trans stilbene

trans-Stilbene-d2 is the deuterated form of trans-Stilbene. This compound, also known as (E)-Stilbene, is utilized in the production of dye lasers, fluorescent whitening agents, and non-steroidal synthetic estrogens.

trans-Stilbene (1,2-Diphenylethylene (trans)) is a natural product used in the manufacture of dye lasers, optical brighteners, and non-steroidal synthetic estrogens.

trans-Trimethoxyresveratrol (MR-3), a natural methoxylated analog of resveratrol, inhibits breast Y cell invasiveness by downregulation of PI3K/Akt and Wnt/β-catenin signaling cascades and reversal of epithelial-mesenchymal transition.

The nuclear factor-κB (NF-κB) regulates the expression of numerous genes involved in immunity and inflammation, cellular stress responses, growth, and apoptosis. Resveratrol, a polyphenolic trans-stilbene, is a known inhibitor of the activation of NF-κB and exhibits activity against a wide variety of cancer cells. CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 μM compared to 20 μM by resveratrol.