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(2)
By Target- PROTACs
- Wnt/beta-catenin(2)
- APC/C(1)
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By Target By ResearchField- Cancer(2)
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Results for "
xstax-vhll
" in TargetMol Product Catalog.- Inhibitors & Agonists2
- Peptide Products2
- xStAx-VHLLT36275Selective peptide-based β-catenin Degrader. Comprises a β-catenin-targeted stapled peptide, xStAx, linked to a VHL-binding peptide. Reduces β-catenin levels in HEK293T cells and colorectal cancer cell lines. Selectively degrades β-catenin over other Wnt signaling pathway components. Inhibits tumor growth in APCmin/+ mice, with constitutively active Wnt signaling, and reduces survival of patient-derived colorectal cancer cell organoids.
- $1,980
SizeQTY - xStAx-VHLL TFAT36275LxStAx-VHLL TFA is a β-catenin degrader formed by coupling xStAx to VHL ligand, has anti-cancer activity, inhibits Wnt signaling, and can be used in the study of cancer.
- $53
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