated symptoms of nausea, vomiting, photophobia, and pho...
T10495 Befiradol hydrochloride (208110-64-9 free base) Befiradol (NLX-112) hydrochloride is a selective agonist of the 5-HT1A receptor.
T10612 Brexpiprazole S-oxide Brexpiprazole S-oxide (DM-3411) is a main metabolite of Brexpiprazole. Brexpiprazole is a partial agonist of human 5-HT1A and dopamine receptors (Kis: 0.12 nM an...
T10611 Brexpiprazole S-oxide D8 Brexpiprazole S-oxide D8 (DM-3411 D8) is a deuterium labeled Brexpiprazole S-oxide. Brexpiprazole S-oxide is a main metabolite of Brexpiprazole. Brexpiprazole is...
T13275 Vabicaserin hydrochloride Vabicaserin hydrochloride is a selective agonist of 5-hydroxytryptamine 2C (5-HT2C) receptor (EC50: 8 nM).
T13339 Wf-516 Wf-516 is a 5-HT reuptake inhibitor (Kis: 5 nM and 40 nM for 5-HT1A receptor and 5-HT2A receptor in humans, respectively), and with potent antidepressant activit...
T11949 Masupirdine mesylate Masupirdine mesylate (SUVN-502 mesylate) shows high selectivity over 5-HT2A receptor and other 100 target sites, and has potential for treatment of Alzheimer's d...
T17033 Temanogrel Temanogrel is a highly selective antagonist of the 5-HT2A receptor (Ki: 4.9 nM).
T12859 SB 243213 hydrochloride SB 243213 hydrochloride is an orally active, selective and high-affinity antagonist of 5-hydroxytryptamine (5-HT)2C receptor(pKi of 9.37 and a pKb of 9.8).It has...
T21337 Lurasidone Lurasidone is an antagonist of both dopamine D2 and 5-HT7(IC50=1.68 and 0.495 nM, respectively).It also a partial agonist of 5-HT1A receptor(IC50 : 6.75 nM).
T22514 4F 4PP oxalate 4F 4PP oxalate is a 5-HT2A antagonist.
T22987 MK 212 hydrochloride MK 212 hydrochloride is a 5-HT2C receptor agonist
T23168 PNU 22394 hydrochloride PNU 22394 hydrochloride is a 5-HT2C agonist and partial 5-HT2A/5-HT2B agonist
T23310 SB 203186 hydrochloride SB 203186 hydrochloride is a potent 5-HT4 receptor antagonist
T23312 SB 204741 5-HT2B receptor antagonist
T23394 SR 57227 hydrochloride SR 57227 hydrochloride is a potent, orally active and selective 5-HT3 receptor agonist. It with ability to cross the blood brain barrier. It has affinities (IC50...
T8666 Naratriptan Naratriptan is a selective agonist of 5-HT1 receptor and is is used for the treatment of migraine headaches.
T8702 SKF-83566 SKF-83566 is a blood-brain permeable and orally active antagonist of D1-like dopamine receptor and a weaker competitive 5-HT2 receptor antagonist with Ki of 11 n...
T22379L NLX-204 hydrochloride(2170405-10-2 free base) NLX-204 hydrochloride is a potent and selective ERK1/2 phosphorylation-preferring serotonin 5 HT1A receptor agonist(pKi = 10.19).
TN4713 Onitisin Onitisin, onitinoside and onitin can inhibit the contraction of isolated guinea-pig ileum.
T22379L NLX-204 hydrochloride(2170405-10-2 free base) NLX-204 hydrochloride is a potent and selective ERK1/2 phosphorylation-preferring serotonin 5 HT1A receptor agonist(pKi = 10.19).
T21231 Almotriptan Almotriptan is a 5-HT1B/1D-receptor agonist used to treat migraine.Almotriptan is a triptan drug for treatment of migraine headaches.Binding of the drug to the r...
T21013 Clomipramine Clomipramine is a tricyclic antidepressant (TCA). It is used for the treatment of the panic disorder, obsessive-compulsive disorder, major depressive disorder, a...
T4562L Ramosetron hydrochloride Ramosetron hydrochloride is a serotonin 5-HT3 receptor antagonist. It is used to treat diarrhea-predominant irritable bowel syndrome and nausea.
T8720 PRX-07034 PRX-07034 is a selective antagonist of 5-HT6 receptor. It has cognition and memory-enhancing properties and potently decreases food intake and body weight in rod...
T8757 R-Lorcaserin hydrochloride hemihydrate R-Lorcaserin hydrochloride hemihydrate is a selective 5HT2C serotonin receptor agonist.
T8737 GR 125743 GR 125743 is a novel antagonist of 5-HT1B/1D receptor.
T8737 GR 125743 GR 125743 is a novel antagonist of 5-HT1B/1D receptor.
TN5166 Trans-Methylisoeugenol (E)-Methyl isoeugenol (trans-Methylisoeugenol) is a natural food flavour, it also has anxiolytic and antidepressant like properties. Eugenol methyl ether(trans-M...
TMA1122 Moschamine Moschamine is a very potent compound that is able to inhibit COX-I by 58% and COX-II by 54%, at the concentration of 0.1 μmol L⁻1, it may suppress cAMP fo...
T17095 TIK-301 TIK-301 is a chlorinated melatonin derivative and a potent, high-affinity, and orally active melatonin MT1 and MT2 receptors agonist (Kis: 0.081 nM and 0.042 nM,...
T22393 Palonosetron Palonosetron, a 5-HT3 antagonist with Ki of 0.17 nM, is used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV).
T17253 WAY 163909 WAY 163909 is an effective and selective agonist of the 5-HT(2C) receptor (Ki: 10.5±1.1 nM).
T17275 YM348 YM348 is an effective and orally active 5-HT2C receptor agonist. YM348 also shows a high affinity for the cloned human 5-HT2C receptor (Ki: 0.89 nM).
T17285 Zatosetron maleate Zatosetron maleate is an effective and selective antagonist of the 5HT3 receptor.
T22294 Cinitapride Hydrogen Tartrate Cinitapride Hydrogen Tartrate is a gastroprokinetic agent that acts as an antagonist of the 5-HT2 receptors and as an agonist of the 5-HT1 and 5-HT4 receptors
T22296 Cisapride hydrate Cisapride acts directly as a selective agonist of serotonin 5-HT4 receptor with IC50 value of 0.483 μM. And It also acts indirectly as a parasympathomimetic.
T22340 Granisetron Granisetron, a serotonin receptor (5HT-3 selective) antagonist, is used as an antinauseant and antiemetic for cancer chemotherapy.
T22359 MDL 100009 MDL 100009, the S-enantiomer of MDL 100151 and the opposite enantiomer of MDL 100907, is a selective antagonist of 5-HT2A.
T22359 MDL 100009 MDL 100009, the S-enantiomer of MDL 100151 and the opposite enantiomer of MDL 100907, is a selective antagonist of 5-HT2A.
T22425 Sevoflurane Sevoflurane, a noncompetitive inhibitor of 5-HT3 receptor, acts as a low-soluble inhalation anesthetics.
TN4092 Galanolactone Galanolactone has anti-5-HT effect, a diterpenoid isolated from ginger, is related to antagonism of 5-HT3 receptors, it has inhibit nitric oxide production with ...
T22448 Tropisetron Tropisetron is a α7-nicotinic receptor agonist and 5-HT3 receptor antagonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor.
T8593 RU 24969 RU 24969 is a selective agonist of 5-HT1A and 5-HT1B receptors.
T2S0118 Daurinoline Daurinoline is a non-competitive antagonist, it exerts marked relaxation effect on basilar artery of rabbits through non-competitive antagonism, it would have a ...
T2S1397 L-Stepholidine L-Stepholidine, which has dual actions on dopamine D1 and D2 receptors, attenuates heroin self-administration and cue-induced reinstatement. It also elicits anti...
T5S1389 Escin IB Escin Ib inhibits gastric emptying, at least in part, mediated by capsaicin-sensitive sensory nerves, to stimulate the synthesis and/or release of dopamine, to a...
TN2533 1-Hydroxy-2,3,4,7-tetramethoxyxanthone 1-Hydroxy-2,3,4,7-tetramethoxy-xanthone has vasodilatory action, it can cause vasodilation in the coronary artery pre-contracted with 1uM 5-hydroxytryptamine (5-...
TN2534 1-Hydroxy-2,3,5-trimethoxyxanthone 1-Hydroxy-2,3,5-trimethoxyxanthone (HM-1) has vasodilator action ,which involves both an endothelium-dependent mechanism involving NO and an endothelium-independ...
TN3235 7-Hydroxycadalene 7-Hydroxycadalene shows cytotoxicity activity against HCT-15 cell line with IC50 18.89 ± 1.2 uM.
TN3393 Alpha-Yohimbine Alpha-Yohimbine is a 5-HT1A receptor agonist, it is strong selective 2-adrenoceptor antagonist. Alpha-Yohimbine possess aphrodisiac effect.
T12842 SB-269970 SB-269970 is a antagonist of 5-HT7 receptor(pKi of 8.3).
T12859L SB 243213 dihydrochloride SB 243213 dihydrochloride is an orally active, selective and high-affinity antagonist of 5-hydroxytryptamine (5-HT)2C receptor(pKi of 9.37 and a pKb of 9.8 for h...
T5387 LP-211 LP-211 is a brain penetrant selective agonist for a 5-HT7 receptor (Ki: 0.58 nM), and >300-fold selectivity over the 5-HT1A receptor.
TN2030 P-Hydroxyphenethyl trans-ferulate P-Hydroxyphenethyl trans-ferulate exhibits affinity toward 5-HT(7) receptors in a competitive binding assay. P-Hydroxyphenethyl trans-ferulate can double quinone...
T8357 SB-200646 SB-200646 is a selective and potent antagonist of 5-HT2B/5-HT2C receptor
TN1032 Geissoschizine methyl ether Geissoschizine methyl ether, a major indole alkaloid found in Uncaria hook, is a major active component of Yokukansan with psychotropic effects. Geissoschizine m...
TN1415 Auraptenol Auraptenol possesses robust antidepressant-like efficacy in mice.
TN1465 Cannabigerol Cannabigerol is a high affinity α±2-adrenergic receptor agonist, moderate affinity 5-HT1A receptor antagonist, and low affinity CB1 receptor antagonist ; also ...
TN1544 D-Menthol D-Menthol is a common compound in pharmaceutical and commercial products and a popular additive to cigarettes, it attenuates α±7 mediated Ca 2+ transients in t...
TN1740 Homoeriodictyol Homoeriodictyol, a naturally occurring, bitter-masking flavanone, as a promising agent to increase appetite and food intake. The flavanone homoeriodictyol can in...
TN1755 Hyperforin Hyperforin acts as an angiogenesis inhibitor, it as a possible antidepressant component of hypericum extracts.
TN1812 Jujuboside B1 Jujubosides have hypnotic effect on normal rats, may be influenced by circadian rhythm and the serotonergic system may involve in the hypnotic effect of jujubosi...
TN2116 Pteropodine Pteropodine acts as a positive modulator of muscarinic M(1) and 5-HT(2) receptors. Pteropodine shows antigenotoxic, antioxidant and lymphocyte induction effects,...
T8140 Tianeptine Tianeptine is a selective 5-HT uptake facilitator in vitro and in vivo.
T8413 Lasmiditan succinate Lasmiditan succinate is a 5-ht (1F) receptor agonist acting on the central nervous system(Ki value of 2.21 nM).
T8441 Lerisetron Lerisetron is an antagonist of serotonin type 3 (5-HT3) receptor, with antiemetic activity.
T6461 Dapoxetine HCl Dapoxetine HCl is a selectivity short-acting serotonin reuptake inhibitor, used for the therapy of premature ejaculation.
T12046 Mirtazapine D3 Mirtazapine D3 is a deuterium labeled Mirtazapine. Mirtazapine is an inhibitor of 5-HT receptor .
