uridine 5′-diphosphoglucose

Uridine 5′-diphosphoglucose-13C6(disodium) is the 13C-labeled analog of uridine 5′-diphosphoglucose disodium salt. Uridine 5′-diphosphoglucose disodium salt (UDP-D-Glucose disodium salt) serves as a precursor for glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids within animal tissues and certain microorganisms. Additionally, uridine 5′-diphosphoglucose disodium salt (UDP-D-Glucose disodium salt) functions as an agonist for the P2Y14 receptor, a GPCR in the neuroimmune system.

Uridine 5′-diphosphoglucose disodium salt (UDP-Glucose sodium salt) is an endogenous nucleotide sugar involved in glycosyltransferase reactions in metabolism. It is an agonist of the P2Y14 receptor (EC50 = 0.35 μM) and can also bind to and activate GPR17, inducing oligodendrocyte differentiation at a maximal concentration of 100 μM.

Uridine diphosphate glucose (UDP-glucose) is a pyrimidine nucleotide sugar, serving as a precursor for oligosaccharides, polysaccharides, glycoproteins, and glycolipids containing glucose. It is a key intermediate in carbohydrate metabolism and participates in numerous enzymatic reactions, acting as a P2Y14 agonist.

Potent and selective P2Y14 receptor agonist (EC50 = 0.92 nM). Exhibits >2000-fold selectivity over P2Y6. Das et al (2010) Human P2Y14 receptor agonists: truncation of the hexose moiety of uridine-5'-diphosphoglucose and its replacement with alkyl and aryl groups J.Med.Chem. 53 471 PMID:19902968 |Lazarowski et al (2015) UDP-sugars as extracellular signaling molecules: cellular and physiologic consequences of P2Y14 receptor activation. Mol.Pharmacol. 88 151 PMID:25829059

Uridine-5'-diphosphoglucose pyrophosphorylase is a biochemical reagent that serves as a biological material or organic compound, used in life sciences research.