thymosin β-4

Thymosin β4 is a thymic hormone with multiple and different intracellular and extracellular activities affecting wound healing, inflammation, fibrosis and tissue regeneration.

Thymosin β4 (cattle), a Ca2+-independent MLCK activator, demonstrates high affinity [1].

Thymosin β4 (cattle) TFA is a high-affinity activator of MLCK that operates independently of Ca2+ [1].

Ac-Ala-OH (N-Acetyl-L-alanine) is a substrate for Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit, Myelin basic protein, GTP-binding nuclear protein Ran, Tropomyosin alpha 4 chain, HIV-1 Rev binding protein 2, Xaa-Pro dipeptidase, Thymosin beta-10, Actin-like protein 3, Alanine aminotransferase, Serine/threonine protein Phosphatase PP1-beta catalytic subunit,10 kDa heat shock protein (mitochondrial), Calmodulin and Beta-1-syntrophin.

LKKTETQ, a peptide segment within thymosin β 4, constitutes the protein's active site responsible for actin binding, cell migration, and wound healing.

TB-500 is a synthesised peptide, essentially a short-chain version of the naturally occurring Thymosin Beta-4.