T12215 Nexopamil racemate Nexopamil racemate is the racemate of Nexopamil. Nexopamil is a combined Ca2+/5-HT2 antagonist on platelet aggregation in vitro and on thrombus formation in vivo...
T12262L NPS ALX Compound 4a dihydrochloride NPS ALX Compound 4a dihydrochloride is a potent and selective antagonist of 5-HT6 receptor (IC50 of 7.2 nM)
T12262 NPS ALX Compound 4a NPS ALX Compound 4a is a potent and selective antagonist of 5-HT6 receptor (IC50 of 7.2 nM)
T12489L Pimethixene maleate Pimethixene maleate is a highly potent5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4 as well as muscarinic M1 and M2 receptors antagonist(wit...
T8398 Lasmiditan hydrochloride Lasmiditan hydrochloride is a novel, centrally acting, highly selective 5-HT(1F) receptor agonist (K1:2.21 μM)
T8136 Perospirone hydrochloride Perospirone hydrochloride is an atypical antipsychotic agent for the treatment of schizophrenia.  It also displays affinity towards 5HT1A receptors as a partial...
T12480 Pipamperone Pipamperone is a high-affinity 5-HT2A receptor and D4 receptor antagonist (pKi of 8.2 and 8.0,respectively) .
T7350 Nelotanserin Nelotanserin is a potent 5-HT2A inverse agonist(IC50 : 1.7 nM), a moderately potent 5-HT2C partial inverse agonist t(IC50 :79 nM )and a weak 5-HT2B inverse agoni...
T5380 Ansofaxine hydrochloride Ansofaxine (LY03005; LPM570065) is a serotonin-norepinephrine-dopamine reuptake inhibitor (IC50s: 723, 763 and 491 nM, respectively).
T5389 Volinanserin Volinanserin (MDL 100907) is a potent and selective antagonist of the serotonin receptor 5-HT2 (Ki: 0.36 nM) and shows 300-fold selectivity for 5-HT2 receptor ov...
T5271 5-Methoxytryptamine 5-Methoxytryptamine is a tryptamine derivative that acts as a full agonist at the 5-HT1, 5-HT2, 5-HT4, 5-HT6, and 5-HT7 receptors.
T5858 Sertindole Sertindole is an atypical antipsychotic that binds to dopamine D2 receptors and the serotonin (5-HT) receptor subtypes 5-HT1D, 5-HT2A, and 5-HT2C (Kds = 2.7, 20,...
T7103 Idalopirdine Idalopirdine, a selective 5-HT6 receptor antagonist( Ki : 0.83 nM),as a treatment for Alzheimer's disease.
T7135 Phenylbiguanide Phenylbiguanide is a 5-HT3 receptor selective agonist(EC50 : 3.0±0.1 μM)
T7277 SB 242084 dihydrochloride hydrate SB 242084 dihydrochloride hydrate is a psychoactive drug and research chemical which acts as a selective antagonist for the 5HT2C receptor.
T7281 F-15599 F-15599 is a highly selective G-protein biased 5-HT1A receptor agonist(Ki : 3.4 nM).
T7498 Eltoprazine hydrochloride Eltoprazine hydrochloride is a partial agonist at serotonin 5-HT1A, 5-HT1B, and 5-HT2B receptors (Ki value of 40, 52, and 81 nM, respectively).
T8128 Mosapride Mosapride is a selective 5HT4 agonist
T7412 Tandospirone citrate Tandospirone citrate is a potent and selective 5-HT1A receptor partial agonist (Ki : 27 nM)
T7519 RS 127445 RS 127445 is a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist(pKi : 9.5).
T7521 Azaphen Azaphen is the reuptake of serotonin inhibitor.with antidepressant action and has sedative effects, suggesting antihistamine activity.
T7694 6-fluoro-DL-Tryptophan 6-fluoro-DL-Tryptophan is an inhibitor of serotonin (5-HT) synthesis.
TQ0084 Lumateperone Tosylate Lumateperone Tosylate is a 5-HT2A receptor antagonist (Ki: 0.54 nM), a SERT blocker (Ki: 61 nM), a partial agonist of presynaptic D2 receptors and an antagonist ...
TQ0130 CP-809101 CP-809101 is an effective and selective 5-HT2C receptor agonist (pEC50: 9.96/7.19/6.81 for human 5-HT2C/5-HT2B/5-HT2A receptors).
TQ0311 GSK163090 GSK163090 is a specific and orally active 5-HT1A/B/D receptor antagonist (pKis: 9.4/8.5/9.7, and 6.3/6.7 for 5-HT1A/B/D, and dopamine D2/D3).
TQ0315 Tandospirone Tandospirone (SM-3997) is a selective partial agonist of 5-HT1A receptor (Ki: 27 nM) that displays selectivity over SR-2, SR-1C, α1, α2, D1 and D2 receptors (K...
T12489 Pimethixene Pimethixene is a highly potent 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4 as well as muscarinic M1 and M2 receptors antagonist(pKis of 7....
T12565 PRX933 hydrochloride PRX933 hydrochloride is an agonist of 5-HT2c receptor.
T12841 SB-224289 hydrochloride SB-224289 hydrochloride is a selective antagonist of 5-HT1B receptor, with anxiolytic effect.
T14968 Cinanserin hydrochloride Cinanserin hydrochloride is a selective and highly affinity 5-HT2 receptor antagonist (Ki: 41 nM). It has a much higher binding affinity for the 5-HT2 than for t...
T10267 Agomelatine (L(+)-Tartaric acid) Agomelatine (S-20098) L(+)-Tartaric acid is a specific agonist of MT1 and MT2 receptors (Kis: 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and ...
T10294 AM9405 AM9405 is a novel peripherally active cannabinoid type 1 (CB1) and serotonin type 3 receptor agonist. It inhibits twitch contraction of the ileum and the colon (...
T10344 AP521 AP521 is an agonist of the human 5-HT1A receptor (IC50: 94 nM).
T10371 Arotinolol Arotinolol is a nonselective α/β-adrenergic receptor blocker and a vasodilating β-blocker. Arotinolol also shows potency for inhibiting the binding of the rad...
T10380 AS19 AS19 is a potent, selective 5-HT7 receptor agonist (IC50: 0.83 nM; Ki: 0.6 nM). AS19 is selective for 5-HT7 over 5-HT1A, 5-HT1B, 5-HT1D, and 5-HT5A receptors (Ki...
T14782 Brilaroxazine Brilaroxazine (RP5603) is a partial agonist of dopamine (DA) D2, D3, and D4 receptors, 5-HT1A (Ki: 1.5 nM) and 5-HT2A (Ki: 2.5 nM), and has antagonist activity a...
T14830 Bromperidol Bromperidol is a butyrophenone derivative and is used as an antipsychotic in the treatment of schizophrenia.
T14853 Cabergoline Cabergoline is an ergot derived-dopamine D2-like receptor agonist. It has high affinity for D2, D3, and 5-HT2B receptors (Ki=0.7, 1.5, and 1.2, respectively).Cab...
T10837L Clocapramine Clocapramine is a D2 and 5-HT2A receptors antagonist.
T12638 (R)-Praziquantel D11 (R)-Praziquantel D11 is the deuterium labeled (R)-Praziquantel. (R)-Praziquantel is the active enantiomer of Praziquantel, is a partial the human 5-HT2B receptor...
T15026 Cyamemazine Cyamemazine, contains the phenothiazine chromophore, is a neuroleptic agent used as an anxiolytic. Cyamemazine is a potent 5-HT3 (Ki: 12 nM), 5-HT2A (Ki: 1.5 nM)...
T15034 Roluperidone Roluperidone is a novel cyclic amide derivative. It has high equipotent affinities for 5-HT2A and σ2 receptors (Ki of 7.53 nM and 8.19 nM for 5-HT2A and σ2).
T15100 Desmethyl cariprazine Desmethyl cariprazine is a Cariprazine active metabolite. Cariprazine, an antipsychotic drug candidate, shows a high affinity for the D3 (Ki: 0.085 nM) and D2 (K...
T15117 Didesmethyl cariprazine Cariprazine is an antipsychotic drug candidate. It shows high affinity for the D3 and D2 receptors, and moderate affinity for the 5-HT1A receptor. Didesmethyl ca...
T15270 Fananserin Fananserin is an orally bioavailable and selective antagonist of the 5-HT2 receptor (Ki: 0.37 nM for the rat 5-HT2A receptor). It also is an antagonist of dopami...
T15414 GR 113808 GR 113808 displays 300-fold selectivity over 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C and 5-HT3 receptors. GR 113808 is a potent and highly selective antagonist of 5-HT4 ...
T12773 RS102895 hydrochloride RS102895 hydrochloride is a potent antagonist of CCR2(IC50 of 360 nM).
T12806 (S)-Mirtazapine D3 (S)-Mirtazapine D3 is a deuterium labeled (S)-Mirtazapine. (S)-Mirtazapine is a stereoselective antagonist of 5-HT2 receptor. (S)-Mirtazapine is metabolized by C...
T12716 RG-12915 RG-12915 is a selective antagonist of 5-HT3(IC50 value of 0.16 nM).
T12632 (R)-Mirtazapine (R)-Mirtazapine is a R(−)-enantiomer of Mirtazapine with antinociceptive properties in an animal model of acute thermal nociception. (R)-Mirtazapine is a antag...
T10075 2-Methyl-5-HT 2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist with anti-depressive-like effects.
T10053 5HT6-ligand-1 5HT6-ligand-1 is a potent 5-HT6 receptor ligand (Ki: 1.43 nM).
T10075L2 2-Methyl-5-HT hydrochloride 2-Methyl-5-HT hydrochloride (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist with anti-depressive-like effects.
T10114 3-Hydroxy agomelatine 3-Hydroxy agomelatine is an Agomelatine metabolite and a 5-HT2C receptor antagonist (IC50: 3.2 μM; Ki: 1.8 μM).
T10113 3-Hydroxy agomelatine D3 3-Hydroxy agomelatine D3 is a deuterium labeled 3-Hydroxy agomelatine. 3-Hydroxy agomelatine is an Agomelatine metabolite and a 5-HT2C receptor antagonist (IC50:...
T10168 5-HT1A modulator 1 5-HT1A modulator 1 displays very high affinities for the 5HT1A, adrenergic α1, and dopamine D2 receptor (IC50s: 2 nM, 10 nM and 40 nM).
T10498 5-HT2A antagonist 1 5-HT2A antagonist 1 is a 5-HT2A antagonist extracted from patent US5728835A and JP 1007727. It may be useful in the treatment of gastrointestinal disorders circu...
T10162 5-HT3 antagonist 3 5-HT3 antagonist 3 (Compound 15b) is a high-affinity 5-HT3 receptor antagonist. It binds to 5-HT3 receptors in rat brain cortical membranes (Ki: 0.25 nM).
T10006 5-HT3-In-1 5-HT3-In-1 (compound example 8) is extracted from patent EP0748807A1 with 5-HT3 inhibition activity.
T10169 5-HT4 antagonist 1 5-HT4 antagonist 1 is a 5-HT4 receptor antagonist (pKi: 9.6).
T10170 5-HT7 agonist 1 5-HT7 agonist 1 is a selective 5-HT7 receptor agonist (IC50: 222.93 nM), which can be used for the 5-HT7 receptor-related disease, such as CNS disorders.
T12631 (R)-Mirtazapine D3 (R)-Mirtazapine D3 is a deuterium labeled (R)-Mirtazapine.(R)-Mirtazapine is a antagonist of 5-HT3 receptor.
T10192 7-Desmethyl-3-hydroxyagomelatine 7-Desmethyl-3-hydroxyagomelatine is a metabolite of Agomelatine and has less activity than Agomelatine. Agomelatine is a melatonergic (MT1 and MT2) agonist and 5...
