trans stilbene

trans-Stilbene-D2 is the deuterated form of trans-Stilbene (TN2282). This compound, also known as (E)-Stilbene, is utilized in the production of dye lasers, fluorescent whitening agents, and non-steroidal synthetic estrogens.

3,4,5'-Trihydroxy-3'-methoxy-trans-stilbene (Compound 3) is a stilbene derivative identified in Stuhlmannia moavi. It exhibits moderate anti-proliferative and anti-malarial properties, with IC50 values of 54 μM against A2780 human ovarian cancer cells and 27 μM against Plasmodium falciparum. This compound is applicable in ovarian cancer and malaria research.

trans-Stilbene (1,2-Diphenylethylene (trans)) is a natural product used in the manufacture of dye lasers, optical brighteners, and non-steroidal synthetic estrogens.

trans-Trimethoxyresveratrol (MR-3), a natural methoxylated analog of resveratrol, inhibits breast Y cell invasiveness by downregulation of PI3K/Akt and Wnt/β-catenin signaling cascades and reversal of epithelial-mesenchymal transition.

The nuclear factor-κB (NF-κB) regulates the expression of numerous genes involved in immunity and inflammation, cellular stress responses, growth, and apoptosis. Resveratrol, a polyphenolic trans-stilbene, is a known inhibitor of the activation of NF-κB and exhibits activity against a wide variety of cancer cells. CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 μM compared to 20 μM by resveratrol.