tco-peg3-tco

TCO-PEG3-TCO is a PEG-based linker commonly used in PROTAC development to connect two essential ligands within a single molecule. By facilitating the formation of bifunctional degraders, TCO-PEG3-TCO linker supports targeted protein degradation through the ubiquitin–proteasome system, enabling precise modulation of intracellular protein levels.

TCO-C3-PEG3-C3-amine is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Amino-bis-PEG3-TCO is a three-unit cleavable polyethylene glycol (PEG) linker utilized in the synthesis of antibody-drug conjugates (ADCs) [1].

DBCO-PEG3-TCO is a non-cleavable three-unit polyethylene glycol (PEG) linker employed for synthesizing antibody-drug conjugates (ADCs) [1].

Gly-Gly-Gly-PEG3-TCO is a cleavable three-unit polyethylene glycol (PEG) linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

(S)-TCO-PEG3-amine is a PEG-based linker for PROTACs, joining two essential ligands to facilitate selective protein degradation via the ubiquitin-proteasome system within cells.

TCO-PEG3-acid, a PEG-based linker for PROTACs, joins two essential ligands crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

TCO-PEG3-alcohol is a PEG-based linker for PROTACs that connects two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation through the ubiquitin-proteasome system within cells.

TCO-PEG3-amide-C3-triethoxysilane is a polyethylene glycol (PEG)-based linker used in the synthesis of proteolysis targeting chimeras (PROTACs) [1].

TCO-PEG3-amine is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

TCO-PEG3-Biotin is a PEG-based cleavable ADC linker for synthesising antibody-drug conjugates (ADCs). Its TCO moiety undergoes click chemistry iEDDA reactions with molecules containing tetrazine groups.

TCO-PEG3-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

TCO-PEG3-NHS ester is a PEG-based linker for PROTACs that joins two essential ligands, crucial for PROTAC molecule formation, enabling selective protein degradation via the ubiquitin-proteasome system [in cells].

TCO-PEG3-oxyamine is a PEG-based linker for PROTACs that joins two essential ligands, facilitating selective protein degradation through the ubiquitin-proteasome system within cells.

TCO-PEG3-CH2-aldehyde, a cleavable 3-unit PEG ADC linker, is employed in the construction of antibody-drug conjugates (ADCs) [1]. This compound serves as a click chemistry reagent and features a TCO group capable of participating in an inverse electron demand Diels-Alder reaction (iEDDA) with molecules that contain Tetrazine groups.

Mal-PEG4-(PEG3-DBCO)-(PEG3-TCO) serves as a 10-unit PEG ADC linker in the fabrication of antibody-drug conjugates (ADCs) [1]. This compound also functions as a click chemistry reagent, featuring a TCO group capable of participating in an inverse electron demand Diels-Alder reaction (iEDDA) with Tetrazine-containing molecules.

(S)-TCO-PEG3-NH2, an ADC linker featuring three PEG units, utilizes its TCO group to facilitate the inverse electron demand Diels-Alder reaction (iEDDA) with tetrazine-group molecules.

TCO-PEG3-aldehyde, a cleavable 3-unit PEG ADC linker, is used in the synthesis of antibody-drug conjugates (ADCs) [1]. This click chemistry reagent contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

TCO-PEG3-Glu-Val-Cit-PABC-MMAF is a linker-drug conjugate composed of a TCO moiety for click chemistry, a PEG linker, a cleavable Glu-Val-Cit bond, a PABC group, and the cytotoxic molecule MMAF. This compound is utilized in the synthesis of dual-drug ADCs.

TCO-PEG3-NH2 is a click chemistry reagent featuring a TCO group, allowing it to participate in an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing tetrazine groups. The amino group of TCO-PEG3-NH2 can react with compounds containing carboxyl, ester, or other active groups to form stable amide bonds, enabling site-specific conjugation or modification of biomolecules.

(S)-TCO-PEG3-acid is a click chemistry PEG linker featuring a terminal carboxylic acid (COOH) group. This terminal carboxylic acid reacts with primary amines to form stable amide bonds. As a PEG-based PROTAC linker, (S)-TCO-PEG3-acid is utilized in the synthesis of PROTACs.

(S)-TCO-PEG8-acid is a click chemistry PEG linker characterized by a terminal carboxylic acid (COOH) group. This terminal group reacts with primary amine groups to form stable amide bonds. As a PEG-based PROTAC linker, (S)-TCO-PEG8-acid is utilized in PROTAC synthesis. It is longer compared to (S)-TCO-PEG3-acid.

TCO4-PEG3-Maleimide is a PROTAC linker of the PEG class. It contains TCO and Maleimide groups, which can undergo specific "click" reactions with tetrazine groups or thiol groups, respectively, or participate in "thiol-Michael" addition.

TCO4-PEG3-Maleimide is a PROTAC linker from the PEG category. It incorporates TCO and Maleimide groups, which can selectively undergo "click" reactions with tetrazine groups or react with thiol groups through a "thiol-maleimide" reaction.