T10989 Dehydroaripiprazole Dehydroaripiprazole is the active metabolite of aripiprazole. Aripiprazole is an antipsychotic drug, which is metabolized by CYP3A4 and CYP2D6 and mainly forms d...
T10996 Deramciclane Deramciclane has high affinity for 5-HT2A and 5-HT2C receptors. It acts as an antagonist in both receptor subtypes and has inverse agonist properties for 5-HT2C ...
T11075 Donitriptan Donitriptan is an effective agonist for the 5-HT1B/1D receptor, with pKis of 9.4 and 9.3, respectively.
T10075L 2-Methyl-5-HT maleate 2-Methyl-5-HT maleate (2-Methyl-5-hydroxytryptamine maleate) is a potent and selective 5-HT3 receptor agonist, which is shown to display anti-depressive-like eff...
T8445 PU-02 PU-02 is a potent and selective antagonist of 5-HT3 receptor.
T8438 4i 4i is a 5-HT3 receptor antagonist,It modulates the serotonergic system.
T14190 Alniditan Alniditan is a receptors agonist of 5-HT1B/1D in HEK 293 cells (IC50: 1.7 and 1.3 nM). For 5-HT1B/1D receptors, the pKi values are 8.96 and 9.40, respectively....
T14526 Bemesetron Bemesetron (MDL 72222) is an antagonist of 5-HT3 receptor (IC50: nM). It has Neuroprotective effect[2].
T2714 Rotundine Rotundine is extracted from Corydalis yanhusuo W. T. Wang.
NGB2904 HCl
T28167CAS 189060-98-8
NGB2904 is a potent and selective antagonist of dopamine D3 receptor (Ki values are 1.4, 217, 223, 642, > 5000, > 10000 and > 10000 nM for D3, D2, 5-HT2, α1, D4...
Chlorprothixene hydrochloride
T0074LCAS 6469-93-8
Chlorprothixene brings strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors. Chlorprothixene is a t...
SB 742457
T1774CAS 607742-69-8
SB742457 is a highly selective 5-HT6 receptor antagonist, used in trials studying the treatment of Alzheimer's Disease.
Promethazine
T0445CAS 60-87-7
Tafluprost(AFP-168) is an analogue of anti-glaucoma prostaglandin (PG) .
Mebhydrolin napadisylate
T0113CAS 6153-33-9
Mebhydrolin (napadisylate) is an antihistamine used to relieve allergic symptoms caused by histamine release, including nasal allergies and allergic dermatosis.
Tryptamine
T0647CAS 61-54-1
Tryptamine is a monoamine alkaloid found in animals, plants, and fungi. It contains an indole ring structure and is structurally analogous to the tryptophan. It ...
Fluvoxamine maleate
T1077CAS 61718-82-9
Fluvoxamine maleate is a selective serotonin reuptake inhibitor that is used in the treatment of depression and a variety of anxiety disorders.
Cyclobenzaprine hydrochloride
T1509CAS 6202-23-9
Cyclobenzaprine Hydrochloride, a centrally acting muscle relaxant with antidepressant activity, leads to a reduction in muscle spasms.
Dopamine hydrochloride
T1644CAS 62-31-7
Dopamine is a naturally occurring catecholamine formed by decarboxylation of dihydroxyphenylalanine and a precursor of norepinephrine and epinephrine. Dopamine b...
WAY-100635 maleate salt
T3453CAS 634908-75-1
WAY-100635 is a specific and effective 5-HT receptor antagonist (IC50=0.95 nM).
Urapidil hydrochloride
T0088CAS 64887-14-5
Urapidil hydrochloride is 5-HT1A receptor agonist and an α1-adrenoceptor antagonist.
Perphenazine
T1090CAS 58-39-9
Perphenazine is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties.
Dasotraline hydrochloride
T3526CAS 675126-08-6
Dasotraline hydrochloride (SEP-225289 hydrochloride) is a triple reuptake inhibitor  that inhibits dopamine, norepinephrine, and serotonin transporters with IC5...
Chlorpromazine hydrochloride
T1384CAS 69-09-0
Chlorpromazine hydrochloride is the prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are ...
Pimavanserin
T2076CAS 706779-91-1
Pimavanserin(ACP-103) is an effective and specific 5-HT2A receptor inverse agonist (mean pIC50: 8.7, in the cell-based functional assay). Pimavanserin is an atyp...
Pimavanserin tartrate
T6946CAS 706782-28-7
Pimavanserin is an effective and specific serotonin 5-HT2A inverse agonist (pIC50: 8.73), used in the therapy of psychosis associated with Parkinson's disease.
Amisulpride
T0811CAS 71675-85-9
Amisulpride (trade name Solian) is an antipsychotic drug sold by Sanofi-Aventis. It is not approved for use in the United States, but is approved for use in Eu...
Metoclopramide hydrochloride
T1069CAS 7232-21-5
Metoclopramide hydrochloride is a selective dopamine D2 receptor antagonist, used as an antiemetic.
Aniracetam
T0333CAS 72432-10-1
Aniracetam(Ro 13-5057), a nootropic and neuroprotective drug, selectively modulates the AMPA receptor and nAChR.
Ketanserin
T1066CAS 74050-98-9
Ketanserin is a quinazoline derivative and serotonin (5-hydroxytryptamine, 5HT) receptor subtype 2 (5-HTR2) antagonist with potential antihypertensive and antipl...
Citalopram HBr
T1483CAS 59729-32-7
Citalopram, a selective serotonin reuptake inhibitor (SSRI), selectively inhibits the CNS neuronal reuptake of serotonin, thereby potentiating serotonergic activ...
Desipramine hydrochloride
T0991CAS 58-28-6
Desipramine Hydrochloride a secondary amine tricyclic antidepressant (TCA), is the hydrochloride salt form of desipramine. In the central nervous system (CNS), d...
Methiothepin mesylate
T2190CAS 74611-28-2
Methiothepin mesylate is a potent and non-selective 5-HT2 receptor antagonist, used as an antipsychotic.
Trimipramine maleate
T1045CAS 521-78-8
Trimipramine maleate appears to inhibit serotonin transport and norepinephrine uptake by nerve terminals. This increases available norepinephrine or serotonin an...
Elemicin
T3341CAS 487-11-6
Elemicin is a constituent of several plant species' essential oils with anticholinergic effects in human.
Terfenadine
T1266CAS 50679-08-8
Terfenadine is a prodrug that is metabolized by intestinal CYP3A4 to the active form fexofenadine, a selective histamine H1-receptor antagonist with antihistamin...
Vortioxetine
T2395CAS 508233-74-7
Vortioxetine is a serotonergic antidepressant used for major depression disorders. Vortioxetine has been associated with a low rate of minor serum aminotransfera...
Procaine hydrochloride
T0802CAS 51-05-8
Procaine Hydrochloride is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine ...
2-Bromo-6-methoxynaphthalene
T0663CAS 5111-65-9
2-Bromo-6-methoxynaphthalene was used in the synthesis of nabumetone [4-(6-methoxy-2-naphthalenyl)-2-butanone] by Heck reaction.
Histamine
T0965CAS 51-45-6
Histamine is an amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscl...
Pizotifen Malate
T0225CAS 5189-11-7
Pizotifen malate, a highly selective 5-HT receptor blocking agent, is a drug based on benzocycloheptane.
Hesperetin
T2565CAS 520-33-2
Hesperetin belongs to the flavanone class of flavonoids. Hesperetin, in the form of its glycoside hesperidin, is the predominant flavonoid in lemons and oranges....
Tetrahydroberberine THB
T2874CAS 522-97-4
Tetrahydroberberine is an isoquinoline alkaloid isolated from corydalis tuber, has a micromolar affinity for dopamine D(2) receptors.
BRL54443
T2459CAS 57477-39-1
BRL 54443 is a potent 5-HT1E/1F receptor agonist (pKi values are 8.7 and 8.9 respectively).
Haloperidol
T0025CAS 52-86-8
Haloperidol is a highly potent neuroleptic by relieving nervous through the depression of nerve function. In addition, haloperidol has shown about 50-fold effica...
Promazine hydrochloride
T0766CAS 53-60-1
Promazine hydrochloride is a phenothiazine with actions similar to CHLORPROMAZINE but with less antipsychotic activity. It is primarily used in short-term treatm...
Fluoxetine
T0450CAS 54910-89-3
Fluoxetine is the first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than tra...
Amitriptyline hydrochloride
T0678CAS 549-18-8
Amitriptyline Hydrochloride is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptive activities.
WAY181187
T3183CAS 554403-49-5
WAY-181187 has high-affinity binding at the human 5-HT6 receptor.
Alverine citrate
T0428CAS 5560-59-8
Alverine Citrate is utilized in functional gastrointestinal disorders.
Fluoxetine hydrochloride
T0450LCAS 56296-78-7
Fluoxetine is the first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than tra...
Naftopidil DiHCl
T6600CAS 57149-08-3
Naftopidil DiHCl is a selective 5-HT1A and α1-adrenergic receptor antagonist with IC50 of 0.1 μM and 0.2 μM, respectively.
Metadoxine
T3269CAS 74536-44-0
Metadoxine is a neurotransmitter stimulant.
Pirenperone
T2599CAS 75444-65-4
Pirenperone is a putative 5-HT2 receptor antagonist with the central antiserotonergic and antidopaminergic action.
Nuciferine
T3369CAS 475-83-2
Nuciferine is an alkaloid found within the plants Nymphaea caerulea and Nelumbo nucifera. It has a profile of action associated with dopamine receptor blockade.
Alprenolol
T4560CAS 13655-52-2
Alprenolol is a non-selective β-adrenergic receptor (β-AR) antagonist that is also an antagonist of the serotonin (5-HT) receptor subtypes 5-HT1A and 5-HT1B.
Metergoline
T4008CAS 17692-51-2
Metergoline is a dopamine agonist and serotonin antagonist. It has been used similarly to BROMOCRIPTINE as a dopamine agonist and also for migraine disorder ther...
LY 334370
T4266CAS 182563-08-2
LY334370 is a selective 5-HT1F receptor agonist with a Ki of 1.6 nM
Methiothepin maleate
T4375CAS 19728-88-2
Methiothepin is a 5-HT1, 5-HT6, 5-HT7 serotonin receptor antagonist, which blocks serotonin autoreceptors.
SB 271046 hydrochloride
T4118CAS 209481-24-3
SB 271046 hydrochloride is selective, orally active 5-HT6 antagonist (pKi values are 9.02-8.92, 6.35, 6.55, 6.27 at 5-HT6, 5-HT1A, 5-HT1D and D3, and 6.05, 5.95,...
Pergolide mesylate salt
T2226CAS 66104-23-2
PERGOLIDE MESYLATE is a long-acting dopamine agonist which has been used to treat PARKINSON DISEASE and HYPERPROLACTINEMIA but withdrawn from some markets due to...
8-OH-Dpat
T4305CAS 78950-78-4
8-OH-Dpat is a serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin.
Dolasetron
T4568CAS 115956-12-2
Dolasetron(MDL-73147) is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy.
Ramosetron
T4562CAS 132036-88-5
Ramosetron is a serotonin 5-HT3 receptor antagonist for the treatment of nausea and vomiting. It is believed to have higher potency and longer antiemetic action ...
Perospirone
T4576CAS 150915-41-6
Perospirone is an antagonist of serotonin 5HT2A receptors and dopamine D2 receptors. It also displays affinity towards 5HT1A receptors as a partial agonist.
Ondansetron
T6615CAS 99614-02-5
Ondansetron is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic.
Xanthotoxol
T4S1659CAS 2009-24-7
Xanthotoxol is a biologically active linear furocoumarin, shows strong pharmacological activities as anti-inflammatory, antioxidant, 5-HT antagonistic, and neuro...
