wee1 in 3

WEE1-IN-3 (JUN76288) is a potent Wee1 kinase inhibitor with an IC50 of <10 nM. It treatment of cancer and other proliferative diseases.

NSC-37445 has anti-tumor activity, such as inhibits growth of bladder tumor cells in a nude mice model , prevents the recurrence and progression of non-muscle-invasive urothelial cell carcinoma. NSC-37445 can significantly reduce the expression of CDK1-inhibitory kinases, Myt1 and Wee1, and cause cyclin B1 protein accumulation leading to CDK1 activation in T24 cells. 3. Flavokawain A (Flavokavain A) may exert anti-inflammatory responses by suppressing LPS-induced expression of pro-inflammatory mediators via blockage of NF-κB-AP-1-JNK/p38 MAPK signaling pathways in the murine macrophages.

SB405483 is a CRBN (cereblon) orthosteric ligand-binding enhancer that promotes the ubiquitination and proteasomal degradation of CRBN substrates (such as CK1α, Wee1, and IKZF1/3) by stabilizing the CRBN protein conformation and enhancing its binding affinity for substrates. SB405483 can be used in cancer research, such as in multiple myeloma and acute myeloid leukemia.

Aniline-piperazine-C3-NH-Boc (Compound Int-3) is a PROTAC linker utilized in the synthesis of Pomalidomide-C3-adavosertib and AZD1775 (a Wee1 inhibitor).