vitiligo

Monobenzone (Benoquin) is a Depigmenting Agent. The mechanism of action of monobenzone is as a Melanin Synthesis Inhibitor. The physiologic effect of monobenzone is by means of Depigmenting Activity.

Khellin (Methafrone) is a vasodilator that also has bronchodilatory action.

Trioxsalen (Trioxysalen) is a furanocoumarin and a psoralen derivative, in conjunction with UV-A for phototherapy treatment of vitiligo and hand eczema. After photoactivation it creates interstrand cross-links in DNA, which can cause programmed cell death.

PPL agonist-1 (Compound I-3) is a highly selective agonist of Periplakin (PPL) that raises cAMP levels by modulating PPL, enhancing MITF expression, and consequently promoting melanin synthesis. Additionally, it stimulates melanin production by regulating tryptophan metabolism. Compared to Ruxolitinib, PPL agonist-1 demonstrates superior effectiveness and holds potential for vitiligo research.

Carpronium (Actinomin) chloride is a parasympathomimetic agent with a chemical structure resembling acetylcholine. It exhibits cholinergic and local vasodilatory effects, enhancing hair growth by expanding local blood vessels, stimulating the transition of hair from the resting phase to the growth phase, and activating parasympathetic nervous activity. Carpronium chloride is utilized in researching immune therapies for conditions such as alopecia areata, dry seborrheic dermatitis, and vitiligo.

Ammifurin is a Furocoumarin mixture used in treatment of vitiligo.

5-Hydroxy-8-methoxypsoralen (5-Hydroxyxanthotoxin) is a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450) and a metabolite of Xanthotoxin. It is used in the treatment of psoriasis, eczema, vitiligo, and certain cutaneous lymphomas in combination with phototherapy involving exposure to sunlight.

NI-0801 (Anti-CXCL10 / IP-1) is a CHO-expressed humanized monoclonal antibody targeting CXCL10/IP-10 for the study of vitiligo and biliary cirrhosis.

Trioxsalen (Standard) is the standard substance of Trioxsalen, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Trioxsalen (Trioxysalen) is a furanocoumarin and a psoralen derivative, in conjunction with UV-A for phototherapy treatment of vitiligo and hand eczema. After photoactivation it creates interstrand cross-links in DNA, which can cause programmed cell death.