Sodium ferulic
T2S0007CAS 24276-84-4
Sodium ferulate (SF), the sodium salt of ferulic acid, is a drug used in traditional Chinese medicine for treatment of cardiovascular and cerebrovascular disease...
CLOZAPINE N-OXIDE
T4494CAS 34233-69-7
Clozapine N-oxide is a major metabolite of clozapine that can be detected in the earliest excretion time interval after clozapine administration [1]. It is produ...
7-Amino-4-(trifluoromethyl)coumarin
TJS0341CAS 53518-15-3
7-Amino-4-(trifluoromethyl)coumarin is a 5-Hydroxytryptamine Receptor Subtype 1E (HTR1E) antagonist. 7-Amino-4-(trifluoromethyl)coumarin is a Galanin Receptor 2 ...
Scopolamine
T3S0478CAS 51-34-3
1. Scopolamine, a nonselective muscarinic receptor antagonist, induces distinct behaviors of attenuated motility and C-like hyperactivity. 2. Scopolamine can inc...
Isocorynoxeine
T6S0654CAS 51014-29-0
1. Isocorynoxeine shows the effects of lowering blood pressure, vasodilatation, and protection against ischemia-induced neuronal damage. 2. Isocorynoxeine exhibi...
Cariprazine
T4577CAS 839712-12-8
Cariprazine is a novel antipsychotic drug candidate that exhibits high affinity for the D3 (Ki=0.085 nM) and D2 (Ki=0.49 nM) receptors, and moderate affinity for...
Sarpogrelate hydrochloride
T4978CAS 135159-51-2
Sarpogrelate(MCI-9042) hydrochloride, a selective 5-HT2 antagonist, has been widely used as an anti-platelet agent for the treatment of PAD. Target: 5-HT2 Recept...
Flibanserin
T4297CAS 167933-07-5
Flibanserin is a serotonergic antidepressant used to treat hypoactive sexual desire disorder. Flibanserin has been associated with a low rate of minor serum amin...
Ondansetron HCl
T6616CAS 99614-01-4
Ondansetron is a serotonin 5-HT3 receptor antagonist, used to prevent nausea and vomiting caused by cancer chemotherapy, and radiation therapy.
Paroxetine hydrochloride
T1636CAS 78246-49-8
Paroxetine hydrochloride is a serotonin uptake inhibitor that is effective in the treatment of depression.
PRX-08066 Maleic acid
T6959CAS 866206-55-5
PRX-08066 Maleic acid is a selective 5-HT2B receptor antagonist with IC50 of 3.4 nM, prevents the severity of pulmonary arterial hypertension in the MCT rat mode...
Sertraline hydrochloride
T0482CAS 79559-97-0
Sertraline hydrochloride is a selective serotonin uptake inhibitor that is used in the treatment of depression.
Cisapride
T1291CAS 81098-60-4
Cisapride is a serotonin type 4 (5-HT4) receptor agonists are potent prokinetic agents that act on serotonin receptors in the intestine and promote intestinal pe...
Atomoxetine hydrochloride
T0869CAS 82248-59-7
Atomoxetine Hydrochloride is the hydrochloride salt of atomoxetine, a phenoxy-3-propylamine derivative and selective non-stimulant,  norepinephrine reuptake ...
Nefazodone hydrochloride
T3275CAS 82752-99-6
Nefazodone is a serotoninergic modulating antidepressant that is used in therapy of depression, aggressive behavior and panic disorder.
Lamotrigine
T0680CAS 84057-84-1
Lamotrigine is an Anti-epileptic Agent and Mood Stabilizer. The physiologic effect of lamotrigine is by means of Decreased Central Nervous System Disorganized El...
Lorcaserin HCl
T6572CAS 846589-98-8
Lorcaserin is a selective serotonin agonist that has been recently approved as a weight loss agent.
Mirtazapine
T0137CAS 85650-52-8
Mirtazapine is a tetracyclic antidepressant with a somewhat unique mechanism of action. Mirtazapine therapy can be associated with transient asymptomatic elevati...
Asenapine Maleate
T1951CAS 85650-56-2
Asenapine is a second generation (atypical) antipsychotic agent that is taken sublingually and used in the treatment of schizophrenia and manic or mixed episodes...
Dalasetron Mesylate Hydrate
T2589CAS 878143-33-0
Dolasetron mesylate, a selective serotonin receptor antagonist, competitively blocks the action of serotonin at 5HT3 receptors, resulting in suppression of chemo...
Venlafaxine hydrochloride
T0472CAS 99300-78-4
Venlafaxine hydrochloride is a cyclohexanol and phenylethylamine derivative that functions as a SEROTONIN AND NORADRENALINE REUPTAKE INHIBITOR (SNRI) and is used...
Nortriptyline hydrochloride
T1327CAS 894-71-3
Nortriptyline hydrochloride is a metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, ...
Brexpiprazole
T2306CAS 913611-97-9
Brexpiprazole is a partial agonist of human 5-hydroxytryptamine (5-HT) 5-HT1A and dopamine D2 receptors.
Desvenlafaxine
T1580CAS 93413-62-8
Desvenlafaxine is a cyclohexanol and phenol derivative and metabolite of venlafaxine that functions as a serotonin and noradrenaline reuptake inhibitor (SNRI) an...
Vortioxetine HBr
T2395LCAS 960203-27-4
Vortioxetine (Lu AA21004) is a serotonin (5-HT) modulator and stimulator (SMS), inhibits 5-HT1A/1B/3A/7 receptor and SERT (IC50: 15/33/3.7/19/1.6 nM).
Cyproheptadine HCl
T6814CAS 969-33-5
Cyproheptadine HCl is a hydrochloride salt form of cyproheptadine which is a histamine receptor antagonist.
Latrepirdine
T6562CAS 97657-92-6
Latrepirdine is an orally active, and neuroactive antagonist of multiple drug targets, including histamine receptors, GluR, and 5-HT receptors, used as an antihi...
Brompheniramine hydrogen maleate
T0205CAS 980-71-2
Brompheniramine maleate is an antagonist against histamine H1 receptors.
Levodropropizine
T0217CAS 99291-25-5
Levodropropizine is a histamine receptor inhibitor. It is used as an effective and very well tolerated peripheral antitussive drug.
Cinchonidine
T1317CAS 485-71-2
Cinchonidine is an alkaloid extracted from Cinchona officinalis. It is a pseudo-enantiomer and stereoisomer of cinchonine.
Lasmiditan
T3704CAS 439239-90-4
Lasmiditan, also known as COL-144 and LY573144, is a novel, centrally acting, highly selective 5-HT(1F) receptor agonist (K1=2.21 μM) without vasoconstrictor ac...
N-Desmethylclozapine
T5158CAS 6104-71-8
N-Desmethylclozapine is an antagonist of serotonin (5-HT) receptor subtype 5-HT2C (IC50: 7.1 nM). It also is an antagonist at dopamine D4 receptors, an agonist a...
YL0919
T3648CAS 1339058-04-6
YL0919 is a novel antidepressant candidate with dual activity as a 5-HT1A receptor agonist and a selective serotonin reuptake inhibitor.
Escitalopram
T0185CAS 128196-01-0
Escitalopram is a furancarbonitrile that is one of the SEROTONIN UPTAKE INHIBITORS used as an antidepressant. The drug is also effective in reducing ethanol upta...
Ocaperidona
T3497CAS 129029-23-8
Ocaperidona (Ocaperidone), a very high affinity dopamine D2 antagonist.
Aripiprazole
T1566CAS 129722-12-9
Aripiprazole is an antipsychotic agent that is structurally related to piperazines and quinolones. It is a partial agonist of SEROTONIN RECEPTOR, 5-HT1A and DOPA...
Buclizine HCl
T6426CAS 129-74-8
Buclizine HCl is the hydrochloride salt form of buclizine, a piperazine histamine H1 receptor antagonist with primarily antiemetic and antivertigo activities. Bu...
Thioridazine hydrochloride
T0365CAS 130-61-0
Thioridazine, an antipsychotic drug, is used in the therapy of psychosis and schizophrenia and shows serotonin antagonism or D4 selectivity.
Pheniramine maleate
T0370CAS 132-20-7
Pheniramine Maleate, an alkylamine derivative with antihistaminic and vasodilatory properties, binds to histamine H1 receptors, thereby inhibiting phospholipase ...
Olanzapine
T1567CAS 132539-06-1
Olanzapine is an atypical antipsychotic that is used currently in the treatment of schizophrenia and bipolar illness.
Blonanserin
T1180CAS 132810-10-7
Blonanserin is an atypical antipsychotic approved in Japan in January, 2008. Relative to many other antipsychotics, blonanserin has an improved tolerability prof...
Pindolol
T0735CAS 13523-86-9
Pindolol is a moderately lipophilic beta blocker (ADRENERGIC BETA-ANTAGONISTS). It is non-cardioselective and has intrinsic sympathomimetic actions, but little m...
Doxepin hydrochloride
T1540CAS 1229-29-4
Doxepin Hydrochloride is a dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mech...
Palonosetron hydrochloride
T1156CAS 135729-62-3
Palonosetron is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting.
Duloxetine hydrochloride
T1471CAS 136434-34-9
Duloxetine hydrochloride is a thiophene derivative and selective neurotransmitter uptake inhibitor for SEROTONIN and NORADRENALINE (SNRI). It is an ANTIDEPRESSIV...
Agomelatine
T1445CAS 138112-76-2
Agomelatine is structurally closely related to melatonin. Agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2C (5-HT2C) recep...
Ziprasidone hydrochloride monohydrate
T0031CAS 138982-67-9
Ziprasidone(CP88059) is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of the antipsychotic activity.
Zolmitriptan
T1092CAS 139264-17-8
Zolmitriptan selectively binds to and activates serotonin (5-HT) 1B receptors expressed in intracranial arteries and 5-HT 1D receptors located on peripheral trig...
Olopatadine hydrochloride
T1170CAS 140462-76-6
Olopatadine hydrochloride is an antihistamine with mast-cell stabilizing properties used as eye drops in the treatment of ALLERGIC CONJUNCTIVITIS.
TG6-10-1
T2428CAS 1415716-58-3
TG6-10-1 is an EP2 antagonist.
Naratriptan hydrochloride
T6602CAS 143388-64-1
Naratriptan Hydrochloride is the hydrochloride salt form of naratriptan, a sulfonamide with selective serotonin (5-HT) 1 receptor agonistic activity and anti-mig...
Azasetron hydrochloride
T1528CAS 123040-16-4
Azasetron Hydrochloride is a 5-HT3 receptor antagonist which is used as an anti-emetic.
Ziprasidone hydrochloride
T0031LCAS 122883-93-6
Ziprasidone (hydrochloride) is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of antipsychotic activity.
Rizatriptan benzoate
T1512CAS 145202-66-0
Rizatriptan benzoate selectively binds to and activates serotonin (5-HT) 1B receptors and 5-HT 1D receptors providing relief of migraine headaches.
WAY-100635 Maleate
T2631CAS 1092679-51-0
WAY-100635 is a specific and effective 5-HT receptor antagonist (IC50=0.95 nM).
Maprotiline hydrochloride
T0172CAS 10347-81-6
Maprotiline hydrochloride is a bridged-ring tetracyclic antidepressant that is both mechanistically and functionally similar to the tricyclic antidepressants, in...
Sumatriptan succinate
T0203CAS 103628-48-4
Sumatriptan succinate, a serotonin1 (5-HT1) receptor agonist, is used in the acute treatment of a migraine headache.
Ondansetron hydrochloride
T1478CAS 103639-04-9
Ondansetron hydrochloride is a competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chem...
Tropisetron hydrochloride
T1173CAS 105826-92-4
Tropisetron Hydrochloride is the hydrochloride salt form of tropisetron, a selective, competitive serotonin 5-hydroxytryptamine type 3 (5-HT3) receptor antagonis...
