vitamin k-1

Vitamin K1 (Phylloquinone) a fat-soluble, naturally occurring vitamin with antihemorrhagic and prothrombogenic activity.

Cis-Vitamin K1 is an endogenous metabolite of Vitamin K [1].

Vitamin K (Kephton) has blood coagulation action and is important for coagulation factors, matrix-Gla protein, and osteocalcin.

Vitamin K1 2,3-epoxide (Phylloquinone oxide) is reduced to vitamin k and is involved in the vitamin k cycle.

Vitamin K1-D4 is a deuterated compound of Vitamin K1. Vitamin K1 (T1075) has a CAS number of 84-80-0. Vitamin K1 (T1075) (Phylloquinone) is a naturally-occurring vitamin. Vitamin K1 (T1075) is essential for blood clotting, bone and vascular metabolism.

Vitamin K1-D7 is a deuterated compound of Vitamin K1.

Vitamin K1 (Standard) is the standard substance of Vitamin K1, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Vitamin K1 (Phylloquinone) a fat-soluble, naturally occurring vitamin with antihemorrhagic and prothrombogenic activity.

Vitamin K1 2,3-epoxide (Standard) is a reference standard for research and analysis in studies involving Vitamin K1 2,3-epoxide. Vitamin K1 2,3-epoxide (Phylloquinone oxide) is reduced to vitamin k and is involved in the vitamin k cycle.

Vitamin K1-[13C6] (Phytonadione) (Standard) is a reference standard of Vitamin K1-[13C6] (Phytonadione) intended for quantitative analysis, quality control, and related biochemical research applications.

Vitamin K1-D7 (Standard) is a reference standard of Vitamin K1-D7 intended for quantitative analysis, quality control, and related biochemical research applications. Vitamin K1-d7 is a deuterated compound of Vitamin K1.

Vitamin K1-D4 (Standard) is a reference standard of Vitamin K1-D4 intended for quantitative analysis, quality control, and related biochemical research applications. Vitamin K1-d4 is a deuterated compound of Vitamin K1. Vitamin K1 has a CAS number of 84-80-0. Vitamin K1 (Phylloquinone) is a naturally-occurring vitamin. Vitamin K1 is essential for blood clotting, bone and vascular metabolism.

Vitamin K1-[D7] 2,3-Epoxide (Standard) is a reference standard of Vitamin K1-[D7] 2,3-Epoxide intended for quantitative analysis, quality control, and related biochemical research applications.

Betrixaban maleate is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa.

Dicoumarol (Dicumarol) is a hydroxycoumarin originally isolated from molding sweet-clover hay, with anticoagulant and vitamin K depletion activities. Dicoumarol is a competitive inhibitor of vitamin K epoxidereductase; thus, it inhibits vitamin K recycling and causes depletion of active vitamin K in blood. This prevents the formation of the active form of prothrombin and several other coagulant enzymes, and inhibits blood clotting.

Tecarfarin (ATI-5923) is an orally active, potent vitamin K epoxide reductase (VKOR) antagonist and cannabinoid-1 receptor inverse agonist with antithrombotic activity, which attenuates abdominal pain and increases intestinal transit in mice.

mGluR1activator-1 is a stable vitamin K analog and mGluR1 activator capable of crossing the blood-brain barrier. It strongly activates transcription through steroid and xenobiotic receptors and retinoic acid receptors, effectively inducing neurogenesis in neural progenitor cells in mice. mGluR1activator-1 is applicable in studying neurodegenerative diseases, such as Alzheimer's.

PPM-18 (NSC 73233) is a potent anti-inflammatory agent that inhibits the expression of nitric oxide synthase, and also acts as an effective inhibitor of iNOS expression by blocking the binding of NF-κB to the promoter⁽¹⁾. As a vitamin K analog, this compound can also induce autophagy and apoptosis in bladder cancer cells through the ROS and AMPK signaling pathways⁽²⁾.

2-(Isopentylamino)naphthalene-1,4-dione is a vitamin K analog.1It inhibits spasms induced by pentylenetetrazole and tonic hindlimb extension induced by maximal electroshock (MES) in mice (ED50s = 349.2 and 108.1 mg/kg, respectively). It also protects mice against seizures in the 6 Hz psychomotor seizure test (ED50s = 152.7 and 263.7 mg/kg at stimulus intensities of 32 and 44 mA, respectively). 1.Li, X., Himes, R.A., Prosser, L.C., et al.Discovery of the first vitamin K analogue as a potential treatment of pharmacoresistant seizuresJ. Med. Chem.63(11)5865-5878(2020)

Betrixaban (PRT054021) is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa [1]. It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity [3]. Betrixaban, now developed by Portola Pharmaceuticals Inc., is prescribed as a venous thromboembolism (VTE) prophylactic for adult patients with moderate to severe restricted motility or with other risks for VTE [2]. VTE can be manifested as deep vein thrombosis or pulmonary embolism and it is a leading cause of preventable death in hospitalized patients [4].

Phenprocoumon is an antagonist of vitamin K(IC50:1 μM).

SARS-CoV-2-IN-67 (Compound 16), a vitamin K derivative, exhibits anti-SARS-CoV-2 properties with an effective concentration (EC50) of 64.8 μM in VeroE6/TMPRSS2 cells and inhibits SARS-CoV-2 RdRp activity [1].

SARS-CoV-2-IN-66 (1), a derivative of vitamin K, serves as an inhibitor of SARS-CoV-2, with an effective concentration (EC50) of 70.8 μM in VeroE6/TMPRSS2 cells [1].

Activated Protein C (390-404), human, a peptide derived from the vitamin K-dependent serine protease, effectively suppresses the anticoagulant activity of APC [1].

Osteocalcin (Osteocalcin (1-49)) (human) TFA is a vitamin K-dependent bone-specific protein. Osteocalcin (human) TFA exhibits chemotactic activity on several cell types typically found on bone remodeling surfaces.