xmu-mp-1

XMU-MP-1 is a reversible and selective MST1/2 kinase inhibitor, and its IC50 values for MST1 and MST2 are 71.1 nM and 38.1 nM, respectively.

Fluconazole-PEG6-XMU-MP-9 is a PEG-linked conjugate of fluconazole and XMU-MP-9. Fluconazole is a triazole antifungal agent, while XMU-MP-9 enhances the interaction between Nedd4-1 and K-Ras, promoting the ubiquitination and degradation of multiple K-Ras mutants.

Fluconazole-C15-XMU-MP-9 is a fluconazole derivative modified with XMU-MP-9, which enhances the interaction between Nedd4-1 and K-Ras, promoting the ubiquitination and degradation of multiple K-Ras mutants, demonstrating anticancer potential. Fluconazole is an antifungal agent.

XMU-MP-9, a bifunctional compound, targets the C2 domain of Nedd4-1 and the allosteric site of K-Ras. It enhances the interaction and induces conformational changes within the Nedd4-1/K-Ras complex. Furthermore, XMU-MP-9 facilitates the ubiquitination and degradation of various K-Ras mutants and inhibits the proliferation of cells with these mutants. This compound is useful in cancer research.