Risperidal
T0351CAS 106266-06-2
Risperidone is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that act as an atypical antipsychotic agent.
Granisetron hydrochloride
T1042CAS 107007-99-8
Granisetron hydrochloride is a serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic for cancer chemotherapy patients.
RU 24969 hemisuccinate
T2289CAS 107008-28-6
RU 24969 is a selective agonist at the 5-HT1A and 5-HT1B receptors.
Epinastine HCl
T6488CAS 108929-04-0
Epinastine is an antihistamine and mast cell stabilizer that is used in eye drops to treat allergic conjunctivitis.
Triflupromazine hydrochloride
T0302CAS 1098-60-8
Triflupromazine hydrochloride, an antipsychotic medication, is Dopamine D1/D2 receptor antagonists.
Alosetron hydrochloride
T2525CAS 122852-69-1
Alosetron Hydrochloride is the hydrochloride salt form of alosetron, a potent and selective 5-HT3 receptor antagonist. Alosetron blocks the actions of serotonin ...
Quetiapin
T0162CAS 111974-69-7
Quetiapine is used for the therapy of schizophrenia, and for the treatment of acute manic episodes associated with bipolar I disorder. The mechanism of quetiapin...
Quetiapine Fumarate
T6241CAS 111974-72-2
Quetiapine Fumarate, an atypical antipsychotic, is used in the treatment of bipolar I mania, schizophrenia, bipolar II depression, bipolar I depression.
Mosapride Citrate
T6597CAS 112885-42-4
Mosapride Citrate, a gastroprokinetic agent, utilizes as a selective 5HT4 agonist.
Chlorprothixene
T0074CAS 113-59-7
Chlorprothixene is a typical antipsychotic drug of the thioxanthene class, which was the first of the series to be synthesized.
Ataractan
T0318CAS 115-46-8
Azacyclonol is a drug used to diminish hallucinations in psychotic individuals.
Lafutidine
T0081CAS 118288-08-7
Lafutidine is a newly developed histamine H(2)-receptor antagonist, which can inhibit gastric acid secretion.
Dapoxetine
T0039CAS 119356-77-3
Dapoxetine is a selective serotonin reuptake inhibitor, for the treatment of premature ejaculation.
Protriptyline hydrochloride
T0204CAS 1225-55-4
Protriptyline Hydrochloride is the hydrochloride salt form of protriptyline, a tricyclic secondary amine with an antidepressant property. Protriptyline hydrochlo...
Paliperidone
T0076CAS 144598-75-4
Paliperidone(Invega) is used as an atypical antipsychotic. It applies to the acute and maintenance treatment of schizophrenia. Chemically, paliperidone is the pr...
Ziprasidone
T0031L2CAS 146939-27-7
Ziprasidone is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of antipsychotic activity.
Cyproheptadine hydrochloride
T0174CAS 41354-29-4
Cyproheptadine hydrochloride sesquihydrate, an antihistamine, is an antagonist of serotonin and histamine2.
Nafronyl oxalate
T1081CAS 3200-06-4
Nafronyl oxalate is a drug used in the management of peripheral and cerebral vascular disorders. It is claimed to enhance cellular oxidative capacity and to be a...
Dexchlorpheniramine Maleate
T0785CAS 2438-32-6
Dexchlorpheniramine (trade name Polaramine) is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria....
Trazodone hydrochloride
T1619CAS 25332-39-2
Trazodone hydrochloride is a serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depress...
Minaprine
T0338CAS 25905-77-5
Minaprine is a reversible inhibitor of MAO-A, used in the treatment of various depressive states.
SB269970 HCl
T6655CAS 261901-57-9
SB269970 HCl, a hydrochloride salt form of SB-269970, is a 5-HT7 receptor antagonist (pKi of 8.3) and exhibits >50-fold selectivity against other receptors.
Pardoprunox hydrochloride
T3431CAS 269718-83-4
Pardoprunox hydrochloride is a novel partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist, D2 (pKi = 8.1) and D3 receptor (pKi = 8.6...
Pardoprunox
T1769CAS 269718-84-5
Pardoprunox is a partial dopamine D2 agonist and noradrenergic agonist with serotonin 5-HT1A agonist properties. Pardoprunox has been used in trials studying the...
Loxapine succinate salt
T1412CAS 27833-64-3
Loxapine succinate, a D2DR and D4DR inhibitor, is utilized in schizophrenia.
Tianeptine sodium
T2402CAS 30123-17-2
Tianeptine sodium is a selective serotonin reuptake enhancer (SSRE), used to treat major depressive episodes.
Mesoridazine Besylate
T3086CAS 32672-69-8
Mesoridazine (Serentil) is a piperidine neuroleptic drug belonging to the class of drugs called phenothiazines, used in the treatment of schizophrenia. It is a m...
Escitalopram Oxalate
T6493CAS 219861-08-2
Escitalopram Oxalate is a selective serotonin (5-HT) reuptake inhibitor (SSRI) with Ki of 0.89 nM.
Buspirone hydrochloride
T2132CAS 33386-08-2
Buspirone is a 5HT(1A) receptor agonist, used to treat generalized anxiety disorder (GAD).
Urapidil
T0165CAS 34661-75-1
Urapidil, a sympatholytic antihypertensive drug, acts as a 5-HT1A receptor agonist and as an α1-adrenoceptor antagonist.
Lurasidone hydrochloride
T1735CAS 367514-88-3
Lurasidone hydrochloride is a thiazole derivative and atypical antipsychotic agent that functions as a dopamine D2 receptor antagonist; serotonin 5-HT2 receptor ...
Puerarin
T2815CAS 3681-99-0
Puerarin, also known as Kakonein, is a member of the class of compounds known as isoflavonoid C-glycosides. It is a 5-HT2C receptor antagonist.
Piperacetazine
T3085CAS 3819-00-9
Piperacetazine, an antipsychotic prodrug, is used forschizophrenia.
Desvenlafaxine succinate hydrate
T6188CAS 386750-22-7
Desvenlafaxine succinate hydrate is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI).
Azatadine Maleate
T0236CAS 3978-86-7
Azatadine dimaleate is an inhibitor for histamine(IC50=6.5 nM) and cholinergic(IC50=10 nM).
Amitifadine hydrochloride
T2092CAS 410074-74-7
Amitifadine hydrochloride is a triple reuptake inhibitor (TRI) or serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI).
Flopropione
T0525CAS 2295-58-1
Flopropione, a spasmolytic or antispasmodic agent, is used as a 5-HT1A receptor antagonist.
Mianserin hydrochloride
T0783CAS 21535-47-7
Mianserin hydrochloride is a tetracyclic compound with antidepressant effects. it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin r...
Cloperastine hydrochloride
T0723CAS 14984-68-0
Cloperastine hydrochloride is a type of flavonoid.
Eletriptan HBr
T0216CAS 177834-92-3
Eletriptan hydrobromide is an orally active agonist with specific affinity for the 5-hydroxytriptamine1B/1D receptor.
Piboserod
T2278CAS 152811-62-6
Piboserod (SB 207266) is a selective 5-HT(4) receptor antagonist.
Serotonin hydrochloride
T2209CAS 153-98-0
Serotonin hydrochloride is an endogenous 5-HT receptor agonist, a monoamine neurotransmitter in the CNS, and a catechol O-methyltransferase (COMT) inhibitor(Ki=4...
VUF 10166
T6728CAS 155584-74-0
VUF10166 is a novel, potent and competitive antagonist for 5-HT3A receptor with Ki of 0.04 nM, its affinity at 5-HT3AB receptor is significantly lower.
Pizotifen
T1442CAS 15574-96-6
Pizotifen is a strong serotonin and tryptamine antagonist, with weak anticholinergic, anti-histaminic and anti-kinin effects. It also possesses sedative and appe...
Molindone hydrochloride
T0716CAS 15622-65-8
Molindone hydrochloride is an indole derivative effective in schizophrenia and other psychoses by blocking the effects of dopamine in the brain.
Vilazodone HCl
T6232CAS 163521-08-2
Vilazodone HCl, a partial agonist of 5-HT1A receptors and specific serotonin reuptake inhibitor (SSRI), is utilized in treating of the major depressive disorder....
Vilazodone
T1279CAS 163521-12-8
Vilazodone is a selective serotonin (5-HT) reuptake inhibitor (SSRI) and a 5-HT-1A receptor partial agonist, with antidepressant and anti-anxiety activities. Vil...
Clomipramine hydrochloride
T0255CAS 17321-77-6
Clomipramine hydrochloride is a tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily abso...
Prucalopride
T2542CAS 179474-81-8
Prucalopride is a selective, high-affinity 5-HT4A/4B receptor agonist (Ki: 2.5/8 nM). It has >290-fold selectivity for 5-HT4A/4B receptor than other 5-HT recepto...
BMY 7378 dihydrochloride
T3046CAS 21102-95-4
BMY-7378, α1D-adrenergic receptor antagonist, is a weak partial agonist/antagonist of 5-HT1A receptor.
Prucalopride Succinate
T6958CAS 179474-85-2
Prucalopride is a selective, high affinity 5-HT4 receptor agonist, inhibiting human 5-HT(4a) and 5-HT(4b) receptor with Ki value of 2.5 nM and 8 nM, respectively...
Eptapirone
T3179CAS 179756-58-2
F 11440 is a highly effective and selective 5-HT1A receptor agonist with marked antidepressant and anxiolytic potential.
Almotriptan Malate
T2317CAS 181183-52-8
Almotriptan Malate, a selective 5-HT1B/1D receptor agonist, is used in the therapy of Migraine attacks in adults.
LY344864
T2344CAS 186544-26-3
LY344864, a specifc receptor agonist, is an affinity of 6 nM (Ki) at the recently cloned 5-HT1F receptor.
Tegaserod maleate
T1551CAS 189188-57-6
Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. Its use was the only drug approve...
LY310762
T2688CAS 192927-92-7
LY310762 is a 5-HT1D receptor antagonist with Ki of 249 nM.
BRL-15572 dihydrochloride
T6423CAS 193611-72-2
BRL-15572 is a 5-HT1D receptor antagonist with pKi of 7.9, also shows a considerable affinity at 5-HT1A and 5-HT2B receptors, exhibiting 60-fold selectivity over...
RS127445
T6973CAS 199864-87-4
RS-127445 is a selective 5-HT2B receptor antagonist with pKi of 9.5 and pIC50 of 10.4, exhibits >1000-fold selectivity against other 5-HT receptors.
SB271046
T6656CAS 209481-20-9
SB271046 is a potent, selective and orally active 5-HT6 receptor antagonist with pKi of 8.9, exhibits 200-fold greater selectivity over other 5-HT receptor subty...
AVN492
T5179CAS 1220646-23-0
AVN-492 is a potent and selective 5-HT6R Antagonist (Ki: 91 pM).
Zacopride hydrochloride
T5336CAS 101303-98-4
Zacopride is a highly potent 5-HT3 receptor antagonist (Kd = 0.38 nM) and 5-HT4 receptor agonist (Ki = 373 nM). It also is a selective IK1 channel agonist.
Nemifitide acetate(173240-15-8 free base)
TP1127L1CAS TP1127L1
Nemifitide acetate is a synthetic pentapeptide antidepressant with a potential for rapid onset of action. It is a peptide analog of melanocyte-inhibiting factor ...
PF-04995274
T16481CAS 1331782-27-4
PF-04995274 is an effective, high-affinity, and partial serotonin 4 receptor (5-HT4R) agonist. PF-04995274 is brain penetrant and can be used for cognitive disor...
3-AQC
T8475CAS 201216-42-4
3-AQC is a competitive antagonist of 5-HT3.
Isobutyryl-L-carnitine
T19381CAS 25518-49-4
Isobutyryl-L-carnitine is a member of the class of compounds known as acylcarnitines. Isobutyryl-L-carnitine is a product of the acyl-CoA dehydrogenases.
