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Results for "
unc10112785
" in TargetMol Product Catalog- Inhibitors & Agonists1
UNC10112785
UNC-10112785, UNC 10112785
T68758748142-06-5
UNC10112785 is a novel and potent inhibitor of CDK8, CDK19, and CDK9 with IC50 values of 1.05 nM, 2.67 nM, and 19.9 nM, respectively, inducing MYC protein loss via both transcriptional and post-translational mechanisms. UNC10112785 suppresses pancreatic ductal adenocarcinoma (PDAC) growth under both anchorage-dependent and anchorage-independent conditions, causing substantial MYC depletion in two-dimensional and three-dimensional cell culture models.
- $293
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