way 100635

WAY-100635 is a potent 5-HT 1A receptor antagonist with an IC50 = 0.91 nM that abrogates the reduction in hippocampal CA1 pyramidal neuron firing frequency during conditioned reflexes; it also acts as a dopamine D4 receptor agonist with an affinity of 3.3 nM.

WAY-100635 maleate is a selective 5-hydroxytryptamine 1A receptor antagonist with an IC50 value of 0.91 nM and a Ki value of 0.39 nM. It is also a dopamine D4 receptor agonist with pIC50 values of 8.9 and 6.6 for 5-HT1A and α1-adrenergic, respectively.

WAY-100635 Maleate is a specific and effective 5-HT receptor antagonist (IC50=0.95 nM).