Neocarzinostatin
T16283CAS 9014-02-2
Neocarzinostatin is an effective DNA-damaging, anti-tumor antibiotic. It recognizes double-stranded DNA bulge and induces DNA double strand breaks (DSBs). Neocar...
Alprenolol hydrochloride
T22236CAS 13707-88-5
Alprenolol hydrochloride is a non-selective blocker of beta, and also is a antagonist of5-HT1A receptor.
Ogerin
T16378CAS 1309198-71-7
Ogerin is a selective GPR68 positive allosteric modulator (pEC50: 6.83). Ogerin blocks recall in fear conditioning in mice. Ogerin displays inverse agonist and a...
Opiranserin
T16399CAS 1441000-45-8
Opiranserin is a development as an injectable agent for the treatment of postoperative pain. Opiranserin is a non-opioid and non-NSAID analgesic candidate and is...
Org-12962
T16401CAS 132834-56-1
Org-12962 is an effective and selective 5-HT2C receptor agonist pEC50: 7.01). Org-12962 shows antiaversive effects in a rat model of panic-like anxiety. Org-129...
Pancopride
T16433CAS 121650-80-4
Pancopride is a new effective and selective antagonist of the 5-HT3 receptor.
PNU-142633
T16556CAS 187665-65-2
PNU-142633 has anti-migraine efficacy. PNU-142633 is a high affinity and selective 5-HT1D receptor agonist (Kis of 6 nM and > 18 000 nM for human 5-HT1D receptor...
Lintopride
T15760CAS 107429-63-0
Lintopride is an antagonist of 5HT4. It has moderate 5HT3 antagonist properties.
PRX-08066
T16669CAS 866206-54-4
PRX-08066 is a selective 5-hydroxytryptamine receptor 2B (5-HT2BR, IC50= 3.4 nM) antagonist that induces selective vasodilation of pulmonary arteries.
Pumosetrag Hydrochloride
T16683CAS 194093-42-0
Pumosetrag Hydrochloride is an orally available 5-HT3 partial agonist. It is developed for the treatment of irritable bowel syndrome and gastroesophageal reflux ...
Flesinoxan
T16711CAS 98206-10-1
Flesinoxan is a hypotensive agent and is an effective, high affinity, and selective 5-hydroxytryptamine1A receptor agonist (EC50: 24 nM).
Lesopitron dihydrochloride
T11839CAS 132449-89-9
Lesopitron dihydrochloride with IC50 of 125 nM in rat hippocampal membranes, is a full and selective 5-HT1A receptor agonist.
Ritanserin
T16759CAS 87051-43-2
Ritanserin is a highly effective, relatively selective, long-acting antagonist of 5-HT2 receptor (IC50: 0.9 nM), less active on Histamine H1, Dopamine D2, Adren...
Rodatristat ethyl
T16779CAS 1673571-51-1
Rodatristat ethyl decreases the level of 5-HT and significantly reduces pulmonary arterial hypertension. Rodatristat ethyl is a first-in-class oral tryptophan hy...
(S)-Mirtazapine
T12632LCAS 61337-87-9
(S)-Mirtazapine is an S(+)-enantiomer of Mirtazapine. (S)-Mirtazapine is a stereoselective 5-HT2 receptor antagonist.
Masupirdine free base
T11948CAS 701205-60-9
Masupirdine free base (SUVN-502 free base) shows high selectivity over 5-HT2A receptor and other 100 target sites, and has potential for treatment of Alzheimer's...
p-MPPI hydrochloride
T16421CAS 220643-77-6
p-MPPI hydrochloride is a selective antagonist of 5-HT1A receptor, and has antidepressant and anxiolytic-like effects.
Iferanserin
T15552CAS 58754-46-4
Iferanserin (S-MPEC) is a selective antagonist of the 5-HT receptor (serotonin receptor) with an affinity for 5-HT2A receptors. Iferanserin has the potential fo...
SB228357
T16856CAS 181629-93-6
SB228357 is a selective and potent 5-HT2C/2B receptor antagonist (pKi: 6.9, 8.0, and 9.0 for 5-HT2A, 5-HT2B and 5-HT2C, respectively).
Eplivanserin mixture
T11216CAS 130581-13-4
Eplivanserin mixture is a selective serotonin reuptake inhibitor and a 5-HT2A receptor antagonist,
SB-399885 hydrochloride
T12843CAS 402713-81-9
SB-399885 hydrochloride is an antagonist of 5-HT6 receptor.
SB 258719
T12855CAS 195199-95-2
SB 258719 is a selective antagonist of 5-HT7 receptor(pKi of 7.5).
SEP-363856 hydrochloride
T12899LCAS 1310422-41-3
SEP-363856 hydrochloride is an agent of orally active and CNS active psychotropic with a unique, non-D2/5-HT2A mechanism of action, exerts its antipsychotic-lik...
5-HT3 antagonist 2
T12988CAS 128199-93-9
5-HT3 antagonist 2 is an antagonist of 5-HT3 receptor.
ST1936 oxalate
T13007CAS 1782228-83-4
ST1936 oxalate is a selective, nanomolar affinity agonist of 5-HT6 receptor(Ki values of 13 nM, 168 nM and 245 nM for human 5-HT6, 5-HT7 and 5-HT2B receptors, re...
Sulamserod
T13021CAS 219757-90-1
Sulamserod is an antagonist of 5-HT4 receptor, has antiarrhythmic activities.
Tedatioxetine hydrobromide
T13110CAS 960151-65-9
Tedatioxetine hydrobromide is an inhibitor of triple reuptake and antagonist of 5-HT2A, 5-HT2C, 5-HT3 and α1A-adrenergic receptor.
EMDT oxalate
T11183CAS 263744-72-5
EMDT oxalate is a selective 5-HT6 agonist, and has antidepressant effects.
Eplivanserin
T11217CAS 130579-75-8
Eplivanserin was a potent selective oral 5-HT2 receptor antagonist, with a cortical membrane IC50 of 5.8 nM and a Kd of 1.14 nM in rats.
cis-Urocanic acid
T10824CAS 7699-35-6
cis-Urocanic acid is a 5-HT2A receptor agonist (Kd: 4.6 nM). It is an immune modulator that induces immunosuppression by binding to the 5-HT2A receptor.
FK1052 hydrochloride
T11293CAS 129299-81-6
FK1052 hydrochloride is a potent 5-HT3 and 5-HT4 receptor dual antagonist.
Flumexadol
T11302CAS 30914-89-7
Flumexadol is a selective and affinity 5-HT2C receptor agonist with a Ki of 25 nM for the (+)-enantiomer of Flumexadol, and is 40-fold selective over the 5-HT2A ...
Frovatriptan succinate hydrate
T11326CAS 158930-17-7
Frovatriptan succinate hydrate is effective in treating the full spectrum of migraine including the associated symptoms of nausea, vomiting, photophobia, and pho...
Befiradol hydrochloride (208110-64-9 free base)
T10495CAS T10495
Befiradol (NLX-112) hydrochloride is a selective agonist of the 5-HT1A receptor.
Brexpiprazole S-oxide
T10612CAS 1191900-51-2
Brexpiprazole S-oxide (DM-3411) is a main metabolite of Brexpiprazole. Brexpiprazole is a partial agonist of human 5-HT1A and dopamine receptors (Kis: 0.12 nM an...
Brexpiprazole S-oxide D8
T10611CAS T10611
Brexpiprazole S-oxide D8 (DM-3411 D8) is a deuterium labeled Brexpiprazole S-oxide. Brexpiprazole S-oxide is a main metabolite of Brexpiprazole. Brexpiprazole is...
Vabicaserin hydrochloride
T13275CAS 887258-94-8
Vabicaserin hydrochloride is a selective agonist of 5-hydroxytryptamine 2C (5-HT2C) receptor (EC50: 8 nM).
Wf-516
T13339CAS 310392-94-0
Wf-516 is a 5-HT reuptake inhibitor (Kis: 5 nM and 40 nM for 5-HT1A receptor and 5-HT2A receptor in humans, respectively), and with potent antidepressant activit...
Masupirdine mesylate
T11949CAS 1791396-46-7
Masupirdine mesylate (SUVN-502 mesylate) shows high selectivity over 5-HT2A receptor and other 100 target sites, and has potential for treatment of Alzheimer's d...
Temanogrel
T17033CAS 887936-68-7
Temanogrel is a highly selective antagonist of the 5-HT2A receptor (Ki: 4.9 nM).
SB 243213 hydrochloride
T12859CAS 200940-23-4
SB 243213 hydrochloride is an orally active, selective and high-affinity antagonist of 5-hydroxytryptamine (5-HT)2C receptor(pKi of 9.37 and a pKb of 9.8).It has...
Lurasidone
T21337CAS 367514-87-2
Lurasidone is an antagonist of both dopamine D2 and 5-HT7(IC50=1.68 and 0.495 nM, respectively).It also a partial agonist of 5-HT1A receptor(IC50 : 6.75 nM).
4F 4PP oxalate
T22514CAS 144734-36-1
4F 4PP oxalate is a 5-HT2A antagonist.
MK 212 hydrochloride
T22987CAS 61655-58-1
MK 212 hydrochloride is a 5-HT2C receptor agonist
PNU 22394 hydrochloride
T23168CAS 15923-42-9
PNU 22394 hydrochloride is a 5-HT2C agonist and partial 5-HT2A/5-HT2B agonist
SB 203186 hydrochloride
T23310CAS 207572-69-8
SB 203186 hydrochloride is a potent 5-HT4 receptor antagonist
SB 204741
T23312CAS 152239-46-8
5-HT2B receptor antagonist
SR 57227 hydrochloride
T23394CAS 77145-61-0
SR 57227 hydrochloride is a potent, orally active and selective 5-HT3 receptor agonist. It with ability to cross the blood brain barrier. It has affinities (IC50...
Naratriptan
T8666CAS 121679-13-8
Naratriptan is a selective agonist of 5-HT1 receptor and is is used for the treatment of migraine headaches.
SKF-83566
T8702CAS 99295-33-7
SKF-83566 is a blood-brain permeable and orally active antagonist of D1-like dopamine receptor and a weaker competitive 5-HT2 receptor antagonist with Ki of 11 n...
NLX-204 hydrochloride(2170405-10-2 free base)
T22379LCAS T22379L
NLX-204 hydrochloride is a potent and selective ERK1/2 phosphorylation-preferring serotonin 5 HT1A receptor agonist(pKi = 10.19).
Onitisin
TN4713CAS 53823-03-3
Onitisin, onitinoside and onitin can inhibit the contraction of isolated guinea-pig ileum.
NLX-204 hydrochloride(2170405-10-2 free base)
T22379LCAS T22379L
NLX-204 hydrochloride is a potent and selective ERK1/2 phosphorylation-preferring serotonin 5 HT1A receptor agonist(pKi = 10.19).
Almotriptan
T21231CAS 154323-57-6
Almotriptan is a 5-HT1B/1D-receptor agonist used to treat migraine.Almotriptan is a triptan drug for treatment of migraine headaches.Binding of the drug to the r...
Clomipramine
T21013CAS 303-49-1
Clomipramine is a tricyclic antidepressant (TCA). It is used for the treatment of the panic disorder, obsessive-compulsive disorder, major depressive disorder, a...
Ramosetron hydrochloride
T4562LCAS 132907-72-3
Ramosetron hydrochloride is a serotonin 5-HT3 receptor antagonist. It is used to treat diarrhea-predominant irritable bowel syndrome and nausea.
PRX-07034
T8720CAS 903580-39-2
PRX-07034 is a selective antagonist of 5-HT6 receptor. It has cognition and memory-enhancing properties and potently decreases food intake and body weight in rod...
R-Lorcaserin hydrochloride hemihydrate
T8757CAS 856681-05-5
R-Lorcaserin hydrochloride hemihydrate is a selective 5HT2C serotonin receptor agonist.
