triglyceride accumulation

GSK3987 is an LXR ligand. GSK3987 recruits the steroid receptor coactivator-1 to human LXRalpha and LXRbeta with EC50s of 40 nM.

Punicalagin is a major ellagitannin found in pomegranates that is reported to produce antioxidant, anti-inflammatory, and anticancer effects. It has been shown to prevent high-fat diet-induced obesity-associated accumulation of cardiac triglyceride and ch

ZG-2305 is a selective, orally active inhibitor of FIH with Ki values of 79.6 nM and 2786 nM for FIH and PHD2, respectively. It increases EGLN3 gene expression, reduces cellular triglyceride levels, and decreases lipid accumulation, making it suitable for obesity and fatty liver disease research.

NR4A1 agonist 1 is an NR4A1 agonist with a Ki value of 2.96 μM. It demonstrates significant lipid-lowering activity in 3T3-L1 adipocytes, with an EC50 of 0.13 μM, effectively reducing triglyceride (TG) accumulation and lipid droplet formation. NR4A1 agonist 1 is applicable in obesity-related research.

HD202A is an orally active, selective dual inhibitor of MNK1/MNK2 (with IC50 values of 6.09 nM and 8.06 nM, respectively; Kd values of 1.913 μM and 5.244 μM, respectively), and it inhibits the MNK-eIF4E signaling pathway. By downregulating perilipin 2 and SCD1 while upregulating adipose triglyceride lipase and PPARγ coactivator 1α, HD202A enhances mitochondrial fatty acid oxidation and redox homeostasis. This compound effectively curtails weight gain, hepatic lipid accumulation, and elevated serum lipid levels, while significantly improving glucose tolerance and insulin sensitivity, and reducing inflammatory characteristics. HD202A shows significant potential for research applications in metabolic dysfunction-associated fatty liver disease.

TLC-2716 is an orally active LXRα and LXRβ inhibitor, localized to the intestines and liver, with EC50 values of 7 nM and 15 nM, respectively. It suppresses the transcriptional activity of LXRα/β, downregulates genes involved in lipogenesis, lipid absorption, and lipoprotein metabolism, while preserving peripheral cholesterol reverse transport. TLC-2716 reduces lipid accumulation, inhibits the expression of inflammatory and fibrotic genes, enhances the clearance of triglyceride-rich lipoproteins, and improves glucose homeostasis and insulin sensitivity. In animal models and humanized liver mice, TLC-2716 lowers serum and hepatic triglyceride levels, plasma cholesterol levels, and other atherosclerosis-inducing lipid markers. It is applicable in research related to dyslipidemia and associated cardiometabolic disorders.

LP-856866 is an orally active ACSL5 inhibitor, exhibiting IC50 values of 8 nM for mouse ACSL5 and 4 nM for human ACSL5, while demonstrating IC50 values of 6 nM for mouse ACSL1 and 17 nM for human ACSL1. It induces delayed gastric emptying, enhances GLP-1 release, reduces food intake, decreases body weight and fat mass, preserves lean body mass, improves glucose homeostasis, boosts insulin sensitivity, reduces hepatic fat accumulation, and lowers serum triglyceride and total cholesterol levels. LP-856866 is applicable for studies on diet-induced obesity.

PD-1/PD-L1-IN-62 is a PD-L1 inhibitor and mTOR regulator. It inhibits PD-L1 with an IC50 of 6.9 nM and disrupts the PD-1/PD-L1 pathway-mediated immune suppression. By inhibiting mTOR phosphorylation and downregulating downstream target SREBP1, it significantly reduces cholesterol and triglyceride levels to decrease lipid accumulation. Additionally, PD-1/PD-L1-IN-62 enhances the infiltration of CD3+CD8+ T cells into tumor tissue, effectively inhibiting tumor growth. This compound is applicable in hepatocellular carcinoma research.

Euphorbiasteroid (Euphobiasteroid) (25-50 μM) decreased differentiation of 3T3-L1 cells via reduction of intracellular triglyceride (TG) accumulation.

PA-082 is a Novel partial agonist of peroxisome proliferator-activated receptor-γ (PPARγ), recruiting PPARγ-coactivator-1α, preventing triglyceride accumulation, and potentiating insulin signaling in vitro.

Urolithin D is a competitive and selective reversible antagonist of the EphA receptor, an ellagitannin colonic metabolite that inhibits EphA2 phosphorylation in prostate cancer cells, attenuates triglyceride accumulation in adipocytes and hepatocyte cultures, and may be used in the study of metabolic disorders.

PPARγ-IN-3 (compound 9ga), a potent and orally active PPARγ inhibitor, effectively reduces triglyceride (TG) accumulation and exhibits low cytotoxicity. Additionally, it prevents excessive body weight gain, lessens fat and liver mass, and decreases lipid accumulation in both the liver and blood. PPARγ-IN-3 holds promise for research into diet-induced obesity.

Secoisolariciresinol (Standard) is a reference standard for research and analysis in studies involving Secoisolariciresinol. Secoisolariciresinol is an enterolignan precursor, it has antioxidant, and estrogen-like activities, it can significantly suppress triglyceride (TG) accumulation in 3T3-L1 adipocytes.

1-Dehydroxy-3,4-dihydroaucubigenin is a triglyceride accumulation inhibitor found in the extract of Tabebuia avellanedae (known as tahibo). It reduces triglyceride levels in adipocytes without exhibiting cytotoxic effects. Additionally, 1-Dehydroxy-3,4-dihydroaucubigenin is applicable in studies related to obesity induced by estrogen deficiency.

Secoisolariciresinol is an enterolignan precursor, it has antioxidant, and estrogen-like activities, it can significantly suppress triglyceride (TG) accumulation in 3T3-L1 adipocytes.

5-Heneicosylresorcinol shows inhibitory effects on the release of β-hexosaminidase from RBL-2H3 cells, it also prevents triglyceride accumulation in 3T3-L1 cells. 5-Heneicosylresorcinol has nematicidal activity against nematodes Panagrellus redivivus, Cae

Dodoviscin A may be a new promising pigmentation-altering agent for cosmetic and therapeutic applications, it can inhibit melanin biosynthesis induced by 3-isobutyl-1-methylxanthine and PD98059.Dodoviscin A can promote adipocyte differentiation as charact

Myricetin-3-O-β-D-xylopyranosyl-(1→2)-β-D-glucopyranoside is a natural product discovered in Sphaerophysa salsula that inhibits triglyceride accumulation in 3T3-L1 adipocytes.

Tetramethylkaempferol is a PPARγ agonist, it can improve insulin sensitivity by increasing the levels of adiponectin, an important adipocytokine associated with insulin sensitivity in adipose tissue. Tetramethylkaempferol can concentration-dependently enh