toxicant

Gizzerosine, a biogenic amine formed during feed processing, is a toxicant that induces mortality in livestock.

Emamectin Benzoate (MK-244), by binding gamma-aminobutyric acid (GABA) receptor and glutamate-gated chloride channels disrupting nerve signals within arthropods, acts as a chloride channel activator.

Tebufenpyrad (Comanche) (mitochondrial complex-1 inhibitors) is an agro-chemically important acaricide that functions like the known mitochondrial toxicant rotenone.

Bisphenol A is an endogenous metabolic compound of phenols and is widely used in the production of epoxy resins and polycarbonate plastics. It is reproductive, developmental and systemic toxicant and is often classified as an endocrine disruptor. It has been linked to many diseases, including respiratory disease, cardiovascular disease, diabetes, kidney disease, obesity and reproductive disorders.

Calyculin A ((-)-Calyculin A), a toxicant in the Japanese marine sponge CDiscodermia calyxC, is a selective and potent inhibitor of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A), inducing hyperactivation of cryopreserved bovine spermatozoa and inhibiting radiation-induced gammaH2AX DNA repair disease in human lymphocytes. gammaH2AX DNA repair foci in human lymphocytes.

Dichlobenil (2,6-dichloro-Benzonitrile) is a herbicide widely used for weed control, an olfactory toxicant, and a cellulose biosynthesis inhibitor.

Cholesterol β-D-Glucoside (β-D-Glucopyranoside) is a toxicant produced by the human parasite Helicobacter pylori.

FP-biotin is a potent organophosphorus toxicant ideal for identifying novel biomarkers of organophosphorus exposure. It measures FAAH, ABHD6, and MAG-lipase activity specifically in plasma studies, thanks to the efficient purification of biotinylated peptides through binding to immobilized avidin beads.