GR 125743
T8737CAS 148547-33-5
GR 125743 is a novel antagonist of 5-HT1B/1D receptor.
GR 125743
T8737CAS 148547-33-5
GR 125743 is a novel antagonist of 5-HT1B/1D receptor.
trans-Methylisoeugenol
TN5166CAS 6379-72-2
(E)-Methyl isoeugenol (trans-Methylisoeugenol) is a natural food flavour, it also has anxiolytic and antidepressant like properties. Eugenol methyl ether(trans-M...
Moschamine
TMA1122CAS 68573-23-9
Moschamine is a very potent compound that is able to inhibit COX-I by 58% and COX-II by 54%, at the concentration of 0.1 μmol L⁻1, it may suppress cAMP fo...
TIK-301
T17095CAS 118702-11-7
TIK-301 is a chlorinated melatonin derivative and a potent, high-affinity, and orally active melatonin MT1 and MT2 receptors agonist (Kis: 0.081 nM and 0.042 nM,...
Palonosetron
T22393CAS 135729-61-2
Palonosetron, a 5-HT3 antagonist with Ki of 0.17 nM, is used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV).
WAY 163909
T17253CAS 428868-32-0
WAY 163909 is an effective and selective agonist of the 5-HT(2C) receptor (Ki: 10.5±1.1 nM).
YM348
T17275CAS 372163-84-3
YM348 is an effective and orally active 5-HT2C receptor agonist. YM348 also shows a high affinity for the cloned human 5-HT2C receptor (Ki: 0.89 nM).
Zatosetron maleate
T17285CAS 123482-23-5
Zatosetron maleate is an effective and selective antagonist of the 5HT3 receptor.
Cinitapride Hydrogen Tartrate
T22294CAS 1207859-16-2
Cinitapride Hydrogen Tartrate is a gastroprokinetic agent that acts as an antagonist of the 5-HT2 receptors and as an agonist of the 5-HT1 and 5-HT4 receptors
Cisapride hydrate
T22296CAS 260779-88-2
Cisapride acts directly as a selective agonist of serotonin 5-HT4 receptor with IC50 value of 0.483 μM. And It also acts indirectly as a parasympathomimetic.
Granisetron
T22340CAS 109889-09-0
Granisetron, a serotonin receptor (5HT-3 selective) antagonist, is used as an antinauseant and antiemetic for cancer chemotherapy.
MDL 100009
T22359CAS 175673-57-1
MDL 100009, the S-enantiomer of MDL 100151 and the opposite enantiomer of MDL 100907, is a selective antagonist of 5-HT2A.
MDL 100009
T22359CAS 175673-57-1
MDL 100009, the S-enantiomer of MDL 100151 and the opposite enantiomer of MDL 100907, is a selective antagonist of 5-HT2A.
Sevoflurane
T22425CAS 28523-86-6
Sevoflurane, a noncompetitive inhibitor of 5-HT3 receptor, acts as a low-soluble inhalation anesthetics.
Galanolactone
TN4092CAS 115753-79-2
Galanolactone has anti-5-HT effect, a diterpenoid isolated from ginger, is related to antagonism of 5-HT3 receptors, it has inhibit nitric oxide production with ...
Tropisetron
T22448CAS 89565-68-4
Tropisetron is a α7-nicotinic receptor agonist and 5-HT3 receptor antagonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor.
RU 24969
T8593CAS 66611-26-5
RU 24969 is a selective agonist of 5-HT1A and 5-HT1B receptors.
Daurinoline
T2S0118CAS 2831-75-6
Daurinoline is a non-competitive antagonist, it exerts marked relaxation effect on basilar artery of rabbits through non-competitive antagonism, it would have a ...
L-Stepholidine
T2S1397CAS 16562-13-3
L-Stepholidine, which has dual actions on dopamine D1 and D2 receptors, attenuates heroin self-administration and cue-induced reinstatement. It also elicits anti...
Escin IB
T5S1389CAS 26339-90-2
Escin Ib inhibits gastric emptying, at least in part, mediated by capsaicin-sensitive sensory nerves, to stimulate the synthesis and/or release of dopamine, to a...
1-Hydroxy-2,3,4,7-tetramethoxyxanthone
TN2533CAS 14103-09-4
1-Hydroxy-2,3,4,7-tetramethoxy-xanthone has vasodilatory action, it can cause vasodilation in the coronary artery pre-contracted with 1uM 5-hydroxytryptamine (5-...
1-Hydroxy-2,3,5-trimethoxyxanthone
TN2534CAS 22804-49-5
1-Hydroxy-2,3,5-trimethoxyxanthone (HM-1) has vasodilator action ,which involves both an endothelium-dependent mechanism involving NO and an endothelium-independ...
7-Hydroxycadalene
TN3235CAS 2102-75-2
7-Hydroxycadalene shows cytotoxicity activity against HCT-15 cell line with IC50 18.89 ± 1.2 uM.
alpha-Yohimbine
TN3393CAS 131-03-3
Alpha-Yohimbine is a 5-HT1A receptor agonist, it is strong selective 2-adrenoceptor antagonist. Alpha-Yohimbine possess aphrodisiac effect.
SB-269970
T12842CAS 201038-74-6
SB-269970 is a antagonist of 5-HT7 receptor(pKi of 8.3).
SB 243213 dihydrochloride
T12859LCAS 1780372-25-9
SB 243213 dihydrochloride is an orally active, selective and high-affinity antagonist of 5-hydroxytryptamine (5-HT)2C receptor(pKi of 9.37 and a pKb of 9.8 for h...
LP-211
T5387CAS 1052147-86-0
LP-211 is a brain penetrant selective agonist for a 5-HT7 receptor (Ki: 0.58 nM), and >300-fold selectivity over the 5-HT1A receptor.
p-Hydroxyphenethyl trans-ferulate
TN2030CAS 84873-15-4
P-Hydroxyphenethyl trans-ferulate exhibits affinity toward 5-HT(7) receptors in a competitive binding assay. P-Hydroxyphenethyl trans-ferulate can double quinone...
SB-200646
T8357CAS 143797-63-1
SB-200646 is a selective and potent antagonist of 5-HT2B/5-HT2C receptor
Geissoschizine methyl ether
TN1032CAS 60314-89-8
Geissoschizine methyl ether, a major indole alkaloid found in Uncaria hook, is a major active component of Yokukansan with psychotropic effects. Geissoschizine m...
Auraptenol
TN1415CAS 1221-43-8
Auraptenol possesses robust antidepressant-like efficacy in mice.
Cannabigerol
TN1465CAS 25654-31-3
Cannabigerol is a high affinity α±2-adrenergic receptor agonist, moderate affinity 5-HT1A receptor antagonist, and low affinity CB1 receptor antagonist ; also ...
D-Menthol
TN1544CAS 15356-60-2
D-Menthol is a common compound in pharmaceutical and commercial products and a popular additive to cigarettes, it attenuates α±7 mediated Ca 2+ transients in t...
Homoeriodictyol
TN1740CAS 446-71-9
Homoeriodictyol, a naturally occurring, bitter-masking flavanone, as a promising agent to increase appetite and food intake. The flavanone homoeriodictyol can in...
Hyperforin
TN1755CAS 11079-53-1
Hyperforin acts as an angiogenesis inhibitor, it as a possible antidepressant component of hypericum extracts.
Jujuboside B1
TN1812CAS 68144-21-8
Jujubosides have hypnotic effect on normal rats, may be influenced by circadian rhythm and the serotonergic system may involve in the hypnotic effect of jujubosi...
Pteropodine
TN2116CAS 5629-60-7
Pteropodine acts as a positive modulator of muscarinic M(1) and 5-HT(2) receptors. Pteropodine shows antigenotoxic, antioxidant and lymphocyte induction effects,...
Tianeptine
T8140CAS 72797-41-2
Tianeptine is a selective 5-HT uptake facilitator in vitro and in vivo.
Lasmiditan succinate
T8413CAS 439239-92-6
Lasmiditan succinate is a 5-ht (1F) receptor agonist acting on the central nervous system(Ki value of 2.21 nM).
Lerisetron
T8441CAS 143257-98-1
Lerisetron is an antagonist of serotonin type 3 (5-HT3) receptor, with antiemetic activity.
Dapoxetine HCl
T6461CAS 129938-20-1
Dapoxetine HCl is a selectivity short-acting serotonin reuptake inhibitor, used for the therapy of premature ejaculation.
Mirtazapine D3
T12046CAS 1216678-68-0
Mirtazapine D3 is a deuterium labeled Mirtazapine. Mirtazapine is an inhibitor of 5-HT receptor .
Nexopamil racemate
T12215CAS 116759-35-4
Nexopamil racemate is the racemate of Nexopamil. Nexopamil is a combined Ca2+/5-HT2 antagonist on platelet aggregation in vitro and on thrombus formation in vivo...
NPS ALX Compound 4a dihydrochloride
T12262LCAS 1781934-44-8
NPS ALX Compound 4a dihydrochloride is a potent and selective antagonist of 5-HT6 receptor (IC50 of 7.2 nM)
NPS ALX Compound 4a
T12262CAS 299433-10-6
NPS ALX Compound 4a is a potent and selective antagonist of 5-HT6 receptor (IC50 of 7.2 nM)
Pimethixene maleate
T12489LCAS 13187-06-9
Pimethixene maleate is a highly potent5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4 as well as muscarinic M1 and M2 receptors antagonist(wit...
Lasmiditan hydrochloride
T8398CAS 613677-28-4
Lasmiditan hydrochloride is a novel, centrally acting, highly selective 5-HT(1F) receptor agonist (K1:2.21 μM)
Perospirone hydrochloride
T8136CAS 129273-38-7
Perospirone hydrochloride is an atypical antipsychotic agent for the treatment of schizophrenia.  It also displays affinity towards 5HT1A receptors as a partial...
Pipamperone
T12480CAS 1893-33-0
Pipamperone is a high-affinity 5-HT2A receptor and D4 receptor antagonist (pKi of 8.2 and 8.0,respectively) .
Nelotanserin
T7350CAS 839713-36-9
Nelotanserin is a potent 5-HT2A inverse agonist(IC50 : 1.7 nM), a moderately potent 5-HT2C partial inverse agonist t(IC50 :79 nM )and a weak 5-HT2B inverse agoni...
Ansofaxine hydrochloride
T5380CAS 916918-84-8
Ansofaxine (LY03005; LPM570065) is a serotonin-norepinephrine-dopamine reuptake inhibitor (IC50s: 723, 763 and 491 nM, respectively).
Volinanserin
T5389CAS 139290-65-6
Volinanserin (MDL 100907) is a potent and selective antagonist of the serotonin receptor 5-HT2 (Ki: 0.36 nM) and shows 300-fold selectivity for 5-HT2 receptor ov...
5-Methoxytryptamine
T5271CAS 608-07-1
5-Methoxytryptamine is a tryptamine derivative that acts as a full agonist at the 5-HT1, 5-HT2, 5-HT4, 5-HT6, and 5-HT7 receptors.
Sertindole
T5858CAS 106516-24-9
Sertindole is an atypical antipsychotic that binds to dopamine D2 receptors and the serotonin (5-HT) receptor subtypes 5-HT1D, 5-HT2A, and 5-HT2C (Kds = 2.7, 20,...
idalopirdine
T7103CAS 467459-31-0
Idalopirdine, a selective 5-HT6 receptor antagonist( Ki : 0.83 nM),as a treatment for Alzheimer's disease.
Phenylbiguanide
T7135CAS 102-02-3
Phenylbiguanide is a 5-HT3 receptor selective agonist(EC50 : 3.0±0.1 μM)
SB 242084 dihydrochloride hydrate
T7277CAS 181632-25-7
SB 242084 dihydrochloride hydrate is a psychoactive drug and research chemical which acts as a selective antagonist for the 5HT2C receptor.
