unilateral nephrectomy

Deoxycorticosterone acetate (DOCA) is a steroid hormone produced by the adrenal glands, possessing mineralocorticoid activity and serving as a precursor to aldosterone. As an agonist of the mineralocorticoid receptor, DOCA can induce severe kidney damage, including inflammation, fibrosis, glomerular injury, and proteinuria. It is commonly used to establish animal models of chronic kidney injury and hypertension.

RO5234444 is an orally active CCR2 antagonist, exhibiting an IC50 of 22 nM for human CCR2 and 161 nM for mouse CCR2. It mitigates glomerulosclerosis in a unilateral nephrectomy type 2 diabetes db/db mouse model, reduces proteinuria, and significantly improves glomerular filtration rate. RO5234444 is applicable for research in type 2 diabetic nephropathy.