β-tubulin — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T13278	Valecobulin hydrochloride	CKD-516 hydrochloride	Microtubule Associated
	Valecobulin hydrochloride (CKD-516 hydrochloride) is a potent inhibitor of β-tubulin polymerization. Valecobulin hydrochloride is a valine prodrug and a vascular disrupting agent.		Microtubule Associated
TN2190	Scoulerine		Apoptosis , Beta-Secretase , BACE , Parasite
	Scoulerine is an inhibitor of ß-site amyloid precursor protein cleaving enzyme 1(BACE1). Scoulerine a potent antimitotic compound that inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells.		Apoptosis , Beta-Secretase , BACE , Parasite
T10460	Batabulin	T138067	Apoptosis , Microtubule Associated
	Batabulin (T138067) is an antitumor compound, which binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization. Batabulin affects cell morphology and leads to ce...		Apoptosis , Microtubule Associated
T4451	Estramustine phosphate sodium	Ro 21-8837/001,Estramustine phosphate disodium	Apoptosis , Microtubule Associated
	Estramustine phosphate sodium (Ro 21-8837/001) is an antimicrotubule chemotherapy agent; arrests prostate cancer cells in the G2/M phase of the cell cycle.		Apoptosis , Microtubule Associated
T6212	Combretastatin A4	CA4,CRC 87-09	Microtubule Associated
	Combretastatin A4 (CA4) is a microtubule-targeting agent that binds β-tubulin (Kd: 0.4 μM).		Microtubule Associated
T15236	Entasobulin		Microtubule Associated
	Entasobulin is an inhibitor of β-tubulin polymerization. It has a potential anticancer activity.		Microtubule Associated
T23446	TCS 2210		Others
	TCS 2210 is an inducer of neuronal differentiation in mesenchymal stem cells and increases the neuronal markers β-III tubulin expression and neuron-specific enolase expression.		Others
T6272	Fosbretabulin Disodium	Combretastatin A4 Phosphate,CA 4DP,CA 4P,Combretastatin A4 disodium phosphate,Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium	Apoptosis , Microtubule Associated
	Fosbretabulin Disodium (CA 4P), a water-soluble prodrug of Combretastatin A4 (CA4), is a microtubule-targeting agent that binds β-tubulin (Kd: 0.4 μM). Fosbretabulin Disodium(Combretastatin A4 disodium phosphate) inhibit...		Apoptosis , Microtubule Associated
T17228	Sabizabulin	ABI-231,VERU-111	Microtubule Associated
	Sabizabulin (ABI-231) is an effective and orally bioavailable inhibitor of α and β tubulin against panels of melanoma and prostate cancer cell lines. Sabizabulin inhibits tumor growth and metastatic phenotypes of cervica...		Microtubule Associated
T61401	3-(3-Phenoxybenzyl)amino-β-carboline
	3-(3-Phenoxybenzyl)amino-β-carboline is a highly effective tubulin inhibitor, selectively degrading αβ-tubulin heterodimers. It induces cell cycle arrest and apoptosis in the G2/M phase. Additionally, 3-(3-Phenoxybenzyl)...
T13278L	Valecobulin	CKD-516	Others
	Valecobulin is a potent β-tubulin polymerization inhibitor. Valecobulin is a valine prodrug of (S516) and an avascular disrupting compound.		Others
T16543	Pironetin		Microtubule Associated
	Pironetin binds to α-tubulin and is an effective inhibitor of microtubule polymerization. It also has cell cycle arrest and antitumor activity. Pironetin is an α/β unsaturated lactone isolated from Streptomyces species.		Microtubule Associated
T80923	Tubulin polymerization-IN-53
	Tubulin polymerization-IN-53 (compound 4b) serves as an inhibitor of β-tubulin polymerization and is capable of arresting the cell cycle at the G2/M stage. It demonstrates antiproliferative efficacy against the MDA-MB-23...
T40367	Combretastatin A-1 phosphate tetrasodium	Combretastatin A-1 phosphate tetrasodium,OXi-4503 tetrasodium
	Combretastatin A-1 phosphate (OXi-4503) tetrasodium, a prodrug of Combretastatin A-1, is a tubulin-binding microtubule polymerization inhibitor that targets the colchicine-binding site. By inducing tubulin depolymerizati...
T60802	Tubulin polymerization-IN-2
	Tubulin Polymerization-IN-2 is a powerful anticancer agent that targets β-tubulin, exhibiting an IC 50 of 0.92 μM. It demonstrates promising efficacy against a range of cancer cell lines including leukemia, non-small cel...
T63822	VEGFR-2-IN-22
	VEGFR-2-IN-22 (Compound 25) is an inhibitor of VEGFR-2 and β-tubulin polymerization with an IC50=19.82 nM for VEGFR-2. VEGFR-2-IN-22 is capable of inducing apoptosis.
T25043	Alestramustine
	Alestramustine is a cytostatic antineoplastic agent. The drug, via its active metabolites, binds to microtubule-associated proteins and β-tubulin and interferes with microtubule function, thereby suppressing cell divisio...
T41342	Batabulin sodium
	Batabulin sodium (T138067 sodium) is an antitumor agent, which covalently and selectively modifies the β-tubulin isotypes, thereby disrupting microtubule polymerization. Batabulin sodium affects cell morphology and leads...
T10704	CCB02		Microtubule Associated
	CCB02 is a selective CPAP-tubulin interaction inhibitor (IC50: 689 nM) with anti-tumor activity. CCB02 shows no inhibition on the cell cycle- and centrosome-related kinases, or the phosphorylation status of Aurora-A, CDK...		Microtubule Associated
T78798	MY-673
	MY-673, a colchicine binding site inhibitor (CBSI), impedes tubulin polymerization and disrupts the ERK signaling pathway, consequently modulating SMAD4 protein expression in the TGF-β/SMAD pathway. This compound effecti...