F-15599
T7281CAS 635323-95-4
F-15599 is a highly selective G-protein biased 5-HT1A receptor agonist(Ki : 3.4 nM).
Eltoprazine hydrochloride
T7498CAS 98206-09-8
Eltoprazine hydrochloride is a partial agonist at serotonin 5-HT1A, 5-HT1B, and 5-HT2B receptors (Ki value of 40, 52, and 81 nM, respectively).
Mosapride
T8128CAS 112885-41-3
Mosapride is a selective 5HT4 agonist
Tandospirone citrate
T7412CAS 112457-95-1
Tandospirone citrate is a potent and selective 5-HT1A receptor partial agonist (Ki : 27 nM)
RS 127445
T7519CAS 199864-86-3
RS 127445 is a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist(pKi : 9.5).
Azaphen
T7521CAS 24853-80-3
Azaphen is the reuptake of serotonin inhibitor.with antidepressant action and has sedative effects, suggesting antihistamine activity.
6-fluoro-DL-Tryptophan
T7694CAS 7730-20-3
6-fluoro-DL-Tryptophan is an inhibitor of serotonin (5-HT) synthesis.
lumateperone Tosylate
TQ0084CAS 1187020-80-9
Lumateperone Tosylate is a 5-HT2A receptor antagonist (Ki: 0.54 nM), a SERT blocker (Ki: 61 nM), a partial agonist of presynaptic D2 receptors and an antagonist ...
CP-809101
TQ0130CAS 479683-64-2
CP-809101 is an effective and selective 5-HT2C receptor agonist (pEC50: 9.96/7.19/6.81 for human 5-HT2C/5-HT2B/5-HT2A receptors).
GSK163090
TQ0311CAS 844903-58-8
GSK163090 is a specific and orally active 5-HT1A/B/D receptor antagonist (pKis: 9.4/8.5/9.7, and 6.3/6.7 for 5-HT1A/B/D, and dopamine D2/D3).
Tandospirone
TQ0315CAS 87760-53-0
Tandospirone (SM-3997) is a selective partial agonist of 5-HT1A receptor (Ki: 27 nM) that displays selectivity over SR-2, SR-1C, α1, α2, D1 and D2 receptors (K...
Pimethixene
T12489CAS 314-03-4
Pimethixene is a highly potent 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4 as well as muscarinic M1 and M2 receptors antagonist(pKis of 7....
PRX933 hydrochloride
T12565CAS 639029-42-8
PRX933 hydrochloride is an agonist of 5-HT2c receptor.
SB-224289 hydrochloride
T12841CAS 180084-26-8
SB-224289 hydrochloride is a selective antagonist of 5-HT1B receptor, with anxiolytic effect.
Cinanserin hydrochloride
T14968CAS 54-84-2
Cinanserin hydrochloride is a selective and highly affinity 5-HT2 receptor antagonist (Ki: 41 nM). It has a much higher binding affinity for the 5-HT2 than for t...
Agomelatine (L(+)-Tartaric acid)
T10267CAS 824393-18-2
Agomelatine (S-20098) L(+)-Tartaric acid is a specific agonist of MT1 and MT2 receptors (Kis: 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and ...
AM9405
T10294CAS T10294
AM9405 is a novel peripherally active cannabinoid type 1 (CB1) and serotonin type 3 receptor agonist. It inhibits twitch contraction of the ileum and the colon (...
AP521
T10344CAS 151227-08-6
AP521 is an agonist of the human 5-HT1A receptor (IC50: 94 nM).
Arotinolol
T10371CAS 68377-92-4
Arotinolol is a nonselective α/β-adrenergic receptor blocker and a vasodilating β-blocker. Arotinolol also shows potency for inhibiting the binding of the rad...
AS19
T10380CAS 1000578-26-6
AS19 is a potent, selective 5-HT7 receptor agonist (IC50: 0.83 nM; Ki: 0.6 nM). AS19 is selective for 5-HT7 over 5-HT1A, 5-HT1B, 5-HT1D, and 5-HT5A receptors (Ki...
Brilaroxazine
T14782CAS 1239729-06-6
Brilaroxazine (RP5603) is a partial agonist of dopamine (DA) D2, D3, and D4 receptors, 5-HT1A (Ki: 1.5 nM) and 5-HT2A (Ki: 2.5 nM), and has antagonist activity a...
Bromperidol
T14830CAS 10457-90-6
Bromperidol is a butyrophenone derivative and is used as an antipsychotic in the treatment of schizophrenia.
Cabergoline
T14853CAS 81409-90-7
Cabergoline is an ergot derived-dopamine D2-like receptor agonist. It has high affinity for D2, D3, and 5-HT2B receptors (Ki=0.7, 1.5, and 1.2, respectively).Cab...
Clocapramine
T10837LCAS 47739-98-0
Clocapramine is a D2 and 5-HT2A receptors antagonist.
(R)-Praziquantel D11
T12638CAS 1399880-38-6
(R)-Praziquantel D11 is the deuterium labeled (R)-Praziquantel. (R)-Praziquantel is the active enantiomer of Praziquantel, is a partial the human 5-HT2B receptor...
Cyamemazine
T15026CAS 3546-03-0
Cyamemazine, contains the phenothiazine chromophore, is a neuroleptic agent used as an anxiolytic. Cyamemazine is a potent 5-HT3 (Ki: 12 nM), 5-HT2A (Ki: 1.5 nM)...
Roluperidone
T15034CAS 359625-79-9
Roluperidone is a novel cyclic amide derivative. It has high equipotent affinities for 5-HT2A and σ2 receptors (Ki of 7.53 nM and 8.19 nM for 5-HT2A and σ2).
Desmethyl cariprazine
T15100CAS 839712-15-1
Desmethyl cariprazine is a Cariprazine active metabolite. Cariprazine, an antipsychotic drug candidate, shows a high affinity for the D3 (Ki: 0.085 nM) and D2 (K...
Didesmethyl cariprazine
T15117CAS 839712-25-3
Cariprazine is an antipsychotic drug candidate. It shows high affinity for the D3 and D2 receptors, and moderate affinity for the 5-HT1A receptor. Didesmethyl ca...
Fananserin
T15270CAS 127625-29-0
Fananserin is an orally bioavailable and selective antagonist of the 5-HT2 receptor (Ki: 0.37 nM for the rat 5-HT2A receptor). It also is an antagonist of dopami...
GR 113808
T15414CAS 144625-51-4
GR 113808 displays 300-fold selectivity over 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C and 5-HT3 receptors. GR 113808 is a potent and highly selective antagonist of 5-HT4 ...
RS102895 hydrochloride
T12773CAS 1173022-16-6
RS102895 hydrochloride is a potent antagonist of CCR2(IC50 of 360 nM).
(S)-Mirtazapine D3
T12806CAS T12806
(S)-Mirtazapine D3 is a deuterium labeled (S)-Mirtazapine. (S)-Mirtazapine is a stereoselective antagonist of 5-HT2 receptor. (S)-Mirtazapine is metabolized by C...
RG-12915
T12716CAS 136174-04-4
RG-12915 is a selective antagonist of 5-HT3(IC50 value of 0.16 nM).
(R)-Mirtazapine
T12632CAS 61364-37-2
(R)-Mirtazapine is a R(−)-enantiomer of Mirtazapine with antinociceptive properties in an animal model of acute thermal nociception. (R)-Mirtazapine is a antag...
2-Methyl-5-HT
T10075CAS 78263-90-8
2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist with anti-depressive-like effects.
5HT6-ligand-1
T10053CAS 1038988-11-2
5HT6-ligand-1 is a potent 5-HT6 receptor ligand (Ki: 1.43 nM).
2-Methyl-5-HT hydrochloride
T10075L2CAS 845861-49-6
2-Methyl-5-HT hydrochloride (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist with anti-depressive-like effects.
3-Hydroxy agomelatine
T10114CAS 166526-99-4
3-Hydroxy agomelatine is an Agomelatine metabolite and a 5-HT2C receptor antagonist (IC50: 3.2 μM; Ki: 1.8 μM).
3-Hydroxy agomelatine D3
T10113CAS 1079774-23-4
3-Hydroxy agomelatine D3 is a deuterium labeled 3-Hydroxy agomelatine. 3-Hydroxy agomelatine is an Agomelatine metabolite and a 5-HT2C receptor antagonist (IC50:...
5-HT1A modulator 1
T10168CAS 142477-34-7
5-HT1A modulator 1 displays very high affinities for the 5HT1A, adrenergic α1, and dopamine D2 receptor (IC50s: 2 nM, 10 nM and 40 nM).
5-HT2A antagonist 1
T10498CAS 204643-75-4
5-HT2A antagonist 1 is a 5-HT2A antagonist extracted from patent US5728835A and JP 1007727. It may be useful in the treatment of gastrointestinal disorders circu...
5-HT3 antagonist 3
T10162CAS 120635-47-4
5-HT3 antagonist 3 (Compound 15b) is a high-affinity 5-HT3 receptor antagonist. It binds to 5-HT3 receptors in rat brain cortical membranes (Ki: 0.25 nM).
5-HT3-In-1
T10006CAS 186348-68-5
5-HT3-In-1 (compound example 8) is extracted from patent EP0748807A1 with 5-HT3 inhibition activity.
5-HT4 antagonist 1
T10169CAS 261766-73-8
5-HT4 antagonist 1 is a 5-HT4 receptor antagonist (pKi: 9.6).
5-HT7 agonist 1
T10170CAS 334974-31-1
5-HT7 agonist 1 is a selective 5-HT7 receptor agonist (IC50: 222.93 nM), which can be used for the 5-HT7 receptor-related disease, such as CNS disorders.
(R)-Mirtazapine D3
T12631CAS T12631
(R)-Mirtazapine D3 is a deuterium labeled (R)-Mirtazapine.(R)-Mirtazapine is a antagonist of 5-HT3 receptor.
7-Desmethyl-3-hydroxyagomelatine
T10192CAS 166527-00-0
7-Desmethyl-3-hydroxyagomelatine is a metabolite of Agomelatine and has less activity than Agomelatine. Agomelatine is a melatonergic (MT1 and MT2) agonist and 5...
Dehydroaripiprazole
T10989CAS 129722-25-4
Dehydroaripiprazole is the active metabolite of aripiprazole. Aripiprazole is an antipsychotic drug, which is metabolized by CYP3A4 and CYP2D6 and mainly forms d...
Deramciclane
T10996CAS 120444-71-5
Deramciclane has high affinity for 5-HT2A and 5-HT2C receptors. It acts as an antagonist in both receptor subtypes and has inverse agonist properties for 5-HT2C ...
Donitriptan
T11075CAS 170912-52-4
Donitriptan is an effective agonist for the 5-HT1B/1D receptor, with pKis of 9.4 and 9.3, respectively.
2-Methyl-5-HT maleate
T10075LCAS 78263-91-9
2-Methyl-5-HT maleate (2-Methyl-5-hydroxytryptamine maleate) is a potent and selective 5-HT3 receptor agonist, which is shown to display anti-depressive-like eff...
PU-02
T8445CAS 313984-77-9
PU-02 is a potent and selective antagonist of 5-HT3 receptor.
4i
T8438CAS 930478-88-9
4i is a 5-HT3 receptor antagonist,It modulates the serotonergic system.
Alniditan
T14190CAS 152317-89-0
Alniditan is a receptors agonist of 5-HT1B/1D in HEK 293 cells (IC50: 1.7 and 1.3 nM). For 5-HT1B/1D receptors, the pKi values are 8.96 and 9.40, respectively....
Bemesetron
T14526CAS 40796-97-2
Bemesetron (MDL 72222) is an antagonist of 5-HT3 receptor (IC50: nM). It has Neuroprotective effect[2].
Rotundine
T2714CAS 10097-84-4
Rotundine is extracted from Corydalis yanhusuo W. T. Wang.