triacylglycerol lipase

Lipase, triacylglycerol (Alkaline lipase) is a specific enzyme that plays an important role in the catabolism of triacylglycerol to glycerol and fatty acids and is required for the transfer of fatty acids to various tissues of the body, and whose transcriptional receipt of transcripts is subjected to nutrient hormonal regulation and is capable of being upregulated by PPARγ,TNFα downregulation, and insulin-mediated downregulation of FOXO1 nuclear localization.

Orlistat (Tetrahydrolipstatin) is a lipase inhibitor and a fatty acid synthase (FASN) inhibitor. Orlistat has been shown to promote weight loss.

1,3-Dioleoyl-2-octanoyl glycerol, a triacylglycerol, features oleic acid at the sn-1 and sn-3 positions and octanoic acid at the sn-2 position. Its utility lies in the characterization of R. oryzae lipase functionality, specifically for regiodistribution analysis of fats that comprise medium- and short-chain fatty acids.

1,2-Dioleoyl-3-behenoylglycerol (BOO) decreases pancreatic lipase activity and hinders the accumulation of visceral fat as well as hepatic triacylglycerol (TAG) [1].