wye

Wye is a biochemical.

WYE-125132 (WYE-132 (WYE-125132)) is a highly potent, ATP-competitive mTOR inhibitor with IC50 of 0.19 nM; highly selective for mTOR versus PI3Ks or PI3K-related kinases hSMG1 and ATR.

WYE-354(IC50=5 nM) is an effective, selective and ATP-competitive mTOR inhibitor. It blocks mTORC2 P-AKT(S473) and mTORC1 P-S6K(T389), not P-AKT(T308). The selectivity for mTOR is higher than PI3Kα (>100-fold) and PI3Kγ (>500-fold).

WYE-687 is an ATP-competitive and selective inhibitor of mTOR with an IC50 of 7 nM; it blocks mTORC1 pS6K(T389) and mTORC2 P-AKT(S473) without affecting P-AKT(T308). Its selectivity for mTOR is greater than PI3Kα (>100-fold) and PI3Kγ (>500-fold).

WYE-23 is an inhibitor of mammalian target of rapamycin (mTOR).

WYE-176182 is an apical sodium-dependent bile salt transporter (SLC10A2) inhibitor

WYE-687 dihydrochloride is an ATP-competitive inhibitor of mTOR, demonstrating potent activity with an IC50 value of 7 nM. It effectively suppresses the activation of both mTORC1 and mTORC2. Additionally, WYE-687 exhibits inhibitory effects on PI3Kα and PI3Kγ, with IC50 values of 81 nM and 3.11 μM, respectively.

Compound 28 (mTOR inhibitor WYE-28) is a selective inhibitor of mTOR (IC50=0.08 nM). Also inhibits PI3Kα (IC50 6 nM).

MDL-102234 is an adenosine A1 receptor antagonist.

HBY-793 is an HIV-1 proteinase inhibitor.